公开(公告)号：WO1993003709A1

公开(公告)日：1993-03-04

申请号：PCT/US1992004225

申请日：1992-05-19

Applicant: VICAL, INC.

Inventor： VICAL, INC. ,  FELGNER, Philip, L. ,  ABAI, Anna, M. ,  MANTHORPE, Marston, C.

IPC: A61K09/127

CPC classification number: C07K14/4712 ,  A61K9/1271 ,  A61K9/1272 ,  A61K38/465 ,  A61K47/543 ,  A61K48/00 ,  C12Y301/21001 ,  A61K2300/00

Abstract: Disclosed is a pharmaceutical composition suitable for the pulmonary administration of therapeutically effective amounts of DNase, a macromolecule operatively coding for a functional protein to remedy the cellular defect associated with cystic fibrosis and sufficient lipid to form cationic complexes with the macromolecule, effective to deliver the macromolecule into pulmonary cells in vivo. Additionally disclosed are methods for the treatment of cystic fibrosis.

Abstract translation: 公开了适用于肺部给予治疗有效量的DNA酶的药物组合物，其是可操作地编码功能性蛋白质的大分子，用于补救与囊性纤维化相关的细胞缺陷和足够的脂质与大分子形成阳离子配合物，有效递送大分子 在体内进入肺细胞。 另外公开了治疗囊性纤维化的方法。

公开(公告)号：WO2017127830A1

公开(公告)日：2017-07-27

申请号：PCT/US2017/014612

申请日：2017-01-23

Applicant: PUYO, Carlos A.

Inventor： PUYO, Carlos A.

IPC: A61K45/06 ,  A61P29/00 ,  A61P31/00

CPC classification number: A61K31/4706 ,  A61K31/198 ,  A61K38/465 ,  C12Y301/21001 ,  A61K2300/00

Abstract: Disclosed are compositions, medical devices and methods for ameliorating sterile injury due object use in a subject in need thereof. More particularly, the present disclosure relates to compositions including N-Acetylcysteine and an aminoquinoline. The present disclosure also relates to compositions including an endonuclease and an aminoquinoline. The present disclosure also relates to medical devices including a coating comprising N-Acetylcysteine, an aminoquinoline, an endonuclease, and combinations thereof.

Abstract translation: 公开了用于改善有此需要的受试者中由于物体使用导致的无菌伤害的组合物，医疗装置和方法。 更具体地说，本公开涉及包含N-乙酰半胱氨酸和氨基喹啉的组合物。 本公开还涉及包含内切核酸酶和氨基喹啉的组合物。 本公开还涉及包括包含N-乙酰半胱氨酸，氨基喹啉，内切核酸酶及其组合的涂层的医疗装置。

公开(公告)号：WO2017060505A1

公开(公告)日：2017-04-13

申请号：PCT/EP2016/074115

申请日：2016-10-07

Applicant: NOVOZYMES A/S

Inventor： GJERMANSEN, Morten ,  GORI, Klaus ,  GEERTZ-HANSEN, Henrik, Marcus ,  SALOMON, Jesper ,  STRINGER, Mary, Ann ,  BLICHER, Thomas, Holberg ,  SPODSBERG, Nikolaj

IPC: C12N9/22 ,  C11D3/386 ,  C11D3/48

CPC classification number: C12N9/22 ,  C11D3/38636 ,  C11D3/38681 ,  C11D11/0017 ,  C12Y301/21 ,  C12Y301/21001

Abstract: The present invention relates to polypeptides, nucleotides encoding the polypeptide, as well as methods of producing the polypeptides. The present invention also relates to detergent composition comprising polypeptides, a laundering method and the use of polypeptides.

Abstract translation: 本发明涉及多肽，编码该多肽的核苷酸，以及生产该多肽的方法。 本发明还涉及包含多肽的洗涤剂组合物，洗涤方法和多肽的用途。

公开(公告)号：WO2016176240A1

公开(公告)日：2016-11-03

申请号：PCT/US2016/029425

申请日：2016-04-27

Applicant: THE PROCTER & GAMBLE COMPANY

Inventor： LANT, Neil, Joseph ,  WOOD, Rebecca, Louise ,  GUMMEL, Jeremie, Robert Marcel

IPC: C11D3/386

CPC classification number: C11D3/38618 ,  C11D3/38627 ,  C11D3/38636 ,  C11D3/38645 ,  C11D11/0017 ,  C12Y301/21001 ,  C12Y301/30002 ,  C12Y302/01052

Abstract: A method of treating a textile in which a textile is contacted with an aqueous solution comprising a nuclease enzyme, preferably a deoxyribonuclease or ribonuclease enzyme and low levels of alkyl benzene sulphonate surfactant, and optionally rinsing and drying the textile.

