公开(公告)号：WO2021257921A1

公开(公告)日：2021-12-23

申请号：PCT/US2021/037961

申请日：2021-06-17

Applicant: ARCHER DANIELS MIDLAND COMPANY

Inventor： DESTEXHE, Alain ,  CAPITAIN, Volker ,  AKELOGLU, Sena

IPC: A21D13/50 ,  A21D2/18 ,  A21D2/26 ,  A23P30/40

Abstract: A new type of maltodextrin syrup is described having functional properties of a corn syrup having a DE of between 35 -45 while having a DE value less than 20. In the most general embodiment, the syrup contains no more than 70% of total saccharides with a DP of less than 10 while at the same time having least 50% of the saccharides do have a DP of less than 10. The remainder of the saccharides have a DP of 10 or more. For those saccharides having a DP of less than 10 the distribution is weighted toward the higher end with saccharides having a DP of 5 to 9 being more than the saccharides having a DP of 1 to 4.

公开(公告)号：WO2021146134A1

公开(公告)日：2021-07-22

申请号：PCT/US2021/012936

申请日：2021-01-11

Applicant: ARCHER DANIELS MIDLAND COMPANY

Inventor： VESSELS, Kevin

IPC: A23L27/30 ,  A23L33/125 ,  A23P10/25

Abstract: The present invention advantages over conventional methods and products. In an aspect, a method comprises separating a mixture of allulose, fructose, glucose, and glucooligosaccharides, wherein the separating comprises using simulated moving bed chromatography, and recovering allulose at a high purity and yield. In an aspect,the simulated moving bed ("SMB") chromatography to separate a fraction enriched with allulose from a fraction enriched with fructose and glucose, and to separate a fraction enriched with fructose from a fraction enriched with glucose. In an aspect, the method provides separation of an allulose from a mixture of allulose, fructose, and D-glucose, wherein the mixture is produced from high fructose corn syrup ("HFCS") when HFCS is contacted with an allulose epimerase. In an aspect, the method produces a high quality allulose product. In an aspect, the fraction enriched with fructose can be recycled to contact the allulose epimerase.

公开(公告)号：WO2015156803A1

公开(公告)日：2015-10-15

申请号：PCT/US2014/033581

申请日：2014-04-10

Applicant: ARCHER DANIELS MIDLAND COMPANY

Inventor： STENSRUD, Kenneth ,  MA, Chi-Cheng ,  MARTIN, Kevin

IPC: C07C29/60

CPC classification number: C07D307/12 ,  B01J23/462 ,  B01J23/72 ,  B01J25/00 ,  B01J27/053 ,  B01J27/16 ,  B01J27/20 ,  C07C29/132 ,  C07C29/60 ,  C07G3/00 ,  C07C31/26 ,  C07C31/22 ,  C07C31/24

Abstract: Disclosed herein are methods for synthesizing 1,2,5,6-hexanetetrol (HTO), 1,6 hexanediol (HDO) and other reduced polyols from C5 and C6 sugar alcohols or R glycosides. The methods include contacting the sugar alcohol or R-glycoside with a copper catalyst, most desirably a Raney copper catalyst with hydrogen for a time, temperature and pressure sufficient to form reduced polyols having 2 to 3 fewer hydoxy groups than the starting material. When the starting compound is a C6 sugar alcohol such as sorbitol or R-glycoside of a C6 sugar such as methyl glucoside, the predominant product is HTO. The same catalyst can be used to further reduce the HTO to HDO.

