公开(公告)号：WO2015168465A1

公开(公告)日：2015-11-05

申请号：PCT/US2015/028633

申请日：2015-04-30

Applicant: RGENIX, INC.

Inventor： MARTINEZ, Eduardo, J. ,  TAVAZOIE, Sohail, F.

IPC: C07C261/00 ,  C07C269/00 ,  C07C277/00 ,  C07C279/00

CPC classification number: C07C279/14 ,  A61K31/00 ,  A61K31/155 ,  A61K31/337 ,  A61K31/397 ,  A61K31/40 ,  A61K31/4168 ,  A61K31/4402 ,  A61K31/4427 ,  A61K31/505 ,  A61K31/53 ,  A61K31/704 ,  A61K31/7068 ,  A61K31/7105 ,  A61K45/06 ,  C07B2200/05 ,  C07C257/14 ,  C07C259/14 ,  C07C275/70 ,  C07C279/16 ,  C07C279/26 ,  C07C279/36 ,  C07C281/16 ,  C07C281/18 ,  C07C309/15 ,  C07C313/34 ,  C07C2601/02 ,  C07C2601/04 ,  C07D205/04 ,  C07D205/08 ,  C07D207/16 ,  C07D207/22 ,  C07D213/74 ,  C07D213/76 ,  C07D231/12 ,  C07D233/26 ,  C07D233/46 ,  C07D233/52 ,  C07D233/64 ,  C07D233/88 ,  C07D239/06 ,  C07D239/14 ,  C07D249/08 ,  C07D249/14 ,  C07D253/06 ,  C07D257/08 ,  C07D295/32 ,  C07D401/04 ,  C07D405/04 ,  C07D487/04 ,  C07F9/097 ,  C07F9/2458 ,  C07F9/3808 ,  C07F9/4006 ,  C07F9/48 ,  C07F9/5683 ,  C07F9/5721 ,  C07F9/65061 ,  C07H19/06 ,  A61K2300/00

Abstract: This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.

Abstract translation: 本发明涉及抑制肌酸转运和/或肌酸激酶的化合物，包括这些化合物的药物组合物，以及利用这些化合物和组合物治疗癌症的方法。

公开(公告)号：WO03000652A8

公开(公告)日：2004-05-21

申请号：PCT/US0219753

申请日：2002-06-21

Applicant: WYETH CORP ,  KIM KEUN-SIK ,  KIM KWANG-IL ,  LEE SUNG-WOO ,  PARK JIN-SOO ,  CHAI KI-BYUNG

Inventor： KIM KEUN-SIK ,  KIM KWANG-IL ,  LEE SUNG-WOO ,  PARK JIN-SOO ,  CHAI KI-BYUNG

IPC: C07C261/00 ,  C07B61/00 ,  C07C253/30 ,  C07C255/37

CPC classification number: C07C253/30 ,  C07C2601/14 ,  C07C255/37

Abstract: A process for the preparation of cyclohexanol derivatives of formula (I) by reacting a compound of formula (II) with a compound of formula (III) in the presence of a base catalyst of formula (IV) or (V). In the above formula, R1-R9, A, B, X and p have tghe meanings given in the specification.

Abstract translation: 在式（Ⅳ）或（Ⅴ）的碱催化剂存在下，使式（Ⅳ）化合物与式（Ⅳ）化合物反应制备式（Ⅰ）的环己醇衍生物的方法。 在上式中，R1-R9，A，B，X和p具有本说明书中给出的含义。

公开(公告)号：WO03011223A3

公开(公告)日：2003-05-01

申请号：PCT/US0224258

申请日：2002-07-31

Applicant: EISAI CO LTD ,  HAWKINS LYNN D ,  ISHIZAKA SALLY T ,  LEWIS MICHAEL ,  MCGUINNESS PAMELA ,  ROSE JEFFREY

Inventor： HAWKINS LYNN D ,  ISHIZAKA SALLY T ,  LEWIS MICHAEL ,  MCGUINNESS PAMELA ,  ROSE JEFFREY

IPC: A61K39/39 ,  A61P31/04 ,  A61P31/12 ,  A61P31/16 ,  A61P31/18 ,  A61P37/04 ,  C07C275/14 ,  C07F9/09 ,  C07F9/10 ,  C07F9/655 ,  A61K45/00 ,  A61K39/00 ,  A61K39/295 ,  C07C261/00

CPC classification number: C07F9/10 ,  A61K39/39 ,  A61K2039/55511 ,  A61K2039/55555 ,  C07F9/091 ,  C07F9/65515

Abstract: The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.

