公开(公告)号：WO2015066128A1

公开(公告)日：2015-05-07

申请号：PCT/US2014/062819

申请日：2014-10-29

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： VARMA, Niraj

IPC: A61B5/042 ,  A61B18/14

CPC classification number: A61B5/0452 ,  A61B5/0422 ,  A61B5/6853 ,  A61B5/6858 ,  A61B18/1492 ,  A61B18/24 ,  A61B2017/00053 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/0212 ,  A61B2018/1861 ,  A61N7/02

Abstract: A catheter (32) is disclosed that comprises an expansion element (34b) comprising a plurality of electrodes (36 1-N). The expansion element is configured to expand within a heart chamber so that at least a portion of the plurality of electrodes contact a wall of the chamber and a plurality of electrograms can be determined at substantially the same time in response to an electrical perturbation. The catheter may comprise pacing electrodes (82 1-M) to provide the perturbation. An activation map of the chamber can be determined based on the plurality of electrograms. Based on the activation map, a location and a shape of a mechanism of action of an arrhythmia can be determined and a treatment plan can be developed. For example, the treatment plan can include guiding an ablation of the mechanism of action.

Abstract translation: 公开了一种导管（32），其包括包括多个电极（36 1-N）的膨胀元件（34b）。 膨胀元件构造成在心脏腔室内扩张，使得多个电极的至少一部分接触腔室的壁，并且可以在响应于电扰动的基本上相同的时间确定多个电描记图。 导管可以包括起搏电极（82 1-M）以提供扰动。 可以基于多个电描记图确定腔室的激活图。 基于激活图，可以确定心律不齐的作用机制的位置和形状，并且可以开发治疗计划。 例如，治疗计划可以包括引导作用机制的消融。

公开(公告)号：WO2014158940A1

公开(公告)日：2014-10-02

申请号：PCT/US2014/021011

申请日：2014-03-06

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： GRESKOVICH, John, Jr

IPC: A61N5/10 ,  A61M25/00 ,  A61M25/10

CPC classification number: A61N5/1002 ,  A61N2005/1003 ,  A61N2005/1005 ,  A61N2005/1094

Abstract: A system for delivery of radiation to a target portion of a native tissue is provided. The system includes a catheter having a main catheter body. The main catheter body includes an outer catheter surface and an inner catheter surface that defines a longitudinally oriented lumen. The lumen extends between longitudinally spaced proximal and distal catheter face surfaces extending laterally between the inner and outer catheter surfaces. A sheath covers at least a portion of the outer catheter surface. The sheath includes a tapered portion protruding substantially longitudinally distally from a portion of the distal catheter face surface. A plurality of tubes extends through the lumen towards the distal catheter face surface. Each tube of the plurality of tubes is configured to selectively guide exposure of a radiation source to the target portion of the native tissue.

Abstract translation: 提供了用于将辐射递送到天然组织的目标部分的系统。 该系统包括具有主导管主体的导管。 主导管主体包括外导管表面和限定纵向定向内腔的内导管表面。 内腔在纵向间隔开的在导管内表面和外导管表面之间横向延伸的近端和远端导管面表面延伸。 护套覆盖外导管表面的至少一部分。 护套包括从远端导管面表面的一部分基本上纵向远端突出的锥形部分。 多个管延伸穿过内腔朝向远端导管面表面。 多个管中的每个管被配置成选择性地引导辐射源暴露于天然组织的目标部分。

公开(公告)号：WO2014149174A1

公开(公告)日：2014-09-25

申请号：PCT/US2014/012324

申请日：2014-01-21

Applicant: STRIDE TOOL, INC.

Inventor： YENNI, Edward ,  VIELHABER, Timothy ,  RODGERS, David ,  PODHRADSKY, John ,  BERGMANN, James L. ,  SPOHN, William P. ,  NORTHRUP, William ,  BONITATI, Robert James

IPC: G06F19/00

CPC classification number: G05B23/0272 ,  F24F11/30 ,  F24F11/52 ,  F24F11/56 ,  F24F11/58 ,  F24F11/89 ,  G05B15/02 ,  G05B23/0216 ,  G05B2219/25062 ,  G05B2219/2614 ,  G05B2219/2642

Abstract: The smart HVAC manifold system for servicing air conditioning systems is designed to dynamically manage the data acquisition process and to measure and calculate the performance indicators and output as the load conditions and or equipment operation change taking into account variables in the installation that can impact performance. Both visually and by a very specific data set the performance of the equipment and the installation can quickly be assessed and specific problems identified along with suggestions of typical faults or problems that may need addressed by the technician.