Abstract translation: 本文公开了从C5和C6糖醇或R糖苷合成1,2,5,6-己烷四醇（HTO），1,6己二​​醇（HDO）和其他还原多元醇的方法。 所述方法包括使糖醇或R-糖苷与铜催化剂，最优选阮内铜催化剂与氢接触一段时间，足够的温度和压力以形成比原料具有2至3个更少的羟氧基的还原多元醇。 当起始化合物是C6糖醇如山梨醇或C6糖的R-糖苷如甲基葡糖苷时，主要产物是HTO。 可以使用相同的催化剂将HTO进一步还原成HDO。

公开(公告)号：WO2013044042A1

公开(公告)日：2013-03-28

申请号：PCT/US2012/056593

申请日：2012-09-21

Applicant: ARCHER DANIELS MIDLAND COMPANY ,  NOVAZYMES A/S ,  BINDER, Thomas P. ,  ABBAS, Charles ,  BAO, Wu-Li ,  LOVELESS, Lucas

Inventor： BINDER, Thomas P. ,  ABBAS, Charles ,  BAO, Wu-Li ,  LOVELESS, Lucas

IPC: C12P7/14

CPC classification number: C12P17/04 ,  C07D307/08 ,  C07D307/36 ,  C07D307/50 ,  C08B1/003 ,  C08B3/00 ,  C08B3/06 ,  C08B37/14 ,  C08H6/00 ,  C08H8/00 ,  C08L1/12 ,  C08L5/14 ,  C08L97/005 ,  C12P7/06 ,  C12P7/10 ,  C12P7/14 ,  C12P19/00 ,  C12P19/02 ,  C12P19/04 ,  C12P19/14 ,  C12P2201/00 ,  C12P2203/00 ,  C12Y301/00 ,  C12Y302/01004 ,  C13K1/02 ,  C13K13/002 ,  D21C3/04 ,  Y02E50/16 ,  Y02E50/17

Abstract: A process for production of C5 and C6 sugar enriched syrups from lignocellulosic biomass and fermentation products therefrom is described. A lignocellulosic biomass is treated with a C 1 -C 2 acid (e.g., acetic acid) with washing thereof with a C 1 -C 2 acid miscible organic solvent, (e.g., ethyl acetate). A soluble hemicellulose and lignin enriched fraction is obtained separately from a cellulose pulp enriched fraction and lignin is removed from the soluble hemicellulose fraction. These fractions contain acylated (e.g., acetylated) cellulose and hemicellulose, which are deacylated by treatment with an alkali and/or with an acetyl esterase enzyme. The deacylated fractions are then digested with suitable cellulolytic and/or hemicellulolytic enzymes, preferably in the presence of non-ionic detergent to yield the C5 and C6 enriched syrups. Also described are method of fermentation of the syrups to make ethanol to at least 7% w/vol by separate hydrolysis and fermentation (SHF) or simultaneous hydrolysis and fermentation (SSF) methods.

Abstract translation: 描述了从木质纤维素生物质和其发酵产物生产C5和C6糖富集糖浆的方法。 用C1-C2酸（例如乙酸）处理木质纤维素生物质，用C1-C2酸可混溶的有机溶剂（例如乙酸乙酯）洗涤。 从富含纤维素纸浆的级分分别获得可溶性半纤维素和木质素富集部分，并从可溶性半纤维素部分中除去木质素。 这些级分含有酰化（例如，乙酰化的）纤维素和半纤维素，其通过用碱和/或与乙酰酯酶进行处理而脱酰基化。 然后用合适的纤维素分解和/或半纤维素分解酶消化脱酰基化部分，优选在非离子型洗涤剂的存在下，产生富C5和C6的糖浆。 还描述了通过单独的水解和发酵（SHF）或同时水解和发酵（SSF）方法使糖浆发酵以使乙醇达到至少7％w / vol的方法。

公开(公告)号：WO2012087601A1

公开(公告)日：2012-06-28

申请号：PCT/US2011/064074

申请日：2011-12-09

Applicant: ARCHER DANIELS MIDLAND COMPANY ,  JORDAN, Sean ,  FATLAND-BLOOM, Beth ,  LI, Lhing-Yew

