公开(公告)号：WO1998020964A2

公开(公告)日：1998-05-22

申请号：PCT/EP1997006098

申请日：1997-11-05

Applicant: CLARIANT GMBH

Inventor： CLARIANT GMBH ,  PAPENFUHS, Bernd

IPC: B01F17/00

CPC classification number: A61K8/463 ,  A61K47/186 ,  A61Q19/10 ,  C07C211/08 ,  C07C233/36 ,  C07C305/06 ,  C07C305/10 ,  C11D1/14 ,  C11D1/29

Abstract: The invention relates to heavily foaming tenside complexes, which are produced by sulfating alcohol/trialkylamine mixtures in a one-pot method, wherein preferably a gaseous sulfur trioxide in diluted form has been used. The invention further relates to compositions containing known tensides and adequate solvents in addition to the tenside complexes, the latter being adequate for multiple uses, for example, for detergents and cosmetic formulations. In semifluorized form, they can be adequately used as emulsifiers for technical formulations.

Abstract translation: 本发明涉及优选地，其中的气态三氧化硫在其由醇/三烷基胺的混合物的硫酸化的一锅法来制备稀释形式的高发泡表面活性剂的复合物使用。 本发明还涉及含有已知的表面活性剂和合适的溶剂，除了表面活性剂络合物的组合物。 所述表面活性剂复合物适用于多种应用，例如用于洗涤剂和化妆品制剂。 在部分氟化的形式，它们特别适合作为乳化剂对技术的制剂。

公开(公告)号：WO1997039088A1

公开(公告)日：1997-10-23

申请号：PCT/US1997006472

申请日：1997-04-16

Applicant: THE PROCTER & GAMBLE COMPANY ,  CONNOR, Daniel, Stedman ,  CRIPE, Thomas, Anthony ,  VINSON, Phillip, Kyle ,  WILLMAN, Kenneth, William ,  BURCKETT-ST. LAURENT, James, Charles, T., R. ,  DUPONT, Jeffrey, Scott

Inventor： THE PROCTER & GAMBLE COMPANY

IPC: C11D01/14

CPC classification number: A61K8/463 ,  A61K2800/596 ,  A61Q5/02 ,  A61Q11/00 ,  A61Q19/10 ,  C07C303/24 ,  C07C305/06 ,  C07C305/10 ,  C11D1/123 ,  C11D1/126 ,  C11D1/146 ,  C11D1/29 ,  C11D1/521 ,  C11D1/62 ,  C11D1/65 ,  C11D1/72 ,  C11D3/08 ,  C11D3/128 ,  C11D3/18

Abstract: Mixtures of mid-chain branched primary alkyl sulfate surfactants useful in cleaning compositions, especially for lower water temperature applications, alone or formulated with other surfactants for the purpose of modifying the low temperature cleaning properties of the cleaning formulations. The present invention also relates to novel mid-chain branched primary alkyl sulfate surfactants suitable for use in surfactant mixtures.

Abstract translation: 用于清洁组合物，特别是用于较低水温应用的中链支化伯烷基硫酸盐表面活性剂的混合物，单独使用或与其它表面活性剂一起配制以改进清洁制剂的低温清洗性能。 本发明还涉及适用于表面活性剂混合物的新型中链支链伯烷基硫酸盐表面活性剂。

公开(公告)号：WO1997016416A1

公开(公告)日：1997-05-09

申请号：PCT/EP1996004565

申请日：1996-10-21

Applicant: HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN ,  GRAFFUNDER, Valter ,  VIEL FERRO, Nelson

Inventor： HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN

IPC: C07C303/24

CPC classification number: C07C303/24 ,  C07C305/06

Abstract: The invention concerns a process for preparing short-chain alkyl sulphates in which alcohols of formula (I), R OH, in which R stands for a linear or branched, saturated or unsaturated alkyl group with between 6 and 12 carbon atoms, are sulphated with a mixture of SO3 and inert gas in a stirrer vessel cascade arrangement comprising at least two stirrer vessels which can be supplied with gas independently of each other. The alcohols are then neutralized with aqueous bases. Sulphation is carried out in the presence of acid anionic surfactants of formula (II), R OSO3H, in which R has the above meaning. In this way, high yields of high-quality alkyl sulphates are obtained and the risk of explosive alcohol mixtures igniting in the exhaust air purified by electrostatic filters is simultaneously prevented.

