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公开(公告)号：WO2010037207A1
公开(公告)日：2010-04-08
申请号：PCT/CA2009/001302
申请日：2009-09-16
IPC分类号： C07D207/12 , A61K31/40 , C12Q1/40
CPC分类号： C07D207/12 , C12Q1/34 , G01N2500/00
摘要： The application relates to an immoalditol compound for selectively inhibiting glycosidases, a prodrug thereof and a pharmaceutical composition comprising the compound or the prodrug The application also relates to the use of the immoalditol compound for treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-G1cNAc Such diseases and disorders include neurodegenerative diseases, tauopathy, cancers, and cardiac disorders
摘要翻译： 本申请涉及用于选择性抑制糖苷酶的前体糖苷化合物，其前体药物和包含该化合物或前体药物的药物组合物本申请还涉及用于治疗与O-GlcNAcase的缺乏或过表达相关的疾病和病症的用途 ，O-G1cNAc的积累或不足这些疾病和障碍包括神经变性疾病，tau病，癌症和心脏病
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公开(公告)号：WO2008092246A1
公开(公告)日：2008-08-07
申请号：PCT/CA2008/000179
申请日：2008-01-29
CPC分类号： A61N1/3611 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/3601 , A61N1/36139 , A61N1/36185
摘要： Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.
摘要翻译： 用于经血管神经刺激的电极结构将电极与电绝缘背衬层结合。 背衬层增加通过血管内腔中的血液的电路径的电阻抗，从而增加通过周围组织的电流的流动。 可以施加电极结构以刺激神经，例如膈神经，迷走神经，三叉神经，闭孔或其他神经。
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公开(公告)号：WO2008052306A1
公开(公告)日：2008-05-08
申请号：PCT/CA2007/001723
申请日：2007-09-27
CPC分类号： B81C1/00142 , H01L2224/48091 , H01L2924/1461 , H01L2924/00014 , H01L2924/00
摘要： Microstructures can be formed as patterned layers on a substrate and then erecting the microstructures out of the plane of the substrate. The microstructures may be formed over circuits in the substrate. In some embodiments the patterned layer provides resiliently-flexible members such as cantilevers or springs that can be buckled to permit an edge defined by the patterned layer to engage a surface of the substrate. In some embodiments deformation of the resiliently-flexible members results the edge being forced against the substrate. Such microstructures may be applied in a wide range of applications including supporting optical elements, sensors, antennas or the like out of the plane of a substrate. Examples of accelerometer structures are described.
摘要翻译： 微结构可以在衬底上形成为图案层，然后将微结构竖立在衬底的平面之外。 微结构可以形成在衬底中的电路上。 在一些实施例中，图案化层提供弹性柔性构件，例如悬臂或弹簧，其可以被弯曲以允许由图案化层限定的边缘接合衬底的表面。 在一些实施例中，弹性 - 柔性构件的变形导致边缘被迫抵靠衬底。 这样的微结构可以应用在广泛的应用中，包括在基板的平面外支撑光学元件，传感器，天线等。 描述加速度计结构的示例。
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公开(公告)号：WO2008025170A1
公开(公告)日：2008-03-06
申请号：PCT/CA2007/001554
申请日：2007-08-31
发明人： VOCADLO, David , McEACHERN, Ernest
IPC分类号： C07D513/04 , A61K31/429 , C07D513/14 , C12Q1/34
CPC分类号： G01N33/6803 , C07D513/04 , C07D513/14 , C07F9/6561 , C07H9/06
摘要： The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc
摘要翻译： 本发明提供了用于选择性抑制糖苷酶，化合物前药和包含化合物或药物前体药物的药物组合物的式（I）化合物。本发明还提供治疗与O-GlcNAcase的缺乏或过表达相关的疾病和病症的方法， O-GlcNAc的积累或不足
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公开(公告)号：WO2007098597A1
公开(公告)日：2007-09-07
申请号：PCT/CA2007/000330
申请日：2007-03-02
申请人： SIMON FRASER UNIVERSITY , PINTO, Brian Mario , JOHNSTON, Blair, D. , GHAVAMI, Ahmad , SZCZEPINA, Monica Gabriela , LIU, Hui , SADALAPURE, Kashinath , JENSEN, Henrik H. , NASI, Ravindranath , KUMAR, Nag Sharwan
发明人： PINTO, Brian Mario , JOHNSTON, Blair, D. , GHAVAMI, Ahmad , SZCZEPINA, Monica Gabriela , LIU, Hui , SADALAPURE, Kashinath , JENSEN, Henrik H. , NASI, Ravindranath , KUMAR, Nag Sharwan
IPC分类号： C07D333/32 , A61K31/095 , A61K31/381 , A61K31/40 , C07C391/00 , C07D207/12
CPC分类号： C07D207/12 , C07D333/32 , C07D335/02 , C07D345/00 , C07D495/04
摘要： Methods for synthesizing Salacinol, its stereoisomers, and analogues, homologues and other derivatives thereof potentially useful as glycosidase inhibitors are described. In some embodiments the compounds of the invention may have the general formula (I) or (II). The synthetic schemes may comprise reacting a cyclic sulfate with a 5-membered ring sugar containing a heteroatom (X). The heteroatom preferably comprises sulfur, selenium, or nitrogen. The cyclic sulfate and ring sugar reagents may be readily prepared from carbohydrate precursors, such as D-glucose, L-glucose, D-xylose and L-xylose. The target compounds are prepared by opening of the cyclic sulfates by nucleophilic attack of the heteroatoms on the 5-membered ring sugars. The resulting heterocyclic compounds have a stable, inner salt structure comprising a heteroatom cation and a sulfate anion. The synthetic schemes yield various stereoisomers of the target compounds in moderate to good yields with limited side-reactions. Chain-extended analogues of Salacinol are also described.
