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    COMPOUNDS THAT ASSOCIATE ON THE INTERMOLECULAR LEVEL AND AGGREGATE BODIES THAT CONTAIN THEM
    72.
    发明申请
    COMPOUNDS THAT ASSOCIATE ON THE INTERMOLECULAR LEVEL AND AGGREGATE BODIES THAT CONTAIN THEM 审中-公开
    分子间缔合连接和综合该聚合

    公开(公告)号：WO01002018A2

    公开(公告)日：2001-01-11

    申请号：PCT/EP2000/006139

    申请日：2000-06-30

    IPC: A61K31/7008 ,  A61K39/395 ,  A61K47/42 ,  A61K47/48 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07H13/04 ,  C07H15/04 ,  C07H15/18 ,  C07K5/00 ,  C07K7/06 ,  C07K9/00 ,  G01N33/531

    CPC classification number: C07H13/04 ,  A61K47/54 ,  A61K47/6929 ,  C07H15/04 ,  C07H15/18 ,  C07K7/06 ,  C07K9/001 ,  G01N33/531

    Abstract: The invention relates to a compound of the general formula (I) X(B)m, wherein X is a unit of the value m and the members B are the same or different and represent K-R, wherein K represents a bond or A -(A -A )k-sp, wherein A is (CH2)tY(CH2)u, wherein Y is >C=0, >NH, -O-, -S- or a bond, t is an integer from 0 to 6 and u is an integer from 0 to 6, A represents -NHCO-, -CONH-, -OCONH- or SCONH-, or -CO-, A is (CH2)r, O(CH2)r, NH(CH2)r, S(CH2)r, or -(CHQ)-, wherein r is an integer from 1 to 6 and Q is a substituted or unsubstituted alkyl or aryl group, sp represents a bivalent spacer or a bond, and k is an integer from 5 to 100, and R represents hydrogen, a ligand that is suitable to specifically bind to a receptor, a marker molecule or a catalytically active group, and m is at least 2, with the proviso that (1) in the compound at least one R is different from hydrogen, (2) at least 2 K are present that do not represent a bond, and (3) X, the members B and m are selected in such a manner that K can be associated on the intermolecular level in the liquid phase by the formation of hydrogen bonds and the simultaneous formation of aggregate bodies that represent on their surfaces several R that are different from hydrogen, and (4) the molar mass of fragment X(K)m is less than 20.000.

    Abstract translation: 通式（I）的化合物：X（B）m表示，其中X表示m价基团和B是相同或不同，并且是CR，其中K是键，或A <1> - （A < 2> -A <3>）K-SP，其中a <1>（对于（CH2）TY CH2）u代表，其中Y是> C = O，> NH，-O - ， - S-或键 中，t是从0至6的整数，u是0至6的整数，a <2>是-NHCO - ， - CONH - ，或-OCONH- SCONH-，或为CO， 一个<3>是（CH 2）R，O（CH 2）R NH（CH 2）R，S（CH 2）r或 - （CHQ） - ，其中R a为从1至6的整数，并且Q是 取代或未取代的烷基或芳基，Sp表示二价间隔或一个键，k表示5-100的整数，R表示氢，适合的特异性结合到受体配体，标记物的容器 分子或其催化活性基团，和m是至少为2，其条件是（1）在化合物中至少一个R NIC HT是氢，（2）存在于至少两个的K，这不是一个键，并且（3）X，其被乙选择和米，使得K的液相分子间缔合通过氢桥键的形成，以形成 本的多个R，除氢以外的表面上的聚集体，是可能的，和（4）的片段X（K）M的分子量小于20,000。

    NOVEL QUATERNARY AMMONIUM DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL USE
    73.
    发明申请
    NOVEL QUATERNARY AMMONIUM DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL USE 审中-公开
    新的季铵衍生物，其制备方法和药物使用方法

