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    USE OF INDOLE AND INDOLINE DERIVATIVES IN THE TREATMENT OF OBESITY OR FOR THE REDUCTION OF FOOD INTAKE
    41.
    发明申请
    USE OF INDOLE AND INDOLINE DERIVATIVES IN THE TREATMENT OF OBESITY OR FOR THE REDUCTION OF FOOD INTAKE 审中-公开
    在治疗肥胖或减少食物摄入时使用吲哚和吲哚衍生物

    公开(公告)号：WO2003035061A1

    公开(公告)日：2003-05-01

    申请号：PCT/SE2002/001929

    申请日：2002-10-22

    Applicant: BIOVITRUM AB ,  CALDIROLA, Patrizia

    Inventor： CALDIROLA, Patrizia

    IPC: A61K31/4045

    CPC classification number: A61K31/4045 ,  C07D209/16

    Abstract: The invention provides the use of an indole or indoline derivative of Formula, II or III: wherein the substituents are as described in the specification; in the manufacture of a medicament for the treatment or prophylaxis of obesity or for the reduction of food intake. The invention also relates to the use of indole or indoline derivatives of Formula I, II or III for improving the bodily appearance of a mammal by causing loss of weight, as well as cosmetic compositions containing said compounds.

    Abstract translation: 本发明提供了式II或III的吲哚或二氢吲哚衍生物的用途：其中取代基如说明书所述; 在制备用于治疗或预防肥胖或减少食物摄取的药物中。 本发明还涉及式I，II或III的吲哚或二氢吲哚衍生物用于通过引起重量损失来改善哺乳动物的身体外观以及含有所述化合物的化妆品组合物的用途。

    PROCESS FOR BULK AUTOCLAVING
    43.
    发明申请
    PROCESS FOR BULK AUTOCLAVING 审中-公开
    大容量自动化程序

    公开(公告)号：WO2003002159A1

    公开(公告)日：2003-01-09

    申请号：PCT/SE2002/001302

    申请日：2002-06-28

    Applicant: BIOVITRUM AB ,  LJUNGQUIST, Olle

    Inventor： LJUNGQUIST, Olle

    IPC: A61L2/04

    CPC classification number: C08B37/0072 ,  A61L2/0023 ,  A61L2/04 ,  C08B37/0003

    Abstract: Process for bulk autoclaving of polysaccharides, wherein the process includes: a) dissolving the polysaccharides in an aqueous solution and mixing until a homogeneous solution is obtained; b) filling the resulting solution in at least one container; c) placing the filled container(s) including the solution in an autoclave; d) placing a sensor in at least one of the containers; and e) autoclaving the filled containers.

    Abstract translation: 多糖的大量高压灭菌方法，其中该方法包括：a）将多糖溶解在水溶液中并混合直至得到均匀的溶液; b）将所得溶液填充在至少一个容器中; c）将包括溶液的填充容器放置在高压釜中; d）将传感器放置在至少一个容器中; 和e）高压灭菌填充的容器。

    DISPENSER
    44.
    发明申请
    DISPENSER 审中-公开
    饮水机

    公开(公告)号：WO2003002005A1

    公开(公告)日：2003-01-09

    申请号：PCT/SE2002/001198

    申请日：2002-06-19

    Applicant: BIOVITRUM AB ,  LJUNGQUIST, Olle

    Inventor： LJUNGQUIST, Olle

    IPC: A61B17/00

    CPC classification number: A61B17/00491 ,  A61B2017/00495 ,  B05C17/00553 ,  B05C17/0109 ,  B05C17/0136

    Abstract: A dispenser comprising at least two parallel, hollow cylinders (14, 16) for sup- plying different mutually reactive components to a mixing device (33) located downstream of said cylinders. The dispenser comprises a respective first piston moveable in each of the cylinders (14, 16) and displaceable by a piston rod (22, 24) connected to the respective piston. A means for actuating the pistons rods (22, 24) to perform a forward stroke of the pistons in their respective cylinders (14, 16) for dispensing an amount of said reactive components to the mixing device (33) comprises at least one rotatable member (38) biased in a rotational direction by a torsion spring, and at least one flexible string (42, 44) attached to the rotatable member (38) and to an element (26) connected to the piston rods (22, 24). A manually operable brake member (46, 50) is arranged to normally act on the rotatable member (38) to hold it still, but, when deactivated, adapted to release the rotatable member (38) thereby causing the pistons to dispense the reactive components to the mixing device (33).