Inventor： JORDAN, Sean ,  FATLAND-BLOOM, Beth ,  LI, Lhing-Yew

IPC: C12N1/19

CPC classification number: C12N15/81 ,  C12N9/0006 ,  C12N9/92 ,  C12P7/10 ,  C12Y101/01009 ,  C12Y503/01005 ,  Y02E50/16 ,  Y02E50/17 ,  Y02P20/52

Abstract: Disclosed herein is a newly discovered problem and solution for engineering S. cerevisiae to ferment xylose to make ethanol utilizing xylose isomerase to convert xylose to xylulose for entry, via xylulokinase, into the pentose phosphate pathway. When grown on a media containing xylose xylitol tends to accumulate in the cell despite the absence of xylose reductase activity in S. cerevisiae. Xylitol inhibits the activity of xylose isomerases. One solution described is to simultaneously express an exogenous xylitol dehydrogenase along with the exogenous xylose isomerase while optionally also overexpressing xylulokinase in the absence of expression of a xylose reductase. Another solution is a xylose isomerase from Bacteroides fragilis which is less inhibited by xylitol than other xylose isomerases, exemplified by E.coli xylose isomerase. Expression ofthe Bacteroidesfragilis xylose isomerase may be used alone, or in combination with expression ofaxylitol dehydrogenase and optionally over expression of xylulokinase to improve ethanol production from xylose.

Abstract translation: 本文公开了一种新发现的问题和解决方案，用于工程酿酒酵母发酵木糖以制备乙醇，利用木糖异构酶将木糖转化成木酮糖，通过木酮糖激酶进入戊糖磷酸途径。 当在含有木糖木糖醇的培养基上生长时，尽管在酿酒酵母中没有木糖还原酶活性，但是在细胞中趋于积聚。 木糖醇抑制木糖异构酶的活性。 所描述的一种溶液是同时表达外源性木糖异构酶外源木糖醇脱氢酶，而在不存在木糖还原酶表达的情况下，任选也可以过表达木酮糖激酶。 另一种溶液是来自脆弱拟杆菌的木糖异构酶，木糖异构酶比其它木糖异构酶抑制木糖醇少，例如大肠杆菌木糖异构酶。 拟杆菌属变种木糖异构酶的表达可以单独使用，或与表达木糖醇脱氢酶组合使用，任选地过度表达木酮糖激酶以改善从木糖产生乙醇。

公开(公告)号：WO2011131933A1

公开(公告)日：2011-10-27

申请号：PCT/GB2011/000608

申请日：2011-04-20

Applicant: UCL BUSINESS PLC ,  KIRKBY, Paul, A. ,  NADELLA, K. M. Naga Srinivas ,  SILVER, R., Angus

Inventor： KIRKBY, Paul, A. ,  NADELLA, K. M. Naga Srinivas ,  SILVER, R., Angus

IPC: G02F1/33 ,  G01N21/64 ,  G02B21/00

CPC classification number: G02F1/33 ,  G01N21/6458 ,  G02B21/0036 ,  G02B21/16 ,  G02B26/08

Abstract: Methods and apparatus for optimising, improving or maximising the efficiency of an acousto-optic lens (AOL) system are disclosed. Data relating to efficiency is used to select drive frequencies of the acousto-optic devices (AODs) forming the AOL, thereby both increasing the usable field of view and reducing a prior art patternation problem. Preferably according to the invention, drive frequencies are selected that maximise efficiency of transmission through the AOL. When scanning, the centre of each scan is optimised to be of maximum efficiency.

