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1.发明申请6-MEMBERED UNSATURATED HETEROCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE 审中-公开6成员不饱和杂环化合物可用于选择性抑制凝聚剂CASCADE
公开(公告)号：WO2003029224A1
公开(公告)日：2003-04-10
申请号：PCT/US2002/031784
申请日：2002-10-03
Applicant: PHARMACIA CORPORATION , SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffrey, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J. , ZENG, Qingping , ABBAS, Zaheer , FENTON, Ricky, L. , KUSTURIN, Carrie, L. , HAYAT, Rahman, K. , SAMPLE, Kirby, R. , SCHWEITZER, Barbara, A. , WOOD, Rhonda, S. , SZALONY, Jim , SULEYMANOV, Osman, D. , SALYERS, Anita , NICHOLSON, Nancy, S.
Inventor： SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffrey, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J. , ZENG, Qingping , ABBAS, Zaheer , FENTON, Ricky, L. , KUSTURIN, Carrie, L. , HAYAT, Rahman, K. , SAMPLE, Kirby, R. , SCHWEITZER, Barbara, A. , WOOD, Rhonda, S. , SZALONY, Jim , SULEYMANOV, Osman, D. , SALYERS, Anita , NICHOLSON, Nancy, S.
IPC: C07D239/47
CPC classification number: C07D231/38 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D211/56 , C07D211/98 , C07D213/74 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D409/12 , C07D413/12 , C07D471/04
Abstract: The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
Abstract translation: 本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。 本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。
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公开(公告)号：WO2010061329A1
公开(公告)日：2010-06-03
申请号：PCT/IB2009/055232
申请日：2009-11-20
Applicant: PFIZER INC. , DEVRAJ, Rajesh Venkateswaran , HUANG, Wei , HUGHES, Robert Owen , ROGIER JR., Donald Joseph , TRUJILLO, John Isidro , TURNER, Steve Ronald
Inventor： DEVRAJ, Rajesh Venkateswaran , HUANG, Wei , HUGHES, Robert Owen , ROGIER JR., Donald Joseph , TRUJILLO, John Isidro , TURNER, Steve Ronald
IPC: C07D487/08 , A61K31/407 , A61P29/02 , A61P35/00
CPC classification number: C07D487/08
Abstract: There is provided a compound of Formula I(a) or I(b) or a pharmaceutically acceptable salt thereof, wherein the various substitutents are defined herein.
Abstract translation: 提供式I（a）或I（b）的化合物或其药学上可接受的盐，其中各种取代基在本文中定义。
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公开(公告)号：WO2009153720A1
公开(公告)日：2009-12-23
申请号：PCT/IB2009/052515
申请日：2009-06-12
Applicant: PFIZER LIMITED , HUANG, Wei , MANTELL, Simon John , STRANG, Ross Sinclair , THORARENSEN, Atli , TRUJILLO, John Isidro , TURNER, Steve Ronald , YEAP, Siew Kuen
Inventor： HUANG, Wei , MANTELL, Simon John , STRANG, Ross Sinclair , THORARENSEN, Atli , TRUJILLO, John Isidro , TURNER, Steve Ronald , YEAP, Siew Kuen
IPC: C07D213/81 , A61K31/455 , A61P37/08 , A61P11/00
CPC classification number: C07D401/12 , C07D213/82 , C07D405/12 , C07D413/12
Abstract: The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are defined herein, to compositions containing such compounds and to the uses of such compounds for the treatment of allergic and respiratory conditions.
Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂化物，其中取代基在本文中定义，涉及含有此类化合物的组合物，以及涉及这些化合物用于治疗的用途 过敏和呼吸系统疾病。
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4.发明申请NICOTINAMIDE DERIVATIVES AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES 审中-公开作为H-PGDS的抑制剂的NICOTINAMIDE衍生物及其用于治疗PROSTAGLANDIN D2介导的疾病的用途
公开(公告)号：WO2008104869A1
公开(公告)日：2008-09-04
申请号：PCT/IB2008/000467
申请日：2008-02-15
Applicant: PFIZER PRODUCTS INC. , BLAKE, Tanisha, Danielle, Rowe , HAMPER, Bruce, Cameron , HUANG, Wei , KIEFER, James, Richard, Jr. , MOON, Joseph, Blair , NEAL, Bradley, E. , OLSON, Kirk, Lang , PELC, Matthew, James , SCHWEITZER, Barbara, Ann , THORARENSEN, Atli , TRUJILLO, John, I. , TURNER, Steve, R.
