公开(公告)号：WO2005113102A3

公开(公告)日：2006-11-02

申请号：PCT/US2005015982

申请日：2005-05-09

Applicant: EKSIGENT TECHNOLOGIES LLC ,  ARNOLD DON W ,  PAUL PHILLIP H

Inventor： ARNOLD DON W ,  PAUL PHILLIP H

IPC: B01F3/08 ,  B01D15/08 ,  B01D15/16 ,  B01F5/02 ,  B01F5/04 ,  B01F13/00 ,  B01F15/02 ,  B01J4/00 ,  B01J19/00 ,  B81B7/04

CPC classification number: B01J4/002 ,  B01D15/166 ,  B01F5/0256 ,  B01F5/045 ,  B01F13/0059 ,  B01F13/0066 ,  B01J4/001 ,  B01J19/0093 ,  B01J2219/0086 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00995

Abstract: Methods and apparatus for mixing fluids are provided. The devices and methods operate without moving parts, and generate well-mixed fluids over a broad dynamic range of flow rates. Preferred embodiments include junction-type mixers, bundled mixers, and co­axial mixers. The devices and methods are optimized to produce rapid, accurate gradients to improve associated system throughput and reproducibility.

Abstract translation: 提供了混合流体的方法和装置。 这些装置和方法在没有移动部件的情况下运行，并且在宽的动态动态范围内产生良好混合的流体。 优选实施例包括结型混合器，捆扎式混合器和同轴混合器。 优化设备和方法以产生快速，准确的梯度，以改善相关的系统吞吐量和重复性。

公开(公告)号：WO2005113102A2

公开(公告)日：2005-12-01

申请号：PCT/US2005/015982

申请日：2005-05-09

Applicant: EKSIGENT TECHNOLOGIES, LLC ,  ARNOLD, Don, W. ,  PAUL, Phillip, H.

Inventor： ARNOLD, Don, W. ,  PAUL, Phillip, H.

IPC: B01D15/08

CPC classification number: B01J4/002 ,  B01D15/166 ,  B01F5/0256 ,  B01F5/045 ,  B01F13/0059 ,  B01F13/0066 ,  B01J4/001 ,  B01J19/0093 ,  B01J2219/0086 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00995

Abstract: Methods and apparatus for mixing fluids are provided. The devices and methods operate without moving parts, and generate well-mixed fluids over a broad dynamic range of flow rates. Preferred embodiments include junction-type mixers, bundled mixers, and co­axial mixers. The devices and methods are optimized to produce rapid, accurate gradients to improve associated system throughput and reproducibility.

Abstract translation: 提供了混合流体的方法和装置。 这些装置和方法在没有移动部件的情况下运行，并且在宽的动态动态范围内产生良好混合的流体。 优选实施例包括结型混合器，捆扎式混合器和同轴混合器。 优化设备和方法以产生快速，准确的梯度，以改善相关的系统吞吐量和重复性。

公开(公告)号：WO2005028108A2

公开(公告)日：2005-03-31

申请号：PCT/US2004030202

申请日：2004-09-15

Applicant: EKSIGENT TECHNOLOGIES LLC ,  REHM JASON E ,  PAUL PHILLIP H ,  CYR DOUGLAS R ,  DATWANI SAMMY S ,  DAHL KLAUS J

Inventor： REHM JASON E ,  PAUL PHILLIP H ,  CYR DOUGLAS R ,  DATWANI SAMMY S ,  DAHL KLAUS J

IPC: G01F1/66 ,  G01F15/00 ,  G05D7/01 ,  B01L

CPC classification number: F16K99/0001 ,  B01L3/502738 ,  B01L2200/143 ,  B01L2300/0816 ,  B01L2400/0487 ,  B01L2400/0605 ,  B01L2400/0616 ,  B01L2400/0633 ,  F16K99/0011 ,  F16K99/0021 ,  F16K99/0057 ,  F16K2099/0084 ,  G01F1/661 ,  G01F1/662 ,  G01F15/005 ,  G05D7/0186 ,  Y10T137/7904

Abstract: A device for microfluidic control comprising a regulator that is moveable in a conduit where the regulator is a composite polymer formed from a composite mixture comprising a polymerizable precursor and a particulate filler.

