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    SYSTEMS AND METHODS FOR SIMULATION OF OCCLUDED ARTERIES AND OPTIMIZATION OF OCCLUSION-BASED TREATMENTS
    21.
    发明申请
    SYSTEMS AND METHODS FOR SIMULATION OF OCCLUDED ARTERIES AND OPTIMIZATION OF OCCLUSION-BASED TREATMENTS 审中-公开
    系统和方法，用于模拟受试动物和优化基于卵巢的治疗

    公开(公告)号：WO2016073249A1

    公开(公告)日：2016-05-12

    申请号：PCT/US2015/057743

    申请日：2015-10-28

    Applicant: HEARTFLOW, INC.

    Inventor： SANKARAN, Sethuraman ,  GRADY, Leo, J. ,  TAYLOR, Charles, A. ,  ZARINS, Christopher, K.

    IPC: G06F19/00

    CPC classification number: G16H50/50 ,  G06F17/18 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3481

    Abstract: Systems and methods are disclosed for simulation of occluded arteries and/or optimization of occlusion-based treatments. One method includes obtaining a patient-specific anatomic model of a patient's vasculature; obtaining an initial computational model of blood flow through the patient's vasculature based on the patient-specific anatomic model; obtaining a post-treatment computational model by modifying portions of the initial computational model based on an occlusion-based treatment; generating a pre-treatment blood flow characteristic using the initial computational model or computing a post-treatment blood flow using the post- treatment computational model; and outputting a representation of the pre-treatment blood flow characteristic or the post-treatment blood flow characteristic.

    Abstract translation: 公开了用于模拟闭塞动脉和/或基于阻塞的治疗的优化的系统和方法。 一种方法包括获得患者脉管系统的患者特异性解剖模型; 基于患者特异性解剖模型获得通过患者脉管系统的血流的初始计算模型; 通过基于基于遮挡的处理修改初始计算模型的部分来获得后处理计算模型; 使用初始计算模型产生预处理血流特征或使用后处理计算模型计算后处理血流量; 并输出预处理血流特性或后处理血流特性的表示。

    SYSTEMS AND METHODS FOR MODELING CHANGES IN PATENT-SPECIFIC BLOOD VESSEL GEOMETRY AND BOUNDARY CONDITIONS
    23.
    发明申请
    SYSTEMS AND METHODS FOR MODELING CHANGES IN PATENT-SPECIFIC BLOOD VESSEL GEOMETRY AND BOUNDARY CONDITIONS 审中-公开
    专利文献血管几何和边界条件下建立变化的系统与方法

    公开(公告)号：WO2015148401A1

    公开(公告)日：2015-10-01

    申请号：PCT/US2015/022062

    申请日：2015-03-23

    Applicant: HEARTFLOW, INC.

    Inventor： TAYLOR, Charles, A. ,  KIM, Hyun, Jin ,  SANKARAN, Sethuraman ,  SCHAAP, Michiel ,  EBERLE, David ,  CHOI, Gilwoo ,  GRADY, Leo, J.

    IPC: G06F19/00

    CPC classification number: G06F19/3437 ,  G06F17/5009 ,  G06F19/00 ,  G16H50/50

    Abstract: Systems and methods are disclosed for modeling changes in patient-specific blood vessel geometry and boundary conditions resulting from changes in blood flow or pressure. One method includes determining, using a processor, a first anatomic model of one or more blood vessels of a patient; determining a biomechanical model of the one or more blood vessels based on at least the first anatomic model; determining one or more parameters associated with a physiological state of the patient; and creating a second anatomic model based on the biomechanical model and the one or more parameters associated with the physiological state.

    Abstract translation: 公开了系统和方法，用于模拟患者特异性血管几何形状和由血流或压力变化引起的边界条件的变化。 一种方法包括使用处理器确定患者的一个或多个血管的第一解剖模型; 至少基于所述第一解剖模型确定所述一个或多个血管的生物力学模型; 确定与患者的生理状态相关联的一个或多个参数; 以及基于生物力学模型和与生理状态相关联的一个或多个参数创建第二解剖模型。

    SYSTEMS AND METHODS FOR CARDIOVASCULAR BLOOD FLOW AND MUSCULOSKELETAL MODELING FOR PREDICTING DEVICE FAILURE OR CLINICAL EVENTS
    26.
    发明申请
    SYSTEMS AND METHODS FOR CARDIOVASCULAR BLOOD FLOW AND MUSCULOSKELETAL MODELING FOR PREDICTING DEVICE FAILURE OR CLINICAL EVENTS 审中-公开
    用于预测器械失败或临床事件的心血管流量和肌纤维蛋白模型的系统和方法

    公开(公告)号：WO2016168017A1

    公开(公告)日：2016-10-20

    申请号：PCT/US2016/026149

    申请日：2016-04-06

    Applicant: HEARTFLOW, INC.

