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    CONTINUOUS FLOW-THROUGH PERITONEAL DIALYSIS (CFPD) METHOD WITH CONTROL OF INTRAPERITONEAL PRESSURE
    2.
    发明申请
    CONTINUOUS FLOW-THROUGH PERITONEAL DIALYSIS (CFPD) METHOD WITH CONTROL OF INTRAPERITONEAL PRESSURE 审中-公开
    连续流量通过腹膜透析（CFPD）方法控制腹膜内压

    公开(公告)号：WO9817333A2

    公开(公告)日：1998-04-30

    申请号：PCT/US9719489

    申请日：1997-10-22

    申请人： HEMOCLEANSE INC ,  ASH STEPHEN R

    发明人： ASH STEPHEN R

    IPC分类号： A61M1/16 ,  A61M1/28 ,  A61M1/34 ,  A61M

    CPC分类号： A61M1/28 ,  A61M1/1696 ,  A61M1/281 ,  A61M1/284 ,  A61M1/285 ,  A61M1/32 ,  A61M1/3489

    摘要： The present invention relates generally to advantageous devices and methods for treating patients suffering from renal insufficiency and/or hepatic insufficiency. More particularly, the invention relates in certain aspects to devices and methods for performing continuous flow-through peritoneal dialysis (CFPD). In other aspects of the invention, peritoneal dialysis systems are provided which utilizes a bioreactor to regenerate peritoneal fluid for re-infusion into a peritoneal cavity. The invention, therefore, provides advantageous systems for passing fluid through a patient's peritoneal cavity at a relatively high flow rate, while maintaining in the peritoneal cavity an optimal dialysate pressure, to thereby alter the contents of the patient's blood by diffusion of molecules through the peritoneal membrane.

    摘要翻译： 本发明一般涉及用于治疗患有肾功能不全和/或肝功能不全的患者的有利的装置和方法。 更具体地，本发明在某些方面涉及用于进行连续流通腹膜透析（CFPD）的装置和方法。 在本发明的其它方面，提供腹膜透析系统，其利用生物反应器再生腹膜液以重新输注到腹膜腔中。 因此，本发明提供了一种有利的系统，用于以相当高的流速将流体通过患者的腹膜腔，同时在腹膜腔中保持最佳的透析液压力，从而通过扩散分子通过腹膜来改变患者血液的内容物 膜。

    METHOD FOR IRON DELIVERY TO A PATIENT BY TRANSFER FROM DIALYSATE
    3.
    发明申请
    METHOD FOR IRON DELIVERY TO A PATIENT BY TRANSFER FROM DIALYSATE 审中-公开
    通过从DIALYSATE转移给患者的铁递送方法

    公开(公告)号：WO1998006482A1

    公开(公告)日：1998-02-19

    申请号：PCT/US1997014232

    申请日：1997-08-13

    申请人： HEMOCLEANSE, INC. ,  ASH, Stephen, R.

    发明人： HEMOCLEANSE, INC.

    IPC分类号： B01D61/00

    CPC分类号： A61M1/1654 ,  A61K33/26 ,  A61M1/287 ,  Y10S514/814

    摘要： The invention relates to methods and compositions for delivering iron to an iron-deficient patient, more particularly, to methods whereby an iron complex comprising divalent or trivalent ionic iron complexed with one or more low molecular weight anions is administered to a patient by transfer from dialysate. A complex selected according to the invention is non-polymeric; soluble in an aqueous medium; chemically stable, thereby preventing the dissociation of iron ions from the anions under conditions according to the invention; and can be well absorbed into blood and the living body. Also provided are dialysate compositions including therein an iron complex selected according to the invention, and dialysate concentrates which may be diluted to yield an inventive dialysate composition.

    摘要翻译： 本发明涉及用于将铁递送到缺铁患者的方法和组合物，更具体地涉及一种方法，其中通过从透析液转移向患者施用包含与一种或多种低分子量阴离子络合的二价或三价离子铁的铁络合物 。 根据本发明选择的络合物是非聚合物; 溶于水介质; 化学稳定，从而防止在根据本发明的条件下铁离子与阴离子的离解; 并可以很好的吸收血液和活体。 还提供了包含其中根据本发明选择的铁络合物的透析液组合物和可以稀释以产生本发明透析液组合物的透析液浓缩物。

    HEMOFILTRATION AND PLASMAFILTRATION DEVICES AND METHODS
    5.
    发明申请
    HEMOFILTRATION AND PLASMAFILTRATION DEVICES AND METHODS 审中-公开

    公开(公告)号：WO1995018671A1

    公开(公告)日：1995-07-13

    申请号：PCT/US1995000395

    申请日：1995-01-11

    申请人： HEMOCLEANSE, INC.

    发明人： HEMOCLEANSE, INC. ,  ASH, Stephen, R.

    IPC分类号： B01D61/00

    CPC分类号： B01D63/16 ,  A61M1/10 ,  A61M1/1005 ,  A61M1/1006 ,  A61M1/1062 ,  A61M1/1086 ,  A61M1/1627 ,  A61M1/1643 ,  A61M1/1649 ,  A61M1/1692 ,  A61M1/1696 ,  A61M1/26 ,  A61M1/267 ,  A61M1/30 ,  A61M1/304 ,  A61M1/308 ,  A61M1/3417 ,  A61M1/3427 ,  A61M1/3431 ,  A61M1/3458 ,  A61M1/3472 ,  A61M1/3475 ,  A61M1/3493 ,  A61M2205/12 ,  A61M2205/7563 ,  B01D61/00 ,  B01D61/145 ,  B01D61/243 ,  B01D61/58 ,  B01D65/08 ,  B01D2321/2066 ,  B01D2321/2083

    摘要： Devices and methods for providing extracorporeal treatment of blood for effective plasmafiltration or hemofiltration are disclosed. The device incorporates a hollow fiber membrane device (HFD) connected in series with a parallel plate dialyzer (PPD). Sorbent suspension from a sorbent bag (101) first passes through the sorbent inlet (102) of the PPD, exits through sorbent outlet (103), is drawn into accumulator reservoir (104), is expelled from accumulator reservoir (104) and passes through check valve (105) in response to alternating positive pressure and negative pressure applied to the accumulator reservoir (104). The sorbent suspension then passes into HFD inlet (106) and through the outer chamber of the HFD, thus agitating and mixing the sorbent suspension into contact with exterior surfaces of the hollow fibers (107) in the HFD. Sorbent suspension exits the HFD from outlet (108) and passes through blood leak detector (109) and back into the sorbent bag (101).

    摘要翻译： 公开了用于提供血液体外处理用于有效等离子体过滤或血液滤过的装置和方法。 该装置包括与平行板式透析器（PPD）串联连接的中空纤维膜装置（HFD）。 来自吸附剂袋（101）的吸附剂悬浮液首先通过PPD的吸附剂入口（102），通过吸附剂出口（103）离开，被吸入蓄能器储存器（104），从蓄液器储存器（104）排出并通过 响应于施加到蓄能器储存器（104）的交替正压和负压，止回阀（105）。 吸附剂悬浮液然后进入HFD入口（106）并通过HFD的外部室，从而搅拌和混合吸附剂悬浮液与HFD中的中空纤维（107）的外表面接触。 吸附剂悬浮液从出口（108）离开HFD并通过血液泄漏检测器（109）并返回到吸附袋（101）中。