公开(公告)号：WO2015187496A1

公开(公告)日：2015-12-10

申请号：PCT/US2015/033269

申请日：2015-05-29

Applicant: CHILDREN'S HOSPITAL MEDICAL CENTER

Inventor： AZAM, Mohammad ,  KESARWANI, Meenu

IPC: C07C41/00

CPC classification number: A61K31/517 ,  A61K31/12 ,  A61K31/135 ,  A61K31/357 ,  A61K31/365 ,  A61K31/404 ,  A61K31/437 ,  A61K45/06 ,  A61K2300/00

Abstract: A pharmaceutically acceptable composition and method for solid tumor therapy in a patient in need of such therapy. The composition contains, as the only active agents, the combination of (a) an inhibitor of c-Fos, and (b) an inhibitor of Dusp-1, and optionally (c) an inhibitor of a tyrosine kinase. The composition is administered to the patient in a dosing regimen for a period sufficient to provide therapy for solid tumors.

Abstract translation: 用于需要这种治疗的患者中用于实体瘤治疗的药学上可接受的组合物和方法。 组合物含有（a）c-Fos抑制剂和（b）Dusp-1抑制剂和任选地（c）酪氨酸激酶抑制剂的组合，作为唯一的活性剂。 组合物以给药方案给予患者足够长的时间以提供实体瘤的治疗。

公开(公告)号：WO2013191987A1

公开(公告)日：2013-12-27

申请号：PCT/US2013/045412

申请日：2013-06-12

Applicant: INVISTA TECHNOLOGIES S.A R.L.

Inventor： SUN, Qun ,  DORAI, Suri, N.

IPC: C08G65/00 ,  C08G65/30 ,  C08G65/32 ,  C07C41/00

CPC classification number: C08G65/48 ,  B01J19/24 ,  B01J2219/24 ,  C08G65/30 ,  C08G65/3311

Abstract: The present invention provides an improved process and apparatus for alkanolysis of polytetramethylene ether diacetate to polytetraalkylene ether glycol in the presence of a C1 to C4 alkanol and an alkali or alkaline earth metal catalyst wherein the catalyst component of the product mixture comprising polytetraalkylene ether glycol, alkanol and catalyst, essentially free of the alkanol acetate by-product, e.g., methyl acetate is removed by contacting the mixture in the absence of added water with certain ion exchange resin at specified contact conditions. The invention further provides a highly efficient method for removing the catalyst component of a mixture comprising polytetraalkylene ether glycol, alkanol and alkali or alkaline earth metal catalyst by contacting the mixture in the absence of added water with certain ion exchange resin at specified contact conditions,

Abstract translation: 本发明提供了在C1至C4链烷醇和碱金属或碱土金属催化剂存在下将聚四亚甲基醚二乙酸酯分解成聚四亚乙基醚二醇的改进方法和装置，其中产物混合物的催化剂组分包含聚四亚乙基醚二醇，链烷醇 和催化剂，基本上不含链烷醇乙酸酯副产物，例如，在特定接触条件下，通过在不加入水的情况下将某些离子交换树脂与混合物接触来除去乙酸甲酯。 本发明还提供了一种用于通过在不存在加入水的情况下将混合物与特定的离子交换树脂在特定的接触条件下接触来除去包含聚四亚烷基醚二醇，链烷醇和碱金属或碱土金属催化剂的混合物的催化剂组分的高效方法，

公开(公告)号：WO2011005821A1

公开(公告)日：2011-01-13

申请号：PCT/US2010/041150

申请日：2010-07-07

Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ,  FRANZINI, Raphael M. ,  KOOL, Eric Todd

Inventor： FRANZINI, Raphael M. ,  KOOL, Eric Todd

IPC: C07C247/00 ,  C07C205/00 ,  C07C41/00

CPC classification number: C07C247/04 ,  A61K49/0017 ,  C12Q1/6818 ,  G01N33/532 ,  C12Q2563/107

Abstract: Probes comprising one or more selectively cleavable α-azidoether moieties are provided; and linkers comprising the one or more selectively cleavable α-azidoether moieties. The α-azidoether moiety will undergo a Staudinger reaction with a suitable reducing agent, resulting in cleavage. The probes find use in a variety of detection assays, e.g. specific polynucleotide binding assays, polypeptide binding assays, etc. The cleavable linkers are suitable for synthetic reactions, e.g. to prepare probes of the invention; in the synthesis of cleavable peptide conjugates; and the like.

