CHEMICAL PRODUCTION MODULE AND DOSE SYNTHESIS CARD FOR PET BIOMARKER PRODUCTION SYSTEM
    13.
    发明申请
    CHEMICAL PRODUCTION MODULE AND DOSE SYNTHESIS CARD FOR PET BIOMARKER PRODUCTION SYSTEM 审中-公开
    PET生物标记生产系统的化学生产模块和剂量合成卡

    公开(公告)号:WO2011037615A1

    公开(公告)日:2011-03-31

    申请号:PCT/US2010/002577

    申请日:2010-09-21

    Abstract: A microfluidic radiopharmaceutical production system and process for synthesizing per run approximately one (1) to four (4) unit dose of a radiopharmaceutical biomarker for use in positron emission tomography (PET). The system includes a reaction vessel that receives a radioisotope from an accelerator or other radioisotope generator. Organic and aqueous reagents are introduced into the reaction vessel, and the mixture is heated to synthesize a solution of a pre-selected radiopharmaceutical. The radiopharmaceutical solution is passed through a solid phase extraction column and a filter for purification. The synthesis process reduces waste and allows for the production of radiopharmaceutical on an as-needed basis. The synthesis process allows for production on-site and close to the location where the unit dose will be administered to the patient, which reduces time between synthesis and administration, thereby minimizing the loss of active isotopes through decay and allowing the production of lesser amounts of radioisotopes overall.

    Abstract translation: 一种微流体放射性药物生产系统和用于合成每个运行大约一(1)至4(4)个单位剂量的用于正电子发射断层摄影(PET)的放射性药物生物标志物的微流体放射性药物生产系统和方法。 该系统包括从加速器或其它放射性同位素发生器接收放射性同位素的反应容器。 将有机和含水试剂引入反应容器中,并加热混合物以合成预先选择的放射性药物的溶液。 放射性药物溶液通过固相萃取柱和净化过滤器。 合成过程减少浪费,并允许根据需要生产放射性药物。 该合成方法允许在现场生产并且靠近将向患者施用单位剂量的位置,这减少了合成和给药之间的时间,从而通过衰变使活性同位素的损失最小化,并允许产生较少量的 放射性同位素整体。

    MICROREACTOR PROCESS FOR MAKING BIODIESEL
    15.
    发明申请
    MICROREACTOR PROCESS FOR MAKING BIODIESEL 审中-公开
    生物物质微生物过程

    公开(公告)号:WO2007142983A2

    公开(公告)日:2007-12-13

    申请号:PCT/US2007012763

    申请日:2007-05-30

    Abstract: Embodiments of a method for using a microreactor to produce biodiesel. For example, the method may comprise flowing a first fluid comprising an alcohol and a second fluid comprising an oil to the microreactor. Alcohols typically, but not necessarily, are lower aliphatic alcohols, including methanol, ethanol, propanol, butanol, amyl alcohol or combinations thereof. Biodiesel production can be under supercritical conditions, where such conditions typically are determined relative to the alcohol component. Suitable sources of oil products include soy, inedible tallow and grease, corn, edible tallow and lard, cotton, rapeseed, sunflower, canola, peanut, safflower, and combinations thereof. Catalysts can be used to facilitate biodiesel production, such as metal oxides, metal hydroxides, metal carbonates, alcoholic metal carbonates, alkoxides, mineral acids and enzymes. Oil conversion to biodiesel typically increases with increasing mean microreactor residence time. Certain embodiments of the present invention include blending biodiesel produced by the method with petroleum-based products.

