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    GALECTIN-3 TO TREAT OVARIAN CANCER
    32.
    发明申请
    GALECTIN-3 TO TREAT OVARIAN CANCER 审中-公开
    GALECTIN-3治疗卵巢癌

    公开(公告)号：WO2015085207A1

    公开(公告)日：2015-06-11

    申请号：PCT/US2014/068855

    申请日：2014-12-05

    Applicant: TEXAS TECH UNIVERSITY SYSTEM

    Inventor： CHIRIVA-INTERNATI, Maurizio ,  FIGUEROA, Jose, A. ,  COBOS, Everardo

    IPC: A61K38/17 ,  A61P35/00

    CPC classification number: A61K38/1732 ,  A61K31/337 ,  A61K48/00 ,  C07K14/4726 ,  G01N33/57449 ,  G01N2500/10 ,  A61K2300/00

    Abstract: The present invention includes a method for the treatment of an advanced ovarian cancer, comprising: identifying a patient with advanced ovarian cancer; and administering to the patient an effective amount of truncated, dominant negative form of Galectin-3 sufficient to reduce the advanced ovarian cancer. In certain aspects, the truncated, dominant negative form of Galectin-3 is provided in an amount sufficient to reduce at least one of growth, motility, invasion, angiogenesis, or prevents Akt/NF-ĸΒ activation of the ovarian cancer.

    Abstract translation: 本发明包括一种治疗晚期卵巢癌的方法，包括：鉴定晚期卵巢癌患者; 并向患者施用足够减少晚期卵巢癌的有效量的截短，显性阴性形式的Galectin-3。 在某些方面，提供半数优势阴性形式的半乳凝素-3以足以减少生长，运动，侵袭，血管发生或抑制卵巢癌的Akt / NF-κB活化中的至少一种的量。

    LOW PALMITIC ACID COTTON LINES
    33.
    发明申请
    LOW PALMITIC ACID COTTON LINES 审中-公开
    低棕榈酸棉线

    公开(公告)号：WO2015035312A1

    公开(公告)日：2015-03-12

    申请号：PCT/US2014/054576

    申请日：2014-09-08

    Applicant: TEXAS TECH UNIVERSITY

    Inventor： AULD, Dick, L.

    IPC: A01H1/06

    CPC classification number: C12N15/8247 ,  A01H1/02 ,  A01H1/04 ,  A01H1/06 ,  A01H5/02 ,  A01H5/10 ,  C12N15/8245 ,  C12N15/8274 ,  C12N15/8275 ,  C12N15/8278 ,  C12N15/8279 ,  C12N15/8286 ,  C12N15/8289

    Abstract: Disclosed is an invention of cotton lines 2-340/1-422, 1-422/SCM 3-7-3, 1-422/2-340, 1-136/2-340, AFIS 1-422, AFIS 2-340, AFIS 1-136, and SCM 3-7-3, and relates to seeds, plants, plant cells, plant tissue and harvested products, lint, and oil, as well as to hybrid cotton plants and seeds and other plants, cultivars, and varieties produced by essentially deriving such plants, cultivars, and varieties from cotton lines 2-340/1-422, 1-422/SCM 3-7-3, 1-422/2-340, 1-136/2-340, AFIS 1-422, AFIS 2-340, AFIS 1-136, and SCM 3-7-3. The present invention particularly relates to the development of specific cotton lines for the regulation of palmitic acid for the production of seeds having cottonseed oil content with reduced levels of palmitic acid. The cotton lines of the present disclosure have lower levels of palmitic acid content, and allows for the germination of seed at lower soil temperatures than current commercially available cotton cultivars.

    Abstract translation: 公开了棉线2-340 / 1-422，1-422 / SCM 3-7-3,1-4-22 / 2-340,1 / 36 / 2-340，AFIS 1-422，AFIS 2- 340，AFIS 1-136和SCM 3-7-3，涉及种子，植物，植物细胞，植物组织和收获产品，棉绒和油，以及杂种棉花植物和种子等植物，品种 ，以及通过从棉花线2-340 / 1-422,1-4-22 / SCM 3-7-3,1-4-22 / 2-340,1 -36 / 2-基本衍生这样的植物，品种和品种产生的品种， 340，AFIS 1-422，AFIS 2-340，AFIS 1-136和SCM 3-7-3。 本发明特别涉及用于调节棕榈酸以生产具有降低棕榈酸水平的棉籽油含量的种子的特定棉花生产线的开发。 本公开的棉花线具有较低水平的棕榈酸含量，并且允许在比当前市售的棉花品种更低的土壤温度下种子的发芽。

    FIBRILLAR STRUCTURES TO REDUCE VISCOUS DRAG ON AERODYNAMIC AND HYDRODYNAMIC WALL SURFACES
    34.
    发明申请
    FIBRILLAR STRUCTURES TO REDUCE VISCOUS DRAG ON AERODYNAMIC AND HYDRODYNAMIC WALL SURFACES 审中-公开
    减少航空动力和水动力墙面上的粘弹带的结构

    公开(公告)号：WO2014165106A1

    公开(公告)日：2014-10-09

    申请号：PCT/US2014/024409

    申请日：2014-03-12

    Applicant: TEXAS TECH UNIVERSITY SYSTEM ,  NANOGRIPTECH, INC.