Abstract translation: 一种用于微流控制的装置，包括可在管道中移动的调节器，其中调节器是由包含可聚合前体和颗粒填料的复合混合物形成的复合聚合物。

公开(公告)号：WO2005011081A2

公开(公告)日：2005-02-03

申请号：PCT/US2004/023623

申请日：2004-07-21

Applicant: EKSIGENT TECHNOLOGIES, LLC ,  PAUL, Phillip, H. ,  NEYER, David, W.

Inventor： PAUL, Phillip, H. ,  NEYER, David, W.

IPC: H02K

CPC classification number: F04B19/006 ,  F04B17/00

Abstract: In accordance with the present invention, stable electroosmotic flow systems and methods for designing the same are disclosed. The invention provides electroosmotic flow systems comprising electroosmotic flow elements, including bridge elements, that have matching flux ratios, i.e., when two or more elements of an electroosmotic flow system are in fluidic and electrical communication at a junction, the flux ratio for each of the elements is selected so that the difference in flux ratios system adjacent two elements is less than a target value. The invention also provides methods for designing such systems.

Abstract translation: 根据本发明，公开了稳定的电渗流系统及其设计方法。 本发明提供了电渗流系统，其包括具有匹配通量比的电渗流元件（包括桥元件），即当电渗流系统的两个或多个元件在连接处处于流体和电连通时，每个的通量比 选择元件，使得相邻两个元件的通量比的差异小于目标值。 本发明还提供了用于设计这种系统的方法。

公开(公告)号：WO2004092702A2

公开(公告)日：2004-10-28

申请号：PCT/US2004010234

申请日：2004-04-02

Applicant: EKSIGENT TECHNOLOGIES LLC ,  CYR DOUGLAS R ,  FARROW ROGER L ,  ARNOLD DON W

Inventor： CYR DOUGLAS R ,  FARROW ROGER L ,  ARNOLD DON W

IPC: G01N21/05 ,  G01N30/60 ,  G01N30/74 ,  G01N

CPC classification number: G01N30/74 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/161 ,  G01N21/05 ,  G01N30/6086 ,  G01N30/6095 ,  G01N2021/0346 ,  G01N2030/746 ,  Y10T156/1052

Abstract: A microfluidic detection device for examining liquid chromatography samples, particularly samples from microcolumns. The sample enters and leaves a detection cell through a restricted passageway having an annular shape, so that the velocity of the sample is higher as it enters and as it leaves the detection cell. This reduces dispersion of the sample in the detection cell.

Abstract translation: 用于检查液相色谱样品的微流体检测装置，特别是来自微柱的样品。 样品通过具有环形形状的受限通道进入并离开检测单元，使得样品的速度随着其进入并离开检测单元时更高。 这减少了样品在检测单元中的分散。

公开(公告)号：WO2004007080A2

公开(公告)日：2004-01-22

申请号：PCT/US0322306

申请日：2003-07-16

Applicant: EKSIGENT TECHNOLOGIES LLC ,  PAUL PHILLIP H ,  NEYER DAVID W ,  REHM JASON E

Inventor： PAUL PHILLIP H ,  NEYER DAVID W ,  REHM JASON E

IPC: G01N37/00 ,  B01D61/18 ,  B01F5/06 ,  B01F13/00 ,  B01F15/02 ,  B01J19/00 ,  B01L3/00 ,  B67D99/00 ,  F04B19/00 ,  F04B43/04 ,  F04B43/06 ,  F15C5/00 ,  F16K99/00 ,  G01N27/447 ,  G01N30/02 ,  G01N30/28 ,  G01N30/32 ,  G01N30/34 ,  G01N30/46 ,  G01N30/52 ,  G01N30/60

CPC classification number: B01F13/0076 ,  B01D61/18 ,  B01F5/0682 ,  B01F5/0692 ,  B01F15/0201 ,  B01F15/0232 ,  B01L3/5023 ,  B01L3/502707 ,  B01L3/502753 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2400/0418 ,  F04B19/006 ,  F04B43/043 ,  F04B43/06 ,  F16K99/0001 ,  F16K99/0025 ,  F16K99/0049 ,  G01N27/44791 ,  G01N30/461 ,  G01N30/6065 ,  G01N30/6095 ,  G01N2030/027 ,  G01N2030/285 ,  G01N2030/326 ,  G01N2030/347 ,  G01N2030/525 ,  G01N2030/528 ,  Y10T156/1046