Abstract translation: 一种处理纺织品的方法，其中织物与包含核酸酶，优选脱氧核糖核酸酶或核糖核酸酶和低水平烷基苯磺酸盐表面活性剂的水溶液接触，并任选地漂洗和干燥纺织品。

公开(公告)号：WO2016118476A1

公开(公告)日：2016-07-28

申请号：PCT/US2016/013847

申请日：2016-01-19

Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION

Inventor： WAGNER, Denisa D. ,  WONG, Siu Ling

IPC: A61K38/46

CPC classification number: C12Y301/21001 ,  A61K38/465

Abstract: Embodiments of the technology described herein are based, in part, upon the discovery that NETosis, the formation of neutrophil extracellular traps (NETs) is increased in wounds, in organ fibrosis and in subjects with diabetes. Accordingly, methods for treating wounds, fibrosis and NET associated complications in diabetes are provided. The methods comprise administrating a therapeutically effective amount of at least one anti-NET compound to a subject in need of treatment, e.g. a PAD 4 inhibitor, a DNase, a histone-degrading enzyme; an inhibitor of chromatin decondensation; an antibody against a component of a NET; an inhibitor of NET release, a protease inhibitor, or an elastase inhibitor.

Abstract translation: 本文描述的技术的实施方案部分地基于NETosis的发现，中性粒细胞胞外捕获物（NETs）的形成在伤口，器官纤维化和糖尿病受试者中增加。 因此，提供了治疗糖尿病中的伤口，纤维化和NET相关并发症的方法。 所述方法包括向需要治疗的受试者施用治疗有效量的至少一种抗NET化合物，例如， PAD4抑制剂，DNA酶，组蛋白降解酶; 染色质解链抑制剂; 针对NET组分的抗体; NET释放抑制剂，蛋白酶抑制剂或弹性蛋白酶抑制剂。

公开(公告)号：WO2015181286A1

公开(公告)日：2015-12-03

申请号：PCT/EP2015/061828

申请日：2015-05-28

Applicant: NOVOZYMES A/S

Inventor： BALTSEN, Lilian Eva Tang ,  ALLESEN-HOLM, Marie ,  GORI, Klaus

IPC: C11D3/386

CPC classification number: C11D3/38636 ,  C11D3/0036 ,  C11D3/0068 ,  C12Y301/21001 ,  D06L4/40

Abstract: The present invention concerns the use of a polypeptide having deoxyribonuclease (DNase) activity for preventing or reducing redeposition of soil on an item during a subasequent cleaning or laundering process. The invention further concerns a detergent composition comprising a polypeptide having deoxyribonuclease (DNase) activity and a method for preventing or reducing redeposition of soil on an item during a subsequent cleaning or laundering process.

Abstract translation: 本发明涉及具有脱氧核糖核酸酶（DNA酶）活性的多肽在次要清洗或洗涤过程中用于预防或减少物品在物品上的再沉积的用途。 本发明还涉及包含具有脱氧核糖核酸酶（DNA酶）活性的多肽的洗涤剂组合物和在随后的清洗或洗涤过程中防止或减少物品上的物质再沉积的方法。

公开(公告)号：WO2014205187A1

公开(公告)日：2014-12-24

申请号：PCT/US2014/043131

申请日：2014-06-19

Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： BACHRAN, Christopher H. ,  LEPPLA, Stephen H.

IPC: B82Y5/00 ,  C07K14/32 ,  C12N15/62

CPC classification number: C12N9/22 ,  A61K38/164 ,  A61K38/465 ,  A61K38/4886 ,  A61K47/6415 ,  C07K14/285 ,  C07K14/32 ,  C07K2319/55 ,  C12N9/54 ,  C12Y301/00 ,  C12Y301/21001 ,  C12Y304/24083

Abstract: Disclosed is a protein comprising a cytolethal distending toxin subunit B (CdtB) conjugated or fused to a Bacillus anthracis toxin lethal factor (LF) or a functional portion of LF. Related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, methods of treating or preventing cancer, and methods of inhibiting the growth of a target cell are also disclosed.

