MICROFLUIDIC FOIL STRUCTURE FOR METERING OF FLUIDS
    10.
    发明申请
    MICROFLUIDIC FOIL STRUCTURE FOR METERING OF FLUIDS 审中-公开
    用于测量流体的微流体结构

    公开(公告)号:WO2009156045A2

    公开(公告)日:2009-12-30

    申请号:PCT/EP2009/003908

    申请日:2009-06-02

    Abstract: The invention relates to a microfluidic device for metering liquids into a microfluidic network. The microfluidic channels or chambers are at least partly formed by the introduction of suitable structures into a film above the substrate carrier, so that at least some of the flow of fluid through the network takes place above the plane of the substrate. In order to form a stable channel structure or chamber structure in the film, it is envisaged that in the edge zone between the unattached and attached portions a wedge of material is formed by the viscous flow of the film material as the film is bonded to the substrate, this wedge forming a transition between the chamber wall and the substrate and raising the chamber wall above the plane of the substrate. In one method of producing a finished microfluidic structure a flat planar film is laminated onto a flat sheet-like substrate. During the lamination a mask having at least one recess or opening is pressed onto the film and onto the substrate under pressure and/or under the effect of heat. The film is thereby brought to a temperature at which there is a viscous flow of film and/or substrate medium into the region of the recess or opening, so that a wedge of material is formed and the film bulges up in the region of the recess to form a chamber. The invention further relates to methods of metering at least one liquid in a microfluidic network, in which a capillary stop is overcome by actuating the film, the film being wetted as the capillary stop is removed.

    Abstract translation: 本发明涉及用于将液体计量到微流控网络中的微流体装置。 微流体通道或室至少部分地通过将合适的结构引入到衬底载体上方的膜中而形成,使得通过网络的流体中的至少一些流动发生在衬底的平面之上。 为了在膜中形成稳定的通道结构或腔室结构,设想在未连接和附接部分之间的边缘区域中,当膜粘合到膜材料上时,由材料的粘性流形成楔形材料 衬底,该楔形件形成在室壁和衬底之间的过渡部分,并且使腔壁在衬底的平面上方升高。 在制造成品微流体结构的一种方法中,将平坦的平面薄膜层压在平板状基片上。 在层压期间,具有至少一个凹部或开口的掩模在压力和/或受热的作用下被压在膜上和衬底上。 因此,膜被带到膜和/或基底介质粘性流入凹部或开口的区域的温度,使得形成楔形材料,并且膜在凹部的区域中凸起 形成一个房间。 本发明还涉及在微流体网络中计量至少一种液体的方法,其中通过致动膜来克服毛细管阻挡物,当除去毛细管停止物时,膜被润湿。

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