    公开(公告)号：WO01000621A1

    公开(公告)日：2001-01-04

    申请号：PCT/FR2000/001731

    申请日：2000-06-22

    IPC: A61K31/165 ,  A61K31/4045 ,  A61K31/5415 ,  A61K31/555 ,  A61K31/7008 ,  A61K49/00 ,  A61K51/00 ,  A61P19/00 ,  C07C231/12 ,  C07C237/20 ,  C07D259/00 ,  C07D279/02 ,  C07D409/06 ,  C07D417/12 ,  C07F13/00 ,  C07H5/06 ,  C07H15/12 ,  C07H15/26

    CPC classification number: C07D409/06 ,  C07C237/20 ,  C07D259/00 ,  C07D279/02 ,  C07D417/12 ,  C07F13/005 ,  C07H5/06 ,  Y10S436/811

    Abstract: The invention concerns compounds of formulae (Ia) or (Ib) wherein M: represents a molecule for use in the treatment or diagnosis of pathologies affecting the cartilage; R1, R2, R3 represent an alkyl group, or R1, R 2, R3 together with the nitrogen atom which bears them form a heterocycle; X represents a C1-C6 alkyl chain wherein one or several -CH2- groups are optionally substituted by a sulphur, an oxygen atom, a -NR, -CO-, -CO-NH-, -CO2-, SO- or SO2- group; n represents 0 or 1; Hal represents a halogen atom, or the formula (Ib); R4 represents an alkyl group; Hal represents a halogen atom. General formula (F1) represents a molecule for use in the treatment or diagnosis of pathologies affecting the cartilage, provided that the nitrogen atom can optionally be included in a saturated or unsaturated nitrogenous heterocyclic system, or involved in a double bond.

    Abstract translation: 本发明涉及式（Ia）或（Ib）化合物，其中M：代表用于治疗或诊断影响软骨病理的分子; R 1，R 2，R 3表示烷基，或者R 1，R 2，R 3与它们的氮原子一起形成杂环; X表示C1-C6烷基链，其中一个或多个-CH 2 - 基团任选被硫，氧原子，-NR，-CO-，-CO-NH-，-CO 2 - ，SO-或SO 2 - 组; n表示0或1; Hal表示卤素原子，或式（Ib）; R4表示烷基; Hal代表卤原子。 通式（F1）表示用于治疗或诊断影响软骨的病理学的分子，条件是氮原子可以任选地包括在饱和或不饱和的含氮杂环体系中或参与双键。

    COMPANION ANIMAL THERAPEUTIC TREAT
    76.
    发明申请
    COMPANION ANIMAL THERAPEUTIC TREAT 审中-公开
    公司动物治疗

    公开(公告)号：WO00001399A1

    公开(公告)日：2000-01-13

    申请号：PCT/US1999/015168

    申请日：1999-07-06

    IPC: A61K31/7008 ,  A61K31/70 ,  A61K35/56 ,  A61K35/616 ,  A61K36/18 ,  A61K36/82 ,  A61P29/00 ,  A61P43/00 ,  A61K35/78

    CPC classification number: A61K36/82 ,  A61K35/616 ,  A61K2300/00

    Abstract: The present invention relates to a palatable dosage form of a "jerky stick" or treat for companion animals which includes sea cucumber fractions alone or in combination with glucosamine sulfate and/or glucosamine hydrochloride, and/or sea vegetables, and/or green tea; such jerky stick containing an effective amount of sea cuccumber material for the inhibition or modulation or arthritic or nutritional problems in dogs or cats, and containing palatability co-factors which render the jerky stick attractive to the animal in need.

    Abstract translation: 本发明涉及一种“干燥棒”的可口的剂型或用于伴侣动物的可口的剂型，其包括单独的海参部分或与硫酸葡糖胺和/或盐酸葡糖胺，和/或海鲜蔬菜和/或绿茶组合的海参; 这种干燥的棒包含有效量的海参素材料，用于抑制或调节或在狗或猫中的关节炎或营养问题，并且含有令人讨厌的辅助因子，使得干燥的棒对有需要的动物有吸引力。

