-
公开(公告)号：WO2017062973A3
公开(公告)日：2017-05-26
申请号：PCT/US2016056318
申请日：2016-10-10
Applicant: DICE MOLECULES SV LLC , PATTEN PHILLIP , HARBURY PEHR , SCHMIDT DONALD , LINSELL MARTIN
Inventor： PATTEN PHILLIP , HARBURY PEHR , SCHMIDT DONALD , LINSELL MARTIN , WLASICHUK KENNETH , PRINCE ROBIN , CHURCH TIMOTHY J , VAN DER LINDEN WOUTER
CPC classification number: G01N33/92 , B01D15/325 , C07H21/04 , C12Q1/68 , C12Q1/6804 , C12Q1/6876 , C12Q2600/136 , G01N30/02 , G01N33/15 , G01N33/6803 , G01N2030/027 , C12Q2563/179 , C12Q2565/125 , C12Q2565/514 , C12Q2565/119 , C12Q2565/137
Abstract: Disclosed herein are methods of estimating LogD of compounds comprising a ligand operatively linked to a recognition element. The methods generally involve contacting the compounds with a matrix, measuring the interaction of the compounds with the matrix and relating the interaction of the compounds with the matrix to LogD of the compounds. Also, described herein, are novel compounds which include a ligand operatively linked to a recognition element and linkers that connect the ligand to the recognition element.
Abstract translation: 本文公开了估计包含可操作地连接至识别元件的配体的化合物的LogD的方法。 该方法通常包括使化合物与基质接触，测量化合物与基质的相互作用并将化合物与基质的相互作用与化合物的LogD相关联。 此外，本文所述的新化合物包括与识别元件有效连接的配体和将配体连接至识别元件的接头。
-
公开(公告)号：WO2017062973A2
公开(公告)日：2017-04-13
申请号：PCT/US2016/056318
申请日：2016-10-10
Applicant: DICE MOLECULES SV, LLC , PATTEN, Phillip , HARBURY, Pehr , SCHMIDT, Donald , LINSELL, Martin
Inventor： PATTEN, Phillip , HARBURY, Pehr , SCHMIDT, Donald , LINSELL, Martin , WLASICHUK, Kenneth , PRINCE, Robin , CHURCH, Timothy, J. , VAN DER LINDEN, Wouter
CPC classification number: G01N33/92 , B01D15/325 , C07H21/04 , C12Q1/68 , C12Q1/6804 , C12Q1/6876 , C12Q2600/136 , G01N30/02 , G01N33/15 , G01N33/6803 , G01N2030/027 , C12Q2563/179 , C12Q2565/125 , C12Q2565/514 , C12Q2565/119 , C12Q2565/137
Abstract: Disclosed herein are methods of estimating LogD of compounds comprising a ligand operatively linked to a recognition element. The methods generally involve contacting the compounds with a matrix, measuring the interaction of the compounds with the matrix and relating the interaction of the compounds with the matrix to LogD of the compounds. Also, described herein, are novel compounds which include a ligand operatively linked to a recognition element and linkers that connect the ligand to the recognition element.
