公开(公告)号：WO2004034012A3

公开(公告)日：2006-11-23

申请号：PCT/US0233350

申请日：2002-10-18

Applicant: VIRTUAL ARRAYS INC ,  RAVKIN IIYA ,  GOLDBARD SIMON ,  ZAROWITZ MICHAEL A ,  HYUN WILLIAM C

Inventor： RAVKIN IIYA ,  GOLDBARD SIMON ,  ZAROWITZ MICHAEL A ,  HYUN WILLIAM C

IPC: G01N21/29 ,  G01N20060101 ,  G01N1/00 ,  G01N33/543 ,  G01N33/558 ,  G01N33/58

CPC classification number: G01N33/585 ,  G01N33/54313 ,  G01N33/558

Abstract: Systems including apparatus, methods, compositions, and kits for multiplexed analysis of biological samples or reagents using coded particles. The coded particles may be used to form positionally flexible arrays of samples and/or reagents in which the samples and/or reagents are identified by codes on the particles.

Abstract translation: 包括用于使用编码的颗粒复制分析生物样品或试剂的装置，方法，组合物和试剂盒的系统。 编码的颗粒可以用于形成位置灵活的样品和/或试剂阵列，其中样品和/或试剂通过颗粒上的代码来鉴定。

公开(公告)号：WO2006073782A3

公开(公告)日：2006-11-16

申请号：PCT/US2005046005

申请日：2005-12-16

Applicant: 3M INNOVATIVE PROPERTIES CO

Inventor： BOMMARITO G MARCO ,  LAKSHMI BRINDA B

IPC: G01N33/543 ,  G01N21/29 ,  G01N33/544

CPC classification number: C12Q1/04 ,  G01N21/29 ,  G01N21/78 ,  G01N31/22 ,  G01N33/5432 ,  G01N33/544 ,  G01N33/56938 ,  G01N2333/21 ,  G01N2333/245 ,  G01N2333/31 ,  G01N2333/75

Abstract: Colorimetric sensors for detection of an analyte are disclosed. Methods of using the colorimetric sensor and a kit for the colorimetric detection of an analyte are also disclosed.

公开(公告)号：WO2006042332A3

公开(公告)日：2006-09-28

申请号：PCT/US2005037122

申请日：2005-10-12

Applicant: FASTRAQ INC ,  WITTY THOMAS R ,  CASE ROBERT ,  CASTANON SCOTT

Inventor： WITTY THOMAS R ,  CASE ROBERT ,  CASTANON SCOTT

IPC: G01N21/00 ,  G01N21/29 ,  G01N21/62 ,  G01N21/77

CPC classification number: G01N33/54366 ,  B01F5/0609 ,  B01F13/0059 ,  B01L3/5027 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0409 ,  B01L2400/0457 ,  B01L2400/0487

Abstract: An apparatus is provided for testing fluid samples includes a sensor (18), which can be light source (14), directed to a flow cell (12, 50) and a photo sensor for detecting a light beam (17) reflected from the flow cell. The photo sensor monitors the fluid in the flow cell by sensing the reflected light beam from the flow cell, thereby monitoring the test process. The flow cell has a flow channel (60) the allows fluid sample to flow at a rate where sufficient incubation of the fluid will occur before the fluid enters an area where analyte levels will be detected.

Abstract translation: 提供了一种用于测试流体样品的装置，包括可以是光源（14）的传感器（18），其被定向到流动池（12,50）和用于检测从流体反射的光束（17）的光传感器 细胞。 光传感器通过感测来自流动池的反射光束来监测流动池中的流体，从而监测测试过程。 流动池具有流动通道（60），允许流体样品​​以在流体进入将被检测分析物水平的区域之前将发生充分温育的流体的速率流动。

公开(公告)号：WO2005079544A3

公开(公告)日：2006-09-28

申请号：PCT/US2005005743

申请日：2005-02-22

Applicant: SIRKIS JAMES S ,  MOON JOHN A ,  BRUCATO ROBERT N ,  PUTNAM MARTIN A ,  LI TUO ,  TRAYNOR JOSEPH

Inventor： SIRKIS JAMES S ,  MOON JOHN A ,  BRUCATO ROBERT N ,  PUTNAM MARTIN A ,  LI TUO ,  TRAYNOR JOSEPH

IPC: G01B11/00 ,  B01L3/00 ,  B32B5/02 ,  B32B27/04 ,  B32B27/12 ,  C12M1/34 ,  C12M1/36 ,  C12M1/38 ,  C12M3/00 ,  G01B11/14 ,  G01N1/00 ,  G01N21/00 ,  G01N21/01 ,  G01N21/27 ,  G01N21/29 ,  G01N21/31 ,  G01N21/41 ,  G01N21/47 ,  G01N21/59 ,  G01N21/64 ,  G01N21/66