Abstract translation: 提供包含一个或多个可选择性切割的叠氮基醚部分的探针; 和包含一个或多个可选择性切割的叠氮基醚部分的连接体。 α-叠氮醚部分将与合适的还原剂进行Staudinger反应，导致裂解。 探针可用于各种检测分析，例如。 特异性多核苷酸结合测定，多肽结合测定等。可切割接头适合于合成反应，例如 制备本发明的探针; 在可切割肽缀合物的合成中; 等等。

公开(公告)号：WO2007021693A3

公开(公告)日：2007-02-22

申请号：PCT/US2006/030919

申请日：2006-08-09

Applicant: REPLIDYNE, INC. ,  GUILES, Joseph, W. ,  QIU, Jian ,  TARASOW, Theodore, M.

Inventor： GUILES, Joseph, W. ,  QIU, Jian ,  TARASOW, Theodore, M.

IPC: C07C41/00 ,  C07C43/02

Abstract: Methods for introducing a 1-halo-l-haloalkene compound onto an aromatic or heteroaromatic ring are provided, including processes for the production of certain 1-halovinyl aryl or heteroaryl derivatives in which the 1-halovinyl group is either 1-fluoro or 1-chlorovinyl and the aromatic species phenyl or thiophene, the processes including coupling an arylmagnesium species with a dihalo olefin in the presence of a nickel or iron catalyst.

公开(公告)号：WO2006052464A2

公开(公告)日：2006-05-18

申请号：PCT/US2005/038694

申请日：2005-10-26

Applicant: CHEMIMAGE CORPORATION ,  TUSCHEL, David ,  BANGALORE, Arjun, S.

Inventor： TUSCHEL, David ,  BANGALORE, Arjun, S.

IPC: C07C41/00 ,  C07C45/00

CPC classification number: B01D9/00 ,  B01D9/0077 ,  C07B61/00 ,  C07C45/81 ,  C07C49/255 ,  G01N21/65 ,  G01N2021/656 ,  G11B7/245

Abstract: The invention relates to methods of assessing the polymorphic form of a substance by assessing Raman-shifted radiation scattered by a particle of the substance. The method is useful, for example, for assessing particle sizes and size distributions in mixtures containing both particles of the substance and other materials. The invention also relates to methods of selecting and controlling polymorph formation by illuminating a material with non-resonant (i.e., non-absorbed) laser radiation as it is thermally driven through a phase transition temperature.

Abstract translation: 本发明涉及通过评估物质颗粒散射的拉曼位移辐射来评估物质的多晶形式的方法。 该方法例如用于评估含有物质颗粒和其它材料的混合物的粒度和尺寸分布是有用的。 本发明还涉及通过在通过相变温度热驱动的情况下照射具有非共振（即，未吸收的）激光辐射的材料来选择和控制多晶型形成的方法。

公开(公告)号：WO2005079537A2

公开(公告)日：2005-09-01

申请号：PCT/US2005/005548

申请日：2005-02-17

Applicant: E.I. DUPONT DE NEMOURS AND COMPANY ,  ARTHUR, Samuel, David ,  KUNITSKY, Keith ,  TROST, Barry, M. ,  WAGMAN, Mark, E.

Inventor： ARTHUR, Samuel, David ,  KUNITSKY, Keith ,  TROST, Barry, M. ,  WAGMAN, Mark, E.

