Abstract:
A resistive floating electrode device (RFED) provides a logic cell or non¬ volatile storage or dynamic or static random access memory on an extremely compact matrix with individual cells scalable to the minimum available lithographic feature size regime by providing atomic switches connected in anti-parallel relationship, preferably with a common inert electrode. Programming is facilitated by limiting current to a compliance current level in order to maintain an OB state from which the cell can be written to either the 0 or 1 state. A perfecting feature of the invention provides for selective operation of a cell as a diode or in a volatile or non-volatile storage mode within the same memory array. A series connection of three or more RFEDs in accordance with the invention having different ON state currents, OFF state currents and reset currents can be used as adaptive, neural or chaotic logic cells.
Abstract:
The present invention relates to compounds and methods for inhibiting cancer metastasis. In an embodiment, the compound of the present invention contains the sulfatide binding region of the N-terminal phosphotyrosine binding domain (N-PTB) of Disabled-2 (Dab2).
Abstract:
The present invention provides systems, methods, and devices for electroporation- based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
Abstract:
The present invention relates to esters of diacids and cellulosic materials and methods for making thereof. The ester has the chemical composition of Formula (I) Formula I where R1, R2, and R3 can be the same or different, and each of which is selected from -H, -COR', -R'", or -COR" COOH, with the proviso that at least one of the R1, R2, or R3 is -COR" COOH; R' is an alkyl, alkenyl, alkynyl, or aromatic group; R" is an alkyl, alkenyl, or alkynyl group having 4 or more carbon atoms (≥C 4 ); and R'" is an alkyl, alkenyl, alkynyl, polyol, or aromatic group.
Abstract:
The present invention relates to the field of x-ray imaging. More particularly, embodiments of the invention relate to methods, systems, and apparatus for imaging, which can be used in a wide range of applications, including medical imaging, security screening, and industrial non-destructive testing to name a few. Specifically provided as embodiments of the invention are systems for x-ray imaging comprising: a) a first collimator-and-detector assembly having a first operable configuration to provide at least one first dataset comprising primary x-ray signals as a majority component of its data capable of being presented as a first image of an object subjected to x-ray imaging; b) a second collimator-and-detector assembly having a second operable configuration or wherein the first collimator-and-detector assembly is adjustable to a second configuration to provide at least one second dataset comprising primary and dark- field x-ray signals as a majority component of its data capable of being presented as a second image of the object; and c) a computer operably coupled with the collimator-and- detector assemblies comprising a computer readable medium embedded with processing means for combining the first dataset and the second dataset to extract the dark-field x-ray signals and produce a target image having higher contrast quality than the images based on the first or second dataset alone. Such systems can be configured to comprise at least two collimator-and- detector assemblies or configurations differing with respect to collimator height, collimator aperture, imaging geometry, or distance between an object subjected to the imaging and the collimator-and-detector assembly.
Abstract:
The present invention provides microtubule targeting compounds that are myelo-sparing. Particularly, the MTCs of the invention are structurally designed to exhibit specificity for inhibiting β-tubulin isotypes that are not related to the myelosuppression associated with other known MTCs. The invention further provides pharmaceutical compositions incorporating the inventive MTCs and methods of treating cancer using the MTCs. The invention still further provides various assays for identifying myelo-sparing compounds and determining whether such compounds are indicated for use with specific patients.
Abstract:
Embodiments of the present invention overcome the well-known recalcitrance of lignocellulosic biomass in an economically viable manner. A process and a system are provided for the efficient fractionation of lignocellulosic biomass into cellulose, hemicellulose, and lignin. The cellulose and hemicellulose thus obtained are highly amorphous and can be readily converted into highly concentrated mixtures of five and six carbon sugars using known methods. Typical yields of sugars exceed 100 grams of sugars per liter of sugar solution. Other products, such as alcohols, can easily be prepared according to methods of the invention. The modest process conditions and low solvent/solid ratios of some embodiments of the invention require relatively low capital and processing costs.
Abstract:
The present invention includes insecticidal carbamates that are useful, for example, for the control of insects, such as mosquitoes, which can be used in applications where exposure to and/or contact with humans is likely. The insecticides of the present invention include phenyl TV-methyl carbamates and compositions comprising them that exhibit species-selective inhibition of acetylcholinesterase (AChE) and are preferably toxic to mosquitoes but not humans. Of particular interest are compounds of Formula (I) and Formula (II): Compounds of Formula (I) and Formula (II) are especially suitable for insecticide treated nets and indoor residual spraying for mosquito control.
Abstract:
Supramolecular complexes that target and cleave DNA are provided. The supramolecular complexes include at least one metal-to-ligand charge transfer (MLCT) light absorbing unit, at least one Pt based DNA binding unit, and at least one bridging unit that serves to connect the components. The Pt-based DNA binding unit binds the complex to DNA, and the MLCT unit absorbs light, thereby sensitizing molecular oxygen to produce reactive oxygen species in close proximity to the complex and the bound DNA. The reactive oxygen species cleave the bound DNA.
Abstract:
An electromagnetic vibrator (Figure 2) has a movable magnet (20) that can move linearly in an axial direction. A field coil (28a, 28b) surrounds the movable magnet. Magnetic bumpers (26a, 26bO are disposed on opposite ends of the vibrator, and are oriented to repel the movable magnet.