    1-GALACTOSE DERIVATIVES
    77.
    发明申请
    1-GALACTOSE DERIVATIVES 审中-公开
    1-GALACTOSE衍生物

    公开(公告)号：WO9958540A3

    公开(公告)日：2000-01-13

    申请号：PCT/CA9900399

    申请日：1999-04-29

    Applicant: SYNSORB BIOTECH INC ,  HINDSGAUL OLE

    Inventor： HINDSGAUL OLE

    IPC: C07H7/02 ,  A61K31/351 ,  A61K31/70 ,  A61K31/7004 ,  A61K31/7008 ,  A61P1/00 ,  A61P1/06 ,  A61P1/12 ,  A61P31/04 ,  C07D309/10 ,  C07H7/04 ,  C07H15/20 ,  C07H15/26

    CPC classification number: C07H15/20 ,  C07H15/26

    Abstract: Disclosed are novel 1-galactose derivatives of formula (I) having a carbon- or nitrogen-containing aglycon linkage. The disclosed compounds inhibit binding of toxins, such as heat-labile enterotoxin or cholera toxin, to their receptors either in vitro or in vivo. The disclosed compounds also inhibit binding of enterovirulent organisms (e.g., bacteria, virus, fungi, and the like), such as Vibrio cholerae and enterotoxigenic strains of Escherichia coli, to their cell surface receptors.

    Abstract translation: 公开了具有含碳或含氮糖苷配基键的式（I）的新颖的1-半乳糖衍生物。 所公开的化合物在体外或体内抑制毒素如热不稳定肠毒素或霍乱毒素与其受体的结合。 所公开的化合物还抑制肠病毒生物体（例如细菌，病毒，真菌等）与其大肠杆菌的结合，例如霍乱弧菌和肠毒素致病菌株对其细胞表面受体的结合。

    THE USE OF ANABOLIC AGENTS, ANTI-CATABOLIC AGENTS, ANTIOXIDANT AGENTS, AND ANALGESICS FOR PROTECTION, TREATMENT AND REPAIR OF CONNECTIVE TISSUES IN HUMANS AND ANIMALS
    78.
    发明申请
    THE USE OF ANABOLIC AGENTS, ANTI-CATABOLIC AGENTS, ANTIOXIDANT AGENTS, AND ANALGESICS FOR PROTECTION, TREATMENT AND REPAIR OF CONNECTIVE TISSUES IN HUMANS AND ANIMALS 审中-公开
    抗生素，抗菌剂，抗氧化剂和用于人类和动物的连接组织的保护，治疗和修复的方法的使用

    公开(公告)号：WO99062459A2

    公开(公告)日：1999-12-09

    申请号：PCT/US1999/012152

    申请日：1999-06-03

    IPC: A61K38/00 ,  A61K31/00 ,  A61K31/137 ,  A61K31/4164 ,  A61K31/557 ,  A61K31/65 ,  A61K31/7004 ,  A61K31/7008 ,  A61K31/7076 ,  A61K31/737 ,  A61K36/00 ,  A61K38/44 ,  A61K45/06 ,  A61P17/02 ,  A61K

    CPC classification number: A61K31/00 ,  A61K45/06

    Abstract: The present invention relates to compositions for the protection, treatment and repair of connective tissues in humans and animals comprising any or all of anabolic, anti-catabolic, anti-oxidant and analgesic agents, including aminosugars, S-adenosylmethionine, arachadonic acid, GAGs, including pentosan, collagen type II, tetracyclines or tetracycline-like compounds, diacerin, super oxide dismutase, L-ergothionine, one or more avocado/soybean unsaponifiables, hydroxyproline and an analgesic, e.g., acetaminophen, and to methods of treating humans and animals by administration of these novel compositions to humans and animals in need thereof.

    Abstract translation: 本发明涉及用于保护，治疗和修复包括氨基糖，S-腺苷甲硫氨酸，花生四烯酸，GAGs，合成代谢，抗氧化和止痛剂中任何一种或全部的人和动物结缔组织的组合物， 包括戊聚糖，II型胶原，四环素或四环素样化合物，diacerin，超氧化物歧化酶，L-麦角硫蛋白，一种或多种鳄梨/大豆不皂化物，羟脯氨酸和止痛剂，例如对乙酰氨基酚，以及通过 将这些新型组合物给予需要的人和动物。

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