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    LAK細胞の増殖方法
    51.
    发明申请
    LAK細胞の増殖方法 审中-公开
    增加LAK细胞的方法

    公开(公告)号：WO2008016078A1

    公开(公告)日：2008-02-07

    申请号：PCT/JP2007/065068

    申请日：2007-08-01

    Applicant: アリジェン製薬株式会社 ,  渡来 仁 ,  西川 茂

    Inventor： 渡来 仁 ,  西川 茂

    IPC: C12N5/06 ,  A61K35/14 ,  A61P31/00 ,  A61P35/00 ,  A61P37/02

    CPC classification number: C12N5/0638 ,  A61K35/12 ,  A61K2039/515 ,  C12N2501/23 ,  C12N2501/59

    Abstract: 　この発明は非ヒト動物にも適用できるほどの費用で、各種癌、免疫不全症、感染症に有効な治療方法やそれに関連する細胞の増殖・活性化方法などを提供する。 　この発明の増殖・活性化方法は、細胞を培養する際に、培地にコンカナバリンAなどの植物レクチンと、インターロイキン2様活性を有する増殖因子とを添加する。これにより、癌、免疫不全症、感染症の細胞性免疫に関連するαβ型T細胞を優先的に増殖・活性化することができる。

    Abstract translation: 针对各种癌症，免疫缺陷病和感染有效的治疗方法，以及与其相关的细胞增殖/激活的方法，其费用如适用于非人动物的成本。 提供了一种增殖/激活方法，其包括在细胞培养阶段向培养基中加入植物凝集素如刀豆蛋白A和具有白介素2样活性的生长因子。 因此，与细胞免疫癌症，免疫缺陷性疾病和感染相关的β型T细胞可以在优先的基础上增殖/激活。

    ISOLATED EMBRYONIC-LIKE STEM CELLS DERIVED FROM HUMAN UMBILICAL CORD BLOOD
    53.
    发明申请
    ISOLATED EMBRYONIC-LIKE STEM CELLS DERIVED FROM HUMAN UMBILICAL CORD BLOOD 审中-公开
    来自人脐带血的分离的胚胎样干细胞

    公开(公告)号：WO2007044314A3

    公开(公告)日：2007-09-13

    申请号：PCT/US2006038524

    申请日：2006-10-03

    Applicant: UNIV ILLINOIS ,  ZHAO YONG ,  MAZZONE THEODORE

    Inventor： ZHAO YONG ,  MAZZONE THEODORE

    IPC: C12N5/074 ,  C12N5/0783

    CPC classification number: C12N5/0607 ,  A61K2035/122 ,  C12N5/0636 ,  C12N2501/23 ,  C12N2501/59 ,  C12N2502/03

    Abstract: The present invention is related generally to embryonic-like stem cells isolated from human umbilical cord blood, designated herein as cord blood-stem cells (CB-SCs), which display the characteristics of embryonic stem cells and hematopoietic cells. These cells have the capability of proliferation and are able to differentiate to multiple types of cells. In addition, the CB-SC display low immunogenicity and immune regulation. These cells are, therefore, suitable for use in stem cell-based therapies for the treatment of diseases such as Parkinson's disease, diabetes, spinal cord damage, multiple sclerosis, cardiovascular disease, stroke and birth defects.

    Abstract translation: 本发明一般涉及从人脐带血分离的胚胎样干细胞，本文称为脐带血干细胞（CB-SC），其显示胚胎干细胞和造血细胞的特征。 这些细胞具有增殖能力并能够分化为多种类型的细胞。 此外，CB-SC显示低免疫原性和免疫调节。 因此，这些细胞适用于基于干细胞的治疗，用于治疗诸如帕金森病，糖尿病，脊髓损伤，多发性硬化症，心血管疾病，中风和出生缺陷等疾病。

    ANTIGEN PRESENTING CELLS, METHOD FOR THEIR PREPARATION AND THEIR USE FOR CANCER VACCINES
    58.
    发明申请
    ANTIGEN PRESENTING CELLS, METHOD FOR THEIR PREPARATION AND THEIR USE FOR CANCER VACCINES 审中-公开
    抗原呈递细胞，其制备方法及其用于癌症疫苗的方法

    公开(公告)号：WO2003012086A1

    公开(公告)日：2003-02-13

    申请号：PCT/IT2002/000488

    申请日：2002-07-25

    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. ,  DE SANTIS, Rita

    Inventor： DE SANTIS, Rita

    IPC: C12N5/10

    CPC classification number: C12N5/0694 ,  A61K39/0011 ,  A61K2039/5152 ,  A61K2039/5154 ,  C12N2501/06 ,  C12N2501/23 ,  C12N2501/52 ,  C12N2501/59 ,  C12N2502/99 ,  C12N2506/11 ,  C12N2510/04

    Abstract: The present invention discloses a method of generation of antigen presenting cells, comprising: a. collecting said cells from a subject, b. activating said collected cells; c. culturing and optionally expanding ex vivo said activated cells; d. treating said cultured and optionally expanded cells with DNA hypomethylating agents so that said cells concomitantly express multiple tumor associated antigens. The cells obtainable according to the method of the present invention, as well as the cellular components thereof whether alone or in combination with said cells, are useful for prevention and treatment of malignancies of different histotype that constitutively express one or more of the multiple tumor associated antigens that are expressed in said cells. Conveniently, said cells and/or cellular components are in the form of a vaccine. Said vaccines are advantageous over the prior art in that as they concomitantly express multiple/all methylation-regulated tumor associated antigens.

