公开(公告)号：WO03033649A3

公开(公告)日：2003-07-03

申请号：PCT/US0230460

申请日：2002-09-25

Applicant: UNIV MISSOURI

IPC: C07C39/15 ,  A61K9/14 ,  A61K9/16

CPC classification number: C07C39/15 ,  Y10S977/84

Abstract: A composition comprising a guest/host assembly having a spheroidal host assembly comprised of a hexamer of a methylene-bridged trihydroxybenzene tetramer and a guest component encapsulated within the spheroidal host assembly to provide a highly stable guest/host assembly. A guest component, specifically a pharmaceutically active agent, is encapsulated within the spheroidal host assembly to provide a guest/host assembly exhibiting a high stability, being stable upon a solubilization in a mixture of acetone and water in a one-to-one ratio for a period of one day at a temperature of 37 DEG C. The pharmaceutically active agent encapsulated within the spheroidal hexamer is selected from the group consisting of Depakote, Wellbutrin, Allegra, Neurontin, Zovirax, and Claritin. A process for the preparation of a hexameric complex, as described above, from a methylene-bridged tetramer solubilized in an amphiphilic organic solvent. An activator is incorporated into the amphiphilic solvent containing the tetramer. The activator comprises an organic compound of a lower molecular weight than that of the tetramer which is functionalized with at least one of an acidic group, a halogen, an amino group, an amido group, an ester group, or an hydroxy group. The tetramer may be prepared from an aldehyde and pyrogallol which are reacted under conditions to produce a condensation product of the methylene-bridged cyclic tetramer.

Abstract translation: 包含客体/主体组合物的组合物，其具有由亚甲基桥接的三羟基苯四聚体的六聚体组成的球形主体组合物和封装在球状主体组件内的客体组分，以提供高度稳定的客体/主体组件。 将客体组分，特别是药物活性剂包封在球状宿主组合物内，以提供呈现高稳定性的客体/主体组合物，其以一对一比例溶解于丙酮和水的混合物中是稳定的 在37℃的温度下一天的时间。包封在球形六聚体内的药物活性剂选自Depakote，Wellbutrin，Allegra，Neurontin，Zovirax和Claritin。 如上所述，从溶解在两亲性有机溶剂中的亚甲基桥连四聚体制备六聚体络合物的方法。 将活化剂掺入含有四聚体的两亲溶剂中。 所述活化剂包括比用酸性基团，卤素，氨基，酰胺基，酯基或羟基中的至少一个官能化的四聚物的分子量低的有机化合物。 四聚体可以由醛和连苯三酚制备，其在条件下反应以产生亚甲基桥连的环状四聚体的缩合产物。

公开(公告)号：WO03026494A2

公开(公告)日：2003-04-03

申请号：PCT/US0231273

申请日：2002-09-30

Applicant: SIDNEY KIMMEL CANCER CT ,  UNIV MISSOURI ,  JOLLA INST ALLERGY IMMUNOLOG

Inventor： HUFLEJT MARGARET E ,  MOSSINE VALERI V ,  CROFT MICHAEL

IPC: A61K38/00 ,  C07K14/47 ,  G01N33/574 ,  A61B

CPC classification number: G01N33/574 ,  A61K38/00 ,  C07K14/4726 ,  G01N33/57415 ,  G01N2333/4724

Abstract: Methods of prognosis and of prophylactic and therapeutic treatment of tumors based on the involvement of galectin-4 in tumor development are described.

Abstract translation: 描述了基于半乳凝素-4参与肿瘤发展的预后和预防和治疗性治疗肿瘤的方法。

公开(公告)号：WO0233053A3

公开(公告)日：2003-04-03

申请号：PCT/US0132516

申请日：2001-10-17

Applicant: UNIV MISSOURI ,  ZHAO GUANG-QUAN ,  YING YING

Inventor： ZHAO GUANG-QUAN ,  YING YING

IPC: A61K35/12 ,  C12N5/074 ,  C12N5/06 ,  A01K67/027 ,  C12N5/08

CPC classification number: C12N5/0611 ,  A61K35/12 ,  C12N2501/155 ,  C12N2502/99 ,  C12N2506/02

Abstract: Methods for enhancing the generation of primordial germ cells in pluripotent embryonic cells by contacting the pluripotent cells with at least one 60A class BMP protein and at least one DPP class BMP protein are provided. Also provided are methods for treating sterility and for the introduction of at least one transgene into the germ line of an animal.