Abstract: Liquid flow devices, particularly microfluidic devices, containing solid porous materials. Flow in the devices can be pressure-driven flow and/or electroosmotic flow. The porous materials are preferably pre-shaped, for example divided from a sheet of porous material, so that they can be assembled with liquid-impermeable barrier materials around them. The devices can for example be prepared by lamination. A wide variety of devices, including mixing devices, is disclosed. A mixing device is illustrated in Figure 23.

Abstract translation: 液体流动装置，特别是含有固体多孔材料的微流体装置。 装置中的流动可以是压力驱动的流动和/或电渗流。 多孔材料优选预先成形，例如由多孔材料片分开，以便它们可以与它们周围的液体不可渗透的阻挡材料组装。 这些装置可以例如通过层压来制备。 披露了各种各样的设备，包括混合设备。 图23中显示了混合装置。

公开(公告)号：WO02101474A3

公开(公告)日：2003-05-01

申请号：PCT/US0219121

申请日：2002-06-13

Applicant: EKSIGENT TECHNOLOGIES LLC ,  NEYER DAVID W ,  PAUL PHILLIP H ,  ARNOLD DON WESLEY ,  BAILEY CHRISTOPHER G

Inventor： NEYER DAVID W ,  PAUL PHILLIP H ,  ARNOLD DON WESLEY ,  BAILEY CHRISTOPHER G

IPC: B01D61/56 ,  G01N30/32 ,  G05D7/06 ,  G05D11/13 ,  B01D61/44

CPC classification number: G01N30/32 ,  B01D61/56 ,  G01N2030/324 ,  G01N2030/326 ,  G05D7/0694 ,  G05D11/132 ,  Y10T137/85978 ,  Y10T137/85986 ,  Y10T137/86027 ,  G01N30/34 ,  G01N2030/285

Abstract: A flow controller which uses a combination of hydrostatic pressure and electroosmotic flow to control the flow of a fluid. A driving fluid (1204) whose flow rate is dependent on both hydrostatic pressures and electroosmotic flow can be used (a) directly as a working fluid in an operable device, for example a chromatograph, or (b) to displace a working fluid (1203) from a storage container (625) into an operable device (1301), or both (a) and (b). The driving fluid (1204) can be composed of one or more fluids. Part or all the driving fluid (1204) is passed through an electroosmotic device (100) so as to increase or decrease the flow rate induced by hydrostatic pressure.

Abstract translation: 流量控制器，其使用静水压力和电渗流量的组合来控制流体的流动。 其流量取决于流体静力压力和电渗流量的驱动流体（1204）可以（a）直接用作可操作装置（例如色谱仪）中的工作流体，或（b）将工作流体（1203） ）从存储容器（625）移动到可操作装置（1301）或（a）和（b）中。 驱动流体（1204）可以由一种或多种流体组成。 部分或全部驱动流体（1204）通过电渗装置（100），以增加或减少由静水压力引起的流速。

公开(公告)号：WO2002101474A2

公开(公告)日：2002-12-19

申请号：PCT/US2002/019121

申请日：2002-06-13

Applicant: EKSIGENT TECHNOLOGIES, LLC ,  NEYER, David W. ,  PAUL, Phillip H. ,  ARNOLD, Don Wesley ,  BAILEY, Christopher G.

Inventor： NEYER, David W. ,  PAUL, Phillip H. ,  ARNOLD, Don Wesley ,  BAILEY, Christopher G.

IPC: G05B

CPC classification number: G01N30/32 ,  B01D61/56 ,  G01N2030/324 ,  G01N2030/326 ,  G05D7/0694 ,  G05D11/132 ,  Y10T137/85978 ,  Y10T137/85986 ,  Y10T137/86027 ,  G01N30/34 ,  G01N2030/285

Abstract: A flow controller which uses a combination of hydrostatic pressure and electroosmotic flow to control the flow of a fluid. A driving fluid (1204) whose flow rate is dependent on both hydrostatic pressures and electroosmotic flow can be used (a) directly as a working fluid in an operable device, for example a chromatograph, or (b) to displace a working fluid (1203) from a storage container (625) into an operable device (1301), or both (a) and (b). The driving fluid (1204) can be composed of one or more fluids. Part or all the driving fluid (1204) is passed through an electroosmotic device (100) so as to increase or decrease the flow rate induced by hydrostatic pressure.

