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    COMPOSITIONS AND METHODS FOR MODULATION OF SUPPRESSOR T CELL ACTIVATION
    3.
    发明申请
    COMPOSITIONS AND METHODS FOR MODULATION OF SUPPRESSOR T CELL ACTIVATION 审中-公开
    用于调节抑制剂T细胞活化的组合物和方法

    公开(公告)号：WO2007084775A2

    公开(公告)日：2007-07-26

    申请号：PCT/US2007/001677

    申请日：2007-01-22

    申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  THE CHILDREN'S HOSPITAL OF PHILADELPHIA ,  WANG, Bin ,  GREENE, Mark, I. ,  SAQUAF, Sandra ,  LI, Bin ,  ZHANG, Hongtao ,  HANCOCK, Wayne, W.

    发明人： WANG, Bin ,  GREENE, Mark, I. ,  SAQUAF, Sandra ,  LI, Bin ,  ZHANG, Hongtao ,  HANCOCK, Wayne, W.

    IPC分类号： A61K35/14

    CPC分类号： C12N5/0636 ,  A61K31/19 ,  A61K35/17 ,  A61K38/1793 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/39 ,  A61K49/0008 ,  C12N15/1137 ,  C12N2310/14 ,  A61K2300/00

    摘要： Methods of treating autoimmune disorders, coronary artery disease, allergy symptoms, allograft rejection sepsis/toxic shock are disclosed. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3 in combination with a T suppressor stimulus and/or an antigen. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3. Some methods comprise administering soluble GITR or antibodies that bind to GITR ligand. Methods of treating cancer, infectious diseases, and immune deficiency are also disclosed as are vaccination methods. The methods comprise administering one or more regulatory compositions to inactivate the T suppressor cells by reducing the acetylation level and/or protein level of FOXP3. Improved vaccines and vaccination methods are disclosed. Methods of identifying compounds that are useful to modulate acetylation level and/or protein level of FOXP3 and treat diseases are disclosed.

    摘要翻译： 公开了治疗自身免疫性疾病，冠状动脉疾病，过敏症状，同种异体移植排斥败血症/中毒性休克的方法。 一些方法包括施用一种或多种调节组合物以通过与T抑制刺激和/或抗原组合增加FOXP3的乙酰化水平和/或蛋白水平来激活T抑制细胞。 一些方法包括施用一种或多种调节组合物以通过增加FOXP3的乙酰化水平和/或蛋白质水平来激活T抑制细胞。 一些方法包括施用可结合GITR配体的可溶性GITR或抗体。 疫苗接种方法也公开了治疗癌症，感染性疾病和免疫缺陷的方法。 所述方法包括施用一种或多种调节组合物以通过降低FOXP3的乙酰化水平和/或蛋白质水平来灭活T抑制细胞。 公开了改进的疫苗和疫苗接种方法。 公开了鉴定可用于调节FOXP3的乙酰化水平和/或蛋白质水平并治疗疾病的化合物的方法。

    COMPOSITIONS AND METHODS FOR TREATING FOXP3+ TREG RELATED DISEASES
    7.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING FOXP3+ TREG RELATED DISEASES 审中-公开
    用于治疗FOXP3 + TREG相关疾病的组合物和方法

    公开(公告)号：WO2012075291A1

    公开(公告)日：2012-06-07

    申请号：PCT/US2011/062896

    申请日：2011-12-01

    申请人： THE CHILDREN'S HOSPITAL OF PHILADELPHIA ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE ,  HANCOCK, Wayne, W. ,  ALBELDA, Steven, M. ,  COLE, Philip, A.

    发明人： HANCOCK, Wayne, W. ,  ALBELDA, Steven, M. ,  COLE, Philip, A.

    IPC分类号： A61P37/02

    CPC分类号： A61K31/4155 ,  A61K31/7076 ,  A61K38/16 ,  A61K39/0011 ,  G01N33/5011 ,  G01N33/505 ,  A61K2300/00

    摘要： Methods for treating or preventing a Foxp3+ T regulatory cell (Treg) related disease in a subject in need thereof comprise administering to the subject an effective amount of a pharmaceutical composition comprising an inhibitor of a histone/protein acetyltransferase (HAT). Methods for identifying an agent useful for treating or preventing a Foxp3+ T regulatory cell (Treg) related disease comprise (a) contacting a candidate agent with a test sample comprising Foxp3+ T regulatory cells (Tregs), and (b) comparing a function of the Foxp3+ Tregs in the test sample with that in a control sample, wherein inhibition of the function of the Foxp3+ Tregs in the test sample when compared with the control sample indicates that the candidate agent is an agent useful for treating or preventing a Foxp3+ Treg related disease.

    摘要翻译： 在有需要的受试者中治疗或预防Foxp3 + T调节细胞（Treg）相关疾病的方法包括向受试者施用有效量的包含组蛋白/蛋白质乙酰转移酶（HAT）抑制剂的药物组合物。 用于鉴定可用于治疗或预防Foxp3 + T调节细胞（Treg）相关疾病的药剂的方法包括（a）使候选药剂与包含Foxp3 + T调节细胞（Treg）的测试样品接触，和（b）比较 测试样品中的Foxp3 + Treg与对照样品中的Foxp3 + Treg相比，其中与对照样品相比，测试样品中Foxp3 + Treg的功能的抑制表明候选试剂是可用于治疗或预防Foxp3 + Treg相关疾病的药剂 。

    COMPOSITIONS AND METHODS FOR MODULATION OF SUPPRESSOR T CELL ACTIVATION
    8.
    发明申请
    COMPOSITIONS AND METHODS FOR MODULATION OF SUPPRESSOR T CELL ACTIVATION 审中-公开
    用于调节抑制剂T细胞活化的组合物和方法