CPC classification number: G01N21/6452 ,  B01J2219/005 ,  B01J2219/0054 ,  B01J2219/00549 ,  B01J2219/0056 ,  B01J2219/00576 ,  B01J2219/00722 ,  B01L3/5025 ,  B01L3/502761 ,  B01L2200/0605 ,  B01L2200/0668 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0877 ,  B01L2400/0487

Abstract: A method and apparatus are provided for aligning optical elements or microbeads, wherein each microbead has an elongated body with a code embedded therein along a longitudinal axis thereof to be read by a code reading device. The microbeads are aligned with a positioning device so the longitudinal axis of the microbeads is positioned in a fixed orientation relative to the code reading device. The microbeads are typically cylindrically shaped glass beads between 25 and 250 microns (µm) in diameter and between 100 and 500 µm long, and have a holographic code embedded in the central region of the bead, which is used to identify it from the rest of the beads in a batch of beads with many different chemical probes. A cross reference is used to determine which probe is attached to which bead, thus allowing the researcher to correlate the chemical content on each bead with the measured fluorescence signal. Because the code consists of a diffraction grating typically disposed along an axis, there is a particular alignment required between the incident readout laser beam and the readout detector in two of the three rotational axes. The third axis, rotation about the center axis of the cylinder, is azimuthally symmetric and therefore does not require alignment.

Abstract translation: 提供了一种用于对准光学元件或微珠的方法和装置，其中每个微珠具有细长体，其沿着其纵向轴线嵌入其中的代码，以被代码读取装置读取。 微珠与定位装置对准，使得微珠的纵向轴线相对于代码读取装置定位成固定的取向。 微珠通常为直径为25至250微米（μm）且长度为100至500μm的圆柱形玻璃珠，并且具有嵌入珠的中心区域中的全息代码，其用于从其余部分识别它 珠子中有一批具有许多不同化学探针的珠粒。 交叉参考用于确定哪个探针连接到哪个珠，从而允许研究者将每个珠上的化学成分与测量的荧光信号相关联。 由于代码由通常沿轴线设置的衍射光栅组成，因此在三个旋转轴中的两个中存在入射读出激光束和读出检测器之间所需的特定对准。 第三轴，围绕气缸的中心轴线的旋转是方位对称的，因此不需要对准。

公开(公告)号：WO2005081684A3

公开(公告)日：2005-12-29

申请号：PCT/US2004030811

申请日：2004-09-20

Applicant: SARNOFF CORP ,  PLETCHER TIMOTHY ALLEN ,  COYLE PETER JAMES ,  MCGINN JOSEPH THOMAS ,  KELLER DAVID

Inventor： PLETCHER TIMOTHY ALLEN ,  COYLE PETER JAMES ,  MCGINN JOSEPH THOMAS ,  KELLER DAVID

IPC: B03C3/36 ,  G01N15/14 ,  B01L3/00 ,  B01L3/02 ,  G01N1/10 ,  G01N1/22 ,  G01N21/29 ,  G01N21/64 ,  G01N21/76 ,  G01N27/00 ,  G01N27/02 ,  G01N31/12 ,  G01N35/08

CPC classification number: B03C3/36 ,  G01N15/1404 ,  G01N15/1459 ,  G01N2015/149 ,  Y10T436/117497 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/25875

Abstract: An apparatus (100) for airborne particle sorting is provided. The apparatus includes a charging system (104) adapted for applying an electrostatic charge to the particles, such that particles of at least a first group are deflected to a greater extent than particles of a second group are deflected. A focusing system (106) is adapted for electrostatically focusing substantially at least the particles of the first group into a focused stream that is narrower than the input air stream. A deposition system (108) is adapted for sustantially depositing the particles of the first group from the focused stream upon a target surface, where the target surface may be transported to an analysis system (112) capable of analyzing the particles deposited thereon.

