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公开(公告)号：WO2009156045A2
公开(公告)日：2009-12-30
申请号：PCT/EP2009/003908
申请日：2009-06-02
Applicant: BOEHRINGER INGELHEIM MICROPARTS GMBH , KUROWSKI, Dirk , HEMPEL, Mario , BLANKENSTEIN, Gert , RODENFELS, Tobias
Inventor： KUROWSKI, Dirk , HEMPEL, Mario , BLANKENSTEIN, Gert , RODENFELS, Tobias
CPC classification number: F16K99/0001 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/0689 , B01L2300/0887 , B01L2400/0406 , B01L2400/0442 , B01L2400/0638 , B01L2400/0688 , B01L2400/082 , B29C65/18 , B29C66/1122 , B29C66/328 , B29C66/53461 , B29C66/71 , B29C66/723 , B29C66/81419 , B29C66/81422 , B29C66/8181 , B29C66/8322 , B29L2031/756 , F04B43/043 , B29K2021/003 , B29K2023/00 , B29K2023/06 , B29K2023/08 , B29K2023/083 , B29K2023/12 , B29K2023/14 , B29K2023/16 , B29K2027/18 , B29K2033/08 , B29K2077/00
Abstract: The invention relates to a microfluidic device for metering liquids into a microfluidic network. The microfluidic channels or chambers are at least partly formed by the introduction of suitable structures into a film above the substrate carrier, so that at least some of the flow of fluid through the network takes place above the plane of the substrate. In order to form a stable channel structure or chamber structure in the film, it is envisaged that in the edge zone between the unattached and attached portions a wedge of material is formed by the viscous flow of the film material as the film is bonded to the substrate, this wedge forming a transition between the chamber wall and the substrate and raising the chamber wall above the plane of the substrate. In one method of producing a finished microfluidic structure a flat planar film is laminated onto a flat sheet-like substrate. During the lamination a mask having at least one recess or opening is pressed onto the film and onto the substrate under pressure and/or under the effect of heat. The film is thereby brought to a temperature at which there is a viscous flow of film and/or substrate medium into the region of the recess or opening, so that a wedge of material is formed and the film bulges up in the region of the recess to form a chamber. The invention further relates to methods of metering at least one liquid in a microfluidic network, in which a capillary stop is overcome by actuating the film, the film being wetted as the capillary stop is removed.
Abstract translation: 本发明涉及用于将液体计量到微流控网络中的微流体装置。 微流体通道或室至少部分地通过将合适的结构引入到衬底载体上方的膜中而形成，使得通过网络的流体中的至少一些流动发生在衬底的平面之上。 为了在膜中形成稳定的通道结构或腔室结构，设想在未连接和附接部分之间的边缘区域中，当膜粘合到膜材料上时，由材料的粘性流形成楔形材料 衬底，该楔形件形成在室壁和衬底之间的过渡部分，并且使腔壁在衬底的平面上方升高。 在制造成品微流体结构的一种方法中，将平坦的平面薄膜层压在平板状基片上。 在层压期间，具有至少一个凹部或开口的掩模在压力和/或受热的作用下被压在膜上和衬底上。 因此，膜被带到膜和/或基底介质粘性流入凹部或开口的区域的温度，使得形成楔形材料，并且膜在凹部的区域中凸起 形成一个房间。 本发明还涉及在微流体网络中计量至少一种液体的方法，其中通过致动膜来克服毛细管阻挡物，当除去毛细管停止物时，膜被润湿。
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Patent Agency Ranking
公开(公告)号：WO2007093443A3
公开(公告)日：2007-12-06
申请号：PCT/EP2007001409
申请日：2007-02-19
Applicant: BOEHRINGER INGELHEIM MICROPART , HEMPEL MARIO , STOETERS WOLFGANG , PETERS RALF-PETER , HOLAKOVSKY HOLGER
Inventor： HEMPEL MARIO , STOETERS WOLFGANG , PETERS RALF-PETER , HOLAKOVSKY HOLGER
CPC classification number: B01D67/0004 , B01D19/0031 , B01D19/0036 , B01D61/00 , B01D67/0009 , B01D67/0027 , B01D67/0083 , B01D69/10 , B01D69/12 , B01D71/32 , B01D71/44 , B01D2323/46 , B01D2325/023
Abstract: A membrane structure for gas separation, a degassing device having such a membrane structure, and also method for production of the same are proposed. A porous carrier layer is joined flat to a thin polymer membrane, in particular made of amorphous PTFE. In particular, the polymer membrane is produced on or from the carrier layer. This makes possible a simple and inexpensive structure and also an effective gas separation. Particularly preferably, the polymer membrane is formed by applying a polymer solution in the liquid state to the carrier layer and drying it.