    Inventor： CASTILLO, Luciano ,  AKSAK, Burak ,  SITTI, Metin

    IPC: B64C21/10 ,  B64C23/00 ,  F15D1/10

    CPC classification number: F15D1/003 ,  B63B1/36 ,  B64C21/10 ,  B64C2230/26 ,  F15D1/0035 ,  Y02T50/166 ,  Y02T70/121

    Abstract: An aerodynamic or hydrodynamic wall surface has an array of fibrillar structures disposed on and extending from the wall surface, wherein each fibrillar structure comprises a stalk and a tip. The stalk has a first end and a second end, wherein the first end is attached to the wall surface, and the stalk is oriented with respect to the wall surface at a stalk angle between approximately 1 degrees and 179 degrees. The tip has a first side and a second side, wherein the first side is attached proximate to the second end of the stalk, the tip has a larger cross-sectional area than the stalk, and the second side comprises a substantially planar surface that is oriented with respect to the stalk at a tip angle between approximately 0 degrees and 90 degrees.

    Abstract translation: 空气动力学或流体动力学壁表面具有布置在壁表面上并从壁表面延伸的纤维结构阵列，其中每个纤维结构包括茎和尖端。 茎具有第一端和第二端，其中第一端附接到壁表面，并且茎以约1度至179度之间的柄角相对于壁表面定向。 尖端具有第一侧和第二侧，其中第一侧靠近杆的第二端附接，尖端具有比杆更大的横截面面积，第二侧包括基本平坦的表面， 在约0度和90度之间的尖端角度相对于杆定向。

    DENDRITIC CELL ENHANCEMENT OF PROTECTION BY HUMAN MUC1-STIMULATED MONONUCLEAR CELLS AGAINST CANCER
    35.
    发明申请
    DENDRITIC CELL ENHANCEMENT OF PROTECTION BY HUMAN MUC1-STIMULATED MONONUCLEAR CELLS AGAINST CANCER 审中-公开
    人类MUC1刺激的单核细胞对癌症的保护作用的细胞增殖

    公开(公告)号：WO2014130823A1

    公开(公告)日：2014-08-28

    申请号：PCT/US2014/017704

    申请日：2014-02-21

    Applicant: TEXAS TECH UNIVERSITY SYSTEM

    Inventor： WRIGHT, Stephen, E.

    IPC: C12N5/0784 ,  A61K35/26 ,  A61P35/00

    CPC classification number: C12N5/0639 ,  A61K35/15 ,  A61K35/17 ,  A61K39/0011 ,  A61K2039/5154 ,  A61K2039/57 ,  C12N5/0638 ,  C12N2501/056 ,  C12N2501/22 ,  C12N2501/25

    Abstract: The present invention includes compositions and methods for improving a cytotoxic immune response to a cancer antigen comprising obtaining peripheral blood mononuclear cells from a subject; incubating adherent peripheral blood mononuclear cells with the cancer antigen and GM-CSF in the absence of IL-4 to mature the adherent peripheral blood mononuclear cells into dendritic cells; and isolating the matured dendritic cells, wherein the matured dendritic cells stimulate cytotoxic T cells specific for the cancer antigen in vivo.

    Abstract translation: 本发明包括用于改善对癌抗原的细胞毒性免疫应答的组合物和方法，包括从受试者获得外周血单核细胞; 在不存在IL-4的情况下，将粘附的外周血单核细胞与癌抗原和GM-CSF一起培养，使粘附的外周血单核细胞成熟为树突状细胞; 并分离成熟的树突状细胞，其中成熟的树突细胞在体内刺激对癌抗原特异性的细胞毒性T细胞。

    IDENTIFICATION AND QUANTIFICATION OF INTACT GLYCOPEPTIDES IN COMPLEX SAMPLES
    37.
    发明申请
    IDENTIFICATION AND QUANTIFICATION OF INTACT GLYCOPEPTIDES IN COMPLEX SAMPLES 审中-公开
    复杂样品中的确定性糖蛋白的鉴定和定量

    公开(公告)号：WO2013177121A2

    公开(公告)日：2013-11-28

    申请号：PCT/US2013/041962

    申请日：2013-05-21

    Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION ,  TEXAS TECH UNIVERSITY SYSTEM

    Inventor： TANG, Haixu ,  MECHREF, Yehia S.