Abstract translation: 提供了通过使多能细胞与至少一种60A类BMP蛋白和至少一种DPP类BMP蛋白接触来增强多能胚胎细胞中原始生殖细胞的产生的方法。 还提供了治疗无菌性和将至少一种转基因导入动物胚系的方法。

公开(公告)号：WO0026185A2

公开(公告)日：2000-05-11

申请号：PCT/US9925592

申请日：1999-10-29

Applicant: UNIV MISSOURI

Inventor： PHILLIPS JEFFREY O

IPC: A61K31/4439 ,  A61K33/00 ,  A61K47/02 ,  C07D

CPC classification number: A61K47/02 ,  A61K31/4439 ,  A61K33/00 ,  A61K2300/00

Abstract: A method of treating gastric acid disorders by administering to a patient a pharmaceutical composition including a proton pump inhibitor in a pharmaceutically acceptable carrier including a bicarbonate salt of a Group IA metal where the administering step consists of a single dosage form without requiring further administering of the bicarbonate salt of the Group IA metal. A pharmaceutical composition includes a dry formulation of a proton pump inhibitor in a pharmaceutically acceptable carrier including a bicarbonate salt of a Group IA metal. A pharmaceutical composition for making a dry formulation of a proton pump inhibitor which includes a proton pump inhibitor and a bicarbonate salt of a Group IA metal in a form for convenient storage, whereby when the composition is in a dry formulation which is suitable for enteral administration.

Abstract translation: 通过向患者施用包含质子泵抑制剂的药物组合物在包括IA族金属的碳酸氢盐的药学上可接受的载体中治疗胃酸失调的方法，其中所述施用步骤由单一剂型组成，而不需要进一步施用 IA族金属的碳酸氢盐。 药物组合物包括在包括IA族金属的碳酸氢盐的可药用载体中的质子泵抑制剂的干制剂。 用于制备质子泵抑制剂的干燥制剂的药物组合物，其包含质子泵抑制剂和第IA族金属的碳酸氢盐以便于储存的形式，由此当组合物处于适于肠内施用的干燥制剂中时 。

公开(公告)号：WO2016018507A2

公开(公告)日：2016-02-04

申请号：PCT/US2015033449

申请日：2015-06-01

Applicant: UNIV MISSOURI ,  HILMAS GREGORY EUGENE ,  FAHRENHOLTZ WILLIAM GENE ,  WATTS JEREMY LEE ,  KING DEREK SCOTT ,  LANDWEHR SEAN

Inventor： HILMAS GREGORY EUGENE ,  FAHRENHOLTZ WILLIAM GENE ,  WATTS JEREMY LEE ,  KING DEREK SCOTT ,  LANDWEHR SEAN

IPC: C04B37/00 ,  C04B35/565

CPC classification number: C04B37/005 ,  C04B35/565 ,  C04B37/001 ,  C04B2235/6562 ,  C04B2235/6565 ,  C04B2235/662 ,  C04B2235/77 ,  C04B2237/083 ,  C04B2237/086 ,  C04B2237/16 ,  C04B2237/365 ,  C04B2237/60 ,  C04B2237/708 ,  C04B2237/72

Abstract: A method of producing a ceramic weld, including identifying a ceramic first surface an a ceramic second surface to he bonded together, maintaining a non-oxidizing atmosphere over the first and second surfaces, and engaging the first and second surfaces to define a joint, An arc is generated between an electrode and the joint to create a liquid phase, and the liquid phase is cooled to yield a solid fusion layer, wherein the first and second surfaces are joined in the fusion layer.