    Abstract translation: 一种分配器，包括至少两个平行的中空圆柱体（14,16），用于向位于所述气缸下游的混合装置（33）提供不同的相互反应的部件。 分配器包括可在每个气缸（14,16）中移动的相应的第一活塞，并且可由连接到相应活塞的活塞杆（22,24）移动。 用于致动活塞杆（22,24）以在其各自的气缸（14,16）中执行活塞的向前冲程的装置，用于将一定数量的所述反作用部件分配到混合装置（33），包括至少一个可旋转构件 （38），其通过扭转弹簧沿旋转方向偏置，以及至少一个连接到所述可旋转构件（38）的柔性绳索（42,44）以及连接到所述活塞杆（22,24）的元件（26）。 布置成可手动操作的制动构件（46,50），以正常地作用在可旋转构件（38）上以将其保持静止，但是当被停用时，适于释放可旋转构件（38），从而使活塞分配反应组件 到混合装置（33）。

    NEW METHOD
    46.
    发明申请
    NEW METHOD 审中-公开
    新方法

    公开(公告)号：WO2002081748A1

    公开(公告)日：2002-10-17

    申请号：PCT/SE2002/000677

    申请日：2002-04-04

    Applicant: BIOVITRUM AB ,  EKBLOM, Jonas

    Inventor： EKBLOM, Jonas

    IPC: C12Q1/68

    CPC classification number: C12N15/1034 ,  C12Q1/6811 ,  C12Q2563/125 ,  C12Q2527/107

    Abstract: The invention concerns a method for identifying RNA-binding molecules, comprising the steps of: predicting the structure of an RNA-fragment by an in silico method, choosing a suitable predicted RNA-fragment, synthesizing the cDNA-fragment corresponding to the predicted RNA-fragment, inserting the cDNA-fragment in the upstream proximity of a reporter assay gene, which reporter assay gene produces a signal upon translation, thereby forming a reporter construct, and performing a reporter gene assay, which assay monitors the interaction between a molecule to be tested for RNA-binding and the RNA-fragment of the reporter construct. Furthermore, the invention relates to the use of specific RNA-fragments in the method of the invention.

    Abstract translation: 本发明涉及一种鉴定RNA结合分子的方法，包括以下步骤：通过计算机方法预测RNA片段的结构，选择合适的预测RNA片段，合成与预测的RNA-片段相对应的cDNA片段， 片段，将cDNA片段插入报告基因测定基因的上游附近，该报告基因测定基因在翻译时产生信号，从而形成报道构建体，并进行报告基因测定，该测定监测待分离的分子之间的相互作用 测试RNA结合和报道构建体的RNA片段。 此外，本发明涉及本发明方法中特异性RNA片段的用途。

    FUSION PROTEIN
    48.
    发明申请
    FUSION PROTEIN 审中-公开

    公开(公告)号：WO2019201866A1

    公开(公告)日：2019-10-24

    申请号：PCT/EP2019/059692

    申请日：2019-04-15

    Applicant: SWEDISH ORPHAN BIOVITRUM AB (PUBL)

    Inventor： JAMES, Stephen ,  KAISER, Christina ,  NILSSON, Joakim ,  NORDLING, Erik ,  STRÖMBERG, Patrik ,  SVENSSON GELIUS, Stefan ,  LETHAGEN, Stefan ,  CORNVIK, Tobias ,  SVENSSON, Robert

