利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

721 条记录 (耗时 0.017 秒)

    PROCESS FOR THE PREPARATION OF ACETYL-AMIDINIOPHENYLALANYL-CYCLOHEXYLGLYCYL-PYRIDINIOALANINAMIDES
    92.
    发明申请
    PROCESS FOR THE PREPARATION OF ACETYL-AMIDINIOPHENYLALANYL-CYCLOHEXYLGLYCYL-PYRIDINIOALANINAMIDES 审中-公开
    制备乙酰氨基戊二醇 - 环己基氨基 - 吡啶二异氰酸酯的方法

    公开(公告)号：WO01055175A3

    公开(公告)日：2002-02-21

    申请号：PCT/EP2001/000523

    申请日：2001-01-18

    IPC分类号： A61K38/00 ,  A61P7/02 ,  B01J31/24 ,  C07B53/00 ,  C07B61/00 ,  C07C255/60 ,  C07C257/18 ,  C07D213/56 ,  C07D213/58 ,  C07K1/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/068 ,  C07K5/078 ,  C07K5/08 ,  C07K5/09 ,  C07K5/097

    CPC分类号： C07K5/0821 ,  C07K5/06139

    摘要： The present invention relates to a process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides of formula (I), in which the anions X are physiologically acceptable anions, and their analogs, which are effective inhibitors of the blood coagulation factor Xa and which can be used, for example, for preventing thromboses. The process according to the invention comprises the coupling of 2-[2-acetylamino-3-(4-amidinophenyl)propionylamino]-2-cyclohexylacetic acid, which is obtained from 2-[2-acetylamino-3-(4-cyanophenyl)-acryloylamino]-2-cyclohexylacetic acid by asymmetric hydrogenation and conversion of the cyano group into the amidine, or a salt thereof, with a 3-(2-amino-2-carbamoylethyl)-1-methylpyridinium salt or a salt thereof. The invention furthermore provides starting materials and intermediates for this process, processes for their preparation and acetyl-(S)-4-amidiniophenylalanyl-(S)-cyclohexylglycyl-(S)-(1-methyl-3-pyridinio)alaninamide as ditosylate salt.

    摘要翻译： 本发明涉及一种制备式（I）的乙酰基 - 脒基苯脒基 - 环己基甘氨酰 - 吡啶并吡喃酰胺的方法，其中阴离子X是生理上可接受的阴离子，以及它们的类似物，它们是凝血因子Xa的有效抑制剂， 可用于例如用于预防血栓形成。 根据本发明的方法包括2- [2-乙酰氨基-3-（4-脒基苯基）丙酰基氨基] -2-环己基乙酸的偶联，其由2- [2-乙酰氨基-3-（4-氰基苯基） - 丙烯酰基氨基] -2-环己基乙酸，通过不对称氢化，并用3-（2-氨基-2-氨基甲酰基乙基）-1-甲基吡啶鎓盐或其盐将氰基转化成脒或其盐。 本发明还提供了该方法的起始原料和中间体，其制备方法和乙酰基 - （S）-4-脒基苯基丙氨酰 - （S） - 环己基甘氨酰 - （S） - （1-甲基-3-吡啶鎓）丙烯酰胺作为二甲苯磺酸盐 。

    SEPARATION OF REACTION PRODUCTS CONTAINING ORGANOPHOSPHORUS COMPLEXES
    94.
    发明申请
    SEPARATION OF REACTION PRODUCTS CONTAINING ORGANOPHOSPHORUS COMPLEXES 审中-公开
    含有机磷复合物的反应产物的分离

    公开(公告)号：WO0168250A3

    公开(公告)日：2002-01-31

    申请号：PCT/US0108173

    申请日：2001-03-14

    申请人： UNION CARBIDE CHEM PLASTIC

    发明人： ARGYROPOULOS JOHN NICHOLAS ,  KANEL JEFFREY SCOTT ,  TULCHINSKY MICHAEL LEO ,  MILLER DAVID JAMES ,  MORRISON DONALD LEE ,  FOLEY PAUL ,  BRYANT DAVID ROBERT ,  PHILLIPS AILENE GARDNER ,  ROESCH BRIAN MICHAEL ,  BRIGGS JOHN ROBERT ,  LEE MAX MIN ,  MAHER JOHN MICHAEL

    IPC分类号： B01D11/04 ,  B01J23/46 ,  B01J31/18 ,  B01J31/24 ,  B01J31/40 ,  B01J38/00 ,  C07B61/00 ,  C07B63/00 ,  C07C45/50 ,  C07C45/80 ,  C07C47/19 ,  C07F9/02

    CPC分类号： C07C45/50 ,  C07B63/00 ,  Y02P20/582 ,  C07C47/02

    摘要： This invention relates to a process for separating one or more organophosphorus ligand degradation products, one or more reaction byproducts and one or more products from a continuously generated reaction product fluid comprising one or more unreacted reactants, a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, said one or more organophosphorus ligand degradation products, said one or more reaction byproducts, said one or more products, one or more nonpolar solvents and one or more polar solvents by phase separation wherein (i) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more products is expressed by a partition coefficient ratio Ef1 which is a value greater than about 2.5, (ii) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more organosphosphorus ligand degradation products is expressed by a partition coefficient ratio Ef2 which is a value greater than about 2.5, and (iii) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more reaction byproducts is expressed by a partition coefficient ratio Ef3 which is a value greater than about 2.5.