摘要翻译： 描述了可能用作糖苷酶抑制剂的Salacinol，其立体异构体和类似物，同系物和其它衍生物的合成方法。 在一些实施方案中，本发明的化合物可以具有通式（I）或（II）。 合成方案可以包括使环硫酸盐与含有杂原子（X）的5元环糖反应。 杂原子优选包含硫，硒或氮。 环状硫酸盐和环糖试剂可以容易地从碳水化合物前体如D-葡萄糖，L-葡萄糖，D-木糖和L-木糖制备。 通过在5元环糖上的杂原子的亲核攻击来打开环状硫酸盐来制备目标化合物。 所得的杂环化合物具有包含杂原子阳离子和硫酸根阴离子的稳定的内盐结构。 合成方案以有限的副反应以中等到良好的产率产生目标化合物的各种立体异构体。 还描述了Salacinol的链延长类似物。
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86.发明申请METHODS AND APPARATUS FOR DETECTING DEFECTS IN IMAGING ARRAYS BY IMAGE ANALYSIS 审中-公开用于通过图像分析检测图像阵列中的缺陷的方法和装置
公开(公告)号：WO2007036055A1
公开(公告)日：2007-04-05
申请号：PCT/CA2006/001619
申请日：2006-10-02
申请人： SIMON FRASER UNIVERSITY , CHAPMAN, Glenn Harrison , KOREN, Israel , KOREN, Zahava , DUDAS, Jozsef , JUNG, Cory
CPC分类号： H04N5/367 , H04N17/002
摘要： Methods for detecting defective pixels in imaging arrays involve establishing probabilities that individual pixels are defective and updating those probabilities by analysing images acquired by the imaging arrays. Probabilities may be evaluated for each of two or more defect conditions. The methods may be used to detect defects such as stuck-low, stuck-high, high-sensitivity, low sensitivity, hot, and defect-free conditions. Other more complicated defect conditions can also be detected. Apparatus for detecting defective pixels may be integrated with a camera or other imaging device or provided separately.
摘要翻译： 用于检测成像阵列中的缺陷像素的方法包括建立各个像素有缺陷的概率，并通过分析由成像阵列获取的图像来更新这些概率。 可以针对两个或更多个缺陷条件中的每一个评估概率。 该方法可用于检测诸如卡滞低，卡住高，高灵敏度，低灵敏度，热和无缺陷条件的缺陷。 还可以检测其他更复杂的缺陷条件。 用于检测缺陷像素的装置可以与照相机或其它成像装置集成或分开提供。
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公开(公告)号：WO2007006134A1
公开(公告)日：2007-01-18
申请号：PCT/CA2006/001108
申请日：2006-07-11
CPC分类号： A61B5/0059 , A61B5/489 , A61M5/427
摘要： A vein locator comprises an energy source for directing incident energy toward organism tissue. At least a portion of the incident energy is reflected from structures within the organism tissue as reflected energy. The vein locator comprises an energy detector connected to detect energy reflected from the organism tissue. The incident energy is moved across a scan region a first time and the energy detector produces a corresponding first signal representative of at least one characteristic of the first reflected energy. A controller receives the first signal, identifies an extremum in the first signal and determines a threshold level based on the identified extremum. The incident energy is then moved across the scan region a second time and the energy detector produces a corresponding second signal representative of at least one characteristic of the second reflected energy. The controller compares the second signal to the threshold level to determine whether a current location of the incident beam represents a location of a vein.
