公开(公告)号：WO2016076959A1

公开(公告)日：2016-05-19

申请号：PCT/US2015/053165

申请日：2015-09-30

Applicant: BLUE CUBE IP LLC

Inventor： FISH, Barry B. ,  PRETZ, Matthew T. ,  TIRTOWIDJOJO, Max M.

IPC: C07C17/00 ,  C07C17/10 ,  C07C21/06

CPC classification number: C07C17/10 ,  C01B7/01 ,  C07C5/44 ,  C07C21/06 ,  C07C11/04

Abstract: A process is provided for the chlorination of ethane using chlorine as the chlorinating agent to produce primarily vinyl chloride (VCM), ethylene, hydrogen chloride (HCl).

Abstract translation: 提供了一种使用氯作为氯化剂氯化乙烷的方法，主要生产氯乙烯（VCM），乙烯，氯化氢（HCl）。

公开(公告)号：WO2016033082A1

公开(公告)日：2016-03-03

申请号：PCT/US2015/046752

申请日：2015-08-25

Applicant: BLUE CUBE IP LLC

Inventor： SONG, Xiaomei ,  CHEN, Hongyu ,  MULLINS, Michael J.

IPC: C08G59/24 ,  C08G59/32 ,  C08G59/62 ,  C08L61/14 ,  C08L63/00

CPC classification number: C08L63/04 ,  B32B15/092 ,  C08G59/24 ,  C08G59/245 ,  C08G59/3218 ,  C08G59/621 ,  C08L61/14 ,  C08L63/00

Abstract: A multifunctional naphthol-based epoxy resin composition which is a reaction product of a) a naphthol which is a reaction product of i) from 1 to 99 weight percent 1-naphthol and ii) from 1 to 99 weight percent 2-naphthol; and b) an epihalohydrin, is disclosed. Also disclosed is a curable composition comprising: a) an epoxy component comprising the multifunctional naphthol-based epoxy resin composition; and b) a hardener component comprising i) a phenolic resin component selected from the group consisting of phenol novolac resins, triphenolalkane phenolic resins, aralkyl phenolic resins, biphenyl phenolic resin, biphenyl aralkyl phenolic resins, substituted naphthalene phenolic resins unsubstituted naphthalene phenolic resins, and combinations thereof; and ii) a phosphorus-containing composition which is the reaction product of an etherified resole with 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO). The curable composition can be used to prepare prepregs, electrical laminates, printed circuit boards, and printed wiring boards.

Abstract translation: 一种多官能萘酚系环氧树脂组合物，其为a）萘酚，其为i）1〜99重量％的1-萘酚和ii）1〜99重量％的2-萘酚的反应产物; 和b）表卤代醇。 还公开了一种可固化组合物，其包含：a）包含多官能萘酚基环氧树脂组合物的环氧组分; 和b）硬化剂组分，其包含i）选自苯酚酚醛清漆树脂，三酚烷烃酚醛树脂，芳烷基酚醛树脂，联苯酚醛树脂，联苯芳烷基酚醛树脂，取代萘酚醛树脂，未取代萘酚醛树脂和酚醛树脂， 其组合; 和ii）作为醚化的甲阶酚醛与9,10-二氢-9-氧杂-10-磷杂菲-10-氧化物（DOPO）的反应产物的含磷组合物。 可固化组合物可用于制备预浸料，电层压板，印刷电路板和印刷线路板。

公开(公告)号：WO2006107814A3

公开(公告)日：2006-10-12

申请号：PCT/US2006/012200

申请日：2006-04-04

Applicant: WASHINGTON UNIVERSITY IN ST. LOUIS ,  BATEMAN, Randall John ,  HOLTZMAN, David Michael

Inventor： BATEMAN, Randall John ,  HOLTZMAN, David Michael

IPC: A61K49/00 ,  A61K51/00 ,  G01N24/00

Abstract: The present invention relates to methods of diagnosing, monitoring, and assessing treatment effects for neurological and neurodegenerative diseases and disorders, such as Alzheimer's Disease, early in the course of clinical disease or prior to the onset of brain damage and clinical symptoms. Methods of measuring the in vivo metabolism of biomolecules produced in the CNS in a subject are provided.

公开(公告)号：WO2003038109A3

公开(公告)日：2003-05-08

申请号：PCT/US2002/029597

申请日：2002-09-18

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： MINER, Jess, L. ,  RAGSDALE, Stephen, W. ,  TAKACS, James, M.