Abstract translation: 本发明涉及用于生产短链烷基硫酸盐的方法，其中所述式（I）R的醇<1> OH，<1>，其中R是直链或支链的，饱和或不饱和烷基基团的碳原子数为6〜12，在 搅拌釜级联由执行<1>的至少两个搅拌釜反应器的OSO 3 H，其可以与SO3 /惰性气体混合物充气独立地硫酸化，随后用含水的碱和式（II）R的酸性阴离子表面活性剂的存在下硫酸化中和，其中R < 1>具有上文所示的含义。 这使以高收率高质量硫酸盐和避免了在排出空气，这是由静电过滤器同时清洗醇的爆炸性混合物的点火的风险。

公开(公告)号：WO1995008613A1

公开(公告)日：1995-03-30

申请号：PCT/EP1994003075

申请日：1994-09-14

Applicant: HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN ,  BEHLER, Ansgar ,  UPHUES, Günther ,  WAHLE, Bernd

Inventor： HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN

IPC: C11D01/29

CPC classification number: D21H21/24 ,  B01F17/0057 ,  C07C305/06 ,  C11D1/16 ,  C11D1/28 ,  C11D3/001 ,  C11D3/0015 ,  C14C9/00 ,  C14C11/00 ,  D06M7/00 ,  D06M13/224 ,  D06M13/262 ,  D06M2200/40

Abstract: Sulphated polyol fatty acid esters have the formula (I), in which R CO stands for a linear or branched, saturated and/or unsaturated acyl residue with 6 to 22 carbon atoms, R stands for hydrogen, an OCR residue or a SO3X residue, R stands for hydrogen or a (OCH2CH2)mOR residue, n equals 0 or stands for a number from 1 to 5, m equals 0 or stands for a number from 1 to 10 and X stands for an alkaline metal, alkaline earth metal, ammonium, alkylammonium, alkanolammonium or glucammonium. These compounds are suitable as raw materials for producing brighteners and linen softeners.

Abstract translation: 式（I），其中R <1> CO是直链或支链，饱和和/或不饱和的酰基基团，具有6至22个碳原子，R的硫酸化的多元醇<2>为氢，OCR <1>基团或SO 3 X 基，R <3>是氢或（OCH 2 CH 2）M <2>基团，n为0或数字1至5，m是0或数字1至10，X是碱金属，碱土金属，铵， 烷基铵，链烷醇铵或葡糖，适合作为用于生产精加工和织物柔软剂的原料。

公开(公告)号：WO2018165257A1

公开(公告)日：2018-09-13

申请号：PCT/US2018/021292

申请日：2018-03-07

Applicant: TRANSLATE BIO, INC.

Inventor： HEARTLEIN, Michael ,  DEROSA, Frank ,  KARVE, Shrirang

IPC: C07C305/06 ,  A61K47/20 ,  C07C317/18 ,  C08G65/00 ,  A61K47/54 ,  A61K9/127

CPC classification number: C07C305/06 ,  A61K9/1272 ,  A61K31/7105 ,  A61K47/543 ,  A61K47/58 ,  C07C317/18 ,  C08G65/00

Abstract: Disclosed are dendritic anionic lipids which are compounds of Formula (I) : wherein R and R 1 are non-polar groups, L is a linking moiety, and Dm is a dendritic moiety of m generations, each as defined herein. These dendritic anionic lipids are useful for delivery and expression of m RNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