Abstract translation: 一种陶瓷焊接的制造方法，其特征在于，将陶瓷第一表面与陶瓷第二表面接合，将陶瓷第二表面结合在一起，在第一表面和第二表面上保持非氧化气氛，并与第一表面和第二表面接合以限定接头。 在电极和接头之间产生电弧以产生液相，并且将液相冷却以产生固体熔融层，其中第一和第二表面在熔融层中接合。

公开(公告)号：WO2014165227A2

公开(公告)日：2014-10-09

申请号：PCT/US2014024865

申请日：2014-03-12

Applicant: PIONEER HI BRED INT ,  UNIV IOWA STATE RES FOUND INC ,  UNIV NORTH CAROLINA STATE ,  UNIV GEORGIA ,  UNIV MISSOURI

Inventor： WEI JUN-ZHI ,  WU GUSUI ,  SIMMONS CARL R ,  BAUM THOMAS ,  DAVIS ERIC ,  HUSSEY RICHARD ,  MITHCHUM MELISSA G

CPC classification number: C12N15/8285 ,  A01N43/90 ,  C07K14/4354 ,  C12N15/8218 ,  Y02A40/164

Abstract: The present invention comprises methods and compositions for controlling nematode parasitism in host plant. The present invention comprises novel polynucleotides and polypeptides encoded by such polynucleotides comprising one or more nucleic acid sequences disclosed herein having a nucleotide sequence comprising any one of SEQ ID NOs: 1-142 or 161, a fragment or variant thereof, or a complement thereof, or a polypeptide sequence comprising any one of SEQ ID NOs: 143-160, a fragment or variant thereof.

Abstract translation: 本发明包括用于控制宿主植物中线虫寄生的方法和组合物。 本发明包括新的多核苷酸和由这样的多核苷酸编码的多肽，所述多核苷酸包含本文所公开的一种或多种核酸序列，其具有包含SEQ ID NO：1-142或161中任一项的核苷酸序列，其片段或变体，或其互补序列， 或包含SEQ ID NO：143-160中任一项的多肽序列，其片段或变体。

公开(公告)号：WO2012092114A3

公开(公告)日：2012-10-11

申请号：PCT/US2011066797

申请日：2011-12-22

Applicant: UNIV MISSOURI ,  ZOU XIAOQING ,  HYDER SALMAN M ,  LIANG YAYUN ,  GRINTER SAM Z ,  HUANG SHENGYOU

Inventor： ZOU XIAOQING ,  HYDER SALMAN M ,  LIANG YAYUN ,  GRINTER SAM Z ,  HUANG SHENGYOU

IPC: A61K31/5395 ,  A61K31/357 ,  A61K31/505 ,  A61K31/54 ,  A61K38/16 ,  A61P35/00

CPC classification number: A61K31/452 ,  A61K31/12 ,  A61K31/135 ,  A61K31/138 ,  A61K31/343 ,  A61K31/381 ,  A61K31/416 ,  A61K31/423 ,  A61K31/428 ,  A61K31/44 ,  A61K31/4425 ,  A61K31/4439 ,  A61K31/536 ,  A61K31/5685 ,  C12Q1/26 ,  C12Q1/533 ,  G01N33/5011 ,  G01N2333/904 ,  G01N2333/99

Abstract: The present invention identifies the cholesterol biosynthetic pathway, including the enzyme oxidosqualene cyclase, as new protein targets for anti-tumor therapeutics. The present invention further provides a class of oxidosqualene cyclase inhibitors containing a tertiary amine linked with aromatic ring structures, as a new class of anticancer agents. Compounds disclosed herein have been tested in 19 cell lines including breast cancer, prostate cancer, lung cancer (including drug-resistant lung cancer H69AR), colon cancer, ovarian cancer (including drug-resistant OVCAR-3), and pancreatic cancer cells, as wells as in human breast and prostate xenograft tumor growth in nude mice, and have been shown to be active.

Abstract translation: 本发明鉴定了胆固醇生物合成途径，包括酶氧化四环素环化酶，作为抗肿瘤治疗剂的新蛋白质靶标。 本发明还提供了一类含有与芳环结构连接的叔胺的氧化四环素环化酶抑制剂，作为新一类抗癌剂。 本文公开的化合物已经在包括乳腺癌，前列腺癌，肺癌（包括耐药性肺癌H69AR），结肠癌，卵巢癌（包括耐药性OVCAR-3）和胰腺癌细胞在内的19种细胞系中进行了测试，如 在人类乳腺和前列腺异种移植肿瘤生长的裸鼠中的孔，并已被证明是活跃的。

