公开(公告)号：WO2015044454A3

公开(公告)日：2015-05-21

申请号：PCT/EP2014070937

申请日：2014-09-30

Applicant: STEMME GÖRAN ,  LENK GABRIEL ,  BECK OLOF ,  ROXHED NICLAS

Inventor： STEMME GÖRAN ,  LENK GABRIEL ,  BECK OLOF ,  ROXHED NICLAS

IPC: B01L3/00 ,  F16K99/00

CPC classification number: B01L3/502738 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/0605 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2300/126 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0677 ,  F16K99/003 ,  F16K99/0057 ,  F16K2099/0084 ,  F16K2099/0086

Abstract: The invention relates to a microfluidic device comprising an inlet port for liquid, a capillary channel in fluid connection to the inlet port for receiving liquid from the inlet port, the channel having a defined volume. At least one dissolvable valve is provided comprising a dissolvable membrane having a first side oriented towards the capillary channel, and capillary means connected to the second side of the dissolvable membrane such that when the membrane is dissolved by the liquid, liquid is transported through the valve to the second side of the membrane by capillary action. The invention relates to uses of the device, methods of fabricating the device and method of controlling a flow of liquid.

Abstract translation: 本发明涉及一种微流体装置，其包括用于液体的入口端口，与入口端口流体连接以从入口端口接收液体的毛细管通道，所述通道具有限定体积。 提供至少一个可溶解的阀门，其包括具有朝向毛细管通道的第一侧的可溶解膜和连接到可溶解膜的第二侧的毛细管装置，使得当膜被液体溶解时，液体通过阀 通过毛细作用到膜的第二侧。 本发明涉及该装置的用途，制造该装置的方法和控制液体流动的方法。

公开(公告)号：WO2012120140A1

公开(公告)日：2012-09-13

申请号：PCT/EP2012/054180

申请日：2012-03-09

Applicant: SENSA BUES AB ,  BECK, Olof ,  HAMMARLUND, Bo

Inventor： BECK, Olof ,  HAMMARLUND, Bo

IPC: G01N33/497 ,  A61B5/097

CPC classification number: G01N33/497 ,  A61B5/082 ,  A61B5/091 ,  A61B5/097 ,  A61B5/4845 ,  B29C65/46 ,  B29C65/665 ,  B29K2023/10 ,  B29K2033/04 ,  B29K2105/256 ,  B29K2105/258 ,  G01N2033/4975

Abstract: A portable drug sampling device for handheldly collecting a sample from exhaled breath of a subject for further sensor based analysis. The device comprising: a housing (406) comprising at least one inlet (407) and at least one outlet (408) for the exhaled breath to exit through, and a sampling membrane (302) arranged in the housing. A tubular element (40) having a mouthpiece section (401) for the subject to exhale into, and a saliva trap section comprising baffles (103) to create a non-straight gas flow path for letting aerosols pass through the tubular element. The sampling membrane (302) is arranged to collect the aerosols from the exhaled breath. The portable drug testing device further comprises a volume collecting element (208).

Abstract translation: 一种便携式药物采样装置，用于从用于进一步基于传感器的分析的呼吸呼吸中手持收集样品。 该装置包括：壳体（406），包括至少一个入口（407）和用于呼出的呼吸排出的至少一个出口（408）和布置在壳体中的取样膜（302）。 管状元件（40）具有用于受试者呼出的吸口部分（401）和包括挡板（103）的唾液陷阱部分，以产生用于使气溶胶通过管状元件的非直线气流通道。 取样膜（302）布置成从呼出的呼吸中收集气溶胶。 便携式药物检测装置还包括容积收集元件（208）。

公开(公告)号：WO1998024819A1

公开(公告)日：1998-06-11

申请号：PCT/SE1997002035

申请日：1997-12-05

Applicant: PHARMACIA & UPJOHN AB ,  BRANDT, Ragnhild ,  BECK, Olof ,  HELANDER, Anders ,  JÖNSSON, Rose-Marie ,  UNGER, Eric ,  BORG, Stefan ,  ÅKERBLOM, Eva

Inventor： PHARMACIA & UPJOHN AB

IPC: C07K16/44

CPC classification number: C07H17/02 ,  C07K16/44 ,  Y10T436/14 ,  Y10T436/145555 ,  Y10T436/17 ,  Y10T436/173845 ,  Y10T436/203332 ,  Y10T436/25

Abstract: Antibody specific for a 5-HTOL compound. A glucuronide with 5-hydroxytryptophol (5-HTOL) characterized in that it comprises the structure of the beta -glucuronide between the 5-hydroxy group of 5-HTOL and D-glucopyranosiduronic acid. An immunoassay and a diagnostic method utilizing the immunoassay wherein a 5-hydroxytryptophol (5-HTOL) compound is determined by the use of an antibody specific for a 5-HTOL compound is used.

