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公开(公告)号：WO2008039875A1
公开(公告)日：2008-04-03
申请号：PCT/US2007/079601
申请日：2007-09-26
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , VAN DAM, Robert, M. , HEATH, James, R. , ELIZAROV, Arkadij
Inventor： VAN DAM, Robert, M. , HEATH, James, R. , ELIZAROV, Arkadij
CPC classification number: G01N35/1095 , B01L3/502715 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , G01N2035/00158
Abstract: An interface system and device for interfacing a microfluidic chip system is disclosed comprising an adapter having channels and ports connecting to the microfluidic chip system and an external fluidic system. An interface, device and method are provided herein, that disclose the connection of larger volumes of an external fluidic system to smaller volumes of a microfludiic chip system and the ability to effectively purge microfluidic channels without contamination.
Abstract translation: 公开了一种用于接口微流控芯片系统的接口系统和设备，其包括具有连接到微流体芯片系统和外部流体系统的通道和端口的适配器。 本文提供了一种界面，装置和方法，其公开了较大体积的外部流体系统与较小体积的微离子芯片系统的连接以及有效地清除微流体通道而不被污染的能力。
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公开(公告)号：WO2007075289A3
公开(公告)日：2008-01-10
申请号：PCT/US2006046714
申请日：2006-12-07
Applicant: HONEYWELL INT INC , PADMANAHAN ARAVIND , REZACHEK TOM , BARDELL RON L , BIRD DOUGLAS
Inventor： PADMANAHAN ARAVIND , REZACHEK TOM , BARDELL RON L , BIRD DOUGLAS
IPC: B01L3/00 , B01L9/00 , F04C2/10 , G01N33/483
CPC classification number: B01L9/527 , B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2300/0809 , B01L2300/0877 , B01L2300/123 , B01L2400/0481 , F04C2/18 , F04C13/001 , G01N33/18 , G01N2035/00158
Abstract: Instrument-cartridge interfaces for fluidic analyzers that have an instrument and a removable cartridge are disclosed. For example, and in one illustrative embodiment, the instrument may include a needle that is adapted to penetrate a septum on a removable cartridge. In another illustrative embodiment, the instrument. may include a plunger that is adapted to deform a deformable membrane on a removable cartridge. In yet another illustrative embodiment, the instrument may include a nozzle that is adapted to mate and seal with a flow channel on a removable cartridge. Techniques for detecting the flow rate in a flow channel on a removable cartridge, as well as the position of fluid in a flow channel of a removable cartridge, are also disclosed.
Abstract translation: 公开了具有仪器和可移除盒的流体分析仪的盒式磁带接口。 例如，并且在一个说明性实施例中，该仪器可以包括适于穿透可移除盒的隔膜的针。 在另一说明性实施例中，仪器。 可以包括适于将可变形膜变形成可移除盒的柱塞。 在另一个说明性实施例中，仪器可以包括适于与可移除盒的流动通道配合和密封的喷嘴。 还公开了用于检测可移除盒上的流动通道中的流速以及可移除盒的流动通道中的流体位置的技术。
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公开(公告)号：WO2007106552A3
公开(公告)日：2007-11-29
申请号：PCT/US2007006521
申请日：2007-03-14
Applicant: MICRONICS INC , HUNTER WILLIAM SAMUEL
Inventor： HUNTER WILLIAM SAMUEL
CPC classification number: B01F13/0059 , A61B10/0045 , A61B10/0051 , A61B10/0096 , B01F13/0818 , B01L3/502715 , B01L3/5029 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/10 , B01L2300/0627 , B01L2300/1805 , B01L2300/1827 , B01L2300/185 , B01L2400/0683 , G01N2001/028
Abstract: A biosafe apparatus is disclosed for assay and diagnosis of respiratory pathogens comprising a nasal sampling device, a single entry, disposable microfluidic cartridge for target nucleic acid amplification, and an instrument with on-board assay control platform and target detection means.