Abstract translation: 用于维修空调系统的智能HVAC歧管系统设计用于动态管理数据采集过程，并且在负载条件和/或设备操作变化考虑到可能影响性能的安装中的变量时，测量和计算性能指标和输出。 在视觉上和通过非常具体的数据集，可以快速评估设备和安装的性能，并确定具体问题以及技术人员可能需要解决的典型故障或问题的建议。

公开(公告)号：WO2014137344A1

公开(公告)日：2014-09-12

申请号：PCT/US2013/029583

申请日：2013-03-07

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： PAPAY, Francis A.

IPC: A61B18/14 ,  A61M25/00

CPC classification number: A61B18/1477 ,  A61B2018/00029 ,  A61B2018/00434 ,  A61B2018/00839 ,  A61B2218/002 ,  A61B2218/007

Abstract: One aspect of the present disclosure relates to a treatment probe comprising an elongated body member and a needle portion. The elongated body member can have a proximal end portion and a distal end portion. The needle portion can be connected to the distal end portion. The needle portion can include at least one electrode and at least one fluid port. The at least one electrode and the at least one fluid port can be configured to deliver electrical energy and a tumescent fluid, respectively, so that superficial tissue planes overlying a target nerve are protected from inadvertent heat damage as a result of application of electrical energy to a target nerve.

Abstract translation: 本公开的一个方面涉及包括细长主体构件和针部分的治疗探针。 细长主体构件可以具有近端部分和远端部分。 针部可以连接到远端部。 针部分可以包括至少一个电极和至少一个流体端口。 所述至少一个电极和所述至少一个流体端口可以被配置为分别递送电能和肿胀流体，使得覆盖在目标神经上的表面组织平面被保护免受由于施加电能而导致的无意的热损伤 目标神经。

公开(公告)号：WO2014116968A1

公开(公告)日：2014-07-31

申请号：PCT/US2014/012977

申请日：2014-01-24

Applicant: VANDERBILT UNIVERSITY

Inventor： BAUDENBACHER, Franz ,  EAGLE, Susan ,  HARDER, Rene ,  WHITFIELD, Jonathan ,  DIEDRICH, Andre ,  PIETSCH, John B. ,  MANDERS, Eric-Jan

IPC: G06F19/00

CPC classification number: A61B5/6898 ,  A61B5/0024 ,  A61B5/04 ,  A61B5/1112 ,  A61B5/4836 ,  A61B5/486 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/7455 ,  A61B2560/0475 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3481 ,  G09B5/00 ,  G09B19/00 ,  G16H40/63

Abstract: One aspect of the present disclosure is a smart patient monitoring system. A sensor is coupled to a patient and configured to detect biometric data associated with the patient. A mobile computing device includes a memory that stores computer-executable instructions and a processor executes the computer-executable instructions. The mobile computing device receives the biometric data from the sensor; processes the biometric data to monitor a health status of the patient; and provides therapeutic feedback related to the health status.

Abstract translation: 本公开的一个方面是智能患者监测系统。 传感器耦合到患者并且被配置为检测与患者相关联的生物特征数据。 移动计算设备包括存储计算机可执行指令的存储器，并且处理器执行计算机可执行指令。 移动计算设备从传感器接收生物特征数据; 处理生物特征数据以监测患者的健康状况; 并提供与健康状况相关的治疗反馈。

公开(公告)号：WO2014066383A1

公开(公告)日：2014-05-01

申请号：PCT/US2013/066173

申请日：2013-10-22

Applicant: THE CLEVELAND CLINIC FOUNDATION ,  BAVARIA MEDICAL TECHNOLOGY, CANADA INC.

