公开(公告)号：WO2010039308A1

公开(公告)日：2010-04-08

申请号：PCT/US2009/048855

申请日：2009-06-26

Applicant: PROTEOTECH INC. ,  ESPOSITO, Luke, A. ,  HUDSON, F., Michael ,  LAKE, Thomas ,  CUMMINGS, Joel ,  WEIGELE, Manfred ,  SNOW, Alan, D. ,  LARSEN, Lesley

Inventor： ESPOSITO, Luke, A. ,  HUDSON, F., Michael ,  LAKE, Thomas ,  CUMMINGS, Joel ,  WEIGELE, Manfred ,  SNOW, Alan, D. ,  LARSEN, Lesley

IPC: A01N47/28

CPC classification number: C07C311/29 ,  A61K31/05 ,  A61K31/18 ,  A61K31/4164 ,  A61K31/4196 ,  C07C37/16 ,  C07C39/10 ,  C07C39/17 ,  C07C2603/74 ,  C07D231/12 ,  C07D233/54 ,  C07D233/64 ,  C07D249/08

Abstract: Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of β-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

Abstract translation: 二羟基芳基化合物和药学上可接受的酯，它们的合成，含有它们的药物组合物，以及它们在治疗β-淀粉样蛋白疾病中的用途，例如在阿尔茨海默病中观察到的和突触核蛋白病，例如在帕金森病中观察到的药物的制备 这样的治疗。

公开(公告)号：WO2008154083A3

公开(公告)日：2008-12-18

申请号：PCT/US2008/062082

申请日：2008-04-30

Applicant: PROTEO TECH INC. ,  ESPOSITO, Luke ,  CUMMINGS, Joel ,  HUDSON, F., Michael ,  SNOW, Alan

Inventor： ESPOSITO, Luke ,  CUMMINGS, Joel ,  HUDSON, F., Michael ,  SNOW, Alan

IPC: A61K38/00

Abstract: Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as Parkinson's disease, and the manufacture of medicaments for such treatment.

公开(公告)号：WO2012118935A1

公开(公告)日：2012-09-07

申请号：PCT/US2012/027222

申请日：2012-03-01

Applicant: PROTEOTECH INC ,  ESPOSITO, Luke ,  YADON, Marisa, C. ,  CUMMINGS, Joel ,  HUDSON, F., Michael ,  LAKE, Thomas ,  HEFTI, Franz, F. ,  GOLDING, Geoffrey ,  CHOI, Seok-Rye ,  LI, Ximin ,  SNOW, Alan, D. ,  QUBAI, Hu ,  JUDY, Cam

Inventor： ESPOSITO, Luke ,  YADON, Marisa, C. ,  CUMMINGS, Joel ,  HUDSON, F., Michael ,  LAKE, Thomas ,  HEFTI, Franz, F. ,  GOLDING, Geoffrey ,  CHOI, Seok-Rye ,  LI, Ximin ,  SNOW, Alan, D. ,  QUBAI, Hu ,  JUDY, Cam

IPC: A01N31/00 ,  A61K31/045

CPC classification number: C07D285/08 ,  A61J1/00 ,  C07C39/15 ,  C07C205/20 ,  C07C205/22 ,  C07C235/56 ,  C07C255/53 ,  C07D231/06 ,  C07D249/06 ,  C07D263/32 ,  C07D263/56 ,  C07D263/57 ,  C07D271/10 ,  C07D271/107 ,  C07D277/24 ,  C07D277/32 ,  C07D285/12 ,  C07D333/16 ,  C07D333/28 ,  C07D409/14

Abstract: Compounds and their pharmaceutically acceptable salts for treatment of synucleinopathies, such as Parkinson's disease and tauopathies.

Abstract translation: 用于治疗突触核蛋白病的化合物及其药学上可接受的盐，例如帕金森病和tau蛋白病。

公开(公告)号：WO2008154083A2

公开(公告)日：2008-12-18

申请号：PCT/US2008062082

申请日：2008-04-30

Applicant: PROTEO TECH INC ,  ESPOSITO LUKE ,  CUMMINGS JOEL ,  HUDSON F MICHAEL ,  SNOW ALAN

Inventor： ESPOSITO LUKE ,  CUMMINGS JOEL ,  HUDSON F MICHAEL ,  SNOW ALAN

IPC: A61K31/045 ,  A61K31/135 ,  A61K31/16 ,  A61K31/165 ,  A61K31/36 ,  C07C39/15 ,  C07C39/16 ,  C07C39/17 ,  C07C69/017

CPC classification number: C07C39/15 ,  C07C39/16 ,  C07C39/17 ,  C07C69/017 ,  C07C215/50 ,  C07C217/32 ,  C07C233/56 ,  C07C235/24 ,  C07C235/38 ,  C07C235/52 ,  C07C235/54 ,  C07C235/56 ,  C07C235/74 ,  C07C235/76 ,  C07C273/1827 ,  C07C275/34 ,  C07C275/40 ,  C07D207/16 ,  C07D211/74 ,  C07D213/30 ,  C07D213/69 ,  C07D213/85 ,  C07D221/08 ,  C07D221/18 ,  C07D231/06 ,  C07D241/08 ,  C07D263/38 ,  C07D265/38 ,  C07D295/096 ,  C07D295/192 ,  C07D311/60 ,  C07D317/50 ,  C07D317/54 ,  C07D317/58 ,  C07D317/60 ,  C07D317/66 ,  C07D317/68 ,  C07D333/16 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D451/06 ,  C07D471/04 ,  C07D487/08 ,  C07D491/08

Abstract: Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as Parkinson's disease, and the manufacture of medicaments for such treatment.

Abstract translation: 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，它们的合成，含有它们的药物组合物及其在治疗突触核蛋白病（例如帕金森病）中的用途以及制备用于这种治疗的药物。