公开(公告)号：WO2006086754A2

公开(公告)日：2006-08-17

申请号：PCT/US2006/004968

申请日：2006-02-10

Applicant: ECOSYNTHETIX INC. ,  BLOEMBERGEN, Steven ,  STROM, Erik ,  NEBELING, Robert, H.

Inventor： BLOEMBERGEN, Steven ,  STROM, Erik ,  NEBELING, Robert, H.

IPC: B32B37/02

CPC classification number: B31F1/2818 ,  B05C1/0813 ,  B05C1/0834 ,  Y10T428/273

Abstract: The invention relates to an application system for water-based adhesives to produce corrugated and laminated board products using less adhesive than traditionally possible. The water based colloidal adhesive is selected from the group consisting of biopolymer nanoparticles and formulations based thereon, polyvinyl acetate and formulations based thereon, polyvinyl alcohol blends and formulations based thereon, dextrins and formulations based thereon, polyacrylics and formulations based thereon, vinyl acetate-acrylic copolymers and formulations based thereon, ethylene-vinyl acetate copolymers and formulations based thereon, vinyl acetate-ethylene copolymers and formulations based thereon, and other adhesives of similar characteristics, and blends of any of the former.

Abstract translation: 本发明涉及一种用于水性粘合剂的应用系统，其使用比传统可能性更少的粘合剂来生产波纹和层压板产品。 水基胶体粘合剂选自生物聚合物纳米颗粒和基于其的制剂，聚乙酸乙烯酯和基于其的制剂，聚乙烯醇共混物和基于其的制剂，糊精和基于其的制剂，基于其的聚丙烯酸和制剂，乙酸乙烯酯 - 丙烯酸酯 基于其的共聚物和制剂，乙烯 - 乙酸乙烯酯共聚物和基于其的制剂，乙酸乙烯酯 - 乙烯共聚物和基于其的制剂，以及具有相似特征的其它粘合剂，以及任何前者的共混物。

公开(公告)号：WO2008022127A3

公开(公告)日：2008-02-21

申请号：PCT/US2007/075901

申请日：2007-08-14

Applicant: ECOSYNTHETIX INC. ,  WILDI, Robert, H. ,  VAN EGDOM, Edward ,  BLOEMBERGEN, Steven

Inventor： WILDI, Robert, H. ,  VAN EGDOM, Edward ,  BLOEMBERGEN, Steven

IPC: C08L3/00 ,  C08B30/00 ,  B29C31/00

Abstract: A process for producing a biopolymer nanoparticles product is disclosed. In this process, biopolymer feedstock and a plasticizer are fed to a feed zone of an extruder having a screw configuration in which the feedstock is process using shear forces in the extruder, and a crosslinking agent is added to the extruder downstream of the feed zone. The biopolymer feedstock and plasticizer are preferably added separately to the feed zone. The screw configuration may include two or more steam seal sections. Shear forces in a first section of the extruder may be greater than shear forces in an adjacent second section of the extruder downstream of the first section. In a post reaction section located after a point in which the crosslinking reaction has been completed, water may be added to improve die performance.

公开(公告)号：WO2012075414A3

公开(公告)日：2012-09-13

申请号：PCT/US2011063102

申请日：2011-12-02

Applicant: ECOSYNTHETIX LTD ,  BLOEMBERGEN STEVEN ,  MCLENNAN IAN J ,  JONES NATHAN ,  WAGNER RYAN ,  GANESH SHERMON AAREET KRSNA ,  ELSAYED ABDEL RAHMAN ,  LIU JUEWEN

Inventor： BLOEMBERGEN STEVEN ,  MCLENNAN IAN J ,  JONES NATHAN ,  WAGNER RYAN ,  GANESH SHERMON AAREET KRSNA ,  ELSAYED ABDEL RAHMAN ,  LIU JUEWEN

IPC: A61K9/00 ,  B82B1/00

CPC classification number: A61K9/145 ,  A61K9/1676 ,  A61K9/5161 ,  A61K31/704 ,  A61K47/36 ,  A61K47/549 ,  A61K47/6939 ,  B82Y5/00 ,  C08B31/003 ,  C08B31/185 ,  C08B33/00 ,  C08B35/00 ,  Y10T428/2982

Abstract: A delivery device for an active agent comprises nanoparticles based on a biopolymer such as starch is disclosed. The device may be in the form of an aptamer-biopolymer-active agent conjugat, where the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked nydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the cross-linked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for the sustained release of a drug and for the transportation and uptake of the conjugate into targeted cells.