IPC: C12P5/02

Abstract: The current invention is directed toward a method for inhibiting methanogenesis and/or the growth of methanogens. The method comprises contacting a methanogenic archaea medium with a methane inhibiting amount and/or a growth inhibiting amount of a compound that specifically inhibits methane formation and inhibits the growth of methanogens. A method to increase feed efficiency in a ruminant is also provided via administering to the animal an effective rumen modifying amount of a compound that specifically inhibits methanogenesis.

公开(公告)号：WO2003029224A1

公开(公告)日：2003-04-10

申请号：PCT/US2002/031784

申请日：2002-10-03

Applicant: PHARMACIA CORPORATION ,  SOUTH, Michael, S. ,  WEBBER, Ronald, K. ,  HUANG, Horng-Chih ,  TOTH, Mihaly, V. ,  MOORMANN, Alan, E. ,  SNYDER, Jeffrey, S. ,  SCHOLTEN, Jeffrey, A. ,  GARLAND, Danny, J. ,  RUEPPEL, Melvin, L. ,  NEUMANN, William, L. ,  LONG, Scott ,  WEI, Huang ,  TRUJILLO, John ,  PARLOW, John, J. ,  JONES, Darin, E. ,  CASE, Brenda ,  HAYES, Michael, J. ,  ZENG, Qingping ,  ABBAS, Zaheer ,  FENTON, Ricky, L. ,  KUSTURIN, Carrie, L. ,  HAYAT, Rahman, K. ,  SAMPLE, Kirby, R. ,  SCHWEITZER, Barbara, A. ,  WOOD, Rhonda, S. ,  SZALONY, Jim ,  SULEYMANOV, Osman, D. ,  SALYERS, Anita ,  NICHOLSON, Nancy, S.

Inventor： SOUTH, Michael, S. ,  WEBBER, Ronald, K. ,  HUANG, Horng-Chih ,  TOTH, Mihaly, V. ,  MOORMANN, Alan, E. ,  SNYDER, Jeffrey, S. ,  SCHOLTEN, Jeffrey, A. ,  GARLAND, Danny, J. ,  RUEPPEL, Melvin, L. ,  NEUMANN, William, L. ,  LONG, Scott ,  WEI, Huang ,  TRUJILLO, John ,  PARLOW, John, J. ,  JONES, Darin, E. ,  CASE, Brenda ,  HAYES, Michael, J. ,  ZENG, Qingping ,  ABBAS, Zaheer ,  FENTON, Ricky, L. ,  KUSTURIN, Carrie, L. ,  HAYAT, Rahman, K. ,  SAMPLE, Kirby, R. ,  SCHWEITZER, Barbara, A. ,  WOOD, Rhonda, S. ,  SZALONY, Jim ,  SULEYMANOV, Osman, D. ,  SALYERS, Anita ,  NICHOLSON, Nancy, S.

IPC: C07D239/47

CPC classification number: C07D231/38 ,  C07C257/18 ,  C07C2601/04 ,  C07C2601/10 ,  C07D207/32 ,  C07D211/56 ,  C07D211/98 ,  C07D213/74 ,  C07D231/48 ,  C07D237/04 ,  C07D239/10 ,  C07D239/22 ,  C07D241/04 ,  C07D241/20 ,  C07D249/14 ,  C07D253/06 ,  C07D253/075 ,  C07D263/48 ,  C07D265/02 ,  C07D277/42 ,  C07D307/22 ,  C07D333/36 ,  C07D401/12 ,  C07D403/10 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04

Abstract: The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

Abstract translation: 本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。 本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。

公开(公告)号：WO2017139113A9

公开(公告)日：2017-08-17

申请号：PCT/US2017/015552

申请日：2017-01-30

Applicant: MALLINCKRODT HOSPITAL PRODUCTS IP LIMITED

Inventor： POTENZIANO, Jim ,  GREENE, Douglas, Alan ,  FLANAGAN, Craig

IPC: A61K33/00 ,  A61M16/12 ,  A61B5/026

Abstract: Described are systems and methods for administration of nitric oxide (NO) with use of left ventricular assists devices (LVADs), as well as systems and methods for monitoring the NO delivery devices and/or the LVAD.