Abstract translation: 公开了用于呼吸道病原体的测定和诊断的生物安全装置，其包括鼻取样装置，用于靶核酸扩增的单入口，一次性微流体盒，以及具有板载测定控制平台和目标检测装置的仪器。
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公开(公告)号：WO2007110779A2
公开(公告)日：2007-10-04
申请号：PCT/IB2007/001756
申请日：2007-03-29
Applicant: INVERNESS MEDICAL SWITZERLAND GMBH , LOWE, Phillip , KEATCH, Steven, Alexander , HOWELL, Steven , MARQUORDT, Claus , POLWART, Ruth , THOMSON, Alan, Kenneth
Inventor： LOWE, Phillip , KEATCH, Steven, Alexander , HOWELL, Steven , MARQUORDT, Claus , POLWART, Ruth , THOMSON, Alan, Kenneth
CPC classification number: G01N33/558 , B01L3/5027 , B01L3/502715 , B01L3/502761 , B01L3/502769 , B01L9/527 , B01L2200/0621 , B01L2200/0668 , B01L2300/0636 , B01L2300/0645 , B01L2300/0672 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/0406 , B01L2400/0683 , B01L2400/0688 , B01L2400/086 , G01N33/54326 , G01N33/54366 , G01N35/0098
Abstract: An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample liquid. The magnetically susceptible particles can be located (via an applied magnetic field) at the liquid-air interface when a second liquid contacts the interface to form a liquid-liquid interface. The magnetic particles travel across the liquid-liquid interface to the second liquid. The magnetically susceptible particles are configured to transport an analyte across the interface into the second liquid. An assay for the analyte is performed in the second liquid. An assay for another analyte can also be performed in the sample liquid.
Abstract translation: 测定方法和装置可以在样品液体的单个等分试样上进行至少一个（例如，至少两个）测定。 该装置可以将样品液体与包含磁敏感颗粒的测定试剂混合。 该装置被配置为产生与样品液体的样品液 - 空界面。 当第二液体接触界面以形成液 - 液界面时，磁敏感颗粒可以在液 - 空界面处（通过施加的磁场）定位。 磁性颗粒穿过液体 - 液体界面移动到第二液体。 磁敏感颗粒被配置成将分析物通过界面输送到第二液体中。 在第二液体中进行分析物的测定。 也可以在样品液体中进行另一分析物的测定。
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公开(公告)号：WO2007106552A2
公开(公告)日：2007-09-20
申请号：PCT/US2007/006521
申请日：2007-03-14
Applicant: MICRONICS, INC. , HUNTER, William Samuel
Inventor： HUNTER, William Samuel
IPC: C12N15/00
CPC classification number: B01F13/0059 , A61B10/0045 , A61B10/0051 , A61B10/0096 , B01F13/0818 , B01L3/502715 , B01L3/5029 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/10 , B01L2300/0627 , B01L2300/1805 , B01L2300/1827 , B01L2300/185 , B01L2400/0683 , G01N2001/028
Abstract: A biosafe apparatus is disclosed for assay and diagnosis of respiratory pathogens comprising a nasal sampling device, a single entry, disposable microfluidic cartridge for target nucleic acid amplification, and an instrument with on-board assay control platform and target detection means.