    Inventor： CHOI, Gilwoo ,  TAYLOR, Charles, A. ,  GRADY, Leo

    IPC: G06F19/00

    CPC classification number: G06F19/3437 ,  A61B5/0022 ,  A61B5/02007 ,  A61B5/021 ,  A61B5/026 ,  A61B5/055 ,  A61B5/1118 ,  A61B5/72 ,  A61B34/00 ,  A61B34/10 ,  A61B2034/105 ,  A61B2562/0219 ,  G06F19/00 ,  G16H50/30 ,  G16H50/50

    Abstract: Computer-implemented methods are disclosed for assessing the effect of musculoskeletal activities on disease and/or clinical events, the method comprising: receiving a patient-specific vascular and musculoskeletal model of a patient's anatomy, including at least one vessel of the patient; receiving at least one characteristic of the patient's musculoskeletal activity; generating or updating a computational anatomic vascular and musculoskeletal model of the patient's anatomy based on the received at least one characteristic of musculoskeletal activity; performing at least one of a computational fluid dynamics analysis or a structural mechanics simulation on the computational anatomic vascular and musculoskeletal model; and estimating at least one of the patient's risk of disease or clinical events based on the performed computational fluid dynamics analysis and/or structural mechanics simulation. Systems and computer readable media for executing these methods are also disclosed.

    Abstract translation: 公开了用于评估肌肉骨骼活动对疾病和/或临床事件的影响的计算机实施的方法，所述方法包括：接收患者解剖结构的患者特异性血管和肌肉骨骼模型，包括患者的至少一个血管; 接受患者肌肉骨骼活动的至少一种特征; 基于所接收的肌肉骨骼活动的至少一个特征，产生或更新患者解剖结构的计算解剖血管和肌肉骨骼模型; 对计算解剖血管和肌肉骨骼模型执行计算流体动力学分析或结构力学模拟中的至少一个; 以及基于执行的计算流体动力学分析和/或结构力学模拟来估计患者的疾病或临床事件的风险中的至少一个。 还公开了用于执行这些方法的系统和计算机可读介质。

    SYSTEMS AND METHODS FOR PROVIDING PERSONALIZED ESTIMATES OF BIOHEAT TRANSFER
    27.
    发明申请
    SYSTEMS AND METHODS FOR PROVIDING PERSONALIZED ESTIMATES OF BIOHEAT TRANSFER 审中-公开
    用于提供生物转移的个性化估计的系统和方法

    公开(公告)号：WO2016161293A1

    公开(公告)日：2016-10-06

    申请号：PCT/US2016/025567

    申请日：2016-04-01

    Applicant: HEARTFLOW, INC.

    Inventor： GRADY, Leo ,  TAYLOR, Charles, A. ,  ZARINS, Christopher, K.

    IPC: G06F19/00

    CPC classification number: A61B34/10 ,  A61B18/02 ,  A61B18/12 ,  A61B34/00 ,  A61B2018/00577 ,  A61B2034/104 ,  A61F7/00 ,  A61N7/02 ,  G06F19/00 ,  G16H50/50

    Abstract: Systems and methods are disclosed for providing personalized estimates of bioheat transfer through a patient's body or a portion of a patient's body. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model including at least a portion of tissue of the patient's anatomy; receiving an estimate of heat content of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue; determining an estimate of heat distribution of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue based on the vascular model, the tissue model, or the received estimate of heat content; and output the determined estimate of heat distribution to a storage medium or user display.

    Abstract translation: 公开了用于提供通过患者身体或患者身体的一部分的生物热转移的个性化估计的系统和方法。 一种方法包括接收患者解剖结构的患者特异性血管模型，包括患者的至少一个血管; 接收包括患者解剖结构的组织的至少一部分的患者特异性组织模型; 接收患者特定组织模型或组织周围的组织的组织部分的热含量的估计值; 基于所述血管模型，所述组织模型或所接收的热量估计，确定所述患者特异性组织模型或组织周围组织的组织部分的热分布的估计; 并将确定的热分布估计输出到存储介质或用户显示器。

    SYSTEMS AND METHODS FOR DETERMINING AND VISUALIZING A FUNCTIONAL RELATIONSHIP BETWEEN A VASCULAR NETWORK AND PERFUSED TISSUE
    28.
    发明申请
    SYSTEMS AND METHODS FOR DETERMINING AND VISUALIZING A FUNCTIONAL RELATIONSHIP BETWEEN A VASCULAR NETWORK AND PERFUSED TISSUE 审中-公开
    用于确定和观察血管网络与完全组织之间的功能关系的系统和方法

    公开(公告)号：WO2016161274A1

    公开(公告)日：2016-10-06

    申请号：PCT/US2016/025536

    申请日：2016-04-01

    Applicant: HEARTFLOW, INC.

    Inventor： JAQUET, Clara ,  SCHAAP, Michiel ,  BAI, Ying ,  GRADY, Leo ,  TAYLOR, Charles, A.