Inventor： BLAKE, Tanisha, Danielle, Rowe , HAMPER, Bruce, Cameron , HUANG, Wei , KIEFER, James, Richard, Jr. , MOON, Joseph, Blair , NEAL, Bradley, E. , OLSON, Kirk, Lang , PELC, Matthew, James , SCHWEITZER, Barbara, Ann , THORARENSEN, Atli , TRUJILLO, John, I. , TURNER, Steve, R.
IPC: C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61P11/00
CPC classification number: C07D401/12 , C07D401/02 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment of various diseases and conditions such as asthma.
Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其中取代基如本文所定义，含有这些化合物的组合物以及这些化合物用于治疗各种疾病和病症如哮喘的用途。
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公开(公告)号：WO2008075172A2
公开(公告)日：2008-06-26
申请号：PCT/IB2007/003928
申请日：2007-12-03
Applicant: PFIZER PRODUCTS INC. , BLAKE, Tanisha, Danielle, Rowe , HAMPER, Bruce, Cameron , HUANG, Wei , KIEFER, James, Richard, Jr. , MOON, Joseph, Blair , NEAL, Bradley, E. , OLSON, Kirk, Lang , PELC, Matthew, James , SCHWEITZER, Barbara, Ann , THORARENSEN, Alti , TRUJILLO, John, I. , TURNER, Steve, R.
Inventor： BLAKE, Tanisha, Danielle, Rowe , HAMPER, Bruce, Cameron , HUANG, Wei , KIEFER, James, Richard, Jr. , MOON, Joseph, Blair , NEAL, Bradley, E. , OLSON, Kirk, Lang , PELC, Matthew, James , SCHWEITZER, Barbara, Ann , THORARENSEN, Alti , TRUJILLO, John, I. , TURNER, Steve, R.
CPC classification number: C07D401/12 , C07D213/82 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment of various diseases and conditions such as asthma.
Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其中取代基如本文所定义，含有这些化合物的组合物以及这些化合物用于治疗各种疾病和病症例如哮喘的用途。
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Patent Agency Ranking6.发明申请BETA-CARBOLINE COMPOUNDS AND ANALOGUES THEREOF AND THEIR USE AS MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITORS 审中-公开β-环糊精化合物及其类似物及其用作活化蛋白激酶的蛋白激酶蛋白激酶-2抑制剂
公开(公告)号：WO2005009370A3
公开(公告)日：2005-10-20
申请号：PCT/US2004023350
申请日：2004-07-22
Applicant: PHARMACIA CORP , MEYERS MARVIN J , TRUJILLO JOHN I , VERNIER WILLIAM F , ANDERSON DAVID R , REITZ DAVID B , BUCHLER INGRID P , HEGDE SHRIDHAR G , MAHONEY MATTHEW W , WU KUN K
Inventor： MEYERS MARVIN J , TRUJILLO JOHN I , VERNIER WILLIAM F , ANDERSON DAVID R , REITZ DAVID B , BUCHLER INGRID P , HEGDE SHRIDHAR G , MAHONEY MATTHEW W , WU KUN K
IPC: A61K20060101 , A61K31/40 , A61K31/403 , A61K31/407 , A61K31/4745 , A61K31/55 , C07D209/82 , C07D209/94 , C07D471/02 , C07D471/14
CPC classification number: A61K31/40 , C07D471/04 , C07D471/14 , C07D471/18
Abstract: Novel methods and compositions are described for inhibiting mitogen activated protein kinase-activated protein kinase-2 in a subject. The method involves administering to the subject a beta-carboline MK-2 inhibiting compound, or a pharmaceutically acceptable salt, or isomer thereof. The novel compositions are capable of inhibiting mitogen activated protein kinase-activated protein kinase-2 and analogues thereof. Pharmaceutical compositions and kits that include these compounds are also described.
Abstract translation: 描述了用于抑制受试者中丝裂原活化蛋白激酶激活蛋白激酶-2的新方法和组合物。 该方法包括给受试者施用β-咔啉MK-2抑制化合物或其药学上可接受的盐或其异构体。 新型组合物能够抑制丝裂原活化蛋白激酶活化蛋白激酶-2及其类似物。 还描述了包括这些化合物的药物组合物和试剂盒。
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7.发明申请SUBSTITUTED 5-MEMBERED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE 审中-公开取代的5组分多环化合物可用于选择性抑制凝聚剂CASCADE
公开(公告)号：WO2003093242A2
公开(公告)日：2003-11-13
申请号：PCT/US2002/031770
申请日：2002-10-03
Applicant: PHARMACIA CORPORATION , SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffrey, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J.