公开(公告)号：WO2006078914A1

公开(公告)日：2006-07-27

申请号：PCT/US2006/002056

申请日：2006-01-20

Applicant: WASHINGTON UNIVERSITY IN ST. LOUIS ,  ACHILEFU, Samuel

Inventor： ACHILEFU, Samuel

IPC: A61K51/00

CPC classification number: A61K49/0002 ,  A61K47/62 ,  A61K49/0032 ,  A61K49/0056 ,  A61K51/082 ,  A61K51/088

Abstract: The present invention provides compounds that have motifs that target the compounds to cells that express integrins. In particular, the compounds have peptides with one or more RD motifs conjugated to an agent selected from an imaging agent and a targeting agent. The compounds may be used to detect, monitor and treat a variety of disorders mediated by integrins.

Abstract translation: 本发明提供具有将化合物靶向表达整联蛋白的细胞的基序的化合物。 特别地，化合物具有与选自成像剂和靶向剂的试剂缀合的一个或多个RD基序的肽。 该化合物可用于检测，监测和治疗由整联蛋白介导的多种障碍。

公开(公告)号：WO2005111059A2

公开(公告)日：2005-11-24

申请号：PCT/US2005/013376

申请日：2005-04-20

Applicant: SIGMA-ALDRICH CO. ,  RAY, Kevin B. ,  KREADER, Carol A. ,  CHEN, Fuqiang ,  CUTTER, David E.

Inventor： RAY, Kevin B. ,  KREADER, Carol A. ,  CHEN, Fuqiang ,  CUTTER, David E.

IPC: C07H21/04

CPC classification number: C07H21/04 ,  C12N15/101

Abstract: The present invention provides methods for the reduction of endotoxins in a plasmid preparation using a carbohydrate non-ionic detergent with silica chromatography.

Abstract translation: 本发明提供了使用碳水化合物非离子型去垢剂与二氧化硅色谱法在质粒制备物中还原内毒素的方法。

公开(公告)号：WO2004058302A1

公开(公告)日：2004-07-15

申请号：PCT/US2003/040181

申请日：2003-12-17

Applicant: PHARMACIA CORPORATION ,  MASFERRER, Jaime, L.

Inventor： MASFERRER, Jaime, L.

IPC: A61K45/06

CPC classification number: A61K31/135 ,  A61K31/18 ,  A61K31/415 ,  A61K31/42 ,  A61K31/445 ,  A61K31/473 ,  A61K31/50 ,  A61K31/505 ,  A61K31/506 ,  A61K31/675 ,  A61K31/7052 ,  A61K33/24 ,  A61K41/00 ,  A61K41/0038 ,  A61K45/06 ,  C07D215/54 ,  C07D311/22 ,  C07D311/58 ,  C07D311/92 ,  C07D335/06 ,  C07D401/12 ,  C07D405/04 ,  C07D407/04 ,  C07D407/12 ,  C07D409/04 ,  C07D471/04 ,  C07D491/04 ,  C07D493/04 ,  A61K2300/00

Abstract: The present invention provides compositions and methods to treat, prevent or inhibit a neoplasia or a neoplasia-related disorder in a mammal using a combination of a COX-2 inhibitor and a topoisomerase II inhibitor.

Abstract translation: 本发明提供了使用COX-2抑制剂和拓扑异构酶II抑制剂的组合来治疗，预防或抑制哺乳动物中的肿瘤形成或瘤形成相关病症的组合物和方法。

公开(公告)号：WO2003051831A2

公开(公告)日：2003-06-26

申请号：PCT/US2002/040001

申请日：2002-12-13

Applicant: PHARMACIA CORPORATION ,  GOETZ, Gilles, H. ,  HARRIGAN, George, G. ,  LIKOS, John, J. ,  KASTEN, Thomas, P.

Inventor： GOETZ, Gilles, H. ,  HARRIGAN, George, G. ,  LIKOS, John, J. ,  KASTEN, Thomas, P.

IPC: C07D

CPC classification number: C07D403/12

Abstract: The present invention is directed toward a composition comprising a compound isolated from Dysidea species sponges that is capable of inhibiting serine proteases of the coagulation cascade. In particular, this composition inhibits the TF/VIIa complex of the coagulation cascade. The invention is also directed toward methods employing this composition as a part of anticoagulant therapy.

Abstract translation: 本发明涉及包含从Dysidea物种海绵分离的化合物的组合物，其能够抑制凝血级联的丝氨酸蛋白酶。 特别是，该组合物抑制凝血级联的TF / VIIa复合物。 本发明还涉及使用该组合物作为抗凝血剂治疗的一部分的方法。