Abstract translation: 本文公开了估计包含可操作地连接到识别元件的配体的化合物的LogD的方法。 方法通常包括使化合物与基质接触，测量化合物与基质的相互作用并将化合物与基质的相互作用与化合物的LogD相关联。 此外，本文描述的是包括可操作地连接到识别元件的配体和将配体连接到识别元件的接头的新化合物。
-
公开(公告)号：WO2010132768A9
公开(公告)日：2011-09-15
申请号：PCT/US2010034896
申请日：2010-05-14
Applicant: ACHAOGEN INC , DOZZO PAOLA , GOLDBLUM ADAM AARON , AGGEN JAMES BRADLEY , LINSELL MARTIN SHERINGHAM
Inventor： DOZZO PAOLA , GOLDBLUM ADAM AARON , AGGEN JAMES BRADLEY , LINSELL MARTIN SHERINGHAM
IPC: C07H15/236 , A61K31/7036 , A61P31/04
CPC classification number: C07H15/236
Abstract: Antibacterial compounds of structure (I) are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R11 and R12 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Abstract translation: 公开了结构（I）的抗菌化合物，包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，Q3，R11和R12如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
-
公开(公告)号：WO2011044538A9
公开(公告)日：2011-04-14
申请号：PCT/US2010/052109
申请日：2010-10-08
Applicant: ACHAOGEN, INC. , AGGEN, James, Bradley , DOZZO, Paola , GOLDBLUM, Adam, Aaron , HILDEBRANDT, Darin, James , KANE, Timothy, Robert , GLIEDT, Micah, James , LINSELL, Martin, Sheringham
Inventor： AGGEN, James, Bradley , DOZZO, Paola , GOLDBLUM, Adam, Aaron , HILDEBRANDT, Darin, James , KANE, Timothy, Robert , GLIEDT, Micah, James , LINSELL, Martin, Sheringham
IPC: C07H15/232 , A61K31/7036 , A61P31/04
Abstract: Compounds having antibacterial activity are disclosed. The compounds have one of the following structures (I) or (II): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q 1 , Q 2 , R 1 , R 2 , R 3 and Z 1 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
-
公开(公告)号：WO2011044498A1
公开(公告)日：2011-04-14
申请号：PCT/US2010052040
申请日：2010-10-08
Applicant: ACHAOGEN INC , MAIANTI JUAN PABLO , AGGEN JAMES BRADLEY , DOZZO PAOLA , GOLDBLUM ADAM AARON , HILDEBRANDT DARIN JAMES , KANE TIMOTHY ROBERT , GLIEDT MICAH JAMES , LINSELL MARTIN SHERINGHAM , HANESSIAN STEPHEN , GIGUERE ALEXANDRE
Inventor： MAIANTI JUAN PABLO , AGGEN JAMES BRADLEY , DOZZO PAOLA , GOLDBLUM ADAM AARON , HILDEBRANDT DARIN JAMES , KANE TIMOTHY ROBERT , GLIEDT MICAH JAMES , LINSELL MARTIN SHERINGHAM , HANESSIAN STEPHEN , GIGUERE ALEXANDRE
IPC: C07H15/232 , A61K31/7036 , A61P31/04
CPC classification number: C07H15/232
Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): (Formula (I)), including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Abstract translation: 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：（式（I）），其包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，R1，R2，R3，Z1和Z2如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
-
Patent Agency Ranking
公开(公告)号：WO2010132757A3
公开(公告)日：2011-02-24
申请号：PCT/US2010034884
申请日：2010-05-14
Applicant: ACHAOGEN INC , GOLDBLUM ADAM AARON , DOZZO PAOLA , AGGEN JAMES BRADLEY , LINSELL MARTIN SHERINGHAM
Inventor： GOLDBLUM ADAM AARON , DOZZO PAOLA , AGGEN JAMES BRADLEY , LINSELL MARTIN SHERINGHAM
IPC: C07D407/12 , A61K31/351 , A61K31/397 , A61P31/04 , C07D407/14
CPC classification number: C07H15/234
Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I) or (II): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Abstract translation: 公开了具有抗菌活性的化合物。 所述化合物具有以下结构（I）或（II）：包括其立体异构体，药学上可接受的盐和前药，其中Q1，Q2，Q3，R1，R2和R3如本文所定义。 还公开了与这些化合物的制备和使用有关的方法，以及包含这些化合物的药物组合物。