    IPC: G06F19/00

    CPC classification number: A61B34/10 ,  A61B34/25 ,  A61B2034/105 ,  G06F3/048 ,  G06F19/00 ,  G16H50/50

    Abstract: Systems and methods are disclosed for creating an interactive tool for determining and displaying a functional relationship between a vascular network and an associated perfused tissue. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model, including a tissue region associated with the at least one vessel of the patient; receiving a selected area of the vascular model or a selected area of the tissue model; and generating a display of a region of the tissue model corresponding to the selected area of the vascular model or a display of a portion of the vascular model corresponding to the selected area of the tissue model, respectively.

    Abstract translation: 公开了用于创建用于确定和显示血管网络和相关联的灌注组织之间的功能关系的交互式工具的系统和方法。 一种方法包括接收患者解剖结构的患者特异性血管模型，包括患者的至少一个血管; 接收患者特异性组织模型，包括与所述患者的所述至少一个血管相关联的组织区域; 接收血管模型的选定区域或组织模型的选定区域; 以及分别生成对应于所述血管模型的所选区域的组织模型的区域的显示或者对应于所述组织模型的所选区域的所述血管模型的一部分的显示。

    SYSTEMS AND METHODS FOR VESSEL REACTIVITY TO GUIDE DIAGNOSIS OR TREATMENT OF CARDIOVASCULAR DISEASE
    29.
    发明申请
    SYSTEMS AND METHODS FOR VESSEL REACTIVITY TO GUIDE DIAGNOSIS OR TREATMENT OF CARDIOVASCULAR DISEASE 审中-公开
    用于指导诊断或治疗心血管疾病的船只反应性的系统和方法

    公开(公告)号：WO2016069715A1

    公开(公告)日：2016-05-06

    申请号：PCT/US2015/057754

    申请日：2015-10-28

    Applicant: HEARTFLOW, INC.

    Inventor： GRADY, Leo, J. ,  TAYLOR, Charles, A. ,  ZARINS, Christopher, K.

    IPC: A61B5/02 ,  G06F19/00

    CPC classification number: G16H50/50 ,  A61B5/02007 ,  A61B5/026 ,  A61B5/7267 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3481 ,  G16H50/20

    Abstract: Systems and methods are disclosed for using vessel reactivity to guide diagnosis or treatment for cardiovascular disease. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; determining, by measurement or estimation, a first vessel size at one or more locations of a vessel of the patient-specific vascular model at a first physiological state; determining a second vessel size at the one or more locations of the vessel of the patient-specific vascular model at a second physiological state using a simulation or learned information; comparing the first vessel size to the corresponding second vessel size; and estimating a characteristic of the vessel of the patient-specific vascular model based on the comparison.

    Abstract translation: 公开了使用血管反应性来指导心血管疾病诊断或治疗的系统和方法。 一种方法包括接收患者解剖结构的患者特异性血管模型，包括患者的至少一个血管; 通过测量或估计在第一生理状态下确定患者特异性血管模型的血管的一个或多个位置处的第一血管大小; 使用模拟或学习的信息在第二生理状态下确定患者特异性血管模型的血管的一个或多个位置处的第二血管尺寸; 将第一容器尺寸与对应的第二容器尺寸进行比较; 并且基于该比较来估计患者特异性血管模型的血管的特征。

    SYSTEMS AND METHODS FOR AUTOMATICALLY DETERMINING MYOCARDIAL BRIDGING AND PATIENT IMPACT
    30.
    发明申请
    SYSTEMS AND METHODS FOR AUTOMATICALLY DETERMINING MYOCARDIAL BRIDGING AND PATIENT IMPACT 审中-公开
    用于自动测定心肌梗死和患者影响的系统和方法

    公开(公告)号：WO2016032825A1

    公开(公告)日：2016-03-03

    申请号：PCT/US2015/045910

    申请日：2015-08-19

    Applicant: HEARTFLOW, INC.

    Inventor： CHOI, Gilwoo ,  TAYLOR, Charles, A.

    IPC: A61B5/02 ,  A61B6/00 ,  A61B5/00 ,  A61B5/026

    CPC classification number: G06F19/3437 ,  A61B5/0044 ,  A61B5/02007 ,  A61B5/02028 ,  A61B5/0263 ,  A61B5/4836 ,  A61B5/4848 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5217 ,  G06F19/00 ,  G06F19/12 ,  G16H50/50

    Abstract: Embodiments include computer-implemented methods and systems for reporting the presence of myocardial bridging in a patient, the method comprising detecting, within a patient-specific model representing at least a portion of the patient's heart based on patient-specific anatomical image data regarding a geometry of the patient's heart, a segment of an epicardial coronary artery at least partially surrounded by the patient's myocardium to determine the presence of myocardial bridging; and computing, using at least one computer processor, at least one physical feature of the myocardial bridging to identify the severity of the myocardial bridging.

    Abstract translation: 实施例包括用于报告患者心肌桥接的存在的计算机实现的方法和系统，所述方法包括基于患者特异性解剖图像数据来检测在代表患者心脏的至少一部分的患者特定模型内 患者心脏的一段心外膜冠状动脉至少部分被患者的心肌包围以确定心肌桥接的存在; 以及使用至少一个计算机处理器计算所述心肌桥接的至少一个物理特征以识别心肌桥接的严重性。

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