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    LIQUID FORMULATION WITH ENHANCED STABILITY COMPRISING MONTELUKAST OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND METHOD FOR PREPARING SAME
    52.
    发明申请
    LIQUID FORMULATION WITH ENHANCED STABILITY COMPRISING MONTELUKAST OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND METHOD FOR PREPARING SAME 审中-公开
    具有包含MONTELUKAST或药物接受性盐的增强稳定性的液体配方及其制备方法

    公开(公告)号：WO2015170835A1

    公开(公告)日：2015-11-12

    申请号：PCT/KR2015/003529

    申请日：2015-04-08

    申请人： HANMI PHARM. CO., LTD.

    发明人： KIM, Young Hun ,  KWON, Taek Kwan ,  YOUN, Seung Bin ,  PARK, Jae Hyun ,  WOO, Jong Soo

    IPC分类号： A61K47/02 ,  A61K9/08 ,  A61K31/4704

    CPC分类号： A61K47/02 ,  A61K9/0095 ,  A61K31/47 ,  A61K47/183 ,  A61K47/26

    摘要： The present invention relates to a liquid formulation comprising an electrolyte compound, and montelukast or a pharmaceutically acceptable salt thereof as an active ingredient, and a method for preparing the above liquid formulation. According to the present invention, montelukast or a pharmaceutically acceptable salt thereof is substantially dissolved and present in a solution state, thereby improving stability over time, preventing decrease of dissolution and stability over time and increasing its bioavailability. And, owing to its enhanced stability and superior taste and flavor, the liquid formulation of the present invention shows improved medication compliance, and can be effectively used for the treatment of asthma and allergic rhinitis.

    摘要翻译： 本发明涉及包含电解质化合物和孟鲁司特或其药学上可接受的盐作为活性成分的液体制剂，以及制备上述液体制剂的方法。 根据本发明，孟鲁司特或其药学上可接受的盐基本溶解并以溶液状态存在，从而改善随时间的稳定性，防止随时间的溶解和稳定性降低并提高其生物利用度。 而且，由于其稳定性和味道和味道的增强，本发明的液体制剂显示出改善的药物依从性，并且可以有效地用于治疗哮喘和过敏性鼻炎。

    FAST DISSOLVING GRANULATE
    53.
    发明申请
    FAST DISSOLVING GRANULATE 审中-公开
    快速解冻颗粒

    公开(公告)号：WO2015169725A1

    公开(公告)日：2015-11-12

    申请号：PCT/EP2015/059667

    申请日：2015-05-04

    申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH

    发明人： PLOHMANN, Bernd ,  SCHEURING, Uwe

    IPC分类号： A61K9/46 ,  A61K36/84 ,  A61K36/185

    CPC分类号： A61K36/84 ,  A61K9/0095 ,  A61K9/1623 ,  A61K36/185 ,  A61P25/20 ,  A61K2300/00

    摘要： The invention relates to a fast dissolving granulate obtainable by spray-dying of a composition comprising a dry methanolic or ethanolic extract of valerian root, a dry methanolic extract of hop strobiles, optionally a carrier, one or more artificial sweeteners, one or more flavoring agents, optionally an acidifier and water for the treatment of sleep disorders, wherein the said granulate is to be administered upon dissolution in water or an aqueous beverage shortly before bedtime.

    摘要翻译： 本发明涉及一种快速溶解颗粒，其可通过喷雾染色包含缬草根的干燥甲醇或乙醇提取物，啤酒花滴的干燥甲醇提取物，任选的载体，一种或多种人造甜味剂，一种或多种调味剂 ，任选的酸化剂和水，用于治疗睡眠障碍，其中所述颗粒在睡觉前不久溶解于水或含水饮料时施用。

    METHODS AND COMPOSITIONS FOR DELIVERING A PROBIOTIC
    59.
    发明申请
    METHODS AND COMPOSITIONS FOR DELIVERING A PROBIOTIC 审中-公开
    递送生物的方法和组合物

    公开(公告)号：WO2015154140A1

    公开(公告)日：2015-10-15

    申请号：PCT/AU2015/050154

    申请日：2015-04-03

    申请人： KAMBOURIS SHARES PTY LTD

    发明人： KAMBOURIS, Ambrosios

    IPC分类号： A61K35/74 ,  A61K9/46 ,  A61K47/04 ,  A61K47/12 ,  A61P1/14 ,  A61P37/08

    CPC分类号： A23K10/18 ,  A23L33/135 ,  A61K9/0007 ,  A61K9/0095 ,  A61K31/7004 ,  A61K31/7016 ,  A61K35/741 ,  A61K2300/00

    摘要： The present invention provides a method for delivering a probiotic organism to an animal in need thereof, the method comprising the steps of: (i) administering the probiotic organism orally to the animal, and (ii) administering an effervescent agent orally to the animal to cause the generation of an effervescence product within the alimentary tract of the animal, wherein the probiotic organism and effervescence product co-locate at a site in the alimentary tract of the animal such that viability and/or a physiologic effect of the probiotic is improved relative to a method whereby there is no co-location of an effervescence product and the probiotic organism. The method may be used for treating a condition associated with the level or activity of probiotic bacteria in the alimentary tract, such as a digestive condition, an immune function condition, a wellness condition, or an allergic condition.

    摘要翻译： 本发明提供了将益生菌生物递送至有需要的动物的方法，所述方法包括以下步骤：（i）向动物口服施用益生菌，和（ii）向动物口服施用泡腾剂， 导致在动物的消化道中产生泡腾产物，其中益生菌和泡腾产物共同位于动物消化道的部位，使得益生菌的存活力和/或生理效应相对提高 涉及一种不产生泡腾产物和益生菌的共同定位的方法。 该方法可用于治疗与消化道中的益生菌的水平或活性相关的病症，例如消化条件，免疫功能状况，健康状况或过敏状况。