Abstract translation: 已提出了一种用于制造用于气体分离，具有这种膜结构和方法的脱泡装置的膜结构。 多孔质支持层连接平坦的薄的聚合物膜，特别是由无定形的PTFE。 具体而言，形成在或从载体层的聚合物膜。 这使得能够简单且廉价的结构和有效的气相沉积。 特别优选形成的聚合物膜在液体聚合物溶液被施加到背衬层和干燥。
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公开(公告)号：WO2009156045A4
公开(公告)日：2010-05-20
申请号：PCT/EP2009003908
申请日：2009-06-02
Applicant: BOEHRINGER INGELHEIM MICROPART , KUROWSKI DIRK , HEMPEL MARIO , BLANKENSTEIN GERT , RODENFELS TOBIAS
Inventor： KUROWSKI DIRK , HEMPEL MARIO , BLANKENSTEIN GERT , RODENFELS TOBIAS
CPC classification number: F16K99/0001 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/0689 , B01L2300/0887 , B01L2400/0406 , B01L2400/0442 , B01L2400/0638 , B01L2400/0688 , B01L2400/082 , B29C65/18 , B29C66/1122 , B29C66/328 , B29C66/53461 , B29C66/71 , B29C66/723 , B29C66/81419 , B29C66/81422 , B29C66/8181 , B29C66/8322 , B29L2031/756 , F04B43/043 , B29K2021/003 , B29K2023/00 , B29K2023/06 , B29K2023/08 , B29K2023/083 , B29K2023/12 , B29K2023/14 , B29K2023/16 , B29K2027/18 , B29K2033/08 , B29K2077/00
Abstract: The invention relates to a microfluidic device for metering liquids into a microfluidic network. The microfluidic channels or chambers are at least partly formed by the introduction of suitable structures into a film above the substrate carrier, so that at least some of the flow of fluid through the network takes place above the plane of the substrate. In order to form a stable channel structure or chamber structure in the film, it is envisaged that in the edge zone between the unattached and attached portions a wedge of material is formed by the viscous flow of the film material as the film is bonded to the substrate, this wedge forming a transition between the chamber wall and the substrate and raising the chamber wall above the plane of the substrate. In one method of producing a finished microfluidic structure a flat planar film is laminated onto a flat sheet-like substrate. During the lamination a mask having at least one recess or opening is pressed onto the film and onto the substrate under pressure and/or under the effect of heat. The film is thereby brought to a temperature at which there is a viscous flow of film and/or substrate medium into the region of the recess or opening, so that a wedge of material is formed and the film bulges up in the region of the recess to form a chamber. The invention further relates to methods of metering at least one liquid in a microfluidic network, in which a capillary stop is overcome by actuating the film, the film being wetted as the capillary stop is removed.
