公开(公告)号：WO2009070720A1

公开(公告)日：2009-06-04

申请号：PCT/US2008/084952

申请日：2008-11-26

Applicant: ORGANOGENESIS, INC. ,  WANG, Xianyan ,  FARIA, Katherine, C.

Inventor： WANG, Xianyan ,  FARIA, Katherine, C.

IPC: C12N5/00 ,  A61L27/60

CPC classification number: C12N5/0068 ,  A61L27/3633 ,  A61L27/3683 ,  A61L27/3804 ,  C12N5/0698 ,  C12N2500/25 ,  C12N2500/36 ,  C12N2500/38 ,  C12N2500/40 ,  C12N2500/50 ,  C12N2500/90 ,  C12N2500/92 ,  C12N2501/11 ,  C12N2501/148 ,  C12N2501/395 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2533/50 ,  C12N2533/92

Abstract: Bioengineered constructs are formed from cultured cells induced to synthesize and secrete endogenously produced extracellular matrix components without the requirement of exogenous matrix components or network support or scaffold members. The bioengineered constructs of the invention can be treated in various ways such that the cells of the bioengineered constructs can be devitalized and/or removed without compromising the structural integrity of the constructs. Moreover, the bioengineered constructs of the invention can be used in conjunction with biocompatible/bioremodelable solutions that allow for various geometric configurations of the constructs.

Abstract translation: 生物工程化构建体由诱导合成和分泌内源性产生的细胞外基质组分的培养细胞形成，而不需要外源基质组分或网络支持物或支架构件。 可以以各种方式处理本发明的生物工程化构建体，使得生物工程化构建体的细胞可以在不影响构建体的结构完整性的情况下失活和/或去除。 此外，本发明的生物工程化构建体可以与允许构建体的各种几何构型的生物相容/生物可重构溶液结合使用。

公开(公告)号：WO2008140608A2

公开(公告)日：2008-11-20

申请号：PCT/US2007/086985

申请日：2007-12-10

Applicant: BINAX, INC. ,  JOANIS, Dorothy ,  WHIPKEY, Myron ,  HAYES, Erin ,  MUSZYNSKI, Steven ,  DAVIS, Alan, H. ,  GORDON, Kristin ,  PIASIO, Roger, N. ,  MOORE, Norman, J.

Inventor： JOANIS, Dorothy ,  WHIPKEY, Myron ,  HAYES, Erin ,  MUSZYNSKI, Steven ,  DAVIS, Alan, H. ,  GORDON, Kristin ,  PIASIO, Roger, N. ,  MOORE, Norman, J.

IPC: G01N33/569

CPC classification number: G01N33/56938 ,  G01N33/56944

Abstract: Provided are methods and devices for detecting methicillin-resistant Staphylcoccus aureus.

Abstract translation: 提供了用于检测耐甲氧西林金黄色葡萄球菌的方法和装置。

公开(公告)号：WO2008119005A1

公开(公告)日：2008-10-02

申请号：PCT/US2008/058378

申请日：2008-03-27

Applicant: TRUSTEES OF TUFTS COLLEGE ,  BACHOVCHIN, William, W. ,  LAI, Hung-sen ,  WU, Wengen

Inventor： BACHOVCHIN, William, W. ,  LAI, Hung-sen ,  WU, Wengen

IPC: A01N55/08 ,  A61K31/69

CPC classification number: C07F5/025 ,  C07F9/5726

Abstract: One aspect of the present invention relates to inhibitors of post-pro line protease enzymes, such as inhibitors of dipeptidyl peptidase IV, and pharmaceutical compositions thereof. Another aspect of the present invention relates to methods of using the inhibitors to inhibit a dipeptidyl peptidase IV. Yet another aspect of the present invention relates to methods for using the inhibitors in the manufacture of the medicament for inhibiting a post- pro line enzyme in vivo .

Abstract translation: 本发明的一个方面涉及后线蛋白酶的抑制剂，例如二肽基肽酶IV的抑制剂及其药物组合物。 本发明的另一方面涉及使用抑制剂抑制二肽基肽酶IV的方法。 本发明的另一方面涉及使用抑制剂制造用于在体内抑制后续酶的药物的方法。

公开(公告)号：WO2008016919A2

公开(公告)日：2008-02-07

申请号：PCT/US2007/074853

申请日：2007-07-31

Applicant: ORGANOGENESIS INC. ,  HAMMOND, Dennis, C. ,  CODORI-HURFF, Jeanne, M.

Inventor： HAMMOND, Dennis, C. ,  CODORI-HURFF, Jeanne, M.

IPC: A61K48/00

CPC classification number: A61F2/12 ,  A61F2/0063 ,  A61F2210/0004

Abstract: Mastopexy and breast reconstruction prostheses and implantation method that allow for radiographic imaging of the breast tissue. The prostheses are arcuate and elongate optionally meshed to conform with breast tissue when implanted. Prostheses are made from naturally occurring extracellular matrix, primarily collagen, that, allows for mammographic imaging without interference as is expected from synthetic materials.

Abstract translation: Mastopexy和乳房重建假体和植入方法允许乳房组织的射线成像。 当植入时，假体是弓形的并且可选地细长以适应乳房组织。 假体由天然存在的细胞外基质（主要是胶原蛋白）制成，从而可以进行乳腺摄影成像，而不会像合成材料所期望的那样产生干扰。

公开(公告)号：WO2008005520A2

公开(公告)日：2008-01-10

申请号：PCT/US2007/015554

申请日：2007-07-06

Applicant: ORGANOGENESIS INC. ,  RONFARD, Vincent ,  O'REILLY, Christopher, S.

Inventor： RONFARD, Vincent ,  O'REILLY, Christopher, S.