Inventor： SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffrey, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J.
IPC: C07D231/00
CPC classification number: C07D213/74 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D207/46 , C07D211/56 , C07D211/98 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
Abstract: The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
Abstract translation: 本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。 本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。
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8.发明申请6-MEMBERED HETEROCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE 审中-公开用于选择性抑制凝聚剂CASCADE的6组分杂环化合物
公开(公告)号：WO2003029216A1
公开(公告)日：2003-04-10
申请号：PCT/US2002/031769
申请日：2002-10-03
Applicant: PHARMACIA CORPORATION , SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffery, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J.
Inventor： SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffery, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J.
IPC: C07D211/98
CPC classification number: C07D213/74 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D211/56 , C07D211/98 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
Abstract: The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
Abstract translation: 本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。 本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。
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9.发明申请NICOTINAMIDE DERIVATIVES AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES 审中-公开作为H-PGDS的抑制剂的NICOTINAMIDE衍生物及其用于治疗PROSTAGLANDIN D2介导的疾病的用途
公开(公告)号：WO2008075172A3
公开(公告)日：2008-10-02
申请号：PCT/IB2007003928
申请日：2007-12-03
Applicant: PFIZER PROD INC , BLAKE TANISHA DANIELLE ROWE , HAMPER BRUCE CAMERON , HUANG WEI , KIEFER JAMES RICHARD JR , MOON JOSEPH BLAIR , NEAL BRADLEY E , OLSON KIRK LANG , PELC MATTHEW JAMES , SCHWEITZER BARBARA ANN , THORARENSEN ALTI , TRUJILLO JOHN I , TURNER STEVE R
Inventor： BLAKE TANISHA DANIELLE ROWE , HAMPER BRUCE CAMERON , HUANG WEI , KIEFER JAMES RICHARD JR , MOON JOSEPH BLAIR , NEAL BRADLEY E , OLSON KIRK LANG , PELC MATTHEW JAMES , SCHWEITZER BARBARA ANN , THORARENSEN ALTI , TRUJILLO JOHN I , TURNER STEVE R
IPC: C07D213/82 , A61P11/00 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04
CPC classification number: C07D401/12 , C07D213/82 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment of various diseases and conditions such as asthma.
Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其中取代基如本文所定义，含有这些化合物的组合物以及这些化合物用于治疗各种疾病和病症例如哮喘的用途。
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10.发明申请BETA-CARBOLINE COMPOUNDS AND ANALOGUES THEREOF AND THEIR USE AS MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITORS 审中-公开β-咔啉化合物及其类似物及其作为丝氨酸激活的蛋白激酶活化的蛋白激酶-2抑制剂的用途
公开(公告)号：WO2005009370A2
公开(公告)日：2005-02-03
申请号：PCT/US2004/023350
申请日：2004-07-22
Applicant: PHARMACIA CORPORATION , MEYERS, Marvin, J. , TRUJILLO, John, I. , VERNIER, William, F. , ANDERSON, David, R. , REITZ, David, B. , BUCHLER, Ingrid, P. , HEGDE, Shridhar, G. , MAHONEY, Matthew, W. , WU, Kun, K.
Inventor： MEYERS, Marvin, J. , TRUJILLO, John, I. , VERNIER, William, F. , ANDERSON, David, R. , REITZ, David, B. , BUCHLER, Ingrid, P. , HEGDE, Shridhar, G. , MAHONEY, Matthew, W. , WU, Kun, K.
IPC: A61K
CPC classification number: A61K31/40 , C07D471/04 , C07D471/14 , C07D471/18 , Y02A50/475
Abstract: Novel methods and compositions are described for inhibiting mitogen activated protein kinase-activated protein kinase-2 in a subject. The method involves administering to the subject a beta-carboline MK-2 inhibiting compound, or a pharmaceutically acceptable salt, or isomer thereof. The novel compositions are capable of inhibiting mitogen activated protein kinase-activated protein kinase-2 and analogues thereof. Pharmaceutical compositions and kits that include these compounds are also described.
Abstract translation: 描述了用于抑制受试者中促分裂原活化蛋白激酶活化的蛋白激酶-2的新方法和组合物。 该方法涉及向受试者施用β-咔啉MK-2抑制性化合物或其药学上可接受的盐或异构体。 该新型组合物能够抑制促分裂原活化蛋白激酶活化蛋白激酶-2及其类似物。 还描述了包含这些化合物的药物组合物和试剂盒。
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