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    ENZYME SENSOR
    71.
    发明申请
    ENZYME SENSOR 审中-公开
    ENZYME传感器

    公开(公告)号：WO1998021356A1

    公开(公告)日：1998-05-22

    申请号：PCT/DK1997000508

    申请日：1997-11-07

    Applicant: RADIOMETER MEDICAL A/S ,  AHL, Thomas ,  BYRNARD, Allan, Milton

    Inventor： RADIOMETER MEDICAL A/S

    IPC: C12Q01/00

    CPC classification number: C12Q1/002 ,  C12N11/02 ,  C12Q1/005 ,  Y10S435/963 ,  Y10S435/973

    Abstract: The present invention relates to an enzyme sensor for measuring the concentration or activity of an analyte of a test fluid. The sensor has at least one enzyme layer comprising an immobilised enzyme for which the analyte is a substrate. The immobilised enzyme is obtained by formation of one or more covalent link(s), optionally by using a cross-linking agent, between the enzyme and at least one type of macromolecule in the presence of a competitive inhibitor for said enzyme. The present invention also relates to a membrane for an enzyme sensor. Furthermore, the invention relates to a method for stabilising the enzymatic activity of an enzyme sensor.

    Abstract translation: 本发明涉及一种用于测量被测流体分析物的浓度或活性的酶传感器。 该传感器具有至少一个酶层，其包含固定化酶，分析物为基质。 通过在所述酶的竞争性抑制剂存在下，在所述酶和至少一种类型的大分子之间形成一种或多种共价连接，任选地通过使用交联剂获得所述固定化酶。 本发明还涉及一种酶传感器的膜。 此外，本发明涉及稳定酶传感器酶活性的方法。

    ENZYMATIC ARRAY AND PROCESS OF MAKING SAME
    72.
    发明申请
    ENZYMATIC ARRAY AND PROCESS OF MAKING SAME 审中-公开
    ENZYMATIC ARRAY及其制作方法

    公开(公告)号：WO1997014789A2

    公开(公告)日：1997-04-24

    申请号：PCT/US1996016485

    申请日：1996-10-16

    Applicant: GENENCOR INTERNATIONAL, INC.

    Inventor： GENENCOR INTERNATIONAL, INC. ,  BOTT, Richard, R. ,  CLARKSON, Kathleen, A. ,  FOWLER, Timothy ,  LIU, Chung-Cheng ,  WARD, Michael ,  XIA, Hai-Ying

    IPC: C12N11/18

    CPC classification number: C07K14/33 ,  C12N11/02

    Abstract: An enzymatic array is provided, which composition comprises one or more enzymes non-covalently bound to a peptide backbone, wherein at least one of the enzymes is heterologous to the peptide backbone and the peptide backbone is capable of having bound thereto a plurality of enzymes. The array is useful, for example, in recovery systems, targeted multi-enzyme delivery systems, soluble substrate modification, quantification type assays, and other applications in the food industry, feed, textiles, bioconversion, pulp and paper production, plant protection and pest control, wood preservatives, topical lotions and biomass conversions.

    Abstract translation: 提供了一种酶阵列，该组合物包含一种或多种与肽骨架非共价结合的酶，其中至少一种酶与肽骨架是异源的，并且肽主链能够结合多种酶。 该阵列在例如恢复系统，靶向多酶递送系统，可溶底物修饰，定量分析方法以及食品工业，饲料，纺织品，生物转化，纸浆和造纸生产，植物保护和害虫中的其他应用中是有用的 控制，木材防腐剂，局部洗剂和生物质转化。

    CROSSLINKABLE POLYPEPTIDE COMPOSITIONS
    73.
    发明申请
    CROSSLINKABLE POLYPEPTIDE COMPOSITIONS 审中-公开
    可交联聚碳酸酯组合物

    公开(公告)号：WO1996040829A1

    公开(公告)日：1996-12-19

    申请号：PCT/US1996007424

    申请日：1996-05-21

    Applicant: VIVORX PHARMACEUTICALS, INC. ,  SOJOMIHARDJO, Soebianto, A. ,  DESAI, Neil, P. ,  SANDFORD, Paul, A. ,  SOON-SHIONG, Patrick ,  NAGRANI, Shubhi

    Inventor： VIVORX PHARMACEUTICALS, INC.

    IPC: C08L89/00

    CPC classification number: C12N5/0677 ,  A61K9/1652 ,  A61K9/1658 ,  A61K38/28 ,  A61K47/42 ,  A61K2035/128 ,  C07K14/4732 ,  C07K14/76 ,  C07K14/78 ,  C08F290/14 ,  C08H1/00 ,  C12N5/0671 ,  C12N11/02

    Abstract: In accordance with the present invention, there are provided rapidly crosslinkable polypeptides which are obtained upon introduction of unsaturated group(s) into the polypeptide via linkage to amino acid residues on the polypeptide directly through one of three types of linkages, namely, an amide linkage, an ester linkage, or a thioester linkage. Each of these linkages are obtainable in a single step by use of a single derivatizing agent, acrylic anhydride. Also provided are methods for preparing such modified polypeptides and various uses therefor. It has unexpectedly been found that proteins with the above-described chemical modifications have the ability to rapidly crosslink to themselves under suitable conditions. This cross-linking occurs in the absence of any external crosslinking agents (indeed, in the absence of any extraneous agents), resulting in the formation of a solid gel material. Solid crosslinked gels are formed in seconds, starting from a freely flowing solution of polypeptide. Applications of such materials are broad ranging, including the encapsulation of living cells, the encapsulation of biologically active materials, the in situ formation of degradable gels, the formation of wound dressings, the prevention of post-surgical adhesions, gene delivery, drug targetting, as a microcarrier for cultrure of living cells, and the like.

