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    SENSOR AND POLARIMETRIC FILTERS FOR REAL-TIME EXTRACTION OF POLARIMETRIC INFORMATION AT THE FOCAL PLANE, AND METHOD OF MAKING SAME
    81.
    发明申请
    SENSOR AND POLARIMETRIC FILTERS FOR REAL-TIME EXTRACTION OF POLARIMETRIC INFORMATION AT THE FOCAL PLANE, AND METHOD OF MAKING SAME 审中-公开
    用于实时提取极坐标平面上的极性信息的传感器和极化滤波器及其制作方法

    公开(公告)号：WO2007121475A2

    公开(公告)日：2007-10-25

    申请号：PCT/US2007066885

    申请日：2007-04-18

    申请人： UNIV PENNSYLVANIA ,  GRUEV VIKTOR ,  VAN DER SPIEGEL JAN ,  ENGHETA NADER

    发明人： GRUEV VIKTOR ,  VAN DER SPIEGEL JAN ,  ENGHETA NADER

    IPC分类号： H01J40/14 ,  G02F1/01

    CPC分类号： G01J4/04

    摘要： A polarimetric imaging system employs a pixel pitch matched filter for use within, for example, a 2 by 2 pixel neighborhood, in which one pixel samples the scene via a 0 degree polarization filter and a second pixel samples the scene via a 45 degree polarization filter. The remaining two pixels record the intensity of the light within the 2 by 2 neighborhoods. The polarization filters employ organic materials such as polymers or metallic materials that are patterned and etched using reactive ion etching (RIE) or other appropriate etching technique in order to create 14 micron or smaller circular (or square) periodic structures that are patterned into polarization thin films that are deposited on an imaging sensor that includes a processor that computes from the polarization-filtered inputs the first three Stokes parameters in real-time.

    摘要翻译： 偏振成像系统采用像素间距匹配滤波器在例如2×2像素邻域内使用，其中一个像素通过0度偏振滤波器对场景进行采样，而第二像素通过45度偏振滤波器对场景进行采样 。 剩下的两个像素记录2到2个邻域内的光的强度。 偏振滤光器使用有机材料，例如聚合物或金属材料，其使用反应离子蚀刻（RIE）或其他合适的蚀刻技术进行图案化和蚀刻，以便产生14微米或更小的圆形（或正方形）周期性结构，其被图案化为偏振薄 沉积在成像传感器上的胶片包括一个处理器，该处理器实时地从偏振滤波的输入端计算前三个斯托克斯参数。

    IN SITU CLONING FROM PATHOLOGICAL TISSUE SPECIMENS
    82.
    发明申请
    IN SITU CLONING FROM PATHOLOGICAL TISSUE SPECIMENS 审中-公开
    从病理组织样本中克隆

    公开(公告)号：WO2007117700A2

    公开(公告)日：2007-10-18

    申请号：PCT/US2007008880

    申请日：2007-04-09

    申请人： UNIV PENNSYLVANIA ,  EBERWINE JAMES H ,  KELZ MAX B

    发明人： EBERWINE JAMES H ,  KELZ MAX B

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6841 ,  C12Q1/6806 ,  C12Q2525/131 ,  C12Q2525/179 ,  C12Q2539/103

    摘要： The present invention pertains to methods related to cloning nucleic acids from biological samples, particularly pathological tissue samples. This method includes hybridizing a population of oligonucleotide sequence probes comprising degenerate sequence tags to a fixed tissue, isolating the hybridized oligonucleotide sequence probes and amplifying the sequence tags in the hybridized oligonucleotide sequence probes. This method can be utilized to identify genes associated with disease and to quantitate the expression of disease-related transcripts. The method can also be used to identify truncated mRNAs.

    摘要翻译： 本发明涉及从生物样品，特别是病理组织样品中克隆核酸的方法。 该方法包括将包含简并序列标签的寡核苷酸序列探针的群体与固定组织杂交，分离杂交的寡核苷酸序列探针并扩增杂交的寡核苷酸序列探针中的序列标签。 该方法可用于鉴定与疾病相关的基因并定量疾病相关转录物的表达。 该方法也可用于鉴定截短的mRNA。

    COMPOSITIONS AND METHODS FOR MODULATION OF SUPPRESSOR T CELL ACTIVATION
    83.
    发明申请
    COMPOSITIONS AND METHODS FOR MODULATION OF SUPPRESSOR T CELL ACTIVATION 审中-公开
    调节抑制T细胞活化的组合物和方法