Abstract translation: 用于活性剂的递送装置包括基于诸如淀粉的生物聚合物的纳米颗粒。 该装置可以是适体 - 生物聚合物 - 活性剂缀合物的形式，其中适体靶向用于治疗特定疾病的装置。 可以通过在交联剂的存在下施加高剪切力来制备纳米颗粒。 颗粒可以主要在50-150nm的范围内，并且形成交联的nydrogel颗粒在水中的胶态分散体。 生物聚合物可以官能化。 适体可以直接与交联的生物聚合物缀合。 活性剂可以是用于治疗癌症的药物。 递送装置在体内存活足够长的时间以允许药物的持续释放以及将缀合物输送和摄取到靶细胞中。

公开(公告)号：WO2012075414A2

公开(公告)日：2012-06-07

申请号：PCT/US2011/063102

申请日：2011-12-02

Applicant: ECOSYNTHETIX LTD. ,  BLOEMBERGEN, Steven ,  MCLENNAN, Ian, J. ,  JONES, Nathan ,  WAGNER, Ryan ,  GANESH SHERMON, Aareet, Krsna ,  ELSAYED, Abdel, Rahman ,  LIU, Juewen

Inventor： BLOEMBERGEN, Steven ,  MCLENNAN, Ian, J. ,  JONES, Nathan ,  WAGNER, Ryan ,  GANESH SHERMON, Aareet, Krsna ,  ELSAYED, Abdel, Rahman ,  LIU, Juewen

IPC: A61K9/14 ,  C08B31/00 ,  A61K47/36 ,  A61P35/00 ,  B82Y5/00

CPC classification number: A61K9/145 ,  A61K9/1676 ,  A61K9/5161 ,  A61K31/704 ,  A61K47/36 ,  A61K47/549 ,  A61K47/6939 ,  B82Y5/00 ,  C08B31/003 ,  C08B31/185 ,  C08B33/00 ,  C08B35/00 ,  Y10S977/773 ,  Y10S977/906 ,  Y10T428/2982

Abstract: A delivery device for an active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the cross-linked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for the sustained release of a drug and for the transportation and uptake of the conjugate into targeted cells. However, the biopolymer is biocompatible and resorbable.

Abstract translation: 用于活性剂的递送装置包括基于诸如淀粉的生物聚合物的纳米颗粒。 递送装置还可以是适体 - 生物聚合物 - 活性剂缀合物的形式，其中适体靶向用于治疗特定病症的装置。 可以通过在交联剂的存在下施加高剪切力来制备纳米颗粒。 颗粒可以主要在50-150nm的范围内，并形成交联的水凝胶颗粒在水中的胶态分散体。 生物聚合物可以官能化。 适体可以直接与交联的生物聚合物缀合。 活性剂可以是用于治疗癌症的药物。 递送装置在体内存活足够长的时间以允许药物的持续释放以及将缀合物输送和摄取到靶细胞中。 然而，生物聚合物是生物相容性和可再吸收的。

公开(公告)号：WO2002088271A1

公开(公告)日：2002-11-07

申请号：PCT/US2002/013724

申请日：2002-05-02

Applicant: ECOSYNTHETIX INC. ,  BLOEMBERGEN, Steven ,  KAPPEN, Frans ,  BEELEN, Brigit

Inventor： BLOEMBERGEN, Steven ,  KAPPEN, Frans ,  BEELEN, Brigit

IPC: C09J103/02

CPC classification number: C09J103/04 ,  C08L2666/28 ,  C09J103/02

Abstract: Environmentally friendly biopolymer adhesives are described, wherein the adhesives comprise biopolymer particles, more preferably starch microparticles, and most preferably starch nanoparticles, and their aqueous dispersions. Applications for the biopolymer particle adhesives are described, that are environmentally friendly alternatives to petroleum based synthetic adhesives. The biopolymer particle adhesives provide are biodegradable as well as repulpable, and thus provide bio-based recycling-friendly alternatives to synthetic adhesives derived from petroleum resources.