-
公开(公告)号：WO2010132765A3
公开(公告)日：2010-11-18
申请号：PCT/US2010/034893
申请日：2010-05-14
Applicant: ACHAOGEN, INC. , DOZZO, Paola , GOLDBLUM, Adam, Aaron , AGGEN, James, Bradley , LINSELL, Martin, Sheringham
Inventor： DOZZO, Paola , GOLDBLUM, Adam, Aaron , AGGEN, James, Bradley , LINSELL, Martin, Sheringham
IPC: C07H15/236 , A61K31/7036 , A61P31/04
Abstract: Antibacterial compounds of structures (I) and (II) are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q 1 , Q 2 , Q 3 , R 1 , R 2 , R 3 , R 11 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
-
公开(公告)号：WO2009137130A2
公开(公告)日：2009-11-12
申请号：PCT/US2009033946
申请日：2009-02-12
Applicant: ACHAOGEN INC , WAGMAN ALLAN SCOTT , MOSER HEINZ ERNST , MCENROE GLENN A , AGGEN JAMES , LINSELL MARTIN S , GOLDBLUM ADAM AARON , GRIFFIN JOHN H , SIMONS LLOYD J , BELLIOTTI THOMAS R , HARRIS CHRISTINA R , POEL TONI-JO , MELNICK MICHAEL J , GASTON RICKY D
Inventor： WAGMAN ALLAN SCOTT , MOSER HEINZ ERNST , MCENROE GLENN A , AGGEN JAMES , LINSELL MARTIN S , GOLDBLUM ADAM AARON , GRIFFIN JOHN H , SIMONS LLOYD J , BELLIOTTI THOMAS R , HARRIS CHRISTINA R , POEL TONI-JO , MELNICK MICHAEL J , GASTON RICKY D
IPC: C07D487/22
CPC classification number: C07D471/14 , C07D498/14 , C07D513/14
Abstract: Compounds having antibacterial activity are disclosed. The compunds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, D, E, G, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Abstract translation: 公开了具有抗细菌活性的化合物。 该化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中A，B，D，E，G，R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
-
公开(公告)号：WO2006031556A2
公开(公告)日：2006-03-23
申请号：PCT/US2005/031824
申请日：2005-09-08
Applicant: THERAVANCE. INC. , LINSELL, Martin S. , JACOBSEN, John R. , XU, Ningning
Inventor： LINSELL, Martin S. , JACOBSEN, John R. , XU, Ningning
IPC: C07C257/18 , C07D215/26 , C07D413/02 , A61K31/4704 , A61K31/136 , A61P43/00
CPC classification number: C07F7/1856 , C07C257/18 , C07D215/26 , C07D413/12
Abstract: The invention provides novel ß 2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with ß 2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.
Abstract translation: 本发明提供了新颖的β2肾上腺素受体激动剂化合物。 本发明还提供了包含此类化合物的药物组合物，使用此类化合物治疗与β2肾上腺素能受体活性有关的疾病的方法，以及可用于制备此类化合物的方法和中间体。
-
公开(公告)号：WO2005005436A3
公开(公告)日：2005-03-10
申请号：PCT/US2004022319
申请日：2004-07-09
Applicant: THERAVANCE INC , FATHEREE PAUL R , LINSELL MARTIN S , MARQUESS DANIEL , TRAPP SEAN G , MORAN EDMUND J , AGGEN JAMES B
Inventor： FATHEREE PAUL R , LINSELL MARTIN S , MARQUESS DANIEL , TRAPP SEAN G , MORAN EDMUND J , AGGEN JAMES B
IPC: A61K38/14 , A61P31/04 , C07D501/00 , C07K7/64 , C07K9/00 , A61K31/545
CPC classification number: C07K7/64 , C07D501/00 , C07K9/008
Abstract: This invention provides cross-linked glycopeptide - cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
Abstract translation: 本发明提供了可用作抗生素的交联糖肽 - 头孢菌素化合物及其药学上可接受的盐。 本发明还提供含有这些化合物的药物组合物; 用这种化合物治疗哺乳动物细菌感染的方法; 和用于制备这些化合物的方法和中间体。
-
-
-
-
-
-
-
-
-
Search Results
63
records
(took 0.029 seconds)
