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    LIQUID CONTAINMENT FOR INTEGRATED ASSAYS
    2.
    发明申请
    LIQUID CONTAINMENT FOR INTEGRATED ASSAYS 审中-公开

    公开(公告)号：WO2009038628A3

    公开(公告)日：2009-03-26

    申请号：PCT/US2008/010022

    申请日：2008-08-22

    Applicant: CLAROS DIAGNOSTICS, INC. ,  LINDER, Vincent ,  STEINMILLER, David ,  TAYLOR, Jason

    Inventor： LINDER, Vincent ,  STEINMILLER, David ,  TAYLOR, Jason

    IPC: B01L3/00

    Abstract: Microfluidic systems including liquid containment regions (1206) and methods associated therewith for performing chemical, biological, or biochemical analyses are provided. Liquid containment regions (1206) of a microfluidic device may include regions that capture one or more liquids flowing in the device, while allowing gases or other fluids in the device to pass through the region. This may be achieved, in some embodiments, by positioning one or more absorbent materials (1208) in the liquid containment region (1206) for absorbing the liquids. This configuration may be useful for removing air bubbles from a stream of fluid and/or for separating hydrophobic liquids from hydrophilic liquids. In certain embodiments, the liquid containment region (1206) prevents any liquid from passing through the region. In some such cases, the liquid containment region may act as a waste area by capturing substantially all of the liquid in the device, thereby preventing any liquid from exiting the device. This arrangement may be useful when the device is used. as a diagnostic tool, as the liquid containment region may prevent a user from being exposed to potentially-harmful fluids in the device.

    FLUIDIC CONNECTORS AND MICROFLUIDIC SYSTEMS
    3.
    发明申请
    FLUIDIC CONNECTORS AND MICROFLUIDIC SYSTEMS 审中-公开

    公开(公告)号：WO2008137008A3

    公开(公告)日：2008-11-13

    申请号：PCT/US2008/005577

    申请日：2008-05-01

    Applicant: CLAROS DIAGNOSTICS, INC. ,  LINDER, Vincent ,  STEINMILLER, David ,  SIA, Samuel, K.

    Inventor： LINDER, Vincent ,  STEINMILLER, David ,  SIA, Samuel, K.

    IPC: B01L3/00

    Abstract: Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use. Prior to connection of the fluid connector and the substrate, the fluid path may be filled with a sample (e.g., blood). The sample may be obtained, for example, by pricking a finger of a user until blood is drawn from the finger into the fluid path (e.g., by capillary forces). Upon connection of the fluidic connector and the channels of the substrate, the sample can pass through a reaction area within the first channel of the substrate. This process can allow components of the sample to interact with components disposed in the reaction area. Afterwards, reagents from the second channel can flow to the reaction area via the fluid path, allowing components in the reaction area to be processed (e.g., amplified to produce detectable signal). Components in the reaction area can then be determined using various methods of detection.

    STRUCTURES FOR CONTROLLING LIGHT INTERACTION WITH MICROFLUIDIC DEVICES
    4.
    发明申请
    STRUCTURES FOR CONTROLLING LIGHT INTERACTION WITH MICROFLUIDIC DEVICES 审中-公开
    用于控制与微流体装置的轻微相互作用的结构

    公开(公告)号：WO2010087999A1

    公开(公告)日：2010-08-05

    申请号：PCT/US2010/000286

    申请日：2010-02-02

    Applicant: CLAROS DIAGNOSTICS, INC. ,  STEINMILLER, David ,  LINDER, Vincent

    Inventor： STEINMILLER, David ,  LINDER, Vincent

    IPC: B01L3/00 ,  G01N21/03 ,  G01N21/05

    CPC classification number: B01L3/502707 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/12 ,  B01L2300/04 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0861 ,  B01L2300/12 ,  C12Y304/21077 ,  G01N21/0303 ,  G01N21/59 ,  G01N33/53 ,  G01N33/54366 ,  G01N33/54373 ,  G01N33/545 ,  G01N33/57488 ,  G01N2333/96455 ,  Y10T436/11