Abstract translation: 公开了用于优化，改善或最大化声光透镜（AOL）系统的效率的方法和装置。 使用与效率相关的数据来选择形成AOL的声光装置（AOD）的驱动频率，从而增加了可用的视野并减少了现有技术的图案化问题。 优选地，根据本发明，选择驱动频率以使通过AOL的传输效率最大化。 扫描时，每个扫描的中心被优化为最大效率。

公开(公告)号：WO2011089394A3

公开(公告)日：2011-07-28

申请号：PCT/GB2011/000077

申请日：2011-01-21

Applicant: UCL BUSINESS PLC ,  MONTGOMERY, Hugh, E ,  MYTHEN, Michael ,  THORNE, Anthony

Inventor： MONTGOMERY, Hugh, E ,  MYTHEN, Michael ,  THORNE, Anthony

IPC: A61J7/00 ,  A61M5/142 ,  A61M5/168 ,  A61J7/04 ,  A61J1/22

Abstract: The invention relates to a method and apparatus for providing hydration fluids. The invention allows for a 'background' rate of providing a hydration fluid to be automatically supplied by an apparatus to a patient, for example intravenously, and for the patient to receive an extra amount of hydration fluid, or 'bolus dose', to be provided when the patient sends a signal to the apparatus. In preferred embodiments the background supply rate, the volume and rate of supply of the bolus dose and the maximum extra volume that can be provided as bolus doses in a given time can be set, for example, by a nurse.

公开(公告)号：WO2010132740A2

公开(公告)日：2010-11-18

申请号：PCT/US2010/034856

申请日：2010-05-14

Applicant: ARCHER DANIELS MIDLAND COMPANY ,  SANBORN, Alexandra

Inventor： SANBORN, Alexandra

IPC: C07D307/48 ,  C07D307/46

CPC classification number: C07D307/68

Abstract: The disclosure pertains to a process for oxidation of furan aldehydes such as 5- hydroxymethyl)furfural (HMF) and derivatives thereof such as 5-(alkoxymethyl)furfural (AMF), 5-(aryloxymethyl)furfural, 5-(cycloalkoxy-methyl)furfural and 5-(alkoxycarbonyl)furfural compounds in the presence of dissolved oxygen and a Co(II), Mn(II), Ce(III) salt catalyst or mixtures thereof. The products from HMF can be selectively chosen to be predominantly 2,5- diformylfuran (DFF), particularly by inclusion of an aliphatic ketone, like methyl ethyl ketone, or can be further oxidized to 2,5-furandicarboxylic acid (FDCA) by the omission of methyl ethyl ketone and inclusion of bromide.. When the reactant is an ether derivative of HMF the products are surprisingly ester derivatives where either both the ether and aldehyde functional groups have been oxidized or just the ether function group thereby producing one or both of 5-ester-furan-2- acids (i.e., 5-alkoxycarbonylfurancarboxylic acids) or 5-ester-furan aldehydes, (i.e.,- alkoxycarbonylfurfurals a. k. a , 5 -(alkoxycarbonyl)furfural). (I)

Abstract translation: 本发明涉及呋喃醛如5-羟甲基糠醛（HMF）及其衍生物如5-（烷氧基甲基）糠醛（AMF），5-（芳氧基甲基）糠醛，5-（环烷氧基甲基） 糠醛和5-（烷氧基羰基）糠醛化合物在溶解氧和Co（II），Mn（II），Ce（III）盐催化剂或其混合物存在下进行。 来自HMF的产物可以选择性地选择为主要是2,5-二甲基呋喃（DFF），特别是通过包含脂族酮如甲基乙基酮，或者可以通过以下方法进一步氧化成2,5-呋喃二羧酸（FDCA） 省略甲基乙基酮和包含溴化物。当反应物是HMF的醚衍生物时，产物令人惊奇地是酯衍生物，其中醚和醛官能团都被氧化或仅仅是醚官能团，从而产生一种或两种 5-酯 - 呋喃-2-酸（即5-烷氧基羰基呋喃羧酸）或5-酯 - 呋喃醛（即 - 烷氧基羰基糠醛ak a，5-（烷氧基羰基）糠醛）。 （一世）