Abstract translation: 本发明涉及用于将液体计量到微流控网络中的微流体装置。 微流体通道或室至少部分地通过将合适的结构引入到衬底载体上方的膜中而形成，使得通过网络的流体中的至少一些流动发生在衬底的平面之上。 为了在膜中形成稳定的通道结构或腔室结构，设想在未连接和附接部分之间的边缘区域中，当膜粘合到膜材料上时，由材料的粘性流形成楔形材料 衬底，该楔形件形成在室壁和衬底之间的过渡部分，并且使腔壁在衬底的平面上方升高。 在制造成品微流体结构的一种方法中，将平坦的平面薄膜层压在平板状基片上。 在层压期间，具有至少一个凹部或开口的掩模在压力和/或受热的作用下被压在膜上和衬底上。 因此，膜被带到膜和/或基底介质粘性流入凹部或开口的区域的温度，使得形成楔形材料，并且膜在凹部的区域中凸起 形成一个房间。 本发明还涉及在微流体网络中计量至少一种液体的方法，其中通过致动膜来克服毛细管阻挡物，当除去毛细管停止物时，膜被润湿。
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公开(公告)号：WO2009156045A3
公开(公告)日：2010-03-18
申请号：PCT/EP2009003908
申请日：2009-06-02
Applicant: BOEHRINGER INGELHEIM MICROPART , KUROWSKI DIRK , HEMPEL MARIO , BLANKENSTEIN GERT , RODENFELS TOBIAS
Inventor： KUROWSKI DIRK , HEMPEL MARIO , BLANKENSTEIN GERT , RODENFELS TOBIAS
CPC classification number: F16K99/0001 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/0689 , B01L2300/0887 , B01L2400/0406 , B01L2400/0442 , B01L2400/0638 , B01L2400/0688 , B01L2400/082 , B29C65/18 , B29C66/1122 , B29C66/328 , B29C66/53461 , B29C66/71 , B29C66/723 , B29C66/81419 , B29C66/81422 , B29C66/8181 , B29C66/8322 , B29L2031/756 , F04B43/043 , B29K2021/003 , B29K2023/00 , B29K2023/06 , B29K2023/08 , B29K2023/083 , B29K2023/12 , B29K2023/14 , B29K2023/16 , B29K2027/18 , B29K2033/08 , B29K2077/00
Abstract: The invention relates to a microfluidic device for metering liquids into a microfluidic network. The microfluidic channels or chambers are at least partly formed by the introduction of suitable structures into a film above the substrate carrier, so that at least some of the flow of fluid through the network takes place above the plane of the substrate. In order to form a stable channel structure or chamber structure in the film, it is envisaged that in the edge zone between the unattached and attached portions a wedge of material is formed by the viscous flow of the film material as the film is bonded to the substrate, this wedge forming a transition between the chamber wall and the substrate and raising the chamber wall above the plane of the substrate. In one method of producing a finished microfluidic structure a flat planar film is laminated onto a flat sheet-like substrate. During the lamination a mask having at least one recess or opening is pressed onto the film and onto the substrate under pressure and/or under the effect of heat. The film is thereby brought to a temperature at which there is a viscous flow of film and/or substrate medium into the region of the recess or opening, so that a wedge of material is formed and the film bulges up in the region of the recess to form a chamber. The invention further relates to methods of metering at least one liquid in a microfluidic network, in which a capillary stop is overcome by actuating the film, the film being wetted as the capillary stop is removed.