Abstract translation: 描述了环保生物聚合物粘合剂，其中粘合剂包括生物聚合物颗粒，更优选淀粉微粒，最优选淀粉纳米颗粒及其水分散体。 描述了用于生物聚合物颗粒粘合剂的应用，其是对石油基合成粘合剂是环境友好的替代物。 生物聚合物颗粒粘合剂提供是可生物降解的并且可再生的，因此为从石油资源衍生的合成粘合剂提供生物基回收友好的替代品。

公开(公告)号：WO2012045159A1

公开(公告)日：2012-04-12

申请号：PCT/CA2011/001125

申请日：2011-10-07

Applicant: ECOSYNTHETIX LTD. ,  BLOEMBERGEN, Steven ,  MCLENNAN, Ian, J. ,  LEE, Do, Ik

Inventor： BLOEMBERGEN, Steven ,  MCLENNAN, Ian, J. ,  LEE, Do, Ik

IPC: D21H19/56 ,  C08F251/00

CPC classification number: D21H19/58 ,  C08F251/00 ,  C08F290/10 ,  D21H19/20 ,  D21H19/56

Abstract: The present invention provides the novel and nonobvious discovery that sugar macromers can be effectively used to provide a new generation of renewable comonomers for bio-synthetic hybrid paper binder systems having a controlled hydrophilic-hydrophobic balance for improved water retention and film forming properties, on machine runnability, offset printability, biodegradability, enhanced recyclability, and other performance attributes.

Abstract translation: 本发明提供了新的和非显而易见的发现，糖大分子单体可以有效地用于为生物合成混合纸粘合剂体系提供新一代可再生共聚单体，其具有受控的亲水 - 疏水平衡以改善保水性和成膜性，在机器上 运行性，胶版印刷性，生物降解性，增强的可回收性和其他性能属性。

公开(公告)号：WO2006086754A3

公开(公告)日：2008-02-21

申请号：PCT/US2006004968

申请日：2006-02-10

Applicant: ECOSYNTHETIX INC ,  BLOEMBERGEN STEVEN ,  STROM ERIK ,  NEBELING ROBERT H

Inventor： BLOEMBERGEN STEVEN ,  STROM ERIK ,  NEBELING ROBERT H

IPC: B32B37/12 ,  B05D1/28 ,  B05D5/10 ,  B05D7/00 ,  B29C65/52 ,  B32B7/14

CPC classification number: B31F1/2818 ,  B05C1/0813 ,  B05C1/0834 ,  Y10T428/273

Abstract: The invention relates to an application system for water-based adhesives to produce corrugated and laminated board products using less adhesive than traditionally possible. The water based colloidal adhesive is selected from the group consisting of biopolymer nanoparticles and formulations based thereon, polyvinyl acetate and formulations based thereon, polyvinyl alcohol blends and formulations based thereon, dextrins and formulations based thereon, polyacrylics and formulations based thereon, vinyl acetate-acrylic copolymers and formulations based thereon, ethylene-vinyl acetate copolymers and formulations based thereon, vinyl acetate-ethylene copolymers and formulations based thereon, and other adhesives of similar characteristics, and blends of any of the former.

Abstract translation: 本发明涉及一种用于水性粘合剂的应用系统，其使用比传统可能性更少的粘合剂来生产波纹和层压板产品。 水基胶体粘合剂选自生物聚合物纳米颗粒和基于其的制剂，聚乙酸乙烯酯和基于其的制剂，聚乙烯醇共混物和基于其的制剂，糊精和基于其的制剂，基于其的聚丙烯酸和制剂，乙酸乙烯酯 - 丙烯酸 基于其的共聚物和制剂，乙烯 - 乙酸乙烯酯共聚物和基于其的制剂，乙酸乙烯酯 - 乙烯共聚物和基于其的制剂，以及具有相似特征的其它粘合剂，以及任何前者的共混物。

公开(公告)号：WO2002087868A1

公开(公告)日：2002-11-07

申请号：PCT/US2002/013723

申请日：2002-05-02

Applicant: ECOSYNTHETIX INC. ,  BLOEMBERGEN, Steven ,  KAPPEN, Frans ,  VAN LEEUWEN, Marinella

Inventor： BLOEMBERGEN, Steven ,  KAPPEN, Frans ,  VAN LEEUWEN, Marinella

IPC: B31F01/20

CPC classification number: C09J103/02 ,  C08L2666/26 ,  C09J103/04 ,  C09J103/12 ,  Y10T156/1025 ,  Y10T428/234 ,  Y10T428/24694 ,  Y10T428/2982

Abstract: The invention concerns a process for producing corrugated board, wherein a biopolymer latex adhesive is used as the corrugating adhesive. The biopolymer latex adhesive can be obtained by extruding a plasticized biopolymer, especially starch, in the presence of a crosslinking agent such as glyoxal. The preparation of the latex adhesive and its application in corrugating operation do not require a gelatinization step, nor the use of caustic soda or borax.

