公开(公告)号：WO2010047818A1

公开(公告)日：2010-04-29

申请号：PCT/US2009/005772

申请日：2009-10-22

Applicant: MIRAMAR LABS, INC. ,  KIM, Steven ,  FRANCIS, Daniel ,  JOHNSON, Jessi, E. ,  SALAMINI, Alexey ,  SU, Ted ,  CHUNG, Dong, Hoon ,  BEN-HAIM, Yoav ,  LOEW, Christopher ,  KOPELOW, Leo ,  CHEW, Sunmi

Inventor： KIM, Steven ,  FRANCIS, Daniel ,  JOHNSON, Jessi, E. ,  SALAMINI, Alexey ,  SU, Ted ,  CHUNG, Dong, Hoon ,  BEN-HAIM, Yoav ,  LOEW, Christopher ,  KOPELOW, Leo ,  CHEW, Sunmi

IPC: A61H1/00

CPC classification number: A61B18/18 ,  A61B18/1815 ,  A61B2017/00115 ,  A61B2017/00199 ,  A61B2017/00477 ,  A61B2017/306 ,  A61B2018/00023 ,  A61B2018/00702 ,  A61B2018/183 ,  A61B2034/252 ,  A61B2034/254 ,  A61B2090/372 ,  A61H9/0057 ,  A61N5/02

Abstract: A system applies, in a non- invasive manner, energy to a targeted tissue region employing a controlled source of energy, a multiple use applicator, and a single use, applicator- tissue interface carried by the applicator. The system can generate and apply energy in a controlled fashion to form a predefined pattern of lesions that provide therapeutic benefit, e.g., to moderate or interrupt function of the sweat glands in the underarm (axilla).

Abstract translation: 系统以非侵入性的方式将能量应用于使用受控的能量源，多用途施用器和由施用器承载的单次使用的施用器 - 组织界面的目标组织区域。 该系统可以以受控的方式产生和施加能量，以形成提供治疗益处的预定模式的病变，例如在腋下（腋窝）中的汗腺的中度或中断功能。

公开(公告)号：WO03052107A9

公开(公告)日：2004-06-03

申请号：PCT/KR0202279

申请日：2002-12-06

Applicant: SAMCHULLY PHARM CO LTD ,  CHUNG DONG-HOON ,  SONG SEONG-WON ,  SEONG DONG-HO ,  KIM MOON-HEE

Inventor： CHUNG DONG-HOON ,  SONG SEONG-WON ,  SEONG DONG-HO ,  KIM MOON-HEE

IPC: C12N15/70

CPC classification number: C12N15/70

Abstract: The present invention relates to an expression vector comprising a promoter that consists of FIS binding sites, an UP element and a core promoter. Also, the inventive expression vector may additionally comprise and FIS gene, which is regulated by an inducible promoter. The inventive expression vector can maximize the expression level of a target protein of foreign origin, and can use a wide range of E. coli strains as host cells regardless of the genetic characteristics of the strains. Thus, inventive expression vector is useful in industrial fields requiring the production of various proteins.

Abstract translation: 本发明涉及包含由FIS结合位点，UP元件和核心启动子组成的启动子的表达载体。 此外，本发明的表达载体可另外包含由诱导型启动子调节的FIS基因。 本发明的表达载体可以使外来来源的靶蛋白的表达水平最大化，并且可以使用广泛的大肠杆菌菌株作为宿主细胞，而不考虑菌株的遗传特征。 因此，本发明的表达载体可用于需要生产各种蛋白质的工业领域。

公开(公告)号：WO2010096840A3

公开(公告)日：2011-01-20

申请号：PCT/US2010025124

申请日：2010-02-23

Applicant: MIRAMAR LABS INC ,  KIM STEVEN ,  FRANCIS DANIEL ,  JOHNSON JESSI E ,  SALAMINI ALEXEY ,  SU TED ,  CHUNG DONG HOON ,  BEN-HAIM YOAV ,  LOEW CHRISTOPHER

Inventor： KIM STEVEN ,  FRANCIS DANIEL ,  JOHNSON JESSI E ,  SALAMINI ALEXEY ,  SU TED ,  CHUNG DONG HOON ,  BEN-HAIM YOAV ,  LOEW CHRISTOPHER

IPC: A61H7/00 ,  A61B5/00 ,  A61B5/04 ,  A61B5/05 ,  A61M1/00

CPC classification number: A61B18/18 ,  A61B18/1815 ,  A61B90/98 ,  A61B2017/306 ,  A61B2018/00005 ,  A61B2090/3937 ,  A61H9/0057 ,  A61H2201/10 ,  A61H2201/1685 ,  A61N5/02 ,  A61N5/04

Abstract: An applicator-tissue interface is disclosed for use in connection with medical device treatment applicators. The interface provides a cover to protect applicator components against contamination and may be disposable or reusable. Also included are tissue acquisition features including a tissue receiving chamber defined by a bio-barrier with vacuum ports or channels for tissue acquisition. Vacuum balancing is provided to prevent contamination on the applicator side of the bio-barrier. Locking mechanisms are disclosed for ensuring secure attachment between the interface and applicator. Methods of using the applicator-tissue interface in connection with an applicator are also disclosed.

