公开(公告)号：WO2016178064A1

公开(公告)日：2016-11-10

申请号：PCT/IB2015/054587

申请日：2015-06-18

Applicant: SUVEN LIFE SCIENCES LIMITED ,  ARAVA, Veera Reddy ,  GOGIREDDY, Surendra Reddy ,  JASTI, Venkateswarlu

Inventor： ARAVA, Veera Reddy ,  GOGIREDDY, Surendra Reddy ,  JASTI, Venkateswarlu

IPC: C07D209/34 ,  A61K31/404 ,  A61P35/00 ,  A61P11/00

CPC classification number: C07D209/34

Abstract: The present invention provides novel crystalline Form of Nintedanib and process for its preparation. The present invention also provides to a novel process for the preparation of Nintedanib. The present invention further provides to novel intermediates used in the preparation of Nintedanib and process for their preparation.

Abstract translation: 本发明提供了新型的奈非替尼的结晶形式及其制备方法。 本发明还提供了制备尼替替尼的新方法。 本发明进一步提供了用于制备奈非替尼的新型中间体及其制备方法。

公开(公告)号：WO2015159170A3

公开(公告)日：2016-01-28

申请号：PCT/IB2015052303

申请日：2015-03-28

Applicant: SUVEN LIFE SCIENCES LTD ,  CHINNAPILLAI RAJENDIRAN ,  KONDAKINDI INDRASENA REDDY ,  JASTI VENKATESWARLU

Inventor： CHINNAPILLAI RAJENDIRAN ,  KONDAKINDI INDRASENA REDDY ,  JASTI VENKATESWARLU

IPC: C07D243/08 ,  C07D223/04

CPC classification number: C07C213/02 ,  C07C217/58 ,  C07C249/02 ,  C07C251/04

Abstract: The present invention relates to an improved and efficient process for the preparation of highly useful and versatile chiral compound (S)-(-)-l-(4-methoxyphenyl) ethylamine of formula (1) and formula (1-R) from novel chiral compounds (S)-[l-(4-Methoxyphenyl)-ethylidene]-(l-phenylethyl)amine of formula (16) and (R)-[l-(4-Methoxyphenyl)-ethylidene]-(l-phenylethyl)amine of formula (16-R) respectively.

Abstract translation: 本发明涉及一种改进和有效的制备方法，用于从新颖的方法制备式（1）和式（1-R）的高度有用且通用的手性化合物（S） - （ - ） - 1-（4-甲氧基苯基）乙胺 式（16）和（R） - [1-（4-甲氧基苯基） - 亚乙基] - （1-苯乙基）胺的手性化合物（S） - [1-（4-甲氧基苯基） - 亚乙基] ）胺（16-R）。

公开(公告)号：WO2015159170A2

公开(公告)日：2015-10-22

申请号：PCT/IB2015/052303

申请日：2015-03-28

Applicant: SUVEN LIFE SCIENCES LIMITED ,  CHINNAPILLAI, Rajendiran ,  KONDAKINDI, Indrasena Reddy ,  JASTI, Venkateswarlu

Inventor： CHINNAPILLAI, Rajendiran ,  KONDAKINDI, Indrasena Reddy ,  JASTI, Venkateswarlu

CPC classification number: C07C213/02 ,  C07C217/58 ,  C07C249/02 ,  C07C251/04

Abstract: The present invention relates to an improved and efficient process for the preparation of highly useful and versatile chiral compound (S)-(-)-l-(4-methoxyphenyl) ethylamine of formula (1) and formula (1-R) from novel chiral compounds (S)-[l-(4-Methoxyphenyl)-ethylidene]-(l-phenylethyl)amine of formula (16) and (R)-[l-(4-Methoxyphenyl)-ethylidene]-(l-phenylethyl)amine of formula (16-R) respectively.

