公开(公告)号：WO01077182A1

公开(公告)日：2001-10-18

申请号：PCT/JP2001/003017

申请日：2001-04-06

IPC: C07K16/26 ,  C07K17/06 ,  G01N33/543 ,  G01N33/544 ,  G01N33/545 ,  G01N33/546 ,  G01N33/547 ,  G01N33/548 ,  G01N33/549 ,  G01N33/551 ,  G01N33/552 ,  G01N33/553 ,  G01N33/554 ,  G01N33/555 ,  G01N33/556

CPC classification number: C07K17/06 ,  C07K16/26 ,  G01N33/54353

Abstract: An antibody/carrier complex which makes it possible to easily control the sensitivity in an antigen-antibody reaction without newly constructing an antibody. This antibody/carrier complex is a complex containing at least one antibody and has a polymer structure wherein each antigen-binding site of the antibody is arranged so as to react with the antigen.

Abstract translation: 抗体/载体复合物，其能够容易地控制抗原抗体反应的敏感性而不新构建抗体。 该抗体/载体复合物是含有至少一种抗体的复合物，并且具有聚合物结构，其中抗体的每个抗原结合位点被排列成与抗原反应。

公开(公告)号：WO0121825A3

公开(公告)日：2001-10-18

申请号：PCT/US0026042

申请日：2000-09-22

Applicant: GENENCOR INT ,  UNIV GEORGIA RES FOUND

Inventor： SEYFRIED MARKUS ,  WIEGEL JUERGEN ,  WHITED GREGORY

IPC: C12N15/09 ,  C12N1/02 ,  C12N1/20 ,  C12N1/21 ,  C12N9/02 ,  C12N9/04 ,  C12N9/88 ,  C12P7/18 ,  C12P7/62 ,  C12Q1/68 ,  C12R1/01 ,  C12P7/04 ,  C08G63/78 ,  C08G63/82 ,  C08G63/87 ,  G01N33/554 ,  G01N33/569

CPC classification number: C12N9/0004 ,  C12N9/88 ,  C12P7/18

Abstract: The present invention relates to improved methods and reagents for the production of 1,3-propanediol. In particular, the present invention provides novel thermophilic organisms and thermostable enzymes capable of catalyzing the fermentation of glycerol to 1,3-propanediol. The present invention also relates to methods of isolating such thermophilic organisms, methods of cloning polynucleotides that encode such enzymes, polynucleotides encoding such enzymes, and methods of using such enzymes and organisms for the production of 1,3-propanediol.

Abstract translation: 本发明涉及用于生产1,3-丙二醇的改进的方法和试剂。 具体而言，本发明提供了能够催化甘油发酵成1,3-丙二醇的新型嗜热有机体和热稳定酶。 本发明还涉及分离这种嗜热生物体的方法，克隆编码这些酶的多核苷酸的方法，编码这些酶的多核苷酸以及使用这些酶和生物体生产1,3-丙二醇的方法。

公开(公告)号：WO0050633A9

公开(公告)日：2001-10-11

申请号：PCT/US0004925

申请日：2000-02-24

Applicant: GEN HOSPITAL CORP ,  SEED BRIAN ,  TING ADRIAN

Inventor： SEED BRIAN ,  TING ADRIAN

IPC: A61K38/00 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  C07K14/47 ,  C07K14/705 ,  C12N5/10 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/566 ,  G01N33/68 ,  C12Q1/00 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12N5/00 ,  C12N5/02 ,  C12N7/00 ,  C12Q1/66 ,  C12Q1/70 ,  G01N33/554

CPC classification number: C12Q1/6897 ,  G01N33/5011 ,  G01N33/6872

Abstract: The invention features a method of identifying a polypeptide which increases gene expression from a promoter, including (a) contacting a library of polypeptides with a cell that expresses a recombinant anti-cell death gene and that contains a reporter gene operably linked to a promoter (as shown in the figure), whereby expression of the reporter gene is increased if the library includes a polypeptide which increases gene expression from the promoter; (b) determining whether the reporter gene expression is increased in the cell as a result of contact with the polypeptide library; and (c) if reporter gene expression is increased, identifying a polypeptide of the library which increases reporter gene expression.