Abstract translation: 公开了包含与炭疽杆菌毒素致死因子（LF）或LF功能部分共轭或融合的细胞致死性扩张毒素亚基B（CdtB）的蛋白质。 还公开了相关嵌合分子以及相关核酸，重组表达载体，宿主细胞，细胞群，药物组合物，治疗或预防癌症的方法，以及抑制靶细胞生长的方法。

公开(公告)号：WO2014009744A1

公开(公告)日：2014-01-16

申请号：PCT/GB2013/051858

申请日：2013-07-12

Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW

Inventor： WALKER, Daniel ,  SMITH, Karen

IPC: A61K38/16 ,  A23L1/30 ,  A61P1/00 ,  A61P31/04

CPC classification number: A61K38/164 ,  A23L33/127 ,  A23L33/135 ,  A23V2002/00 ,  A61K31/7088 ,  A61K35/74 ,  C07K14/245 ,  C12N9/22 ,  C12Y301/21001 ,  Y02A50/473

Abstract: The Invention relates to materials and methods for the treatment of conditions associated with bacterial biofilms, intracellular bacterial infections and/or adherent-invasive Escherichia coli infections, including Crohns' disease. In particular,, the invention relates to the use of colicins and bacteria producing colicins, for the treatment of such conditions.

Abstract translation: 本发明涉及用于治疗与细菌生物膜，细胞内细菌感染和/或粘附侵入性大肠杆菌感染（包括克罗恩病）相关的病症的材料和方法。 特别地，本发明涉及使用大肠杆菌和大肠杆菌的细菌，用于治疗这些病症。

公开(公告)号：WO2013114371A8

公开(公告)日：2013-10-10

申请号：PCT/IL2013050094

申请日：2013-01-31

Applicant: PROTALIX LTD

Inventor： SHAALTIEL YOSEPH ,  HANANIA URI ,  KIZHNER TALI ,  MATIUHIN YULIA ,  FUX LIAT ,  SHULMAN AVIDOR

IPC: C12N9/22

CPC classification number: A61K38/465 ,  A61K9/007 ,  A61K9/0075 ,  A61K9/14 ,  A61K33/06 ,  A61K33/14 ,  A61K38/47 ,  A61K45/06 ,  C12N9/22 ,  C12N15/8221 ,  C12N15/8257 ,  C12Y301/21001 ,  C12Y302/01052

Abstract: DNase I formulations for pulmonary administration and, more particularly, but not exclusively, a dry powder formulation comprising, as an active ingredient, human DNase I, methods, dry powder inhalation devices and systems for the therapeutic use thereof are provided.

Abstract translation: 提供了用于肺部给药的DNase I制剂，更具体地但不排他地提供了包含作为活性成分的人类DNase I，方法，干粉吸入装置和用于其治疗用途的系统的干粉制剂。

公开(公告)号：WO2009015286A2

公开(公告)日：2009-01-29

申请号：PCT/US2008071055

申请日：2008-07-24

Applicant: NEXBIO INC ,  MALAKHOV MICHAEL ,  FANG FANG

Inventor： MALAKHOV MICHAEL ,  FANG FANG

CPC classification number: A61K9/1682 ,  A61K9/0048 ,  A61K9/0075 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/19 ,  A61K9/5089 ,  A61K31/198 ,  A61K31/337 ,  A61K31/343 ,  A61K31/405 ,  A61K31/43 ,  A61K31/555 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/65 ,  A61K31/7036 ,  A61K31/721 ,  A61K31/724 ,  A61K35/76 ,  A61K38/08 ,  A61K38/12 ,  A61K38/14 ,  A61K38/168 ,  A61K38/1709 ,  A61K38/1808 ,  A61K38/38 ,  A61K38/385 ,  A61K38/42 ,  A61K38/465 ,  A61K38/47 ,  A61K38/4826 ,  C07D305/14 ,  C07K9/008 ,  C07K14/765 ,  C12N7/00 ,  C12N9/96 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/50 ,  C12N2330/30 ,  C12N2770/00021 ,  C12N2770/00051 ,  C12Y301/21001 ,  C12Y301/27005 ,  C12Y302/00 ,  C12Y302/01017 ,  C12Y302/01018 ,  C12Y304/21004

Abstract: Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

Abstract translation: 通过使溶剂中的大分子或小分子溶液与反溶剂和抗衡离子接触并冷却溶液来制备微球。 微球可用于制备具有限定尺寸的药物，营养品，化妆品等。