    摘要翻译： 本发明涉及从连续生成的反应产物流体中分离一种或多种有机磷配体降解产物，一种或多种反应副产物和一种或多种产物，所述反应产物流体包含一种或多种未反应的反应物，金属 - 有机磷配体络合物催化剂， 有机磷配体，所述一种或多种有机磷配体降解产物，所述一种或多种反应副产物，所述一种或多种产物，一种或多种非极性溶剂和一种或多种极性溶剂通过相分离，其中（i）非极性相的选择性为 相对于一种或多种产物的有机磷配体由分配系数比Ef1表示，分配系数比Ef1是大于约2.5的值，（ii）非极性相对有机磷配体相对于一种或多种有机磷配体的选择性 降解产物由分配系数比Ef2表示，分配系数比Ef2是值gre 高于约2.5，以及（iii）非极性相对于一种或多种反应副产物的有机磷配体的选择性由大于约2.5的值的分配系数比Ef3表示。

    PREPARATION OF (R)-2-ALKYL-3-PHENYLPROPIONIC ACIDS.
    96.
    发明申请
    PREPARATION OF (R)-2-ALKYL-3-PHENYLPROPIONIC ACIDS. 审中-公开
    （R）-2-烷基-3-苯基丙酸的制备。

    公开(公告)号：WO02002500A1

    公开(公告)日：2002-01-10

    申请号：PCT/CH2001/000397

    申请日：2001-06-26

    IPC分类号： B01J31/24 ,  C07B53/00 ,  C07B61/00 ,  C07C51/36 ,  C07C59/64 ,  C07C59/66 ,  C07C62/34 ,  C07C67/293

    CPC分类号： C07C59/66 ,  C07C51/36

    摘要： Compounds of formula (I), wherein R1 and R2 are, independently of one another, H, C1-C6alkyl, C1-C6halogenalkyl, C1-C6alkoxy, C1-C6alkoxy-C1-C6alkyl, or C1-C6alkoxy-C1-C6alkyloxy, and R3 is C1-C6alkyl, are obtainable in high yields by stereoselective addition of R3-substituted propionic acid esters to R1- and R2-substituted benzaldehydes of formula R-CHO to form corresponding 3-R-3-hydroxy-2-R3-propionic acid esters, conversion of the OH group to a leavaing group, subsequent regioselective elimination to form 3-R-2-R3-propenic acid esters, and their hydrolysis to form corresponding propenic carboxylic acids and their enantioselective hydrogenation, wherein R is (a).

    摘要翻译： 式（I）化合物，其中R 1和R 2彼此独立地为H，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 1 -C 6烷氧基，C 1 -C 6烷氧基-C 1 -C 6烷基或C 1 -C 6烷氧基-C 1 -C 6烷氧基， R 3是C 1 -C 6烷基，可以通过立体选择性地将R 3取代的丙酸酯加成到式R-CHO的R 1和R 2取代的苯甲醛以高产率获得，形成相应的3-R-3-羟基-2-R3-丙酸 酸酯，OH基转化为脱氯基团，随后进行区域选择性消除以形成3-R-2-R3-丙烯酸酯，并且它们的水解形成相应的丙烯羧酸及其对映选择性氢化，其中R为（a） 。

    BIDENTATE LIGANDS USEFUL IN CATALYST SYSTEM
    98.
    发明申请
    BIDENTATE LIGANDS USEFUL IN CATALYST SYSTEM 审中-公开
    催化剂体系中有争议的配偶

    公开(公告)号：WO01087899A1

    公开(公告)日：2001-11-22

    申请号：PCT/EP2001/005625

    申请日：2001-05-16

    IPC分类号： B01J31/26 ,  B01J31/24 ,  C07B61/00 ,  C07C29/16 ,  C07C31/02 ,  C07C45/50 ,  C07C47/02 ,  C07C67/38 ,  C07F9/50 ,  C07F9/6568 ,  C07F9/6571

    CPC分类号： C07F9/657163 ,  C07C45/50 ,  C07C67/38 ,  C07F9/5027 ,  C07F9/65683 ,  C07C69/54 ,  C07C69/24 ,  C07C47/02

    摘要： Bidentate ligand of formula (II) R R M -R-M R R , wherein M and M are independently P, As or Sb; R , R , R and R independently represent tertiary alkyl groups, or R and R together and/or R and R together represent an optionally substituted bivalent cycloaliphatic group whereby the two free valencies are linked to M or M , and R represents a bivalent aliphatic bridging group containing from 2 to 6 atoms in the bridge, which is substituted with two or more substituents. A catalyst system comprising: a) a source of group VIII metal cations, b) a source of such a bidentate ligand, and c) a source of anions. Use of such a catalyst system in a process for the carbonylation of optionally substituted ethylenically or acetylenically unsaturated compounds by reaction with carbon monoxide and a coreactant.

    摘要翻译： 式（II）的二齿配体R 1 R 2 M 1 -R M 2 R 3，其中M 1和M 2独立地是P，As或Sb ; R 1，R 2，R 3和R 4独立地表示叔烷基，或者R 1和R 2一起和/或R 3和R 4一起代表 任选取代的二价脂环族基团，其中两个自由价与M 1或M 2连接，R表示桥中含有2至6个原子的二价脂族桥基，其被两个或多个取代基取代 。 一种催化剂体系，其包括：a）第VIII族金属阳离子源，b）这种二齿配体的源，和c）阴离子源。 在通过与一氧化碳和共反应物反应的羰基化任选取代的烯属或炔属不饱和化合物的方法中使用这种催化剂体系。