Abstract translation: 本发明涉及一种改进和有效的制备方法，用于从新颖的方法制备式（1）和式（1-R）的高度有用且通用的手性化合物（S） - （ - ） - 1-（4-甲氧基苯基）乙胺 式（16）和（R） - [1-（4-甲氧基苯基） - 亚乙基] - （1-苯乙基）胺的手性化合物（S） - [1-（4-甲氧基苯基） - 亚乙基] ）胺（16-R）。

公开(公告)号：WO2011080750A1

公开(公告)日：2011-07-07

申请号：PCT/IN2010/000209

申请日：2010-03-31

Applicant: SUVEN LIFE SCIENCES LIMITED ,  AHMAD, Ishtiyaque ,  MEKALA, Reddy, Venkat ,  CHILLAKUR, Reddy, Muddukrishna ,  SUBRAMANIAM, Ramkumar ,  RAVULA, Jyothsna ,  PATNALA, Sriramachandra, Murthy ,  NIROGI, Ramakrishna ,  JASTI, Venkateswarlu

Inventor： AHMAD, Ishtiyaque ,  MEKALA, Reddy, Venkat ,  CHILLAKUR, Reddy, Muddukrishna ,  SUBRAMANIAM, Ramkumar ,  RAVULA, Jyothsna ,  PATNALA, Sriramachandra, Murthy ,  NIROGI, Ramakrishna ,  JASTI, Venkateswarlu

IPC: G01N33/566

CPC classification number: G01N33/566 ,  G01N2333/726

Abstract: The present invention provides novel functional assay for G protein coupled receptors (GPCRs), by measuring intracellular cyclic adenosine monophosphate (cAMP) levels utilizing reporter gene driven cell based assay. The novel assay provides both binding affinity as well as mode of action of compounds in a single set. The novel assay of the invention is useful in identification of compounds acting through GPCRs. Furthermore, the assay offers utility in categorizing compounds in to agonist, partial agonist, inverse agonist and antagonist classes. The novel assay can be scaled up to any high throughput format.

Abstract translation: 本发明通过使用基于报告基因驱动细胞的测定法测量细胞内环腺苷一磷酸（cAMP）水平来提供G蛋白偶联受体（GPCR）的新功能测定。 该新型试验提供化合物在单一组中的结合亲和力以及作用方式。 本发明的新型测定法可用于鉴定通过GPCR起作用的化合物。 此外，该测定法将化合物分类为激动剂，部分激动剂，反向激动剂和拮抗剂类别。 该新型检测可以扩大到任何高通量格式。

公开(公告)号：WO2007020653A1

公开(公告)日：2007-02-22

申请号：PCT/IN2005/000346

申请日：2005-10-26

Applicant: SUVEN LIFE SCIENCES LIMITED ,  RAMAKRISHNA, Venkata, Satya, Nirogi ,  SHIRSATH, Vikas, Shreekrishna ,  KAMBHAMPATI, Rama, Sastri ,  VISHWAKARMA, Santosh ,  KANDIKERE, Nagaraj, Vishwottam ,  KOTA, Srinivasulu ,  JASTI, Venkateswarlu

Inventor： RAMAKRISHNA, Venkata, Satya, Nirogi ,  SHIRSATH, Vikas, Shreekrishna ,  KAMBHAMPATI, Rama, Sastri ,  VISHWAKARMA, Santosh ,  KANDIKERE, Nagaraj, Vishwottam ,  KOTA, Srinivasulu ,  JASTI, Venkateswarlu

IPC: C07D209/30 ,  A61K31/404 ,  A61P25/00

CPC classification number: C07D209/30

Abstract: The present invention provides thioether derivatives of formula (I), useful in treatment of a CNS disorder related to or affected by the 5-HT 6 receptor. Pharmacological profile of these compounds includes high affinity binding with 5-HT 6 receptor along with selectivity towards the said receptor. The present invention also includes the stereoisomers, the salts, methods of preparation and medicine containing the said thioether derivatives.