公开(公告)号：WO2012051296A3

公开(公告)日：2012-08-02

申请号：PCT/US2011055962

申请日：2011-10-12

Applicant: UNIV CASE WESTERN RESERVE ,  UNIV MISSOURI ,  REDDY PARKASH V ,  NAIR NANDITHA G ,  SMITH MARK A ,  KUDO WATARU

Inventor： REDDY PARKASH V ,  NAIR NANDITHA G ,  SMITH MARK A ,  KUDO WATARU

IPC: C07D473/34 ,  A61K31/52 ,  A61P25/00 ,  A61P35/00 ,  C07D403/06 ,  C07D473/40

CPC classification number: C07D473/40 ,  A61K31/52 ,  C07D473/34

Abstract: A pharmaceutical composition for inhibiting at least protein kinase in a cell of a subject includes a purine based triazole.

Abstract translation: 用于抑制受试者细胞中至少蛋白激酶的药物组合物包括嘌呤类三唑。

公开(公告)号：WO2010118154A3

公开(公告)日：2011-01-20

申请号：PCT/US2010030270

申请日：2010-04-07

Applicant: UNIV MISSOURI ,  KWON JAE WAN

Inventor： KWON JAE WAN

IPC: G01G17/04 ,  B81B7/00 ,  G01F11/00 ,  G01G3/13 ,  G01G3/16 ,  H01L41/00

CPC classification number: H01L41/1132 ,  G01G3/13 ,  G01N29/022 ,  G01N29/036 ,  G01N29/2437 ,  G01N2291/0256 ,  G01N2291/0426

Abstract: A device for sensing a mass in a liquid environment including a resonator comprising a piezo layer having a top electrode and a bottom electrode, a sensing surface located adjacent and opposite the top electrode, the resonator and the sensing surface defining a gap therebetween, and a post attached to the sensing surface and the resonator.

Abstract translation: 一种用于感测液体环境中的质量的装置，包括包括具有顶部电极和底部电极的压电层的谐振器，与顶部电极相邻并相对的感测表面，谐振器和感测表面在其间限定间隙， 柱连接到感测表面和谐振器。

公开(公告)号：WO2010005917A3

公开(公告)日：2010-05-06

申请号：PCT/US2009049733

申请日：2009-07-06

Applicant: UNIV MISSOURI ,  UNIV COLUMBIA ,  HUNG CLARK T ,  ATESHIAN GERARD A ,  LIMA ERIC G ,  COOK JAMES L ,  BIAN LI MING

Inventor： HUNG CLARK T ,  ATESHIAN GERARD A ,  LIMA ERIC G ,  COOK JAMES L ,  BIAN LI MING

IPC: A61F2/28 ,  A61L27/04 ,  A61L27/12 ,  A61L27/14 ,  A61L27/24 ,  A61L27/52

CPC classification number: B29C39/003 ,  A61F2/28 ,  A61F2/30756 ,  A61F2002/30762 ,  A61F2002/30766 ,  A61F2002/30878 ,  A61F2002/30948 ,  A61F2002/30952 ,  A61F2002/30962 ,  A61F2310/00131 ,  A61L27/3817 ,  A61L27/3852 ,  A61L27/3895 ,  A61L27/52 ,  A61L27/56 ,  A61L2430/06 ,  B29C39/10 ,  C12N5/0655 ,  C12N2501/15 ,  C12N2533/76

Abstract: Implants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the engineered tissue for attaching the implant to a native bone of the biological organism. The engineered tissue includes a scaffold containing a biocompatible material, and a plurality of living chondrocytes supported by the scaffold. Methods for culturing chondrocytes for incorporation into a biocompatible implant are provided. A bioreactor for producing functional cartilaginous tissue from a cell-seeded scaffold and a system for producing functional cartilaginous tissue are also provided.

Abstract translation: 用于重建或修复生物生物体的一个或多个关节软骨表面的植入物包括固定到工程组织的工程组织和生物相容性多孔基底，用于将植入物附着到生物体的天然骨。 工程组织包括含有生物相容性材料的支架和由支架支撑的多个活的软骨细胞。 提供了用于培养软骨细胞并入生物相容性植入物的方法。 还提供了用于从细胞种植支架产生功能性软骨组织的生物反应器和用于产生功能性软骨组织的系统。