Inventor： KAPADIA, Samir ,  BERRADA, Marwane ,  FUENTES-ORTEGA, Cesar ,  MOK, Daniel Wing Fai

IPC: A61B17/34 ,  A61B19/00

CPC classification number: A61M5/427 ,  A61B17/3403 ,  A61B17/3478 ,  A61B34/20 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2017/22069 ,  A61B2017/22095 ,  A61B2017/3405 ,  A61B2017/3411 ,  A61B2017/3488 ,  A61B2018/00279 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/0038 ,  A61B2018/00386 ,  A61B2034/2051

Abstract: An apparatus for targeting a desired target site on a body tissue comprising a wall of a first body cavity of a patient includes a target catheter. The framing member, when deployed into an expanded condition, has a framing member body which includes a three-dimensionally bulbous portion defining a maximum body footprint in a lateral dimension and has longitudinally spaced proximal and distal body ends which are both longitudinally spaced from the maximum body footprint. The proximal body end is attached to the target catheter. A protrusion has a diameter which is smaller than the maximum body footprint diameter. At least one target point is carried by the framing member and is adapted for placement adjacent the desired target site. At least one target pathway is attached to at least one target point. At least a portion of the target pathway is substantially spaced apart from the framing member body.

Abstract translation: 用于靶向包括患者的第一体腔的壁的身体组织上的所需目标部位的装置包括目标导管。 框架构件在展开状态时具有框架构件主体，该框架构件主体包括三维球形部分，其在侧向尺寸上限定最大身体足迹，并且具有纵向间隔开的近端和远侧主体端部， 身体足迹。 近端体端部附接到目标导管。 突起具有比最大身体足迹直径小的直径。 至少一个目标点由框架构件承载，并适于放置在所需目标位置附近。 至少一个目标通路连接至至少一个目标点。 目标通路的至少一部分与框架构件主体基本间隔开。

公开(公告)号：WO2014058840A2

公开(公告)日：2014-04-17

申请号：PCT/US2013/063817

申请日：2013-10-08

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： AVITSIAN, Rafi ,  ZURA, Andrew

IPC: A61M16/00 ,  A61M16/04 ,  A61B1/00

CPC classification number: A61M16/0488 ,  A61B1/00135 ,  A61B1/267 ,  A61M16/04 ,  A61M16/0409 ,  A61M16/0418 ,  A61M16/0434

Abstract: One aspect of the present disclosure relates to a reversible airway device that includes a tubular guide, a laryngeal mask, an endotracheal tube, and a sealing mechanism. The tubular guide can have a distal end portion, a proximal end portion, and a first passageway extending between the distal and proximal end portions. The laryngeal mask can be attached to the distal end portion of the tubular guide. The laryngeal mask can include an opening in fluid communication with the first passageway. The endotracheal tube can be slidably disposed within the first passageway and have a second passageway that is concentric with the first passageway. The sealing mechanism can be disposed within the first passageway and be configured to occlude the flow of a gas through the first passageway.

Abstract translation: 本公开的一个方面涉及一种可逆气道装置，其包括管状引导件，喉罩，气管内导管和密封机构。 管状引导件可具有远端部分，近端部分和在远端部分和近端部分之间延伸的第一通道。 喉罩可以连接到管状引导件的远端部分。 喉罩可以包括与第一通道流体连通的开口。 气管内插管可滑动地设置在第一通道内并具有与第一通道同心的第二通道。 密封机构可以设置在第一通道内并且构造成阻塞气体通过第一通道的流动。

公开(公告)号：WO2014035977A1

公开(公告)日：2014-03-06

申请号：PCT/US2013/056815

申请日：2013-08-27

Applicant: OHIO STATE INNOVATION FUNDATION

Inventor： REZAI, Ali, R. ,  FUNAI, Edward ,  LOCKWOOD, Charles

IPC: A61N1/32 ,  A61N1/36 ,  A61N1/04

CPC classification number: A61K38/4893 ,  A61K31/7088 ,  A61K35/12 ,  A61K38/00 ,  A61N1/0456 ,  A61N1/0551 ,  A61N1/321 ,  A61N1/36007 ,  A61N1/36014 ,  A61N1/3606 ,  A61N2/006

Abstract: A closed-loop therapy delivery system for modulating uterine function in a mammal can include: at least one electrode configured to deliver an electric current to a spinal cord target associated with uterine function; a power source in electrical communication with the at least one electrode; at least one sensor in electrical communication with the at least one electrode; and a controller in electrical communication with each of the at least one electrode and the at least one sensor. The controller can be configured to automatically coordinate operation of the power source. The controller can be configured to direct delivery of the electric current to the at least one electrode to deliver a therapy signal to the spinal cord target in an amount and for a time sufficient to effect a change in sympathetic and/or parasympathetic activity in the mammal and thereby modulate uterine function.