公开(公告)号：WO2008151387A1

公开(公告)日：2008-12-18

申请号：PCT/AU2008/000862

申请日：2008-06-13

Applicant: CYTOMATRIX PTY LTD ,  KIRKLAND, Mark, Alexander ,  VO, Liem, Thanh

Inventor： KIRKLAND, Mark, Alexander ,  VO, Liem, Thanh

IPC: C12N5/06 ,  C12N5/08 ,  A61K38/17

CPC classification number: A61K38/1709 ,  A61K35/34 ,  C12N5/0657 ,  C12N2501/60 ,  C12N2510/00

Abstract: In one embodiment the invention relates to a method of initiating cardiomyocyte differentiation in a responsive mammalian cell, which comprises introducing into the cell an effective amount for initiating cardiomyocyte differentiation within the cell of CSX/Nkx2.5 protein or a functionally equivalent analogue, variant or fragment thereof. In another embodiment the invention relates to a method of treatment of a patient suffering from or prone to suffer from heart failure or ischaemic heart disease, which comprises removing from the patient one or more responsive cells and culturing the cells in a suitable medium, introducing into the cells an effective amount for initiating cardiomyocyte differentiation of CSX/Nkx2.5 protein or a functionally equivalent analogue, variant or fragment thereof and subsequently returning the cells or cells derived from them to the patient. In a further embodiment the invention relates to a method of treatment of a patient suffering from or prone to suffer from heart failure or ischaemic heart disease, which comprises introducing into responsive cells of the patient an effective amount of CSX/Nkx2.5 protein or a functionally equivalent analogue, variant or fragment thereof.

Abstract translation: 在一个实施方案中，本发明涉及在响应性哺乳动物细胞中引发心肌细胞分化的方法，其包括向CSX / Nkx2.5蛋白的细胞内引入有效量的起始心肌细胞分化或功能等同的类似物，变体或 片段。 在另一个实施方案中，本发明涉及治疗患有或易于患有心力衰竭或缺血性心脏病的患者的方法，其包括从患者中除去一种或多种应答细胞并在合适的培养基中培养细胞，将其引入 所述细胞是用于启动CSX / Nkx2.5蛋白或其功能等同的类似物，变体或片段的心肌细胞分化的有效量，随后将从其衍生的细胞或细胞返回给患者。 在另一个实施方案中，本发明涉及治疗患有或易于患有心力衰竭或缺血性心脏病的患者的方法，其包括将有效量的CSX / Nkx2.5蛋白或 功能等同的类似物，变体或片段。

公开(公告)号：WO2008134813A1

公开(公告)日：2008-11-13

申请号：PCT/AU2008/000624

申请日：2008-05-02

Applicant: ST. VINCENT'S HOSPITAL (MELBOURNE) LIMITED ,  DIXON, Barry

Inventor： DIXON, Barry

IPC: A61B5/145 ,  A61B5/1455

CPC classification number: A61B5/14551 ,  A61B5/4064 ,  A61B5/412

Abstract: The invention relates to a method for non-invasive determination of oxygen saturation of blood within a deep vascular structure of a human patient comprising locating on skin of the patient in a vicinity of the deep vascular structure of interest emitter and receiver elements of a light oximeter device, wherein optimal location of said elements is achieved through matching of a plethysmography trace obtained from the oximeter device to known plethysmography characteristics of the deep vascular structure of interest, and wherein oxygen saturation is determined from a ratio of light absorbed at different wavelengths by haemoglobin in the blood within the vascular structure of interest. The invention also relates to modified oximetry devices capable of carrying out the method.

Abstract translation: 本发明涉及一种用于非侵入式确定人类患者深部血管结构内的血液氧饱和度的方法，包括定位在感兴趣的深血管结构附近的患者的皮肤上，所述深血管结构的发射器和轻度血氧计的接收器元件 装置，其中所述元件的最佳位置通过将从血氧计装置获得的体积描记图与匹配感兴趣的深血管结构的已知体积描记图特征相匹配来实现，并且其中氧饱和度是根据血红蛋白在不同波长吸收的光的比例来确定的 在感兴趣的血管结构内的血液中。 本发明还涉及能够实施该方法的改进的血氧测定装置。