    Abstract translation: 根据本发明，提供了快速可交联的多肽，其通过直接通过三种类型的键之一连接到多肽上的氨基酸残基而将不饱和基团引入到多肽中，即三酰胺键 ，酯键或硫酯键。 这些连接中的每一个可以通过使用单一衍生剂丙烯酸酐在一个步骤中获得。 还提供了制备这种修饰的多肽及其各种用途的方法。 意外地发现具有上述化学修饰的蛋白质具有在合适条件下快速与其自身交联的能力。 这种交联发生在没有任何外部交联剂的情况下（实际上，在没有任何外来物质的情况下），导致形成固体凝胶材料。 固体交联凝胶在几秒钟内形成，自由流动的多肽溶液开始。 这些材料的应用范围广泛，包括活细胞的包封，生物活性物质的包封，可降解凝胶的原位形成，伤口敷料的形成，预防手术后粘连，基因递送，药物靶向， 作为用于培养活细胞的微载体等。

    METHOD AND APPARATUS FOR CATALYST CONTAINMENT IN MULTIPHASE MEMBRANE REACTOR SYSTEMS
    78.
    发明申请
    METHOD AND APPARATUS FOR CATALYST CONTAINMENT IN MULTIPHASE MEMBRANE REACTOR SYSTEMS 审中-公开
    多相膜反应器系统催化容纳的方法与装置

    公开(公告)号：WO1990006996A1

    公开(公告)日：1990-06-28

    申请号：PCT/US1989005671

    申请日：1989-12-18

    Applicant: SEPRACOR, INC.

    Inventor： SEPRACOR, INC. ,  LOPEZ, Jorge, L. ,  MATSON, Stephen, L.

    IPC: C12N11/02

    CPC classification number: C12N11/02 ,  C12M25/10 ,  C12M29/16 ,  C12N11/08 ,  C12N11/10

    Abstract: Apparatus for catalysis in multiphase reaction systems is provided in which catalysts are confined within various membranes without the use of covalent coupling. Confinement of the catalysts is achieved by a combination of a small-pore skin on one side of the membrane and the use of a solvent in which the catalysts are not appreciably soluble on the other. Methods are also provided for the preparation of such apparatus and for their regeneration by incorporation of fresh catalyst.

    Abstract translation: 提供了多相反应体系中的催化装置，其中催化剂被限制在各种膜中，而不使用共价偶联。 催化剂的限制通过膜的一侧上的小孔表皮与使用其中催化剂在另一方面不易溶解的溶剂的组合来实现。 还提供了用于制备这种装置并通过掺入新鲜催化剂进行再生的方法。

    WEIGHTED MICROSPONGE FOR IMMOBILIZING BIOACTIVE MATERIAL
    80.
    发明申请
    WEIGHTED MICROSPONGE FOR IMMOBILIZING BIOACTIVE MATERIAL 审中-公开
    称重微孔用于固定生物材料

    公开(公告)号：WO1986005811A1

    公开(公告)日：1986-10-09

    申请号：PCT/US1986000600

    申请日：1986-03-26

    Applicant: VERAX CORPORATION

    Inventor： VERAX CORPORATION ,  DEAN, Robert, C. ,  PHILLIPS, Philip, G. ,  RUNSTADLER, Peter, W., Jr. ,  SILVER, Frederick, H. ,  BERG, Richard, A. ,  CAHN, Frederick

    IPC: C12P21/00

    CPC classification number: C12N1/00 ,  C12N5/0075 ,  C12N11/02 ,  C12N2533/54 ,  C12P1/00

    Abstract: Weighted microsponges preferably having a highly crosslinked collagen matrix suitable for use in culturing organisms in motive reactor systems. The microsponges have an open to the surface pore structure, and pore sizes and volumes suitable for immobilizing a variety of bioactive materials. The microsponges also have an average particle size in the range of about 100 to about 1000 microns and a specific gravity above about 1.05. Also described is an in vitro method for culturing organisms immobilized on a microsponge comprising a highly crosslinked, porous collagen matrix prepared by crosslinking Type I, II or III type collagen using a carbodiimide or a succinimidyl active ester and/or severe dehydration conditions.

    Abstract translation: 加重的微球优选具有适用于在动力反应器系统中培养生物体的高度交联的胶原基质。 微球具有开放的表面孔结构，并且适合于固定各种生物活性材料的孔径和体积。 微球也具有约100至约1000微米范围内的平均粒度和约1.05的比重。 还描述了用于培养固定在微球上的生物体的体外方法，其包括通过使用碳二亚胺或琥珀酰亚胺基活性酯交联I型，II型或III型胶原和/或严重脱水条件制备的高度交联的多孔胶原基质。

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