IPC: C07C41/00 ,  C07C41/03 ,  C07C43/23

CPC classification number: C07C41/03 ,  C08F12/22 ,  C07C43/23

Abstract: A method for preparing p-(2-hydroxyalkyloxy)styrene monomers and oligomers is described. The method comprises a base-catalyzed reaction of a styrene ester, a suitable alcohol and an alkylene oxide in a single vessel reaction. In this method, the reactive p-hydroxystyrene is generated in situ via the base-catalyzed transesterification reaction between the styrene ester and the alcohol in the presence of the base catalyst. The p-hydroxystyrene formed reacts with the alkylene oxide to form the p-(2-hydroxyalkyloxy)styrene monomer or oligomer.

Abstract translation: 描述了制备对 - （2-羟基烷氧基）苯乙烯单体和低聚物的方法。 该方法包括在单容器反应中苯乙烯酯，合适的醇和烯化氧的碱催化反应。 在该方法中，在碱催化剂存在下，通过苯乙烯酯与醇之间的碱催化酯交换反应原位生成反应性对羟基苯乙烯。 所形成的对羟基苯乙烯与烯化氧反应形成对 - （2-羟基烷氧基）苯乙烯单体或低聚物。

公开(公告)号：WO2004033599A3

公开(公告)日：2004-10-14

申请号：PCT/US0330240

申请日：2003-09-24

Applicant: CHEVRON USA INC

Inventor： O'REAR DENNIS J ,  HARRIS THOMAS V ,  CHEN CONG-YAN

IPC: C07C29/10 ,  C10L1/02 ,  C10L1/182 ,  C10L1/22 ,  C07C41/00 ,  C10L1/10 ,  C10L1/18

CPC classification number: C10L10/08 ,  C07C29/10 ,  C10L1/026 ,  C10L1/1824 ,  C07C31/12 ,  C07C31/125

Abstract: Olefins and alcohols present in Fischer-Tropsch products are converted to primary and secondary alkyl alcohols having at least four carbons through acid catalyzed etherification and hydrolysis reactions. The alcohols are added to a highly isoparaffinic distillate fuel blend, improving the lubricity of the mixture, and forming a distillate fuel with improved lubricity.

Abstract translation: 存在于费 - 托产物中的烯烃和醇通过酸催化的醚化和水解反应转化成具有至少四个碳的伯和仲烷基醇。 将醇添加到高度异链烷烃馏分燃料共混物中，改善混合物的润滑性，并形成具有改善的润滑性的馏分燃料。

公开(公告)号：WO2003104168A3

公开(公告)日：2003-12-18

申请号：PCT/US2003/011654

申请日：2003-04-16

Applicant: CATALYTIC DISTILLATION TECHNONLOGIES

Inventor： GROTEN, Willibrord, A. ,  MARASCHINO, Mario, J.

IPC: C07C41/00

Abstract: A process for reacting a first component with itself or a second component to produce a third component in which a first material comprising a first component or said first component and a second component is fed to divided wall column having a catalytic distillation structure in at least one of the separate vertical sections of the divided wall column where concurrently: (1) a first component alone or with a second component is contacted with a catalytic distillation structure in a distillation reaction zone thereby catalytically reacting at least a portion of the first component with itself or with the second component to form a product and (2) a first mixture comprising the first component and the product or the first component, the second component and the product; and withdrawing the product from the distillation column reactor; while within the column concurrently with the catalytic reaction and fractionation a second mixture is fractionated, which contains the first component and the product or first and second components (if a second component is present) and the product in a parallel and separate distillation non reaction zone to fractionate the product and withdrawing the product from said distillation non reaction zone. For example, tertiary amyl methyl ether may be prepared by reacting methanol with isoamylene in a C 5 stream utilizing a distillation column reactor wherein the distillation column reactor comprises one side of a divided wall column. On one side the product, tertiary amyl methyl ether, is separated from the unreacted methanol and C 5 's and on the other side the remaining isoamylenes are reacted with methanol and a separation of the tertiary amyl methyl ether and C 5 's from the methanol/C 5 azeotrope is effected.