公开(公告)号：WO2015164160A1

公开(公告)日：2015-10-29

申请号：PCT/US2015/026060

申请日：2015-04-16

Applicant: MERCK SHARP & DOHME CORP. ,  MCNEVIN, Michael ,  LOHANI, Sachin

Inventor： MCNEVIN, Michael ,  LOHANI, Sachin

IPC: A61K31/551 ,  A61K31/423 ,  C07D413/14

CPC classification number: C07D413/14 ,  A61K31/551 ,  C07B2200/13 ,  C07C305/04 ,  C07C305/06 ,  C07C309/04 ,  C07C309/30 ,  C07C309/66

Abstract: The invention is directed to pharmaceutically acceptable salts of suvorexant, which is an antagonist of orexin receptors. The pharmaceutically acceptable salts of suvorexant are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is further directed to pharmaceutical compositions comprising pharmaceutically acceptable salts of suvorexant.

Abstract translation: 本发明涉及suvorexant的药学上可接受的盐，其是食欲素受体的拮抗剂。 suvorexant的药学上可接受的盐可用于治疗或预防涉及食欲素受体的神经和精神疾病和疾病。 本发明进一步涉及包含药学上可接受的盐酸盐的药物组合物。

公开(公告)号：WO2014195210A1

公开(公告)日：2014-12-11

申请号：PCT/EP2014/061086

申请日：2014-05-28

Applicant: BASF SE

Inventor： BEHLER, Ansgar ,  CLASEN, Frank

IPC: C07C305/06 ,  C07C303/24 ,  C11D1/14

CPC classification number: C07C309/17 ,  A61K8/466 ,  A61K47/20 ,  A61K2800/28 ,  A61Q5/02 ,  A61Q9/02 ,  A61Q19/007 ,  A61Q19/10 ,  C07C67/03 ,  C07C303/18 ,  C07C303/24 ,  C07C305/04 ,  C07C305/06 ,  C11D1/16 ,  C11D1/28

Abstract: Die vorliegende Erfindung betrifft sulfatierte Ester von Oligohydroxycarbonsäuren, kosmetische und pharmazeutische Mittel, die diese Ester enthalten sowie die Verwendung dieser Ester als anionische Tenside.

Abstract translation: 本发明涉及oligohydroxycarboxylic，化妆品和含有这些酯和这些酯的阴离子表面活性剂的药物组合物的硫酸化酯。

公开(公告)号：WO2014151296A2

公开(公告)日：2014-09-25

申请号：PCT/US2014/025393

申请日：2014-03-13

Applicant: MEADWESTVACO CORPORATION

Inventor： MAC EWAN, Kimberley D. ,  NAVARRETE, Reinaldo C. ,  YANG, Chao

IPC: C09K8/584

CPC classification number: C09K8/584 ,  C07C305/06 ,  C07D207/40 ,  C07D209/48 ,  C07D209/56 ,  C07D233/06 ,  C07D233/16 ,  E21B43/16 ,  E21B47/00

Abstract: A method of enhanced oil recovery wherein: (a) a flooding composition is delivered into a subterranean reservoir; (b) the flooding composition includes a sulfur surfactant; and (c) the fluid produced from the subterranean reservoir can also be analyzed to determine if the surfactant is present in the fluid. The surfactant preferably includes a sulfonate moiety or other sulfur-containing moiety. The presence of the surfactant in the fluid produced from the subterranean reservoir is preferably determined by X-ray fluorescence spectroscopy, HPLC-AES, or HPLC-ICP.