    公开(公告)号：WO2007084775A3

    公开(公告)日：2008-07-03

    申请号：PCT/US2007001677

    申请日：2007-01-22

    申请人： UNIV PENNSYLVANIA ,  PHILADELPHIA CHILDREN HOSPITAL ,  WANG BIN ,  GREENE MARK I ,  SAQUAF SANDRA ,  LI BIN ,  ZHANG HONGTAO ,  HANCOCK WAYNE W

    发明人： WANG BIN ,  GREENE MARK I ,  SAQUAF SANDRA ,  LI BIN ,  ZHANG HONGTAO ,  HANCOCK WAYNE W

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： C12N5/0636 ,  A61K31/19 ,  A61K35/17 ,  A61K38/1793 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/39 ,  A61K49/0008 ,  C12N15/1137 ,  C12N2310/14 ,  A61K2300/00

    摘要： Methods of treating autoimmune disorders, coronary artery disease, allergy symptoms, allograft rejection sepsis/toxic shock are disclosed. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3 in combination with a T suppressor stimulus and/or an antigen. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3. Some methods comprise administering soluble GITR or antibodies that bind to GITR ligand. Methods of treating cancer, infectious diseases, and immune deficiency are also disclosed as are vaccination methods. The methods comprise administering one or more regulatory compositions to inactivate the T suppressor cells by reducing the acetylation level and/or protein level of FOXP3. Improved vaccines and vaccination methods are disclosed. Methods of identifying compounds that are useful to modulate acetylation level and/or protein level of FOXP3 and treat diseases are disclosed.

    摘要翻译： 公开了治疗自身免疫性疾病，冠状动脉疾病，过敏症状，同种异体移植排斥败血症/中毒性休克的方法。 一些方法包括施用一种或多种调节组合物以通过与T抑制刺激和/或抗原组合增加FOXP3的乙酰化水平和/或蛋白水平来激活T抑制细胞。 一些方法包括施用一种或多种调节组合物以通过增加FOXP3的乙酰化水平和/或蛋白质水平来激活T抑制细胞。 一些方法包括施用可结合GITR配体的可溶性GITR或抗体。 疫苗接种方法也公开了治疗癌症，感染性疾病和免疫缺陷的方法。 所述方法包括施用一种或多种调节组合物以通过降低FOXP3的乙酰化水平和/或蛋白质水平来灭活T抑制细胞。 公开了改进的疫苗和疫苗接种方法。 公开了鉴定可用于调节FOXP3的乙酰化水平和/或蛋白质水平并治疗疾病的化合物的方法。

    COMPOSITIONS AND METHODS FOR MODULATION OF SUPPRESSOR T CELL ACTIVATION
    9.
    发明申请
    COMPOSITIONS AND METHODS FOR MODULATION OF SUPPRESSOR T CELL ACTIVATION 审中-公开
    调节抑制T细胞活化的组合物和方法

    公开(公告)号：WO2007084775A9

    公开(公告)日：2007-08-30

    申请号：PCT/US2007001677

    申请日：2007-01-22

    申请人： UNIV PENNSYLVANIA ,  PHILADELPHIA CHILDREN HOSPITAL ,  WANG BIN ,  GREENE MARK I ,  SAQUAF SANDRA ,  LI BIN ,  ZHANG HONGTAO ,  HANCOCK WAYNE W

    发明人： WANG BIN ,  GREENE MARK I ,  SAQUAF SANDRA ,  LI BIN ,  ZHANG HONGTAO ,  HANCOCK WAYNE W

    IPC分类号： A61K35/14

    CPC分类号： C12N5/0636 ,  A61K31/19 ,  A61K35/17 ,  A61K38/1793 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/39 ,  A61K49/0008 ,  C12N15/1137 ,  C12N2310/14 ,  A61K2300/00

    摘要： Methods of treating autoimmune disorders, coronary artery disease, allergy symptoms, allograft rejection sepsis/toxic shock are disclosed. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3 in combination with a T suppressor stimulus and/or an antigen. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3. Some methods comprise administering soluble GITR or antibodies that bind to GITR ligand. Methods of treating cancer, infectious diseases, and immune deficiency are also disclosed as are vaccination methods. The methods comprise administering one or more regulatory compositions to inactivate the T suppressor cells by reducing the acetylation level and/or protein level of FOXP3. Improved vaccines and vaccination methods are disclosed. Methods of identifying compounds that are useful to modulate acetylation level and/or protein level of FOXP3 and treat diseases are disclosed.

    摘要翻译： 公开了治疗自身免疫病症，冠状动脉疾病，变态反应症状，同种异体移植排斥败血症/毒性休克的方法。 一些方法包括通过增加FOXP3与T抑制刺激和/或抗原组合的乙酰化水平和/或蛋白水平来施用一种或多种调节性组合物以激活T抑制细胞。 一些方法包括施用一种或多种调节性组合物以通过增加FOXP3的乙酰化水平和/或蛋白质水平来活化T抑制细胞。 一些方法包括施用可溶性GITR或与GITR配体结合的抗体。 还公开了治疗癌症，感染性疾病和免疫缺陷的方法以及疫苗接种方法。 该方法包括施用一种或多种调节性组合物以通过降低FOXP3的乙酰化水平和/或蛋白质水平使T抑制细胞失活。 公开了改进的疫苗和疫苗接种方法。 公开了鉴定可用于调节FOXP3的乙酰化水平和/或蛋白质水平并治疗疾病的化合物的方法。