摘要翻译： 静脉定位器包括用于将入射能量引向生物体组织的能量源。 入射能量的至少一部分作为反射能量从生物体组织内的结构反射。 静脉定位器包括连接以检测从有机体组织反射的能量的能量检测器。 入射能量首先在扫描区域上移动，并且能量检测器产生代表第一反射能量的至少一个特征的对应的第一信号。 控制器接收第一信号，识别第一信号中的极值，并且基于所识别的极值来确定阈值水平。 然后将入射能量第二次移动到扫描区域上，并且能量检测器产生表示第二反射能量的至少一个特征的对应的第二信号。 控制器将第二信号与阈值电平进行比较，以确定入射光束的当前位置是否表示静脉的位置。
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公开(公告)号：WO2005038335A1
公开(公告)日：2005-04-28
申请号：PCT/CA2004/000627
申请日：2004-04-28
申请人： THE UNIVERSITY OF ALBERTA, SIMON FRASER UNIVERSITY, THE UNIVERSITY OF VICTORIA, THE UNIVERSITY OF BRITISH COLUMBIA , HACKMAN, Gregory , BRAUN, Jennifer , DALE, Donald, J. , MORRIS, David Blair
IPC分类号： F17C5/02
CPC分类号： F17C5/02 , F17C6/00 , F17C13/02 , F17C2205/0111 , F17C2205/0192 , F17C2205/0323 , F17C2221/014 , F17C2221/05 , F17C2223/0161 , F17C2223/033 , F17C2227/044 , F17C2250/032 , F17C2250/036 , F17C2250/0452 , F17C2250/0636 , F17C2260/024 , F17C2270/0518
摘要： A cryogenic fluid distribution device may include a fluid flow passage for distributing cryogenic fluid to an apparatus, an overflow passage positioned downstream of the apparatus, and a sensor coupled to the overflow passage, the sensor having an active component for determining if fluid is present in the overflow passage.
摘要翻译： 低温流体分配装置可以包括用于将低温流体分配到装置的流体流动通道，位于装置下游的溢流通道和耦合到溢流通道的传感器，该传感器具有用于确定是否存在流体的活性部件 溢流通道。
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公开(公告)号：WO2004075208A3
公开(公告)日：2004-09-02
申请号：PCT/CA2004/000242
申请日：2004-02-24
IPC分类号： H01J49/04
摘要： This application relates to a process for controllably placing two or more microspots on a target substrate in close proximity to one another. The microspots may then be simultaneously irradiated and the resulting ions detected by mass spectrometry, such as time of flight mass spectrometry. In one embodiment the size and spacing of the microspots on the substrate may be controlled by using an electrodynamic balance during the deposition step. The deposition procedure ensures that at least some of the microspots are spaced-apart on the substrate a distance less than the focused output of a single laser. Simultaneous irradiation of the adjacent microspots may cause desorption plumes of the microspots to interact in a gas phase, such as by ion-molecule reactions. The microspots may be configured to improve the ionization yield of the sample material in the gas phase and/or to increase the frequency of ion-molecule collisions in the gas phase. This allows for desorption of particular classes of compounds to be optimized independently of ionization. Different microspots could include different amounts or types of matrix compounds to enable simultaneously detection of compounds of varied physical and chemical properties within the same sample. One or more of the microspots may include calibrants or other additives for improving detecting accuracy or quantitation. Organized array of closely packed microspots may be created for use as standard reference materials or analyte detectors.
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90.发明申请PHOTOCHROMIC AND ELECTROCHROMIC COMPOUNDS AND METHODS OF SYNTHESIZING AND USING SAME 审中-公开光致变色和电致变色化合物及其合成和使用方法
公开(公告)号：WO2004015024A1
公开(公告)日：2004-02-19
申请号：PCT/CA2003/001216
申请日：2003-08-11
IPC分类号： C09K9/02
CPC分类号： C07D495/04 , C08G61/02 , C08G61/126 , C09K9/02 , C09K2211/1458 , G03H2001/0264 , G03H2260/52 , Y10T428/1041
摘要： This invention relates to novel photochromic and electrochromic monomers and polymers based on 1,2-dithienylcyclopentene derivatives and method of using and synthesizing same. The compounds are reversibly interconvertible between different isomeric forms under suitable photochromic or electrochromic conditions. The electrochromic conversion may be catalytic. The application also relates to ultra-high density homopolymers prepared using ring-opening methathesis polymerization (ROMP) where the central ring of the 1,2-bis(3-thienyl)-cyclopentene is incorporated directly into the polymer backbone. The monomer units may be readily functionalized to enable the synthesis of polymers with diverse structural and electronic properties. The compounds have many potential applications including high-density optical information storage systems, photoregulated molecular switches, reversible holographic systems, ophthalmic lenses, actinometry and molecular sensors, photochromic inks, paints and fibers and optoelectronic systems such as optical waveguides, Bragg reflectors and dielectric mirrors.
摘要翻译： 本发明涉及基于1,2-二噻吩环戊烯衍生物的新型光致变色和电致变色单体和聚合物及其使用和合成方法。 在合适的光致变色或电致变色条件下，化合物在不同的异构体形式之间是可逆的相互转化的。 电致变色可能是催化的。 本申请还涉及使用开环错译聚合（ROMP）制备的超高密度均聚物，其中1,2-双（3-噻吩基） - 环戊烯的中心环直接并入聚合物主链。 单体单元可以容易地官能化以使得能够合成具有不同结构和电子性质的聚合物。 该化合物具有许多潜在的应用，包括高密度光学信息存储系统，光调节分子开关，可逆全息系统，眼用透镜，光化学测量和分子传感器，光致变色油墨，油漆和纤维以及光电子系统，如光波导，布拉格反射器和电介质反射镜 。
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