Abstract translation: 一种提高采油的方法，其中：（a）淹水组合物被输送到地下储层中; （b）淹水组合物包含硫表面活性剂; 和（c）也可以分析从地下储层产生的流体，以确定表面活性剂是否存在于流体中。 表面活性剂优选包括磺酸盐部分或其它含硫部分。 表面活性剂在从地下储层产生的流体中的存在优选通过X射线荧光光谱法，HPLC-AES或HPLC-ICP来确定。

公开(公告)号：WO2011151833A1

公开(公告)日：2011-12-08

申请号：PCT/IL2011/000436

申请日：2011-06-02

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  BRAM, Yaron ,  GAZIT, Ehud

Inventor： BRAM, Yaron ,  GAZIT, Ehud

IPC: A61K38/17 ,  A61P3/10 ,  A61P5/48

CPC classification number: C07K14/575 ,  A61K38/17 ,  A61K39/0005 ,  C07C305/06 ,  C07K16/26 ,  G01N33/6893 ,  G01N2333/4709 ,  G01N2500/10

Abstract: A composition of matter is disclosed which comprises isolated oligomers of human islet amyloid polypeptide (IAPP). Antibodies recognizing same are also disclosed. Use of the composition of matter and the antibodies are also disclosed.

Abstract translation: 公开了一种包含人胰岛淀粉样蛋白多肽（IAPP）的分离寡聚体的物质组合物。 还公开了识别相同的抗体。 还公开了物质组合物和抗体的使用。

公开(公告)号：WO2011086532A1

公开(公告)日：2011-07-21

申请号：PCT/IB2011/050196

申请日：2011-01-17

Applicant: SEDERMA ,  FOURNIAL, Arnaud ,  MONDON, Philippe ,  PESCHARD, Olivier

Inventor： FOURNIAL, Arnaud ,  MONDON, Philippe

IPC: A61K8/46 ,  A61K8/55 ,  A61K31/19 ,  A61K31/661 ,  A61Q19/08 ,  C07C305/06 ,  C07F9/09 ,  A61P17/00

CPC classification number: A61K8/553 ,  A61Q19/00 ,  A61Q19/08 ,  C07C305/06 ,  C07F9/091

Abstract: The compound according to the invention has the following developed fomula IX: Wherein: X = PO(OH) 2 , SO 2 (OH); PO(OH)(Xaa)m or SO 2 (Xaa)m; A = H; OH; NH 2 or akyl (1-6C); n = 1 to 4; Y= -CO- OR 2 ; -CO-NR 3 R 4 , -0-CO-R 2 , -C=CR 2 ; R 2 = an alkyl, aryl, aralkyl, acyl, sulfonyl, sugar or alkoxy chain of 1 to 24 carbon atoms, linear, branched or cyclic, with or without substitutions, saturated or not, hydroxylated or not, sulfurated or not; R 5 = OH, O-alk (1-6C), (Xaa) m , NH 2 or NH-alkyl(l-6C); Xaa = peptide of m aminoacids Xaa with m from 1 to 10; The compound is preferably phosphated, obtained from malic acid and having the following developed formula: A cosmetic composition comprising the compound of the present invention can improve the general condition of the skin, for example hydration, lightening and mechanical properties.

Abstract translation: 根据本发明的化合物具有以下开发的IX：其中：X = PO（OH）2，SO 2（OH）; PO（OH）（Xaa）m或SO2（Xaa）m; A = H; 哦; NH2或烷基（1-6C）; n = 1〜4; Y = -CO- OR2; -CO-NR 3 R 4，-O-CO-R 2，-C = CR 2; R 2 =具有1至24个碳原子的烷基，芳基，芳烷基，酰基，磺酰基，糖或烷氧基链，具有或不具有或不具有羟基化或不饱和或不具有取代基，不具有或不具有取代基，不具有或不具有取代基， R5 = OH，O-烷基（1-6C），（Xaa）m，NH2或NH-烷基（1-6C）; Xaa = m为1〜10的m个氨基酸Xaa的肽; 该化合物优选磷酸化，由苹果酸获得并具有以下显影的配方：包含本发明化合物的化妆品组合物可以改善皮肤的一般状况，例如水合，减轻和机械性能。