Abstract translation: 本发明涉及用于生产瓦楞纸板的方法，其中使用生物聚合物胶乳粘合剂作为波纹粘合剂。 生物聚合物胶乳粘合剂可以通过在交联剂如乙二醛的存在下挤出增塑的生物聚合物，特别是淀粉来获得。 胶乳粘合剂的制备及其在波纹操作中的应用不需要糊化步骤，也不需要使用苛性钠或硼砂。

公开(公告)号：WO2012162845A1

公开(公告)日：2012-12-06

申请号：PCT/CA2012/050375

申请日：2012-06-04

Applicant: ECOSYNTHETIX LTD. ,  TSEITLIN, Alexander ,  VAN ALSTYNE, David ,  BLOEMBERGEN, Steven

Inventor： TSEITLIN, Alexander ,  VAN ALSTYNE, David ,  BLOEMBERGEN, Steven

IPC: C08L3/00 ,  C08J3/24 ,  C08J5/04

CPC classification number: D04H1/587 ,  B29C39/003 ,  C03B37/04 ,  C08J5/24 ,  C08J2303/02 ,  C08J2303/04 ,  C08K5/0025 ,  C08L1/02 ,  C08L3/04 ,  C08L23/00 ,  C08L33/08 ,  C08L61/24 ,  C08L67/00 ,  C08L77/00 ,  C08L77/02 ,  C08L89/00 ,  C08L97/02 ,  C08L2205/16 ,  C08L2205/18 ,  C09J103/04 ,  C09J161/24 ,  Y10T442/2992 ,  C08K7/04 ,  C08K7/14

Abstract: A curable aqueous binder composition comprising sheared or extruded cross linked starch particles and a crosslinking agent for use in the formation of composite materials such as mineral, natural organic or synthetic fibre products including mineral fibre insulation, non-woven mats, fibreglass insulation and related glass fibre products as well as wood based products and construction materials. In one application the curable aqueous starch binder composition may be blended with a second non-formaldehyde resin to make fibreglass insulation. In another application the curable aqueous starch binder composition may be mixed into a formaldehyde based resin to make fibreglass roof shingles.

Abstract translation: 一种可固化水性粘合剂组合物，其包含剪切或挤出的交联淀粉颗粒和用于形成复合材料的交联剂，例如矿物，天然有机或合成纤维产品，包括矿物纤维绝缘层，无纺布垫，玻璃纤维绝缘层和相关玻璃 纤维制品以及木制品和建筑材料。 在一个应用中，可固化水性淀粉粘合剂组合物可与第二非甲醛树脂共混以制备玻璃纤维绝缘体。 在另一个应用中，可固化水性淀粉粘合剂组合物可以混合成甲醛基树脂以制造玻璃纤维屋顶瓦。

公开(公告)号：WO2011084692A1

公开(公告)日：2011-07-14

申请号：PCT/US2010/061052

申请日：2010-12-17

Applicant: ECOSYNTHETIX INC. ,  BLOEMBERGEN, Steven

Inventor： BLOEMBERGEN, Steven

IPC: C08J3/12 ,  C08L3/02

CPC classification number: D21H19/54 ,  B41J2/2107 ,  C09D103/02 ,  C09D109/04 ,  C09D109/08 ,  D21H17/28 ,  D21H19/48 ,  Y10T428/25

Abstract: The invention therefore provides a method of improving print performance in a paper product comprising applying a coating composition comprising (i) a pigment and (ii) a starch dispersion of discrete crosslinked native starch particles in an aqueous liquid, wherein the particle size of the starch particles in the starch dispersion ranges from about 40 nm to about 400μm, to the paper product, wherein the print performance of the paper product is improved. In one embodiment, the coating composition comprises a solids content of from 5 to about 75% weight and comprises (i) about 100 parts by weight of pigment, and (ii) about 1 to about 300 parts by weight of starch, all based on dry weight.

Abstract translation: 因此，本发明提供了一种提高纸产品印刷性能的方法，包括涂覆涂料组合物，其包含（i）颜料和（ii）离散交联天然淀粉颗粒的淀粉分散体在水性液体中，其中淀粉的粒度 淀粉分散体中的颗粒的范围为约40nm至约400μm，其中纸产品的印刷性能得到改善。 在一个实施方案中，涂料组合物包含5至约75重量％的固体含量，并且包含（i）约100重量份的颜料，和（ii）约1至约300重量份的淀粉，全部基于 净重。