Abstract translation: 本发明涉及用于将液体计量加入微流体网络的微流体装置。 微流体通道或腔室至少部分地通过将合适的结构引入基板载体上方的膜中而形成，使得通过网络的流体的至少一些流动发生在基板的平面之上。 为了在薄膜中形成稳定的通道结构或腔室结构，可以设想，在未连接部分和连接部分之间的边缘区域中，当薄膜粘合到薄膜材料上时，通过薄膜材料的粘性流动形成楔形材料 衬底，该楔形物形成腔室壁和衬底之间的过渡部分，并使腔室壁在衬底平面上方升高。 在生产完成的微流体结构的一种方法中，将平坦的平面膜层压到平坦的片状基底上。 在层压过程中，具有至少一个凹部或开口的掩模在压力下和/或在热的作用下被压到膜上和基板上。 由此使薄膜达到这样的温度，在该温度下，薄膜和/或基底介质的粘性流动进入凹槽或开口的区域，从而形成楔形材料并且薄膜在凹槽的区域中隆起 形成一个房间。 本发明还涉及在微流体网络中计量至少一种液体的方法，其中通过致动膜来克服毛细管阻塞，当毛细管阻塞被移除时膜被润湿。
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公开(公告)号：WO2008071351A1
公开(公告)日：2008-06-19
申请号：PCT/EP2007/010656
申请日：2007-12-07
Applicant: BOEHRINGER INGELHEIM MICROPARTS GMBH , BLANKENSTEIN, Gert , RODENFELS, Tobias , KUROWSKI, Dirk , HEMPEL, Mario
Inventor： BLANKENSTEIN, Gert , RODENFELS, Tobias , KUROWSKI, Dirk , HEMPEL, Mario
CPC classification number: B81C1/00119 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/0636 , B01L2200/12 , B01L2300/0681 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0406 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , B81B2201/058 , Y10T137/8593 , Y10T156/10
Abstract: Es werden eine Vorrichtung zur Aufnahme oder Manipulation eines Fluids, insbesondere einer Flüssigkeit, sowie ein Verfahren zur Herstellung einer derartigen Vorrichtung vorgeschlagen. Eine flache, nicht vorgeformte Deckfolie wird auf einen Träger auflaminiert, wobei allein durch das Auflaminieren eine dreidimensional geformte oder gewölbte Kammerwand gebildet wird, die eine Kammer für das Fluid partiell begrenzt. Die Vorrichtung ist einfach herstellbar und universell einsetzbar.
Abstract translation: 它提出了一种用于接收或操纵的流体，特别是液体，和制造这种器件的方法的装置。 扁平的，非预成型的盖片被层压到载体上，从而通过部分地限定一个室用于流体层压单独形成的三维成形的或弯曲的腔室壁。 该设备操作简单，制造和通用性。
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公开(公告)号：WO2007093443A2
公开(公告)日：2007-08-23
申请号：PCT/EP2007/001409
申请日：2007-02-19
Applicant: BOEHRINGER INGELHEIM MICROPARTS GMBH , HEMPEL, Mario , STOETERS, Wolfgang , PETERS, Ralf-Peter , HOLAKOVSKY, Holger
Inventor： HEMPEL, Mario , STOETERS, Wolfgang , PETERS, Ralf-Peter , HOLAKOVSKY, Holger
CPC classification number: B01D67/0004 , B01D19/0031 , B01D19/0036 , B01D61/00 , B01D67/0009 , B01D67/0027 , B01D67/0083 , B01D69/10 , B01D69/12 , B01D71/32 , B01D71/44 , B01D2323/46 , B01D2325/023
Abstract: Es werden ein Membranaufbau zur Gasabscheidung, eine Entgasungsvorrichtung mit einem derartigen Membranaufbau sowie Verfahren zur Herstellung vorgeschlagen. Eine poröse Trägerschicht wird flächig mit einer dünnen Polymermembran, insbesondere aus amorphem PTFE, verbunden. Insbesondere wird die Polymermembran auf oder aus der Trägerschicht hergestellt. Dies ermöglicht einen einfachen und kostengünstigen Aufbau sowie eine effektive Gasabscheidung. Besonders bevorzugt wird die Polymermembran dadurch gebildet, daß eine Polymerlösung flüssig auf die Trägerschicht aufgebracht und eingetrocknet wird.
Abstract translation: 提出了一种用于气体分离的膜结构，具有这种膜结构的脱气装置以及制造方法。 多孔支撑层流体结合到薄聚合物膜，特别是无定形PTFE。 特别地，聚合物膜在背衬层上或从背衬层上制备。 这允许简单和便宜的结构以及有效的气体分离。 最优选地，聚合物膜由θ+ 将聚合物溶液冲洗至背衬并干燥。
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