    公开(公告)号：WO2007084775A9

    公开(公告)日：2007-08-30

    申请号：PCT/US2007001677

    申请日：2007-01-22

    申请人： UNIV PENNSYLVANIA ,  PHILADELPHIA CHILDREN HOSPITAL ,  WANG BIN ,  GREENE MARK I ,  SAQUAF SANDRA ,  LI BIN ,  ZHANG HONGTAO ,  HANCOCK WAYNE W

    发明人： WANG BIN ,  GREENE MARK I ,  SAQUAF SANDRA ,  LI BIN ,  ZHANG HONGTAO ,  HANCOCK WAYNE W

    IPC分类号： A61K35/14

    CPC分类号： C12N5/0636 ,  A61K31/19 ,  A61K35/17 ,  A61K38/1793 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/39 ,  A61K49/0008 ,  C12N15/1137 ,  C12N2310/14 ,  A61K2300/00

    摘要： Methods of treating autoimmune disorders, coronary artery disease, allergy symptoms, allograft rejection sepsis/toxic shock are disclosed. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3 in combination with a T suppressor stimulus and/or an antigen. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3. Some methods comprise administering soluble GITR or antibodies that bind to GITR ligand. Methods of treating cancer, infectious diseases, and immune deficiency are also disclosed as are vaccination methods. The methods comprise administering one or more regulatory compositions to inactivate the T suppressor cells by reducing the acetylation level and/or protein level of FOXP3. Improved vaccines and vaccination methods are disclosed. Methods of identifying compounds that are useful to modulate acetylation level and/or protein level of FOXP3 and treat diseases are disclosed.

    摘要翻译： 公开了治疗自身免疫病症，冠状动脉疾病，变态反应症状，同种异体移植排斥败血症/毒性休克的方法。 一些方法包括通过增加FOXP3与T抑制刺激和/或抗原组合的乙酰化水平和/或蛋白水平来施用一种或多种调节性组合物以激活T抑制细胞。 一些方法包括施用一种或多种调节性组合物以通过增加FOXP3的乙酰化水平和/或蛋白质水平来活化T抑制细胞。 一些方法包括施用可溶性GITR或与GITR配体结合的抗体。 还公开了治疗癌症，感染性疾病和免疫缺陷的方法以及疫苗接种方法。 该方法包括施用一种或多种调节性组合物以通过降低FOXP3的乙酰化水平和/或蛋白质水平使T抑制细胞失活。 公开了改进的疫苗和疫苗接种方法。 公开了鉴定可用于调节FOXP3的乙酰化水平和/或蛋白质水平并治疗疾病的化合物的方法。

    MICROTUBULE STABILIZING COMPOUNDS AND METHODS OF THEIR USE
    85.
    发明申请
    MICROTUBULE STABILIZING COMPOUNDS AND METHODS OF THEIR USE 审中-公开
    MICROTUBULE STABIL化合物及其使用方法

    公开(公告)号：WO2006091728A3

    公开(公告)日：2007-04-05

    申请号：PCT/US2006006401

    申请日：2006-02-24

    申请人： UNIV PENNSYLVANIA ,  TROJANOWSKI JOHN Q ,  SMITH AMOS B III ,  LEE VIRGINIA M Y

    发明人： TROJANOWSKI JOHN Q ,  SMITH AMOS B III ,  LEE VIRGINIA M Y

    IPC分类号： A61K39/00 ,  A01N37/18 ,  A01N61/00 ,  A61K31/00 ,  A61K38/00 ,  A61K39/38

    CPC分类号： A61K31/337 ,  A61K45/06 ,  A61K2300/00

    摘要： Methods for the stabilization of microtubules involved in axonal transport are disclosed. The methods employing compounds which functionally substitute for microtubule binding protein tau are useful, inter alia, in the treatment of neurodegenerative diseases or tauopathies. Microtubule stabilizing compounds are useful for the treatment of neurodegenerative diseases, as well as schizophrenia and other mental disorders that are characterized by disruption of maintain neuronal intracellular transport, neurite architecture, or neuronal migration.

    摘要翻译： 公开了稳定涉及轴突运输的微管的方法。 使用功能性取代微管结合蛋白tau的化合物的方法尤其可用于治疗神经变性疾病或tau蛋白病。 微管稳定化合物可用于治疗神经变性疾病以及精神分裂症和其他精神障碍，其特征在于维持神经元细胞内运输，神经突构造或神经元迁移的破坏。