Abstract translation: 公开了一种与医疗器械治疗敷料器结合使用的涂抹器 - 组织界面。 界面提供了一个保护涂料组件免受污染的盖子，可以是一次性的或可重复使用的。 还包括组织采集特征，包括由具有用于组织采集的真空端口或通道的生物屏障限定的组织接收室。 提供真空平衡以防止生物屏障的施用器侧的污染。 公开了锁定机构以确保接口和施加器之间的牢固连接。 还公开了与施用器相关地使用施用器 - 组织界面的方法。

公开(公告)号：WO1998017663A1

公开(公告)日：1998-04-30

申请号：PCT/KR1997000188

申请日：1997-10-08

Applicant: CHOONGWAE PHARMA CORPORATION ,  MOON, Sung, Hwan ,  CHOI, Hea, Jin ,  LEE, Su, Jin ,  CHUNG, Jea, Uk ,  KIM, Jai, Hyun ,  CHUNG, Dong, Hoon ,  PARK, Moon, Soo ,  CHO, In, Koo ,  CHOI, Kun, Hyock

Inventor： CHOONGWAE PHARMA CORPORATION

IPC: C07D311/94

CPC classification number: C07D311/94

Abstract: The present invention relates to a novel genipin derivative represented by formula (I), which has anti hepatitis B virus (HBV) activity, in which R1 represents lower alkyl, benzyl, etc., R2 represents hydroxymethyl, formyl, acetyl, etc., R3 represents methoxycarbonyl, formyl, etc., its pharmaceutically acceptable salt, and stereoisomer.

Abstract translation: 本发明涉及具有抗乙型肝炎病毒（HBV）活性的式（I）表示的新型京尼平衍生物，其中R1表示低级烷基，苄基等，R2表示羟甲基，甲酰基，乙酰基等， R3表示甲氧基羰基，甲酰基等，其药学上可接受的盐和立体异构体。

公开(公告)号：WO2010096840A2

公开(公告)日：2010-08-26

申请号：PCT/US2010/025124

申请日：2010-02-23

Applicant: MIRAMAR LABS, INC. ,  KIM, Steven ,  FRANCIS, Daniel ,  JOHNSON, Jessi, E. ,  SALAMINI, Alexey ,  SU, Ted ,  CHUNG, Dong, Hoon ,  BEN-HAIM, Yoav ,  LOEW, Christopher

Inventor： KIM, Steven ,  FRANCIS, Daniel ,  JOHNSON, Jessi, E. ,  SALAMINI, Alexey ,  SU, Ted ,  CHUNG, Dong, Hoon ,  BEN-HAIM, Yoav ,  LOEW, Christopher

IPC: A61H7/00 ,  A61M1/00 ,  A61B5/00 ,  A61B5/04 ,  A61B5/05

CPC classification number: A61B18/18 ,  A61B18/1815 ,  A61B90/98 ,  A61B2017/306 ,  A61B2018/00005 ,  A61B2090/3937 ,  A61H9/0057 ,  A61H2201/10 ,  A61H2201/1685 ,  A61N5/02 ,  A61N5/04

Abstract: An applicator-tissue interface is disclosed for use in connection with medical device treatment applicators. The interface provides a cover to protect applicator components against contamination and may be disposable or reusable. Also included are tissue acquisition features including a tissue receiving chamber defined by a bio-barrier with vacuum ports or channels for tissue acquisition. Vacuum balancing is provided to prevent contamination on the applicator side of the bio-barrier. Locking mechanisms are disclosed for ensuring secure attachment between the interface and applicator. Methods of using the applicator-tissue interface in connection with an applicator are also disclosed.

Abstract translation: 公开了一种与医疗器械治疗敷料器结合使用的涂抹器 - 组织界面。 界面提供了一个保护涂料组件免受污染的盖子，可以是一次性的或可重复使用的。 还包括组织采集特征，包括由具有用于组织采集的真空端口或通道的生物屏障限定的组织接收室。 提供真空平衡以防止生物屏障的施用器侧的污染。 公开了锁定机构以确保接口和施加器之间的牢固连接。 还公开了与施用器相关地使用施用器 - 组织界面的方法。

公开(公告)号：WO2003052107A1

公开(公告)日：2003-06-26

申请号：PCT/KR2002/002279

申请日：2002-12-06

Applicant: SAMCHULLY PHARM CO., LTD. ,  CHUNG, Dong-Hoon ,  SONG, Seong-Won ,  SEONG, Dong-Ho ,  KIM, Moon-Hee

Inventor： CHUNG, Dong-Hoon ,  SONG, Seong-Won ,  SEONG, Dong-Ho ,  KIM, Moon-Hee

IPC: C12N15/70

CPC classification number: C12N15/70

Abstract: The present invention relates to an expression vector comprising a promoter that consists of FIS binding sites, an UP element and a core promoter. Also, the inventive expression vector may additionally comprise and FIS gene, which is regulated by an inducible promoter. The inventive expression vector can maximize the expression level of a target protein of foreign origin, and can use a wide range of E. coli strains as host cells regardless of the genetic characteristics of the strains. Thus, inventive expression vector is useful in industrial fields requiring the production of various proteins.

Abstract translation: 本发明涉及包含由FIS结合位点，UP元件和核心启动子组成的启动子的表达载体。 此外，本发明的表达载体可另外包含由诱导型启动子调节的FIS基因。 本发明的表达载体可以使外来来源的靶蛋白的表达水平最大化，并且可以使用广泛的大肠杆菌菌株作为宿主细胞，而不考虑菌株的遗传特征。 因此，本发明的表达载体可用于需要生产各种蛋白质的工业领域。