Abstract translation: 用于调节哺乳动物子宫功能的闭环治疗递送系统可以包括：至少一个电极，被配置为将电流传递到与子宫功能相关联的脊髓靶标; 与所述至少一个电极电连通的电源; 至少一个与所述至少一个电极电连通的传感器; 以及与所述至少一个电极和所述至少一个传感器中的每一个电连通的控制器。 控制器可以配置为自动协调电源的运行。 控制器可以被配置为将电流传送到至少一个电极，以将治疗信号以足以实现哺乳动物的交感神经和/或副交感神经活动变化的量和足够长的时间递送到脊髓靶标 从而调节子宫功能。

公开(公告)号：WO2014025780A1

公开(公告)日：2014-02-13

申请号：PCT/US2013/053790

申请日：2013-08-06

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： SCHICKENDANTZ, Mark S. ,  FARROW, Lutul D.

IPC: A61F2/08 ,  A61B17/17 ,  A61B17/16 ,  A61F2/38

CPC classification number: A61F2/0811 ,  A61B17/1615 ,  A61B17/1714 ,  A61B17/1739 ,  A61F2002/087 ,  A61F2220/005 ,  A61F2230/0084

Abstract: A method of providing a soft-tissue transplant to a receiving bone includes providing a transplant graft, comprising an elongated soft tissue, having first and second soft tissue ends longitudinally separated by a soft tissue body, and a bone block directly connected with the first soft tissue end. The bone block and soft tissue have been integrally formed as a unitary whole. An anchor cavity is machined in the receiving bone. The anchor cavity is shaped to substantially accept the bone block in a mating relationship. A majority of a volume of the bone block is placed in the anchor cavity. The bone block is fastened within the anchor cavity.

Abstract translation: 向接受骨提供软组织移植的方法包括提供移植物移植物，其包括细长的软组织，其具有由软组织体纵向分离的第一和第二软组织端部，以及与第一软件直接连接的骨块 组织结束。 骨块和软组织整体形成为整体。 在接收骨中加工锚定腔。 锚腔被成形为基本上以匹配关系接受骨块。 骨块的大部分体积被放置在锚腔中。 骨块被固定在锚腔内。

公开(公告)号：WO2013177189A1

公开(公告)日：2013-11-28

申请号：PCT/US2013/042059

申请日：2013-05-21

Applicant: VANDERBILT UNIVERSITY

Inventor： CAPRIOLI, Richard ,  VAN DE PLAS, Raf

IPC: G06K9/62 ,  G06T11/00 ,  G06T5/50

CPC classification number: G06K9/0014 ,  G06K9/6211 ,  G06K9/6255 ,  G06K9/629 ,  G06T5/50 ,  G06T2207/10056 ,  G06T2207/30024

Abstract: Systems and methods are provided for generating a model relating parameters generated via a first molecular imaging modality to parameters generated via a second molecular imaging modality. First and second feature extractors extract, from images of a region of interest obtained via respective first and second molecular imaging modalities, respective sets of parameters for respective first and second sets of locations. A mapping component associates respective locations of the first and second sets of locations according to their spatial relationship within the region of interest to produce a training set. Each example in the training set comprises a set of parameters associated with a location in the first set of locations and a set of parameters associated with a location in the second set. A modeling component generates a predictive model relating the parameters associated with the first modality with at least one parameter associated with the second modality.

Abstract translation: 提供的系统和方法用于生成将通过第一分子成像模态产生的参数与通过第二分子成像模态产生的参数相关联的模型。 第一和第二特征提取器从通过相应的第一和第二分子成像模态获得的感兴趣区域的图像提取用于相应的第一和第二组位置的各组参数。 映射组件根据它们在感兴趣区域内的空间关系来关联第一和第二组位置的相应位置以产生训练集。 训练集中的每个示例包括与第一组位置中的位置相关联的一组参数以及与第二组中的位置相关联的一组参数。 建模组件生成将与第一模态相关联的参数与与第二模态相关联的至少一个参数相关联的预测模型。