Abstract translation: 针对5-HTOL化合物的抗体。 具有5-羟基三苯乙醇（5-HTOL）的葡糖苷酸，其特征在于其包含5-羟基5-HTOL和D-吡喃葡萄糖苷二糖酸之间的β-葡萄糖醛酸苷结构。 使用免疫测定法和诊断方法，其中使用5-羟色胺（5-HTOL）化合物通过使用对5-HTOL化合物特异的抗体来测定。

公开(公告)号：WO2011029888A1

公开(公告)日：2011-03-17

申请号：PCT/EP2010/063265

申请日：2010-09-09

Applicant: SENSA BUES AB ,  PALMSKOG, Göran ,  BECK, Olof ,  ANDERSSON, Per Ola

Inventor： PALMSKOG, Göran ,  BECK, Olof ,  ANDERSSON, Per Ola

IPC: G01N21/65 ,  G01N33/497

CPC classification number: G01N21/658 ,  A61B5/082 ,  A61B5/412 ,  G01J3/44 ,  G01N33/497

Abstract: A sensor for detecting a drug substance (15) from exhaled breath of a subject in-situ. Its collecting surface has a Surface Enhanced Raman Spectroscopy (SERS)-active layer (14) of a SERS-active material. The collecting surface is arranged as an outer surface of a waveguide (12) for contact with exhaled breath, such that at least traces of said drug substance (15) in said exhaled breath can contact said SERS-active layer for read-out of a Raman shift spectrum.

Abstract translation: 一种用于从现场呼出的呼吸气体检测药物（15）的传感器。 其收集表面具有SERS活性材料的表面增强拉曼光谱（SERS）活性层（14）。 收集表面被布置为用于与呼出的呼吸接触的波导（12）的外表面，使得所述呼出的呼吸中的至少痕量的所述药物（15）可以接触所述SERS活性层以读出 拉曼位移谱。

公开(公告)号：WO2015044454A2

公开(公告)日：2015-04-02

申请号：PCT/EP2014/070937

申请日：2014-09-30

Applicant: STEMME, Göran ,  LENK, Gabriel ,  BECK, Olof ,  ROXHED, Niclas

Inventor： STEMME, Göran ,  LENK, Gabriel ,  BECK, Olof ,  ROXHED, Niclas

IPC: B01L3/00

CPC classification number: B01L3/502738 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/0605 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2300/126 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0677 ,  F16K99/003 ,  F16K99/0057 ,  F16K2099/0084 ,  F16K2099/0086

Abstract: The invention relates to a microfluidic device comprising an inlet port for liquid, a capillary channel in fluid connection to the inlet port for receiving liquid from the inlet port, the channel having a defined volume. At least one dissolvable valve is provided comprising a dissolvable membrane having a first side oriented towards the capillary channel, and capillary means connected to the second side of the dissolvable membrane such that when the membrane is dissolved by the liquid, liquid is transported through the valve to the second side of the membrane by capillary action. The invention relates to uses of the device, methods of fabricating the device and method of controlling a flow of liquid.

Abstract translation: 本发明涉及一种微流体装置，其包括用于液体的入口端口，与入口端口流体连接的毛细通道，用于从入口端口接收液体，通道具有限定的体积。 提供至少一个可溶解阀，其包括具有朝向毛细管通道的第一侧的可溶性膜，以及连接到可溶解膜的第二侧的毛细管装置，使得当膜被液体溶解时，液体被输送通过阀 通过毛细管作用到膜的第二侧。 本发明涉及装置的使用，制造装置的方法和控制液体流动的方法。

公开(公告)号：WO2011029889A1

公开(公告)日：2011-03-17

申请号：PCT/EP2010/063266

申请日：2010-09-09

Applicant: SENSA BUES AB ,  PALMSKOG, Göran ,  BECK, Olof

Inventor： PALMSKOG, Göran ,  BECK, Olof

IPC: G01N33/497 ,  A61B5/097 ,  H01J49/04

CPC classification number: G01N21/658 ,  A61B5/082 ,  A61B5/412 ,  G01J3/44 ,  G01N33/497

Abstract: A portable system (10) is disclosed for collecting a sample from exhaled breath of a subject. Drug substance in the exhaled breath are detected or determined. The sample is collected for further analysis using mass-spectroscopy. The system comprises a sampling unit (14) and a housing (12) arranged to hold the sampling unit (14), the sampling unit (14) is adapted to collect non-volatile and volatile compounds of the at least one drug substance from the exhaled breath from the subject. The housing (12) has at least one inlet (15) for the subject to exhale into the housing (12) to the sampling unit (14) and at least one outlet (16) for the exhaled breath to exit through.

Abstract translation: 公开了一种便携式系统（10），用于从受试者的呼出气中收集样品。 检测或确定呼出气中的药物。 收集样品以进行质谱分析。 该系统包括一个采样单元（14）和一个布置成保持采样单元（14）的壳体（12），采样单元（14）适用于从该采样单元（14）收集至少一种药物的非挥发性和挥发性化合物 从主题呼出呼吸。 壳体（12）具有至少一个入口（15），用于受试者呼出到采样单元（14）的壳体（12）和用于呼出的呼吸的至少一个出口（16）通过。