Abstract translation: 提供了一种用于空中粒子分选的装置（100）。 该装置包括适于向颗粒施加静电电荷的充电系统（104），使得至少第一组的颗粒比第二组的颗粒更大程度地偏转。 聚焦系统（106）适于将基本上至少第一组的颗粒静电聚焦成比输入空气流更窄的聚焦流。 沉积系统（108）适于将目标表面上的聚焦物流的第一组粒子维持沉积在目标表面上，其中目标表面可被运送到能够分析沉积在其上的颗粒的分析系统（112）。

公开(公告)号：WO2005009581A2

公开(公告)日：2005-02-03

申请号：PCT/US2004022580

申请日：2004-07-13

Applicant: NAGAOKA KK ,  BURSTEIN TECHNOLOGIES INC ,  RANDALL BRANDON LEE ,  POTTATHIL RAVEENDRAN ,  LI SHUGUANG

Inventor： RANDALL BRANDON LEE ,  POTTATHIL RAVEENDRAN ,  LI SHUGUANG

IPC: B01D20060101 ,  B01D11/04 ,  C12M1/34 ,  C12M3/00 ,  C12N1/00 ,  C12Q1/00 ,  G01N15/06 ,  G01N21/00 ,  G01N21/29 ,  G01N21/41 ,  G01N21/47 ,  G01N21/75 ,  G01N31/22 ,  G01N33/00 ,  G01N33/558 ,  G01N35/00 ,  B01D

CPC classification number: G01N33/558 ,  G01N35/00069 ,  Y10S435/96 ,  Y10S435/97

Abstract: Optical bio-discs for biochemical analysis, bio-disc analysis systems and biochemical analysis methods are described herein. In one embodiment, the bio-disc includes a sample analysis circuit that includes a separation membrane for separating an investigational feature of a sample. The bio-disc also includes a conjugate release pad, and an analysis membrane containing analysis zones that may be analyzed for the presence of analytes. An analysis method includes providing a sample to a separation membrane in a bio-disc, separating an investigational feature from the sample using a separation membrane, mixing reagents that include signal elements for detecting an analyte with the investigational feature so as to form a reagent-investigational feature mixture and capturing an analyte with a signal element bound thereto in an analysis zone on an analysis membrane. The method further includes determining the presence of an analyte by analyzing the signal elements present in the capture zone of the analysis membrane.

Abstract translation: 用于生物化学分析的光学生物盘，生物盘分析系统和生化分析方法在本文中描述。 在一个实施例中，生物盘包括样品分析电路，其包括用于分离样品研究特征的分离膜。 生物盘还包括缀合物释放垫，以及含有可分析存在分析物的分析区的分析膜。 分析方法包括：将样品提供到生物盘中的分离膜，使用分离膜从样品中分离研究特征，将包括用于检测分析物的信号元件的试剂与研究特征混合，以形成试剂 - 研究特征混合物并且在分析膜上的分析区域中捕获结合有信号元件的分析物。 该方法还包括通过分析存在于分析膜的捕获区域中的信号元素来确定分析物的存在。

公开(公告)号：WO2004046689B1

公开(公告)日：2005-02-03

申请号：PCT/US0336727

申请日：2003-11-17

Applicant: UNIV CALIFORNIA ,  MAJUMDAR ARUN ,  YUE MIN ,  DAMES CHRIS ,  COTE RICHARD ,  LIN HENRY ,  DATAR RAM ,  SATYANARAYANA SRINATH

Inventor： MAJUMDAR ARUN ,  YUE MIN ,  DAMES CHRIS ,  COTE RICHARD ,  LIN HENRY ,  DATAR RAM ,  SATYANARAYANA SRINATH

IPC: G01N33/543 ,  A47B9/00 ,  C12M1/34 ,  C12M3/00 ,  C12Q1/68 ,  G01N7/00 ,  G01N21/00 ,  G01N21/29 ,  G01N21/41 ,  G01N21/47 ,  G01N21/75 ,  G01N31/00 ,  G01N31/22 ,  G01N33/00

CPC classification number: G01N33/54373

Abstract: Systems and techniques for biomechanical analysis are described. Multiple sensors are used to detect different molecules and/or to analyze multiple samples. A property of the sensors changes in response to a target molecule. The change in the property is detected, which may provide a measure of the concentration of the target molecule.

Abstract translation: 描述了生物力学分析的系统和技术。 多个传感器用于检测不同的分子和/或分析多个样品。 传感器的性质响应目标分子而变化。 检测到性质的变化，其可以提供靶分子的浓度的量度。

公开(公告)号：WO03012406A9

公开(公告)日：2003-03-20

申请号：PCT/US0209440

申请日：2002-03-27

Applicant: HANDYLAB INC

Inventor： PARUNAK GENE ,  HANDIQUE KALYAN ,  WU BETTY ,  GANESAN KARTHIK

IPC: G11C16/06 ,  B01L3/00 ,  B81B1/00 ,  F04B19/00 ,  F04B19/24 ,  F04F1/06 ,  G01N21/29 ,  B01D57/02 ,  C02F1/40 ,  C12M1/34 ,  C12M1/36 ,  C12N13/00 ,  C12Q1/68