Abstract translation: 本发明提供式（I）的硫醚衍生物，其可用于治疗与5-HT 6受体相关或受其影响的CNS紊乱。 这些化合物的药理学特征包括与5-HT 6 N受体的高亲和力结合以及对所述受体的选择性。 本发明还包括立体异构体，盐，制备方法和含有所述硫醚衍生物的药物。

公开(公告)号：WO2004048330A8

公开(公告)日：2005-10-27

申请号：PCT/IN0300209

申请日：2003-06-05

Applicant: SUVEN LIFE SCIENCES LTD ,  RAMAKRISHNA VENKATA SATYA NIRO ,  SHIRSATH VIKAS SHREEKRISHNA ,  KAMBHAMPATI RAMA SASTRI ,  RAO VENKATA SATYA VEERABHADRA ,  JASTI VENKATESWARLU

Inventor： RAMAKRISHNA VENKATA SATYA NIRO ,  SHIRSATH VIKAS SHREEKRISHNA ,  KAMBHAMPATI RAMA SASTRI ,  RAO VENKATA SATYA VEERABHADRA ,  JASTI VENKATESWARLU

IPC: A61K31/4045 ,  A61P25/00 ,  C07D209/10 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D209/20 ,  C07D209/42 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D413/12

CPC classification number: C07D209/10 ,  C07D209/12 ,  C07D209/14 ,  C07D209/20 ,  C07D209/42 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D413/12

Abstract: The present invention relates to novel N-arylsulfonyl-3-substituted indole compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their geometric forms, their N-oxides, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel N-arylsulfonyl-3-substituted indoles of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, and pharmaceutically acceptable compositions containing them. This invention also relates to the process for preparing compounds of the general formula (I), pharmaceutical compositions containing such compounds and the use of such compounds and compositions in medicine. This invention also relates to the novel intermediates involved therein and process of their preparation.

Abstract translation: 本发明涉及新的N-芳基磺酰基-3-取代的吲哚化合物，它们的衍生物，它们的类似物，它们的互变异构形式，它们的立体异构体，它们的几何形式，它们的N-氧化物，它们的多晶型物，它们的药学上可接受的盐，它们的药学上可接受的溶剂合物 和含有它们的药学上可接受的组合物。 本发明特别涉及通式（I）的新型N-芳基磺酰基-3-取代的吲哚，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和药学上可接受的溶剂合物 含有它们的可接受的组合物。 本发明还涉及制备通式（I）的化合物的方法，含有这些化合物的药物组合物以及这些化合物和组合物在医药中的用途。 本发明还涉及其中涉及的新型中间体及其制备方法。

公开(公告)号：WO2005066157A1

公开(公告)日：2005-07-21

申请号：PCT/IN2004/000431

申请日：2004-12-30

Applicant: SUVEN LIFE SCIENCES ,  JASTI, Venkateswarlu ,  RAMAKRISHNA, Venkata, Satya, Nirogi ,  KAMBHAMPATI, Rama, Sastri ,  SHIRSATH, Vikas, Shreekrishna ,  VISHWOTTAM, Nagaraj, Kandikere

Inventor： JASTI, Venkateswarlu ,  RAMAKRISHNA, Venkata, Satya, Nirogi ,  KAMBHAMPATI, Rama, Sastri ,  SHIRSATH, Vikas, Shreekrishna ,  VISHWOTTAM, Nagaraj, Kandikere

IPC: C07D403/04

CPC classification number: C07D403/04

Abstract: The present invention describes 3-(Heterocyclic)indoles with the Formula (I), its stereoisomers and salts, wherein the substituents such as R, R 1 , R 2 , R 3 , R 4 , R 10 , R 11 , R 12 , R 13 , and R 14 are described in the specification. The invention also provides a method to prepare compound with formula (I), pharmaceutical composition containing such compounds and method to manufacture a medicament. These compounds are useful in the treatment of various CNS disorders, hematological disorders, eating disorders, diseases associated with pain, respiratory disease, genito-urological disorders, cardio vascular diseases and cancer.

Abstract translation: 本发明描述了具有式（I）的3-（杂环）吲哚及其立体异构体和盐，其中诸如R，R 1，R 2，R 3，R 4，R 10，R 11，R 12，R 13和R 14的取代基描述于 规格。 本发明还提供了制备式（I）化合物，含有这些化合物的药物组合物和制备药物的方法。 这些化合物可用于治疗各种CNS疾病，血液病症，进食障碍，与疼痛有关的疾病，呼吸系统疾病，泌尿系统疾病，心血管疾病和癌症。