    Abstract translation: 本发明公开了一种产生抗原呈递细胞的方法，包括：a。 从受试者收集细胞，b。 激活所述收集的细胞; C。 培养和任选地扩展离体所述活化细胞; 天。 用DNA低甲基化剂处理所述培养和任选扩增的细胞，使得所述细胞伴随地表达多种肿瘤相关抗原。 根据本发明的方法获得的细胞以及它们的细胞成分，无论是单独还是与所述细胞组合，可用于预防和治疗组成型表达多种肿瘤相关的一种或多种的不同组织型的恶性肿瘤 在所述细胞中表达的抗原。 方便地，所述细胞和/或细胞组分是疫苗的形式。 所述疫苗相对于现有技术是有利的，因为它们同时表达多种/全部甲基化调节的肿瘤相关抗原。

    ANTIBODIES TO DENDRITIC CELLS AND HUMAN DENDRITIC CELL POPULATIONS AND USES THEREOF
    59.
    发明申请
    ANTIBODIES TO DENDRITIC CELLS AND HUMAN DENDRITIC CELL POPULATIONS AND USES THEREOF 审中-公开
    致敏细胞和人类细胞群体的抗体及其用途

    公开(公告)号：WO9958678A9

    公开(公告)日：2001-03-22

    申请号：PCT/EP9903218

    申请日：1999-05-11

    Applicant: MICROMET GMBH ,  RIEBER ERNST PETER

    Inventor： RIEBER ERNST PETER

    IPC: A01K67/027 ,  A61K31/70 ,  A61K35/14 ,  A61K38/00 ,  A61K39/00 ,  A61K39/08 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P31/00 ,  A61P35/00 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  C07K16/46 ,  C07K19/00 ,  C12N5/0784 ,  C12N5/10 ,  C12N5/20 ,  C12N15/02 ,  C12N15/13 ,  C12N15/62 ,  C12N15/86 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577 ,  G01N33/68 ,  C12N5/06

    CPC classification number: C12N5/0639 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/0011 ,  A61K39/08 ,  A61K2039/5154 ,  A61K2039/5158 ,  C07K14/70596 ,  C07K16/28 ,  C12N2501/052 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/59 ,  A61K2300/00

    Abstract: Antibodies specifically recognizing a distinct population of human dendritic cells (DCs) and methods of isolating said DCs using said antibodies. Furthermore, antigens and epitopes recognized by the above-described antibodies as well as polynucleotides encoding said antibodies. Also vectors comprising said polynucleotides as well as host cells transformed therewith and their use in the production of said antibodies. Additionally, polypeptides comprising a domain of the binding site of the aforementioned antibodies, or an antigen or epitope described above and at least one further, preferably functional domain as well as polynucleotides encoding such polypeptides. Furthermore, vectors comprising said polynucleotides, host cells transfected with said polynucleotide or vector and their use for the preparation of the above-described polypeptides. Further a method for isolating or identifying DCs as defined above as well as DCs obtainable by said method and/or characterized by recognition of the above-described antibody, and/or containing the aforementioned antigen or epitope. Moreover, a method for preparing or identifying T cells in a certain status as well as methods for identifying compounds which interfere with T cell mediated activation of immune responses. In addition kits, and compositions, preferably pharmaceutical and diagnostic compositions are provided comprising any of the aforedescribed antibodies, antigens, epitopes, polypeptides, polynucleotides, vectors, dendritic cells or T cells or compounds obtainable by the aforementioned method.

    Abstract translation: 特异性识别人类树状细胞群体（DC）的抗体和使用所述抗体分离所述DC的方法。 此外，由上述抗体识别的抗原和表位以及编码所述抗体的多核苷酸。 还包含包含所述多核苷酸的载体以及转化的宿主细胞及其在产生所述抗体中的用途。 另外，包含上述抗体的结合位点的结构域，或上述抗原或表位的多肽和至少一个其它优选功能结构域以及编码该多肽的多核苷酸的多肽。 此外，包含所述多核苷酸的载体，用所述多核苷酸或载体转染的宿主细胞及其用于制备上述多肽的用途。 此外，分离或鉴定如上定义的DC以及通过所述方法可获得的DC和/或特征在于识别上述抗体和/或含有上述抗原或表位的方法。 此外，用于制备或鉴定某些状态的T细胞的方法以及鉴定干扰T细胞介导的免疫应答激活的化合物的方法。 另外还提​​供试剂盒和组合物，优选提供药物和诊断组合物，其包含任何上述抗体，抗原，表位，多肽，多核苷酸，载体，树突状细胞或T细胞或可通过上述方法获得的化合物。

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