Abstract translation: 本发明涉及当与诸如用于细菌和病毒疾病的疫苗的抗原共同给予包括至少一种本发明的佐剂化合物的新型佐剂制剂与新的免疫刺激组合物共同施用时用作免疫佐剂的新化合物， 包括抗原和至少一种本发明的佐剂化合物，以及通过将本发明化合物与待免疫动物的抗原共同给药的动物免疫方法。

公开(公告)号：WO2002100344A3

公开(公告)日：2002-12-19

申请号：PCT/US2002/018493

申请日：2002-06-11

Applicant: XENOPORT, INC. ,  GALLOP, Mark, A. ,  CUNDY, Kenneth, C. ,  SCHEUERMAN, Randall, A. ,  BARRETT, Ronald, W. ,  ZERANGUE, Noa

Inventor： GALLOP, Mark, A. ,  CUNDY, Kenneth, C. ,  SCHEUERMAN, Randall, A. ,  BARRETT, Ronald, W. ,  ZERANGUE, Noa

IPC: C07C261/00

Abstract: This invention is directed to compounds that provide for sustained systemic concentrations of GABA analogs following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds.

公开(公告)号：WO02085843A2

公开(公告)日：2002-10-31

申请号：PCT/IB0200660

申请日：2002-03-04

Applicant: PFIZER PROD INC ,  SINGER ROBERT ALAN ,  MCKINLEY JASON DANIEL

Inventor： SINGER ROBERT ALAN ,  MCKINLEY JASON DANIEL

IPC: C07D317/30 ,  A61K31/439 ,  A61K31/4985 ,  A61K38/00 ,  A61P1/00 ,  A61P1/04 ,  A61P3/04 ,  A61P9/06 ,  A61P9/10 ,  A61P9/12 ,  A61P25/04 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/30 ,  A61P25/32 ,  A61P25/34 ,  A61P25/36 ,  A61P35/00 ,  C07B61/00 ,  C07C253/30 ,  C07C255/41 ,  C07C255/47 ,  C07C261/00 ,  C07C315/04 ,  C07C317/44 ,  C07D221/16 ,  C07D221/22 ,  C07D401/04 ,  C07D471/04 ,  C07D471/08 ,  C07D498/08 ,  C07D513/08

CPC classification number: C07C317/44 ,  C07C253/30 ,  C07C255/47 ,  C07C2602/08

Abstract: The present invention relates to processes for the preparation of any of the intermediate 1,3-substituted indenes of formulae (Ia, Ib and Ic) or a mixture thereof, wherein R , R , R , R , and R are defined herein. Compounds of formulae (Ia, Ib and Ic) or mixtures thereof are useful in the preparation of compounds of formula (II), wherein R , R and R are also defined herein.

Abstract translation: 本发明涉及制备式（Ia，Ib和Ic）的任何中间体1,3-取代的茚或其混合物的方法，其中R 1，R 2，R 3， R 4和R 5如本文所定义。 式（Ia，Ib和Ic）化合物或其混合物可用于制备式（II）化合物，其中R 2，R 3和R 6也在本文中定义。

公开(公告)号：WO00009477A1

公开(公告)日：2000-02-24

申请号：PCT/EP1999/005757

申请日：1999-08-09

IPC: G03F7/027 ,  C07C261/00 ,  C07C261/02 ,  C07D251/32 ,  C08F8/00 ,  C08F290/14 ,  C08G73/00 ,  C08G73/06 ,  C08J5/04 ,  C09D179/00

CPC classification number: C07C261/02 ,  C07C2603/68

Abstract: The invention relates to unsaturated oligophenol cyanates of the general formula (I) [A-]n[B-A-]xB[-A]m, in which A is a group of formula (II) and B is a group of formula (III), where R , R and R are each hydrogen or a bond with a group B, there being either one or two bonds with B; and both R and R as well as R and R separately or jointly represent a direct bond or hydrogen and a bond with a group A, there being either one or two bonds with A. The indices m and n are 0 or 1 but not both 1 at the same time and x is a whole number between 0 and 10, where at least one of the numbers m, n and x is not 0. The above unsaturated oligophenol cyanates can be prepared by reacting the corresponding oligophenols with chlorine cyanide. They have a low viscosity and owing to their double bonds are able to undergo free-radical polymerization. They are especially suitable for use as matrix materials for fibre-reinforced composites and for radiation-curable varnishes and coatings.