    IPC: C07K16/28 ,  C07K16/36 ,  C07K16/22

    Abstract: A fusion protein is provided, comprising an antibody fragment having a biologic activity, said antibody fragment being selected from the group consisting of a Fab, a ScFv, a dAb, a VHH and a VNAR; and one or more half-life extending polypeptide moieties, each moiety comprising 2 to 136 units, with the proviso that said moiety or multiple moieties in total comprises 10 to 136 units, wherein each unit is independently selected from the group consisting of all amino acid sequences according to SEQ ID NO:1: X1-X2-X3-X4-X5-X6-D-X8-X9-X10-X11 (SEQ ID NO: 1) in which, independently: X1 is P or absent; X2 is V or absent; X3 is P or T; X4 is P or T; X5 is T or V; X6 is D, G or T; X8 is A, Q or S; X9 is E, G or K; X10 is A, E P or T; and X11 is A, P or T. The half-life extending polypeptide moiety has a generally unfolded conformation and provides a fusion protein with a large hydrodynamic radius that may avoid renal clearance. As a result, the biological half-life of the fusion protein is increased and the biological effect of the biologically active polypeptide may thus be prolonged.

    LYSOSOMAL FUSION PROTEIN
    49.
    发明申请
    LYSOSOMAL FUSION PROTEIN 审中-公开

    公开(公告)号：WO2019201855A1

    公开(公告)日：2019-10-24

    申请号：PCT/EP2019/059675

    申请日：2019-04-15

    Applicant: SWEDISH ORPHAN BIOVITRUM AB (PUBL)

    Inventor： NILSSON, Joakim ,  NORDLING, Erik ,  SANDEGREN, Anna ,  SVENSSON GELIUS, Stefan ,  POSSNER, Dominik

    IPC: C12N9/20 ,  A61K38/43

    Abstract: A fusion protein is disclosed, comprising (i) a lysosomal polypeptide; and (ii) a polypeptide moiety comprising 2-68 units, each unit being independently selected from the group consisting of all amino acid sequences according to SEQ ID NO: 1 : in which, independently: X1 is P or absent; X2 is V or absent; X3 is P or T; X4 is P or T; X5 is T or V; X6 is D, G or T; X8 is A, Q or S; X9 is E, G or K; X10 is A, E P or T; and X11 is A, P or T. The fusion protein exhibits improved distribution to target tissue and is useful in enzyme replacement therapy of lysosomal storage disease.

    STABLE POLYPEPTIDES BINDING TO HUMAN COMPLEMENT C5
    50.
    发明申请
    STABLE POLYPEPTIDES BINDING TO HUMAN COMPLEMENT C5 审中-公开
    稳定的聚合物绑定到人体完成C5

    公开(公告)号：WO2015028558A1

    公开(公告)日：2015-03-05

    申请号：PCT/EP2014/068282

    申请日：2014-08-28

    Applicant: SWEDISH ORPHAN BIOVITRUM AB (PUBL)

    Inventor： NILSSON, Joakim ,  NORDLING, Erik ,  STRÖMBERG, Patrik

    IPC: A61K38/00 ,  C07K14/47

    CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/315

    Abstract: The invention relates to a polypeptide capable of binding human complement component 5 (C5), said polypeptide comprising the amino acid sequence [ BM ]-[L2]-QSX 42 X 43 LLX 46 EAKKLX 52 X 53 X 54 Q wherein [ BM ] is a C5 bindingmotif; [L2] is an interconnecting loop; X 42 is selected from A and S; X 43 is selected from N and E; X 46 is selected from A, S and C; X 52 is selected from E, N and S; X 53 is selected from D, E and S, provided that X 53 is not D when X 52 is N; and X 54 is selected from A and S.

    Abstract translation: 本发明涉及能够结合人补体成分5（C5）的多肽，所述多肽包含氨基酸序列[BM] - [L2] -QSX42X43LLX46EAKKLX52X53X54Q，其中[BM]是C5结合蛋白; [L2]是互连环路; X42选自A和S; X43选自N和E; X46选自A，S和C; X52选自E，N和S; X53选自D，E和S，条件是当X52为N时，X53不为D; X54选自A和S.

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