    Abstract: Systems and methods for improved measurement of absorbance/transmission through fluidic systems are described. Specifically, in one set of embodiments, optical elements are fabricated on one side of a transparent fluidic device opposite a series of fluidic channels. The optical elements may guide incident light passing through the device such that most of the light is dispersed away from specific areas of the device, such as intervening portions between the fluidic channels. By decreasing the amount of light incident upon these intervening portions, the amount of noise in the detection signal can be decreased when using certain optical detection systems. In some embodiments, the optical elements comprise triangular grooves formed on or in a surface of the device. The draft angle of the triangular grooves may be chosen such that incident light normal to the surface of the device is redirected at an angle dependent upon the indices of refraction of the external medium (e.g., air) and the device material. Advantageously, certain optical elements described herein may be fabricated along with the fluidic channels of the device in one step, thereby reducing the costs of fabrication. Furthermore, in some cases the optical elements do not require alignment with a detector and, therefore, facilitate assembly and/or use by an end user.

    Abstract translation: 描述了通过流体系统改善吸光度/透射测量的系统和方法。 具体来说，在一组实施例中，在与一系列流体通道相对的透明流体装置的一侧上制造光学元件。 光学元件可以引导通过设备的入射光，使得大多数光从设备的特定区域分散，例如流体通道之间的中间部分。 通过减少入射到这些中间部分的光量，当使用某些光学检测系统时，可以减少检测信号中的噪声量。 在一些实施例中，光学元件包括形成在设备的表面上或表面上的三角形凹槽。 可以选择三角形凹槽的拔模角使得垂直于装置表面的入射光以取决于外部介质（例如空气）和装置材料的折射率的角度被重定向。 有利地，本文所述的某些光学元件可以在一个步骤中与装置的流体通道一起制造，从而降低制造成本。 此外，在一些情况下，光学元件不需要与检测器对准，因此便于最终用户的组装和/或使用。

    IMPROVED REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND METHODS
    5.
    发明申请
    IMPROVED REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND METHODS 审中-公开
    微生物系统中改进的试剂储存和相关文章和方法

    公开(公告)号：WO2010080115A2

    公开(公告)日：2010-07-15

    申请号：PCT/US2009/006596

    申请日：2009-12-17

    Applicant: CLAROS DIAGNOSTICS, INC. ,  TAYLOR, Jason ,  LINDER, Vincent

    Inventor： TAYLOR, Jason ,  LINDER, Vincent

    IPC: B01L3/00 ,  B81C1/00

    CPC classification number: B01L3/5027 ,  B01L3/527 ,  B01L3/561 ,  B01L2200/0673 ,  B01L2200/12 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/069 ,  B01L2300/0809 ,  B01L2300/0874 ,  B01L2300/0883 ,  B01L2300/161 ,  B01L2400/0487

    Abstract: Fluidic devices and methods including those that provide storage and/or facilitate fluid handling of reagents are provided. Fluidic devices described herein may include channel segments positioned on two sides of an article, optionally connected by an intervening channel passing through the article. The channel segments may be used to store reagents in the device prior to first use by an end user. The stored reagents may include fluid plugs positioned in linear order so that during use, as fluids flow to a reaction site, they are delivered in a predetermined sequence. The specific geometries of the channel segments and the positions of the channel segments within the fluidic devices described herein may allow fluid reagents to be stored for extended periods of time without mixing, even during routine handling of the devices such as during shipping of the devices, and when the devices are subjected to physical shock or vibration.

    Abstract translation: 提供了流体装置和方法，包括提供储存和/或促进试剂的流体处理的流体装置和方法。 本文描述的流体装置可以包括定位在制品两侧的通道段，可选地通过穿过物品的居间通道连接。 通道段可以用于在终端用户首次使用之前将试剂存储在设备中。 储存的试剂可以包括以线性顺序定位的流体塞，使得在使用期间，当流体流到反应部位时，它们以预定的顺序递送。 通道段的特定几何形状和本文所述的流体装置内的通道段的位置可以允许流体试剂在不混合的情况下长时间储存​​，即使在设备的例行处理期间，例如装置运输期间， 并且当设备遭受物理冲击或振动时。

    IMPROVED REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND METHODS
    6.
    发明申请
    IMPROVED REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND METHODS 审中-公开
    微流控系统中改进的试剂存储及相关物品和方法