Abstract translation: 公开了一种用于呼吸道病原体的分析和诊断的生物安全装置，其包括用于目标核酸扩增的鼻取样装置，单次进入的一次性微流体盒和具有车载测定控制平台的仪器，以及 目标检测手段。
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Patent Agency Ranking
公开(公告)号：WO2004061418A3
公开(公告)日：2007-09-07
申请号：PCT/US0341241
申请日：2003-12-23
Applicant: MESO SCALE TECHNOLOGIES LLC , GLAZER ELI N , LELAND JONATHAN K , BILLADEAU MARK A , LEGINUS JOSEPH M , JEFFREY-COKER BANDELE , DEBAD JEFF D , PHALNIKAR KOUSTUBH A , JAMBUNATHAN SRIRAM
Inventor： GLAZER ELI N , LELAND JONATHAN K , BILLADEAU MARK A , LEGINUS JOSEPH M , JEFFREY-COKER BANDELE , DEBAD JEFF D , PHALNIKAR KOUSTUBH A , JAMBUNATHAN SRIRAM
IPC: C12M1/34 , B01L3/00 , B01L9/00 , B01L99/00 , C12M3/00 , C12Q1/00 , C12Q1/68 , C40B40/10 , G01N15/06 , G01N21/00 , G01N25/18 , G01N27/02 , G01N31/22 , G01N33/00 , G01N33/48 , G01N33/53 , G01N33/543 , G01N33/553
CPC classification number: G01N21/76 , B01J19/0046 , B01J2219/00653 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , B01L3/502715 , B01L3/5029 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/049 , B01L2400/0688 , B33Y80/00 , C12Q1/001 , C40B40/10 , G01N27/30 , G01N33/5438 , G01N2458/30 , Y10T436/25 , Y10T436/25375 , Y10T436/255
Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
Abstract translation: 测定模块，优选测定盒，被描述为可用于控制模块操作的方面的读取器设备。 模块优选地包括具有集成电极的检测室，其可用于执行电极诱导的发光测量。 描述了以这种控制方式将测定试剂固定在这些电极和其它表面上的方法。 还描述了具有检测室，优选地具有集成电极的测定模块和盒，以及可以包括样品室，废物室，导管，通风口，气泡阱，试剂室，干试剂丸区等的其它流体组分。 在某些优选实施例中，这些模块适于接收和分析在施用器棒上收集的样品。
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公开(公告)号：WO2007085797A1
公开(公告)日：2007-08-02
申请号：PCT/GB2007/000127
申请日：2007-01-17
Applicant: BP OIL INTERNATIONAL LIMITED , HODGES, Michael, Graham
Inventor： HODGES, Michael, Graham
CPC classification number: B01L3/502715 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2300/0645 , B01L2300/0816 , B01L2400/0487 , G01N27/624 , G01N33/2823 , G01N33/2876 , G01N35/1095 , Y10T436/21
Abstract: A sample plate for use with a portable apparatus containing at least two different analytical devices, said plate (1) comprising (i) a receiver (2) for a fluid to be analysed; (ii) at least two fluidic channels (6, 7) each adapted to transfer a portion of said fluid or a component or reaction product thereof from said receiver (2) to one of said analytical devices contained in said associated portable analysis apparatus; (iii) at least one sensor (13) capable of responding to a physical or chemical property of said fluid or a component or reaction product thereof, and/or at least one sample cell (14) for containing a sample of said fluid or a component or reaction product thereof for spectroscopic or optical analysis; and (iv) at least one additional fluidic channel (11, 12) adapted to transfer a portion of said fluid or a component or reaction product thereof from said receiver to said at least one sensor (13) and/or sample cell (14).
Abstract translation: 一种用于与包含至少两种不同分析装置的便携式装置一起使用的样品板，所述板（1）包括（i）用于待分析流体的接收器（2） （ii）至少两个流体通道（6,7），每个流体通道适于将所述流体的一部分或其成分或反应产物从所述接收器（2）转移到所述相关便携式分析设备中包含的所述分析装置之一; （iii）能够响应所述流体或其组分或反应产物的物理或化学性质的至少一个传感器（13），和/或至少一个用于容纳所述流体样品的样品池（14）或 组分或其反应产物用于光谱或光学分析; 和（iv）适于将所述流体的一部分或其组分或反应产物从所述接收器转移到所述至少一个传感器（13）和/或样品池（14）的至少一个附加流体通道（11,12） 。
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公开(公告)号：WO2007084232A1
公开(公告)日：2007-07-26
申请号：PCT/US2006/047792
申请日：2006-12-14
Applicant: HONEYWELL INTERNATIONAL INC. , FRITZ, Bernard, S. , PADMANABHAN, Aravind , REUTIMAN, Peter
Inventor： FRITZ, Bernard, S. , PADMANABHAN, Aravind , REUTIMAN, Peter
CPC classification number: B01L3/502715 , B01L3/502776 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/10 , B01L2200/143 , B01L2300/0672 , B01L2300/0816 , B01L2300/087 , B01L2400/0481 , B01L2400/0487 , B01L2400/0605 , G01N33/5002 , G01N2015/008 , G01N2015/1486
Abstract: An apparatus and approach for performing multipart differentiation such as, for example, three, four and five part differentiation of white blood cells in a card or cartridge. The may be a combination of several kinds of lysing and/or staining/marking in a variety of sequential and parallel runs to achieve the differentiation of the cells. Various cell counts may also be performed.
