Abstract:
The present invention relates to a long-acting interferon beta formulation having improved in vivo duration and stability, comprising an interferon beta conjugate that is prepared by covalently linking interferon beta with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting interferon beta formulation of the present invention maintains in vivo activity of interferon beta at a relatively high level and remarkably increases the serum half-life thereof, thereby being used for various diseases, for which interferon is efficacious.
Abstract:
Laser processing equipment is provided. The laser beam processing equipment includes a laser resonator, an optical system, a chamber, a reflector, and a laser beam aligning unit. The laser resonator resonates a laser beam. The optical system converts the laser beam resonated by the laser resonator to have an energy density of a beam profile with a predetermined beam width. The laser beam converted by the optical system is radiated onto a processing object disposed in the chamber. The reflector is disposed between the laser resonator and the chamber to reflect the laser beam. The laser beam aligning unit aligns the laser beam radiated into the chamber. The laser beam aligning unit includes an aligning member installed between the reflector and the processing object and disposed in a travel path of the laser beam. The aligning member defines a through-hole that is greater in area than a cross-section of the laser beam to enable the laser beam to pass therethrough. The driver drives the reflector to control the travel path of the laser beam reflected by the reflector. The controller controls the driver to control a distance between a center of the laser beam and a center of the through-hole, based on the laser beam detected as passing through the through-hole of the aligning member.
Abstract:
Disclosed is a compound having a solid metal-organic framework (MOF), or a solvate thereof, which can be used as adsorbents, catalyst, or catalyst carriers, etc. Since a metal is coordinated to a triazine group / tricarboxylic group containing compound as an organic ligand, the MOF compound can have a mesopore of an average diameter of about 3.5nm or more and can be utilized in various fields.
Abstract:
Disclosed is a coordination polymer crystal with porous metal-organic frameworks (MOFs), in which, while a crystal state of the coordination polymer crystal is maintained, an additional material selected from the group consisting of an organic compound, a metal cluster, and an organometallic compound is chemically bonded to the coordination polymer crystal. Therefore it is possible easily adsorb and store more guest molecules regardless of a change in an ambient temperature or pressure due to the chemically bonded additional material (such as an organic compound, a metal cluster, and an organometallic compound).
Abstract:
The present invention relates to a A display apparatus comprising includes a display panel to display a picture thereon, and a front cover and a rear cover to support the display panel, further comprising a pen unit provided to be movable on the display panel, and comprising including a light generator provided to emit light and a supersonic wave generator provided to emit a supersonic wave;, a light sensor provided in at the front cover to detect the light emitted from the light generator;, a first supersonic wave sensor provided in at the front cover to detect the supersonic wave emitted from the supersonic wave generator, and disposed adjacent to the light sensor to measure a distance from the pen unit by using detected a time difference with between when the light sensor detects the light and when the first supersonic wave generator detects the supersonic wave;, a second supersonic wave sensor provided in at the front cover to detect the supersonic wave emitted from the supersonic wave generator, and spaced apart from the first supersonic wave sensor to measure a relative distance from the pen unit by using the detected a time difference with between when the first supersonic wave sensor and the second wave sensor detect the supersonic wave;, and a controller to receive a detecting signal from each of the first supersonic wave sensor, the second supersonic wave sensor, and the light sensor, and to detect position information of the pen unit based on the received detecting signals. Thus Accordingly, the present invention provides a display apparatus, which performs a tablet function and reduces production costs by using a simple and general display panel.
Abstract:
Disclosed are a protein conjugate with improved in vivo duration and stability and the use thereof. The protein conjugate includes a physiologically active polypeptide, a non-peptide polymer and an immunoglobulin Fc fragment. Since the three components are covalently linked, the protein conjugate has extended in vivo duration and enhanced stability for the physiologically active polypeptide. The protein conjugate maintains the in vivo activity at relatively high levels and remarkably increases the serum half-life for the physiologically active polypeptide, with less risk of inducing undesirable immune responses. Thus, the protein conjugate is useful for developing long-acting formulations of various polypeptide drugs.
Abstract:
The present invention relates to a non-peptidyl polymer-insulin multimer comprising two or more of a non-peptidyl polymer-insulin conjugate prepared by linking a non-peptidyl polymer and insulin via a covalent bond, in which the conjugates are complexed with cobalt ion to form a multimer, a method and kit for the preparation of the multimer, a pharmaceutical composition for the prevention or treatment of diabetes comprising the multimer as an active ingredient, and a method for preventing or treating diabetes by administering the composition to a subject.
Abstract:
Disclosed is an inlaid type floor sheet having polyvinyl chloride chip and a method of manufacturing thereof. The inlaid type floor sheet having polyvinyl chloride (PVC) chip, includes an inlaid chip layer in which polyvinyl chloride is formed into chips; a UV paint layer which is coated on the inlaid chip layer; and a dimensionally reinforcing layer which is formed of a fabric and pressed on a lower surface of the inlaid chip layer at high temperature. According to the present invention, since the plain-weave type dimensionally reinforcing layer is provided at the lower side of the inlaid type floor sheet having polyvinyl chloride chip, it is possible to improve the durability, realize the dimensional stability and balance of the product and increase the adhesive force with the construction floor.
Abstract:
Disclosed is a digital system. Said digital system comprises: an audio output unit, and a controller unit for controlling the audio output unit so as to output first audio information corresponding to first information including information on the owner of said digital system, whenever said digital system performs a certain function while in a normal mode when said digital system has not been lost or stolen. Said controller unit either receives said first information through a network from an external system, or reads said first information stored in an internal memory unit that is built-in so as to prevent said digital system from being separated, and performs a control so as to output said first audio information corresponding to said first information.
Abstract:
The present invention relates to a Cytokine-bipodal peptide binder specifically binding to Cytokine, comprising: (a) a structure stabilizing region comprising parallel, antiparallel, or parallel and antiparallel, amino acid strands in which interstrand non-covalent bonds are formed; and (b) a KCytokine-target binding region I and a Cytokine-target binding region I which bond to both terminals of the structure stabilizing region and which comprise n and m amino acids randomly selected, respectively. The Cytokine-bipodal peptide binder of the present invention exhibits a very low (for example, nM levels) KD value (dissociation constant) relative to Cytokine and therefore exhibits a very high affinity toward a Cytokine target. The Cytokine-bipodal peptide binder of the present invention may have a use as a pharmaceutical, for in vivo molecular imaging and drug delivery targeting, and be useful as an escort molecule.