Abstract translation: 中描述的通式（I）[A-] n的[B-A-]×B [-A]米的不饱和oligophenol氰酸酯。 其中，每个A是一个基团式（II）的且B为式的基团（III），其中R <1>，R <2>和R <3>各自为氢或一个键合到基团B，以及一个 或两个键与B都存在，且R <4>和R <4“>和R <5>和R <5”>各自enweder一起代表一个直接键或氢，和一个Sindung到的基团的，其中 一个或两个键合到一个存在。 指数m和n是0或1，但不同时为1，并且x为0至10的整数，的数m，其中至少一个，n和x是大于零的其它 所述不饱和oligophenol氰酸酯可以由相应的Oligophenole与氯化氰反应来制备。 它们具有低粘度，是自由基固化由于存在双键。 它们特别适合作为用于纤维增强复合材料和可辐射固化油漆和涂料的基体材料。

公开(公告)号：WO1996033971A1

公开(公告)日：1996-10-31

申请号：PCT/US1996001496

申请日：1996-02-01

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY OF THE NAVY

Inventor： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY OF THE NAVY ,  CONRAD, David, W. ,  CHARLES, Paul, T., Jr.

IPC: C07C261/00

CPC classification number: B82Y30/00 ,  B01J2219/00529 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00711 ,  B01J2219/0072 ,  B01J2219/00722 ,  C07C247/18 ,  C07C271/12 ,  C40B40/06 ,  G01N33/54373 ,  G01N33/5438 ,  Y10T428/31725

Abstract: The presently claimed invention is directed to novel biochips and a method for forming said biochips and novel photoactivatable compounds, 2,6-DOCA, 2-NOCA and LC-ASA Amine.

Abstract translation: 本发明涉及用于形成所述生物芯片和新型可光活化化合物2,6-DOCA，2-NOCA和LC-ASA胺的新型生物芯片和方法。

公开(公告)号：WO2011085280A1

公开(公告)日：2011-07-14

申请号：PCT/US2011/020620

申请日：2011-01-10

Applicant: ISP INVESTMENTS INC. ,  HOOD, David, K. ,  MUSA, Osama, M.

Inventor： HOOD, David, K. ,  MUSA, Osama, M.

IPC: C08G12/34 ,  C07C261/00

CPC classification number: C08G18/8108 ,  C08F12/22 ,  C08F12/26 ,  C08F212/14 ,  C08F226/10 ,  C08F290/062 ,  C08G18/2855 ,  C09D4/00 ,  C09D11/101 ,  C08F222/1006 ,  C08F2222/1013 ,  C08F2222/1026

Abstract: Disclosed herein are compositions comprising a reactive monomer, and, in particular, coating and/or reactive coating compositions. More particularly, compositions containing monomers comprising a lactam moiety, a urethane or urea functional group, and a polymerizable moiety are disclosed.

Abstract translation: 本文公开了包含反应性单体，特别是涂层和/或反应性涂料组合物的组合物。 更具体地，公开了含有内酰胺部分，氨基甲酸酯或脲官能团和可聚合部分的单体的组合物。

公开(公告)号：WO2004089890A3

公开(公告)日：2005-06-30

申请号：PCT/US2004009909

申请日：2004-03-29

Applicant: SMITHKLINE BEECHAM CORP ,  CONDE JOSE J ,  GOLDFINGER LEWILYNN L ,  MCGUIRE MICHAEL A ,  SHILCRAT SUSAN C ,  WALLACE MICHAEL D ,  YU MARVIN SUNGWHAN

Inventor： CONDE JOSE J ,  GOLDFINGER LEWILYNN L ,  MCGUIRE MICHAEL A ,  SHILCRAT SUSAN C ,  WALLACE MICHAEL D ,  YU MARVIN SUNGWHAN

IPC: C07C59/48 ,  C07C69/76 ,  C07C261/00 ,  C07D20060101 ,  C07D223/16 ,  C07D401/12

CPC classification number: C07D401/12 ,  C07D223/16

Abstract: Disclosed is a new process and intermediates for preparing benzazepines of Formula wherein R and R are as defined herein.

Abstract translation: 公开了用于制备式的苯并吖庚因的新方法和中间体，其中R 1和R 2如本文所定义。

公开(公告)号：WO01072699A1

公开(公告)日：2001-10-04

申请号：PCT/US2001/009756

申请日：2001-03-27

IPC: A61K38/55 ,  A61K31/165 ,  A61K31/166 ,  A61K31/192 ,  A61K31/216 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C237/22 ,  C07C271/22 ,  C07C261/00 ,  A61K38/00

CPC classification number: A61K31/216 ,  A61K31/165 ,  A61K31/192

Abstract: Compounds which inhibit tumor growth and angiogenesis, of general formula (II) are provided. These compounds include glycyl lysine derivatives bound to a central aromatic linking core.

Abstract translation: 提供通式（II）抑制肿瘤生长和血管生成的化合物。 这些化合物包括与中心芳族连接核心结合的甘氨酰赖氨酸衍生物。