Abstract translation: 用于进行多部分微分的装置和方法，例如卡或盒中白细胞的三，四和五部分分化。 可以是多种顺序和平行运行中的几种裂解和/或染色/标记的组合，以实现细胞的分化。 也可以执行各种细胞计数。
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公开(公告)号：WO2007075289A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/046714
申请日：2006-12-07
Applicant: HONEYWELL INTERNATIONAL INC. , PADMANAHAN, Aravind , REZACHEK, Tom , BARDELL, Ron, L. , BIRD, Douglas
Inventor： PADMANAHAN, Aravind , REZACHEK, Tom , BARDELL, Ron, L. , BIRD, Douglas
IPC: B01L3/00 , B01L9/00 , G01N33/483
CPC classification number: B01L9/527 , B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2300/0809 , B01L2300/0877 , B01L2300/123 , B01L2400/0481 , F04C2/18 , F04C13/001 , G01N33/18 , G01N2035/00158
Abstract: Instrument-cartridge interfaces for fluidic analyzers that have an instrument and a removable cartridge are disclosed. For example, and in one illustrative embodiment, the instrument may include a needle that is adapted to penetrate a septum on a removable cartridge. In another illustrative embodiment, the instrument. may include a plunger that is adapted to deform a deformable membrane on a removable cartridge. In yet another illustrative embodiment, the instrument may include a nozzle that is adapted to mate and seal with a flow channel on a removable cartridge. Techniques for detecting the flow rate in a flow channel on a removable cartridge, as well as the position of fluid in a flow channel of a removable cartridge, are also disclosed.
Abstract translation: 公开了具有仪器和可移除盒的流体分析仪的盒式磁带接口。 例如，并且在一个说明性实施例中，该仪器可以包括适于穿透可移除盒的隔膜的针。 在另一说明性实施例中，仪器。 可以包括适于将可变形膜变形成可移除盒的柱塞。 在另一说明性实施例中，仪器可以包括适于与可移除盒上的流动通道配合和密封的喷嘴。 还公开了用于检测可移除盒上的流动通道中的流速以及可移除盒的流动通道中的流体位置的技术。
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公开(公告)号：WO2007044088A2
公开(公告)日：2007-04-19
申请号：PCT/US2006020107
申请日：2006-05-23
Applicant: BIOVITESSE INC , MORISETTE DALLAS T , LEE KEVIN F , SELIM HANY , ERIMLI BAHADIR , RAZOUK LAILA R , BASHIR RASHID
Inventor： MORISETTE DALLAS T , LEE KEVIN F , SELIM HANY , ERIMLI BAHADIR , RAZOUK LAILA R , BASHIR RASHID
CPC classification number: B01L3/502715 , B01J2219/0081 , B01L3/0293 , B01L3/565 , B01L9/52 , B01L9/527 , B01L2200/027 , B01L2300/0874 , B01L2300/0887 , C12M23/16 , C12M23/28 , C12M23/42 , G01N35/00 , G01N2035/00158
Abstract: A cartridge includes a first layer to receive a printed circuit board hosting a biochip. A second layer is connected to the first layer and is configured for sample injection to the biochip. The second layer includes a first septum to isolate fluidic ports. A third layer is connected to the second layer and is configured for fluidic purge operations. The third layer includes a second septum to isolate a fluidic channel. A fourth layer is connected to the third layer and is configured to receive and route fluidic samples to the third layer.
Abstract translation: 盒式磁带包括第一层，用于接收承载生物芯片的印刷电路板。 第二层连接到第一层，并被配置用于向生物芯片进行样品注入。 第二层包括隔离流体端口的第一隔膜。 第三层连接到第二层，并被配置为用于流体清洗操作。 第三层包括隔离流体通道的第二隔膜。 第四层连接到第三层，并且被配置为接收并将流体样品路由到第三层。
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