公开(公告)号：WO03006158A3

公开(公告)日：2003-04-03

申请号：PCT/US0223302

申请日：2002-07-13

Applicant: UNIV MICHIGAN STATE

Inventor： SMITH MILTON R III

IPC: B01J31/12 ,  B01J31/14 ,  B01J31/18 ,  B01J31/22 ,  B01J31/24 ,  B01J31/28 ,  C07C1/32 ,  C07C17/269 ,  C07F15/00 ,  C07F17/02 ,  C08G61/10 ,  B01J31/00 ,  C07C41/00 ,  C07C43/02 ,  C07C43/20 ,  C07C211/00 ,  C07D231/00 ,  C07D233/00 ,  C07D235/00 ,  C07D249/00 ,  C07D261/00 ,  C07D263/00 ,  C07D271/00 ,  C07D273/00 ,  C07D275/00 ,  C07D283/00 ,  C07D291/00 ,  C07D293/00 ,  C07D413/00 ,  C07D417/00 ,  C07D419/00 ,  C07D421/00 ,  C07D498/00 ,  C07D513/00 ,  C07D515/00 ,  C07D517/00 ,  C07F5/02 ,  C07F9/02

CPC classification number: C08G61/10 ,  B01J31/1805 ,  B01J31/181 ,  B01J31/22 ,  B01J31/2295 ,  B01J31/24 ,  B01J31/2404 ,  B01J31/2409 ,  B01J2231/4211 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  C07C1/321 ,  C07C17/269 ,  C07C2531/22 ,  C07F15/0033 ,  C07F15/004 ,  C07F15/0073 ,  C07F15/008 ,  C07F17/02 ,  C07C15/00 ,  C07C22/08 ,  C07C25/18

Abstract: A process for producing a ring-substituted arene borane which comprises reacting a ring-substituted arene with an HB organic compound in the presence of a catalytically effective amount of an iridium or rhodium complex with three or more substituents, excluding hydrogen, bonded to the iridium or rhodium and a phosphorus organic ligand, which is at least in part bonded to the iridium or rhodium, to form the ring-substituted arene borane. Also provided are catalytic compounds for catalyzing the process comprising an iridium or rhodium complex with three or substituents, excluding hydrogen, bonded to the iridium or rhodium and optionally, a phosphorus organic ligand, which is at least in part bonded to the iridium or rhodium.

Abstract translation: 一种制备环取代的芳烃硼烷的方法，其包括使环取代的芳烃与HB有机化合物在催化有效量的铱或铑络合物的存在下反应，所述铱或铑络合物与三个或更多个除了与铱结合的氢之外的取代基 或至少部分地与铱或铑结合的铑和磷有机配体，以形成环取代的芳烃硼烷。 还提供了用于催化该方法的催化化合物，该方法包括与铱或铑键合的三个或不包括氢的取代基的铱或铑络合物和任选的至少部分与铱或铑结合的磷有机配体。

公开(公告)号：WO2003020678A2

公开(公告)日：2003-03-13

申请号：PCT/US2002/027146

申请日：2002-08-15

Applicant: EXXONMOBIL CHEMICAL PATENTS INC.

Inventor： LATTNER, James, R. ,  LUMGAIR, David, R., Jr. ,  KABIN, Jeffrey, A. ,  NICOLETTI, Michael, P.

IPC: C07C41/00

CPC classification number: C07C11/02 ,  C07C7/005 ,  C07C7/04 ,  C07C7/08 ,  C07C11/04

Abstract: This invention is directed to a method of removing dimethyl ether from an olefin stream. Dimethyl ether is removed from the olefin stream by first separating the olefin stream into a first stream comprising dimethyl ether and lighter boiling point compounds, and a second stream comprising C 4 + olefin and higher boiling point hydrocarbons. The dimethyl ether is then separated from the first stream using extractive distillation.

Abstract translation: 本发明涉及从烯烃料流中除去二甲醚的方法。 首先将烯烃物流分离成包含二甲醚和较轻沸点化合物的第一物流和包含C 4+烯烃和更高沸点烃的第二物流，从烯烃物流中除去二甲醚。 然后使用萃取蒸馏将二甲醚与第一个物流分离。