CPC classification number: C12N5/0075 ,  C12N2531/00 ,  C12N2533/30 ,  C12N2539/10

Abstract: The invention relates to compositions and methods useful for cell culture in which cell adherence and release of cultured cells can be performed in a temperature-responsive manner.

Abstract translation: 本发明涉及可用于细胞培养的组合物和方法，其中培养细胞的细胞粘附和释放可以温度响应的方式进行。

公开(公告)号：WO2007130677A3

公开(公告)日：2007-11-15

申请号：PCT/US2007/011052

申请日：2007-05-07

Applicant: YALE UNIVERSITY ,  HISTORX, INC. ,  GUSTAVSON, Mark ,  GILTNANE, Jennifer ,  DOLLED-FILHART, Marisa, P. ,  CAMP, Robert, L. ,  RIMM, David, L.

Inventor： GUSTAVSON, Mark ,  GILTNANE, Jennifer ,  DOLLED-FILHART, Marisa, P. ,  CAMP, Robert, L. ,  RIMM, David, L.

IPC: G01N33/50 ,  G01N21/64

Abstract: The method of the invention pertains to determining the signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transduction pathway. Furthermore a combined ratio of expression levels of effector molecules in subcellular compartments with the receptor expression was found to have prognostic significance.

公开(公告)号：WO2007067519A2

公开(公告)日：2007-06-14

申请号：PCT/US2006/046359

申请日：2006-12-05

Applicant: OPHTHALMIC RESEARCH ASSOCIATES, INC. ,  CHAPIN, Matthew, J. ,  ABELSON, Mark, B. ,  OUSLER, George, W., III

Inventor： CHAPIN, Matthew, J. ,  ABELSON, Mark, B. ,  OUSLER, George, W., III

IPC: A61K38/22 ,  A61K31/4172 ,  A61K31/198 ,  A61K31/137 ,  A61K31/195

CPC classification number: A61K38/1709 ,  A61K9/0048 ,  A61K31/137 ,  A61K31/198 ,  A61K31/4172 ,  A61K38/22 ,  A61K38/33 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention further features novel methods and compositions for treating and preventing dry eye by administration of neurotransmitters and/or neuropeptides, optionally in formulation with various other agents, as well as kits for the use of such novel formulations and methods.

Abstract translation: 本发明进一步特征在于通过施用神经递质和/或神经肽，任选地与各种其他试剂一起配制来治疗和预防干眼的新方法和组合物，以及用于使用这种新制剂的试剂盒 和方法。

公开(公告)号：WO2005072126A3

公开(公告)日：2005-08-11

申请号：PCT/US2005/001116

申请日：2005-01-12

Applicant: TANOX, INC. ,  WONG, Hing, C. ,  JIAO, Jin-An

Inventor： WONG, Hing, C. ,  JIAO, Jin-An

IPC: C07K16/00 ,  C12P21/08 ,  C12N15/00 ,  C12N5/16 ,  A61K39/395

Abstract: Disclosed is a method for treating blood coagulation in a mammal that has or is suspected of having septic shock syndrome. In one embodiment, the method includes administering to the mammal an effective amount of an antibody that binds tissue factor in a way that excludes Factor X (FX) binding. The invention has a wide range of useful applications including use to inhibit unwanted blood coagulation associated with sepsis.

公开(公告)号：WO2005065667A2

公开(公告)日：2005-07-21

申请号：PCT/US2004/043847

申请日：2004-12-29

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  THE GENERAL HOSPITAL CORPORATION ,  SINCLAIR, David, A. ,  ALEXANDER-BRIDGES, Maria

Inventor： SINCLAIR, David, A. ,  ALEXANDER-BRIDGES, Maria

IPC: A61K31/00

CPC classification number: A61K31/05 ,  A61K31/00 ,  A61K31/12 ,  A61K31/353

Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.

Abstract translation: 本文提供了用于调节沉默调节蛋白的活性或水平的方法和组合物，从而治疗或预防肥胖或胰岛素抵抗障碍，例如受试者中的糖尿病。 示例性方法包括使细胞与沉默调节蛋白的活化化合物或抑制化合物接触，从而分别增加或减少脂肪蓄积。

公开(公告)号：WO2004069795A2

公开(公告)日：2004-08-19

申请号：PCT/US2004/002881

申请日：2004-02-02

Applicant: PFIZER PRODUCTS INC. ,  OXFORD GLYCOSCIENCES (UK) LTD. ,  BUTT, Richard ,  RUMPEL, Klaus ,  WILLIAMS-JONES, Bryn, I. ,  HERATH, Herath, Mudiyanselage, Athula, Chandrasiri ,  ROHLFF, Christian ,  BRUCE, James, A. ,  PATEL, Thakorbhai, P.

Inventor： BUTT, Richard ,  RUMPEL, Klaus ,  WILLIAMS-JONES, Bryn, I. ,  HERATH, Herath, Mudiyanselage, Athula, Chandrasiri ,  ROHLFF, Christian ,  BRUCE, James, A. ,  PATEL, Thakorbhai, P.

IPC: C07D

CPC classification number: G01N33/6881 ,  A61K38/2006 ,  G01N2500/00 ,  G01N2800/20

Abstract: This invention relates to use of proteins associated with chronic tissue damage, e.g., chronic dermal ulcers. The proteins identified are useful for clinical screening, diagnosis, prognosis, therapy, and prophylaxis, as well as for drug screening and drug development.

Abstract translation: 本发明涉及与慢性组织损伤相关的蛋白质的使用，例如慢性皮肤溃疡。 鉴定的蛋白质可用于临床筛选，诊断，预后，治疗和预防以及药物筛选和药物开发。