公开(公告)号：WO2015162506A1

公开(公告)日：2015-10-29

申请号：PCT/IB2015/052020

申请日：2015-03-19

Applicant: SUVEN LIFE SCIENCES LIMITED ,  ARAVA, Veera Reddy ,  SIRIPALLI, Udaya Bhaskara Rao ,  GORENTLA, Lakshmi Narasimhulu ,  JASTI, Venkateswarlu

Inventor： ARAVA, Veera Reddy ,  SIRIPALLI, Udaya Bhaskara Rao ,  GORENTLA, Lakshmi Narasimhulu ,  JASTI, Venkateswarlu

IPC: C07D487/04 ,  A61K31/4985 ,  A61P3/10

CPC classification number: C07D487/04

Abstract: The present invention provides an improved process for the preparation of β-amino acid derivatives. More particularly, the present invention relates to an improved process for the preparation of Sitagliptin or its pharmaceutically acceptable salts of formula 1. The present invention also provides novel intermediates used in the preparation of Sitagliptin.

Abstract translation: 本发明提供了制备β-氨基酸衍生物的改进方法。 更具体地，本发明涉及一种制备西他列汀或其药学上可接受的式1的盐的改进方法。本发明还提供了用于制备西他列汀的新型中间体。

公开(公告)号：WO2009053997A1

公开(公告)日：2009-04-30

申请号：PCT/IN2008/000281

申请日：2008-05-02

Applicant: SUVEN LIFE SCIENCES LIMITED ,  RAMAKRISHNA, Nirogi, Venkata, Satya ,  KAMBHAMPATI, Rama, Sastri ,  SHINDE, Anil, Karbhari ,  KANDIKERE, Nagaraj, Vishwottam ,  JASTI, Venkateswarlu

Inventor： RAMAKRISHNA, Nirogi, Venkata, Satya ,  KAMBHAMPATI, Rama, Sastri ,  SHINDE, Anil, Karbhari ,  KANDIKERE, Nagaraj, Vishwottam ,  JASTI, Venkateswarlu

IPC: C07D209/08 ,  A61K31/404 ,  A61P25/14 ,  A61P25/18 ,  A61P25/22 ,  A61P25/28

CPC classification number: C07D209/08

Abstract: The present invention relates to novel amino arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them: The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The compounds of the invention are useful in the treatment of various disorders that are related to 5-HT 6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, obesity, anxiety, depression, diseases associated with pain, respiratory diseases, gastrointestinal, cardiovascular diseases and cancer.

Abstract translation: 本发明涉及式（I）的新型氨基芳基磺酰胺化合物，其衍生物，其立体异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物：本发明还涉及制备上述新化合物的方法， 其衍生物，其立体异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物。 本发明的化合物可用于治疗与5-HT 6受体功能相关的各种疾病。 具体地说，本发明的化合物也可用于治疗各种CNS疾病，血液病症，进食障碍，肥胖症，焦虑症，抑郁症，与疼痛相关的疾病，呼吸系统疾病，胃肠道，心血管疾病和癌症。

公开(公告)号：WO2009034581A1

公开(公告)日：2009-03-19

申请号：PCT/IN2008/000280

申请日：2008-05-02

Applicant: SUVEN LIFE SCIENCES LIMITED ,  RAMAKRISHNA, Nirogi, Venkata, Satya ,  SHINDE, Anil, Karbhari ,  KAMBHAMPATI, Rama, Sastri ,  JASTI, Venkateswarlu

Inventor： RAMAKRISHNA, Nirogi, Venkata, Satya ,  SHINDE, Anil, Karbhari ,  KAMBHAMPATI, Rama, Sastri ,  JASTI, Venkateswarlu

IPC: C07D401/12 ,  A61K31/4523 ,  A61P25/00

CPC classification number: C07D401/12

Abstract: The present invention relates to novel substituted indolyl compounds of formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. This invention also relates to the novel intermediates involved therein and process of their preparation. These compounds are useful in the treatment of various disorders that are related to 5-HT 6 receptor functions.

Abstract translation: 本发明涉及式（I）的新型取代的吲哚基化合物，其衍生物，其立体异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物。 本发明还涉及制备上述新化合物，其衍生物，其立体异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物的方法。 本发明还涉及其中涉及的新型中间体及其制备方法。 这些化合物可用于治疗与5-HT 6受体功能相关的各种疾病。