    公开(公告)号：WO2010080115A3

    公开(公告)日：2010-09-16

    申请号：PCT/US2009006596

    申请日：2009-12-17

    Applicant: CLAROS DIAGNOSTICS INC ,  TAYLOR JASON ,  LINDER VINCENT

    Inventor： TAYLOR JASON ,  LINDER VINCENT

    IPC: B01L3/00 ,  B81C1/00

    CPC classification number: B01L3/5027 ,  B01L3/527 ,  B01L3/561 ,  B01L2200/0673 ,  B01L2200/12 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/069 ,  B01L2300/0809 ,  B01L2300/0874 ,  B01L2300/0883 ,  B01L2300/161 ,  B01L2400/0487

    Abstract: Fluidic devices and methods including those that provide storage and/or facilitate fluid handling of reagents are provided. Fluidic devices described herein may include channel segments positioned on two sides of an article, optionally connected by an intervening channel passing through the article. The channel segments may be used to store reagents in the device prior to first use by an end user. The stored reagents may include fluid plugs positioned in linear order so that during use, as fluids flow to a reaction site, they are delivered in a predetermined sequence. The specific geometries of the channel segments and the positions of the channel segments within the fluidic devices described herein may allow fluid reagents to be stored for extended periods of time without mixing, even during routine handling of the devices such as during shipping of the devices, and when the devices are subjected to physical shock or vibration.

    Abstract translation: 提供了包括那些提供储存和/或促进试剂的流体处理的流体装置和方法。 这里描述的流体设备可以包括位于物品的两侧上的通道段，可选地通过穿过物品的中间通道连接。 通道段可以用于在最终用户首次使用之前在设备中存储试剂。 储存的试剂可以包括以线性顺序定位的流体塞，使得在使用期间，随着流体流动到反应位点，它们以预定顺序递送。 本文所述的流体装置内的通道区段的特定几何形状和通道区段的位置可以允许流体试剂长时间储存​​而不会混合，即使在装置的常规处理期间，例如在装置运输期间， 以及设备遭受物理冲击或振动时。

    FLUID MIXING AND DELIVERY IN MICROFLUIDIC SYSTEMS
    8.
    发明申请
    FLUID MIXING AND DELIVERY IN MICROFLUIDIC SYSTEMS 审中-公开
    流体系统中的流体混合和输送

    公开(公告)号：WO2011066361A1

    公开(公告)日：2011-06-03

    申请号：PCT/US2010/057969

    申请日：2010-11-24

    Applicant: CLAROS DIAGNOSTICS, INC. ,  TAN, Enqing ,  LINDER, Vincent ,  TAYLOR, Jason ,  STEINMILLER, David

    Inventor： TAN, Enqing ,  LINDER, Vincent ,  TAYLOR, Jason ,  STEINMILLER, David

    IPC: B01L3/00

    CPC classification number: B01L3/502723 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2400/0487 ,  B01L2400/0694 ,  G01N33/54366 ,  Y10T137/0318 ,  Y10T137/0329 ,  Y10T137/86292 ,  Y10T137/87652

    Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.

    Abstract translation: 本说明书通常公开了用于在微流体系统中混合和输送流体的系统和方法。 在一些实施方案中，流体可包含可参与一种或多种化学或生物反应的试剂。 一些实施例涉及采用一个或多个排气阀以可控地流动和/或混合微流体系统内的流体的部分的系统和方法。 有利地，可以通过打开和关闭一个或多个排气阀并且​​通过施加在一个或多个排气阀上操作的单个流体流（例如真空）来实现诸如流体流动序列和/或流速变化的流体控制 基本恒定的压力。 这可以简化预期用户对设备的操作和使用。

    FLOW CONTROL IN MICROFLUIDIC SYSTEMS
    9.
    发明申请
    FLOW CONTROL IN MICROFLUIDIC SYSTEMS 审中-公开
    微流控系统流量控制

    公开(公告)号：WO2009131677A1

    公开(公告)日：2009-10-29

    申请号：PCT/US2009/002496

    申请日：2009-04-22

    Applicant: CLAROS DIAGNOSTICS, INC. ,  LINDER, Vincent ,  STEINMILLER, David

    Inventor： LINDER, Vincent ,  STEINMILLER, David

    IPC: B01L3/00

    CPC classification number: B01L3/502746 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2200/12 ,  B01L2400/0487 ,  B01L2400/082 ,  B01L2400/084 ,  Y10T137/0318 ,  Y10T137/0324