    IPC: C12Q1/37

    CPC classification number: G01N33/6848 ,  C12Q1/37 ,  G01N33/6842 ,  G01N2440/38 ,  G06F19/70

    Abstract: Illustrative embodiments of methods and apparatus for identifying one or more intact glycopeptides in a sample are disclosed. According to one illustrative embodiment, a method may comprise receiving data representing a plurality of mass spectra obtained from mass spectrometry of the sample, scoring data representing each of the plurality of mass spectra against data associated with target glycopeptides, and identifying one or more intact glycopeptides in the sample based at least in part on the scoring of the data representing each of the plurality of mass spectra.

    Abstract translation: 公开了用于鉴定样品中一种或多种完整糖肽的方法和装置的说明性实施方案。 根据一个说明性实施例，方法可以包括接收表示从样品的质谱法获得的多个质谱的数据，根据与目标糖肽相关的数据表示代表多个质谱中的每一个的数据的数据，以及鉴定一个或多个完整的糖肽 在该样本中至少部分地基于表示多个质谱图中的每一个的数据的评分。

    MEDIA COMPOSITIONS FOR PROMOTING BACTERIAL AND FUNGAL GROWTH
    38.
    发明申请
    MEDIA COMPOSITIONS FOR PROMOTING BACTERIAL AND FUNGAL GROWTH 审中-公开
    用于促进细菌和真菌生长的媒体组合物

    公开(公告)号：WO2013067305A1

    公开(公告)日：2013-05-10

    申请号：PCT/US2012/063246

    申请日：2012-11-02

    Applicant: TEXAS TECH UNIVERSITY SYSTEM

    Inventor： LYTE, Mark

    IPC: C12N1/20 ,  C12N1/38

    CPC classification number: C12N1/20 ,  C12N1/14 ,  C12N1/16 ,  C12N1/38 ,  C12N2500/30 ,  C12N2500/34 ,  C12N2500/36 ,  C12N2500/38 ,  C12Q1/025

    Abstract: Methods and compositions for enhancing or promoting germination of bacterial spores, and yeasts are disclosed herein. The composition of the present invention comprises an extract obtained from banana or any member belonging to the genus Musa that may be used alone or in a growth medium to promote and enhance germination of bacterial spores, growth of bacterial, yeast, and fungal cell cultures.

    Abstract translation: 本文公开了用于增强或促进细菌孢子和酵母的发芽的方法和组合物。 本发明的组合物包括从香蕉或属于Musa属的任何成员获得的提取物，其可以单独使用或在生长培养基中使用以促进和增强细菌孢子的发芽，细菌，酵母和真菌细胞培养物的生长。

    TCR MIMIC ANTIBODIES AS VASCULAR TARGETING TOOLS
    39.
    发明申请
    TCR MIMIC ANTIBODIES AS VASCULAR TARGETING TOOLS 审中-公开
    TCR MIMIC抗体作为血管造影工具

    公开(公告)号：WO2012129520A1

    公开(公告)日：2012-09-27

    申请号：PCT/US2012/030406

    申请日：2012-03-23

    Applicant: TEXAS TECH UNIVERSITY SYSTEM ,  WEIDANZ, John A. ,  BICKEL, Ulrich

    Inventor： WEIDANZ, John A. ,  BICKEL, Ulrich

    IPC: A61K47/48 ,  A61K39/395 ,  A61P25/00

    CPC classification number: A61K39/3955 ,  A61K47/6849 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2833 ,  C07K2317/32 ,  C07K2317/77 ,  C07K2317/94

    Abstract: The present invention includes a method of delivering a therapeutic agent into and across an endothelial cell (EC) in a subject in need thereof, comprising: attaching to a T Cell receptor mimic (TCR mimic) an active agent to form a therapeutic agent; and administering to the subject the therapeutic agent in a pharmaceutically acceptable carrier, wherein the therapeutic agent effectively crosses the EC microvascular barrier. Furthermore, the present invention relates to methods of treating diseases (particularly neuronal diseases) or conditions comprising identifying a subject in need of such a treatment and administering to said subject a composition comprising a TCR mimic conjugated to an active agent.

    Abstract translation: 本发明包括将治疗剂递送到有需要的受试者内和穿过内皮细胞（EC）的方法，所述方法包括：将T细胞受体模拟物（TCR模拟物）附着于活性剂以形成治疗剂; 以及将所述治疗剂施用于药学上可接受的载体中，其中所述治疗剂有效地穿过所述EC微血管屏障。 此外，本发明涉及治疗疾病（特别是神经元疾病）或包括鉴定需要这种治疗的受试者和向所述受试者施用包含与活性剂缀合的TCR模拟物的组合物的方法。

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