Abstract translation: 本发明的特征在于一种识别从启动子增加基因表达的多肽的方法，包括（a）使多肽文库与表达重组抗细胞死亡基因的细胞接触并含有与启动子可操作地连接的报告基因（ 如图所示），如果文库包括增加启动子基因表达的多肽，则报告基因的表达增加; （b）由于与多肽文库的接触，确定该细胞中报告基因表达是否增加; 和（c）如果报道基因表达增加，鉴定增加报道基因表达的文库多肽。

公开(公告)号：WO01002013A1

公开(公告)日：2001-01-11

申请号：PCT/US2000/018261

申请日：2000-06-30

IPC: A61K49/00 ,  A61K45/00 ,  A61K47/00 ,  C12Q1/00 ,  G01N33/53 ,  G01N33/554 ,  G01N33/555 ,  G01N33/567 ,  G01N33/569

CPC classification number: A61K49/0006

Abstract: The present invention in the field of immunotherapy, provides a method for predicting the likelihood of tumor shrinkage in response to administration of immunotherapeutic agents to patients having tumors or cancer, especially lymphoma or myeloma. The present invention further provides methods for optimizing a beneficial outcome of immunotherapy for treating cancer, immune system diseases and infections diseases in an anergic patient by boosting the immune responsiveness of the patient before beginning the immunotherapy, and methods for determining the optimum amount and schedule of an immunotherapeutic agent to administer to treat cancer and immune diseases.

Abstract translation: 本发明在免疫治疗领域中提供了一种用于预测响应于对具有肿瘤或癌症，特别是淋巴瘤或骨髓瘤的患者给予免疫治疗剂而引起肿瘤缩小的可能性的方法。 本发明还提供了通过在开始免疫治疗之前增强患者的免疫反应性来优化用于治疗无效患者的癌症，免疫系统疾病和感染性疾病的免疫治疗的有益结果的方法，以及用于确定最佳量和时间表的方法 用于治疗癌症和免疫疾病的免疫治疗剂。

公开(公告)号：WO00072014A1

公开(公告)日：2000-11-30

申请号：PCT/US2000/014137

申请日：2000-05-24

IPC: G01N33/50 ,  G01N33/53 ,  G01N33/554 ,  G01N33/567

CPC classification number: G01N33/5085 ,  G01N2333/43552

Abstract: The present invention relates to a method of detecting and quantifying a contaminant in a sample utilizing an insect based bioassay system. The method comprises exposing insect hemocytes, either in vivo or in vitro , to the sample to be tested followed by analyzing the cellular and biochemical behavior of the cells in the hemolymph subsequent to the exposure.

Abstract translation: 本发明涉及利用基于昆虫的生物测定系统来检测和定量样品中污染物的方法。 该方法包括将体内或体外的昆虫血细胞暴露于待测试的样品，然后分析随后的血淋巴中的细胞的细胞和生物化学行为 曝光。

公开(公告)号：WO00056355A1

公开(公告)日：2000-09-28

申请号：PCT/US2000/006607

申请日：2000-03-14

IPC: C07K14/195 ,  C12N9/12 ,  G01N33/58 ,  A61K39/00 ,  A61K39/395 ,  C07K1/00 ,  G01N30/02 ,  G01N33/53 ,  G01N33/554

CPC classification number: C12N9/1223 ,  C07K14/195 ,  G01N33/582

Abstract: This invention provides new fluorescent molecules useful for detection of target entities. In particular, it relates to fluorescent adducts comprising an apoprotein and a bilin.