CPC classification number: B01L3/502738 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2400/0442

Abstract: The present invention relates to a system and method for moving samples, such as fluids, within a microfluidic system using a plurality of gas actuators (168, 170, 172) for applying pressure at different locations within the microfluidic. The system includes a substrate (130, 132) which forms a fluid network through which fluid flows, and a plurality of gas actuators (168, 170, 172) integral with the substrate (130, 132). One such actuator (168) is coupled to the network at a first location for providing gas pressure to move a microfluidic sample within the network. Another gas actuator (170) is coupled to the network at a second location for providing gas pressure to further move at least a portion of the microfluidic sample within the network. A valve (915, 216) is coupled to the microfluidic network so that, when the valve is closed, it substantially isolates the second gas actuator from the first gas actuator.

Abstract translation: 本发明涉及一种使用多个用于在微流体内的不同位置施加压力的气体致动器（168,170,172）在微流体系统内移动样品（例如流体）的系统和方法。 该系统包括形成流体流过的流体网络的衬底（130,132）和与衬底（130,132）成一体的多个气体致动器（168,170,172）。 一个这样的致动器（168）在第一位置处联接到网络，以提供气体压力以移动网络内的微流体样本。 另一气体致动器（170）在第二位置处联接到网络，用于提供气体压力以进一步移动网络内微流体样品的至少一部分。 阀（915,216）联接到微流体网络，使得当阀关闭时，阀将基本上将第二气体致动器与第一气体致动器隔离。

公开(公告)号：WO01071314A1

公开(公告)日：2001-09-27

申请号：PCT/US2001/009254

申请日：2001-03-21

IPC: G01N33/543 ,  G01N33/567 ,  G01N33/58 ,  G01N15/06 ,  C03B37/15 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34 ,  C12Q1/68 ,  G01N21/29 ,  G06G7/58

CPC classification number: G01N33/54306 ,  G01N33/582

Abstract: The described invention includes methods and assays to identify compounds that interact with a binding domain of a protein by a competition assay with a labeled ligand targeted to the peptides of the binding domain of that protein. These assays can be used for high throughput compound screening, or used to identify sites of compound interaction with proteins in tissue samples.

Abstract translation: 所描述的发明包括通过竞争测定来鉴定与蛋白质的结合结构域相互作用的化合物的方法和测定法，所述化合物与靶向该蛋白质的结合结构域的肽的标记配体。 这些测定可用于高通量化合物筛选，或用于鉴定与组织样品中的蛋白质的化合物相互作用的位点。

公开(公告)号：WO01006225A1

公开(公告)日：2001-01-25

申请号：PCT/US2000/019892

申请日：2000-07-20

IPC: G01N21/29 ,  G01N21/78 ,  G01N31/22 ,  G01N33/28 ,  G01M25/10 ,  G01N25/02 ,  G01N25/08

CPC classification number: G01N21/78 ,  G01N21/293 ,  G01N31/22 ,  G01N33/2835 ,  G01N33/2858

Abstract: A reactive test strip (10) having a pre-exposure color is used to measure and indicate the concentration of copper ions in brake fluid in terms of a readily visible color change. The strip is immersed in the fluid within a brake fluid container (30) and any resulting color change is compared to a color chart (20) and a known test standard representative of the maximum concentration determined empirically to correspond to a boiling point considered safe for normal operation. If the color change indicates a higher copper concentration, then the fluid is considered inadequate for safe operation and thus recommended for replacement without further tests. Similar copper or metal strips can also be used to determine iron or zinc concentration. An automated embodiment of the invention includes an optical instrument to compare the color obtained during the test against a predetermined test standard and determine whether a brake fluid change is recommended.

Abstract translation: 提供具有预曝光颜色的反应性测试条（10），用于通过即时可见的颜色变化来测量和指示制动流体的铜离子浓度。 将条浸入制动液容器（30）中的液体中，并将​​所得到的颜色变化与颜色图（20）进行比较; 一个已知的测试标准，代表经验确定的最大浓度，对应于正常操作时认为安全的沸点。 如果颜色变化表明铜浓度过高，则液体被认为不适合正常操作，建议在没有进一步测试的情况下更换。 类似的金属或铜带也可用于测定铁或锌的浓度。 本发明的自动化实施例包括光学仪器，其将在测试期间获得的颜色与预定测试标准进行比较，并确定是否推荐改变制动液。