    Abstract: Microfluidic systems and methods including those that provide control of fluid flow are provided. Such systems and methods can be used, for example, to control pressure-driven flow based on the influence of channel geometry and the viscosity of one or more fluids inside the system. One method includes flowing a plug of a low viscosity fluid and a plug of a high viscosity fluid in a channel including a flow constriction region and a non-constriction region. In one embodiment, the low viscosity fluid flows at a first flow rate in the channel and the flow rate is not substantially affected by the flow constriction region. When the high viscosity fluid flows from the non-constriction region to the flow constriction region, the flow rates of the fluids decrease substantially, since the flow rates, in some systems, are influenced by the highest viscosity fluid flowing in the smallest cross-sectional area of the system (e.g., the flow constriction region). This causes the fluids to flow at the same flow rate at which the high viscosity fluid flows in the flow constriction region. Accordingly, by designing microfluidic systems with flow constriction regions positioned at particular locations and by choosing appropriate viscosities of fluids, a fluid can be made to speed up or slow down at different locations within the system without the use of valves and/or without external control.

    Abstract translation: 提供了微流体系统和包括提供流体流动控制的方法。 这样的系统和方法可以用于例如基于通道几何形状的影响和系统内的一种或多种流体的粘度来控制压力驱动流。 一种方法包括将低粘度流体塞和高粘度流体的塞子流入包括流动收缩区域和非收缩区域的通道中。 在一个实施例中，低粘度流体在通道中以第一流速流动，并且流速基本上不受流动收缩区域的影响。 当高粘度流体从非收缩区域流动到流动收缩区域时，流体的流速基本上降低，因为在一些系统中的流速受到最小横截面中流动的最高粘度流体的影响 系统的区域（例如，流动收缩区域）。 这导致流体以高粘度流体在流动收缩区域中流动的相同流速流动。 因此，通过设计具有定位在特定位置处的流动收缩区域并通过选择流体的适当粘度的微流体系统，可以使流体在不使用阀和/或不进行外部控制的情况下在系统内的不同位置加速或减慢 。

    LIQUID CONTAINMENT FOR INTEGRATED ASSAYS
    10.
    发明申请
    LIQUID CONTAINMENT FOR INTEGRATED ASSAYS 审中-公开
    用于集成测定的液体容器

    公开(公告)号：WO2009038628A2

    公开(公告)日：2009-03-26

    申请号：PCT/US2008010022

    申请日：2008-08-22

    Applicant: CLAROS DIAGNOSTICS INC ,  LINDER VINCENT ,  STEINMILLER DAVID ,  TAYLOR JASON

    Inventor： LINDER VINCENT ,  STEINMILLER DAVID ,  TAYLOR JASON

    IPC: B01L3/00

    CPC classification number: A61L2/0082 ,  B01L3/502715 ,  B01L3/502784 ,  B01L2200/025 ,  B01L2200/0673 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0487

    Abstract: Microfluidic systems including liquid containment regions and methods associated therewith for performing chemical, biological, or biochemical analyses are provided. Liquid containment regions of a microfluidic device may include regions that capture one or more liquids flowing in the device, while allowing gases or other fluids in the device to pass through the region. This may be achieved, in some embodiments, by positioning one or more absorbent materials in the liquid containment region for absorbing the liquids. This configuration may be useful for removing air bubbles from a stream of fluid and/or for separating hydrophobic liquids from hydrophilic liquids. In certain embodiments, the liquid containment region prevents any liquid from passing through the region. In some such cases, the liquid containment region may act as a waste area by capturing substantially all of the liquid in the device, thereby preventing any liquid from exiting the device. This arrangement may be useful when the device is used as a diagnostic tool, as the liquid containment region may prevent a user from being exposed to potentially-harmful fluids in the device.

    Abstract translation: 提供了包括液体容纳区域的微流体系统和与其相关的用于进行化学，生物或生化分析的方法。 微流体装置的液体容纳区域可以包括捕获在装置中流动的一种或多种液体的区域，同时允许装置中的气体或其它流体通过该区域。 这在一些实施例中可以通过将液体容纳区域中的一种或多种吸收材料定位以吸收液体来实现。 这种构造可用于从流体流中除去气泡和/或用于将疏水性液体与亲水性液体分离。 在某些实施例中，液体容纳区域防止任何液体通过该区域。 在一些这样的情况下，液体容纳区域可以通过捕获装置中的基本上所有的液体而作为废物区域，从而防止任何液体离开装置。 当装置用作诊断工具时，这种布置可能是有用的，因为液体容纳区域可以防止使用者暴露于装置中潜在有害的流体。

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