    Abstract translation: 使用微反应器生产生物柴油的方法的实施方案。 例如,该方法可以包括将包含醇的第一流体和包含油的第二流体流动到微反应器。 醇通常但不一定是低级脂族醇,包括甲醇,乙醇,丙醇,丁醇,戊醇或其组合。 生物柴油生产可以在超临界条件下,其中通常相对于醇组分确定这些条件。 石油产品的合适来源包括大豆,不可食用的牛脂和油脂,玉米,食用油脂和猪油,棉花,油菜籽,向日葵,卡诺拉,花生,红花及其组合。 催化剂可用于促进生物柴油生产,例如金属氧化物,金属氢氧化物,金属碳酸盐,醇金属碳酸盐,醇盐,无机酸和酶。 石油转化为生物柴油通常随着平均微反应器停留时间的增加而增加。 本发明的某些实施方案包括将通过该方法生产的生物柴油与石油基产物混合。

    成分分離デバイスおよび成分の分離方法
    16.
    发明申请
    成分分離デバイスおよび成分の分離方法 审中-公开
    组件分离装置和分离组件的方法

    公开(公告)号:WO2006115241A1

    公开(公告)日:2006-11-02

    申请号:PCT/JP2006/308542

    申请日:2006-04-24

    Abstract:  成分分離デバイス(30)は、基板(31)と基板(31)に設けられた流路(32)とアクチュエータ(39)とアクチュエータ(39)の周囲に設けられた溝(35)とを有し、流路(32)は、液体成分と固形成分とを含有する流体を収納し、アクチュエータ(39)は流路(32)内に定在波を発生させる。この構成により、振動が溝で反射し流路(32)側へ伝達されることによって振動ロスが低減され、流路(32)内に強度の強い定在波が発生し、小型、高精度な成分分離デバイス(30)が提供される。

    Abstract translation: 部件分离装置(30)具有板(31),设置在板(31)中的流路(32),致动器(39)和设置在致动器(39)周围的槽(35)。 流路(32)接收含有液体成分和固体成分的流体。 致动器(39)在流路(32)中产生静止波。 该结构使得振动被凹槽反射并传递到流路(32)侧,这减少了振动损失并在流路(32)中产生强烈的静止波。 部件分离装置(30)尺寸小,精度高。

    MICROREACTORS INCORPORATING INTERPENETRATING AND/OR SEMI-INTERPENETRATING POLYMERS
    17.
    发明申请
    MICROREACTORS INCORPORATING INTERPENETRATING AND/OR SEMI-INTERPENETRATING POLYMERS 审中-公开
    混合和/或半嵌段聚合物的微生物

    公开(公告)号:WO2006044368A1

    公开(公告)日:2006-04-27

    申请号:PCT/US2005/036508

    申请日:2005-10-12

    Abstract: The present disclosure includes description of chemical, biological, and/or biochemical reactor chips and/or reaction systems such as a microreactor systems having interpenetrating and/or semi-interpenetrating polymer networks, as well as methods for constructing and using such systems. In some cases, the interpenetrating and/or semi-interpenetrating polymer networks may be used to determine analytes, for example, by the incorporation of a reaction entity to a interpenetrating and/or semi-interpenetrating polymer network able to interact with the analytes, which may be physically included within the network (for example, physically entagled), or chemically bonded to a polymer within the network (for example, cross-linked) in some cases. In certain embodiments, a chip and/or a reaction system may be constructed so as to promote cell growth within it. In some embodiments, the chip and/or reaction system may include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In certain embodiments, a chip and/or reaction system is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO 2 concentration, O 2 concentration, relative humidity, pH, etc., associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In certain embodiments, the disclosed devices can employ light-interacting components. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.

    Abstract translation: 本公开内容包括化学,生物和/或生物化学反应堆芯片和/或反应系统的描述,例如具有互穿和/或半互穿聚合物网络的微反应器系统,以及用于构建和使用这种系统的方法。 在一些情况下,互穿和/或半互穿聚合物网络可以用于确定分析物,例如通过将反应实体并入能够与分析物相互作用的互穿和/或半互穿聚合物网络,其中 可能物理上包括在网络内(例如,物理上陷入困境),或者在某些情况下化学键合到网络内的聚合物(例如交联)。 在某些实施方案中,可以构建芯片和/或反应系统以促进细胞内的细胞生长。 在一些实施方案中,芯片和/或反应系统可以包括一个或多个反应位点。 反应位点可以非常小,例如,体积小于约1ml。 在某些实施方案中,芯片和/或反应系统能够检测,测量和/或控制环境因素,例如温度,压力,CO

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