Abstract translation: 本发明提供了用于检测靶物质的新的荧光分子。 特别涉及包含载脂蛋白和胆汁的荧光加合物。

公开(公告)号：WO00023792A1

公开(公告)日：2000-04-27

申请号：PCT/US1999/017589

申请日：1999-08-04

IPC: C12M1/12 ,  C12N1/02 ,  C12Q1/24 ,  G01N33/569 ,  G01N21/77 ,  C12M1/00 ,  C12N1/10 ,  C12N1/12 ,  C12N1/14 ,  C12N1/16 ,  C12N1/18 ,  C12N1/20 ,  C12Q1/04 ,  C12Q1/68 ,  G01N33/44 ,  G01N33/53 ,  G01N33/531 ,  G01N33/537 ,  G01N33/543 ,  G01N33/545 ,  G01N33/549 ,  G01N33/554 ,  G01N33/566 ,  G01N33/567

CPC classification number: G01N33/569 ,  C12M47/02 ,  C12N1/02 ,  C12Q1/24

Abstract: A method for concentrating a particular microorganism or microorganisms of interest in a sample is provided and effected by contacting the sample with a matrix to which is bound an affinity receptor specific for the particular microorganism or microorganisms, the affinity receptor and the matrix being selected so as to allow capture of the microorganism or microorganisms to the matrix via the affinity receptor when present in the sample at a concentration of ultra low levels, thereby obviating the need for a prolonged pre-enrichment step, and in some cases obviating altogether the need for a pre-enrichment step, of the microorganism or microorganisms in the sample.

Abstract translation: 提供了将样品中特定微生物或微生物浓缩的方法，通过将样品与特定微生物或微生物特异的亲和受体结合的基质接触，将亲和受体和基质选择为 以允许微生物或微生物通过亲和性受体以超低浓度浓度存在于样品中，从而避免需要延长的预富集步骤，并且在某些情况下完全消除了对于 样品中的微生物或微生物的预富集步骤。

公开(公告)号：WO00012133A1

公开(公告)日：2000-03-09

申请号：PCT/US1999/020070

申请日：1999-09-01

IPC: G01N33/50 ,  A61K31/711 ,  A61K38/00 ,  A61K39/00 ,  A61K39/095 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P31/04 ,  C07K14/22 ,  C07K16/22 ,  C12N15/09 ,  C12R1/19 ,  G01N33/15 ,  G01N33/53 ,  G01N33/569 ,  A61K39/02 ,  A61K39/40 ,  C07H21/02 ,  C07H21/04 ,  C07K1/00 ,  C07K16/00 ,  C12N15/00 ,  C12Q1/00 ,  C12Q1/68 ,  G01N33/554

CPC classification number: C07K14/22 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00

Abstract: The invention discloses the Neisseria spp. NGSP polypeptide, polypeptides derived therefrom (NGSP-derived polypeptides), nucleotide sequences encoding said polypeptides, and antibodies that specifically bind the NGSP polypeptide and/or NGSP-derived polypeptides. Also disclosed are prophylactic or therapeutic compositions, including antigenic, preferably immunogenic compositions, e.g., vaccines, comprising NGSP polypeptide and/or a NGSP-derived polypeptide or antibodies thereto. The invention additionnally discloses methods of inducing an immune response to Neisseria and Neisseria NGSP polypeptide and an NGSP-derived polypeptide in animals.

Abstract translation: 本发明公开了奈瑟氏菌属 NGSP多肽，源自其的多肽（NGSP衍生的多肽），编码所述多肽的核苷酸序列，以及特异性结合NGSP多肽和/或NGSP衍生多肽的抗体。 还公开了预防或治疗组合物，包括抗原性，优选免疫原性组合物，例如包含NGSP多肽和/或NGSP衍生的多肽或其抗体的疫苗。 本发明另外公开了在动物中诱导针对奈瑟球菌和奈瑟氏球菌NGSP多肽和NGSP衍生多肽的免疫应答的方法。