Abstract translation: 流量控制器，其使用静水压力和电渗流量的组合来控制流体的流动。 其流量取决于流体静力压力和电渗流量的驱动流体（1204）可以（a）直接用作可操作装置（例如色谱仪）中的工作流体，或（b）将工作流体（1203） ）从存储容器（625）移动到可操作装置（1301）或（a）和（b）中。 驱动流体（1204）可以由一种或多种流体组成。 部分或全部驱动流体（1204）通过电渗装置（100），以增加或减少由静水压力引起的流速。

公开(公告)号：WO2013049834A2

公开(公告)日：2013-04-04

申请号：PCT/US2012/058338

申请日：2012-10-01

Applicant: EKSIGENT TECHNOLOGIES, LLC

Inventor： NIP, Kenneth, Kei-ho ,  STROHMANN, Jessica, L. ,  SHIEH, Doris, Sun-chia ,  MAI, Tuan, Quoc ,  LEWIS, Robert, B. ,  HENCKEN, Kenneth, R. ,  BRYANT, Craig, S.

CPC classification number: A61M1/0058 ,  A61F13/00068 ,  A61F2013/00174 ,  A61F2013/00412 ,  A61F2013/00536 ,  A61M1/0025 ,  A61M1/0066 ,  A61M1/0084 ,  A61M1/0088 ,  A61M1/009 ,  A61M2205/52

Abstract: A wound treatment system includes a patch, first and second fluid reservoirs, an electrokinetic pump assembly, and a controller. The patch is configured to enclose a wound area and includes an inlet and an outlet. The first fluid reservoir is fluidically connected to the inlet and the second fluid reservoir is fluidically connected to the outlet. The electrokinetic pump assembly is configured to pump a first treatment fluid from the first fluid reservoir into the patch through the inlet and to pump fluid from the patch through the outlet and into the second fluid reservoir. The controller is configured to operate the electrokinetic pump assembly and to include an electronic memory containing computer readable instructions for operating the electrokinetic pump assembly to perform a wound therapy protocol in the wound area.

Abstract translation: 伤口治疗系统包括补片，第一和第二流体储存器，电动泵组件和控制器。 该贴片构造成包围一个伤口区域并且包括入口和出口。 第一流体储存器流体地连接到入口，并且第二流体储存器流体地连接到出口。 电动泵组件构造成将第一处理流体从第一流体储存器通过入口泵送到补片中，并且将流体从补片泵送通过出口并进入第二流体储存器。 控制器被配置为操作电动泵组件并且包括包含用于操作电动泵组件以在伤口区域中执行伤口治疗方案的计算机可读指令的电子存储器。

公开(公告)号：WO2009076134A1

公开(公告)日：2009-06-18

申请号：PCT/US2008/085390

申请日：2008-12-03

Applicant: EKSIGENT TECHNOLOGIES, LLC ,  SALEKI, Mansour, A. ,  REIS, Antonio

Inventor： SALEKI, Mansour, A. ,  REIS, Antonio

IPC: F04B37/02

CPC classification number: H02K44/02 ,  F04B17/00 ,  F04B43/04 ,  F04B43/06

Abstract: An electrokinetic pump and fluid delivery system is provided that may include any of a number of features. One feature of the fluid delivery system is that it can deliver a fixed volume of fluid with each stroke of the electrokinetic pump. Another feature of the fluid delivery system is that it can accurately deliver fluid at a target flow rate over time. Methods associated with use of the electrokinetic pump and fluid delivery system are also covered.

Abstract translation: 提供了可以包括多个特征中的任何一个的电动泵和流体输送系统。 流体输送系统的一个特征是它可以在电动泵的每个冲程中输送固定体积的流体。 流体输送系统的另一个特征是它可以随着时间精确地以目标流速输送流体。 还涉及与使用电动泵和流体输送系统相关的方法。