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    SURFACE FILM DISTRIBUTION SYSTEM AND METHOD THEREOF
    3.
    发明申请
    SURFACE FILM DISTRIBUTION SYSTEM AND METHOD THEREOF 审中-公开
    表面膜分布系统及其方法

    公开(公告)号：WO2012071415A2

    公开(公告)日：2012-05-31

    申请号：PCT/US2011061851

    申请日：2011-11-22

    申请人： MORE AQUA INC ,  ALAMARO MOSHE ,  EMANUEL KERRY ,  LANGER ROBERT S

    发明人： ALAMARO MOSHE ,  EMANUEL KERRY ,  LANGER ROBERT S

    IPC分类号： E02B1/00 ,  E02B3/00 ,  E02B5/00

    CPC分类号： E02B3/00 ,  B01J19/16 ,  E04H4/1281

    摘要： A surface film distribution system for use with a body of water and method thereof is provided. The system includes a surface film positioned on a surface of at least a portion of the body of water. A first fluid conduit opening is positioned in a first location proximate to the surface of the body of water. A second fluid conduit opening is positioned in a second location proximate to the surface of the body of water. At least one fluid conduit connects the first fluid conduit opening and the second fluid conduit opening. A mixture of surface film and water is collected from the body of water, the mixture of surface film and water located in the at least one fluid conduit. A pump is in fluid connection with the at least one fluid conduit. The distributed surface film may minimize water evaporation from the body of water.

    摘要翻译： 提供了一种用于水体的表面膜分配系统及其方法。 该系统包括定位在水体的至少一部分的表面上的表面膜。 第一流体导管开口定位在靠近水体表面的第一位置。 第二流体导管开口位于靠近水体表面的第二位置。 至少一个流体导管连接第一流体导管开口和第二流体导管开口。 表面膜和水的混合物从水体中收集，表面膜和水的混合物位于至少一个流体导管中。 泵与至少一个流体导管流体连接。 分布式表面膜可以使来自水体的水分蒸发最小化。

    POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF
    4.
    发明申请
    POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF 审中-公开
    聚（氨基 - 氨基醇），其制备及其用途

    公开(公告)号：WO2012027675A3

    公开(公告)日：2012-05-10

    申请号：PCT/US2011049360

    申请日：2011-08-26

    申请人： MASSACHUSETTS INST TECHNOLOGY ,  MA MINGLIN ,  LIU WENDY F ,  LANGER ROBERT S ,  ANDERSON DANIEL GRIFFITH

    发明人： MA MINGLIN ,  LIU WENDY F ,  LANGER ROBERT S ,  ANDERSON DANIEL GRIFFITH

    IPC分类号： C08G73/00 ,  A61K31/16 ,  A61L31/10 ,  C08G65/22 ,  C09D5/14

    CPC分类号： C08G73/0206 ,  A61K9/1273 ,  A61K31/7088 ,  A61K47/34 ,  A61K47/59 ,  A61L31/10 ,  C08G59/22 ,  C08G59/306 ,  C08G59/50 ,  C08G73/02 ,  C09D5/1637 ,  C09D179/02 ,  Y10T428/31725

    摘要： A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.

    摘要翻译： 使用组合聚合制备了一类新的聚（β-氨基醇）（PBAAs）。 本发明的PBAAs可用于生物技术和生物医学应用中，作为涂层（例如用于医疗装置或植入物的膜或多层膜的涂层），添加剂，材料，赋形剂，非生物污垢剂，微图案化剂和细胞包封剂。 当用作表面涂层时，这些PBAAs根据其化学结构在体外和体内引起不同程度的炎症。 这类材料的大化学多样性使我们能够鉴定体外抑制巨噬细胞活化的聚合物涂层。 此外，在皮下植入羧化聚苯乙烯微粒之后，这些涂层减少了炎性细胞的募集，并减少了纤维化。 这些聚合物可用于形成用于细胞包封的聚电解质复合物胶囊。 本发明还可以具有许多其他生物学应用，例如抗微生物涂层，DNA或siRNA递送以及干细胞组织工程。

    POLYMERS FOR BIOMATERIALS AND THERAPEUTICS
    5.
    发明申请
    POLYMERS FOR BIOMATERIALS AND THERAPEUTICS 审中-公开
    聚合物用于生物材料和治疗

    公开(公告)号：WO2011163483A2

    公开(公告)日：2011-12-29

    申请号：PCT/US2011/041644

    申请日：2011-06-23

    申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  FISHER, Omar ,  LEVINS, Christopher, G. ,  LANGER, Robert, S. ,  ANDERSON, Daniel, Griffith

    发明人： FISHER, Omar ,  LEVINS, Christopher, G. ,  LANGER, Robert, S. ,  ANDERSON, Daniel, Griffith

    IPC分类号： A61K47/48 ,  A61P35/00

    CPC分类号： C08B37/0021 ,  A61K9/06 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1652 ,  A61K31/721 ,  A61K31/724 ,  C08B37/0012 ,  C08L5/00 ,  C08L5/02 ,  C08L5/16

    摘要： Described herein are inventive compositions and methods relating to polymer conjugates and, in particular, to polymer conjugates having pendant side groups comprising ring moieties. In one aspect, embodiments are generally related to compositions that mimic naturally- occurring polyphenol compounds. The compositions comprise, in some embodiments, a polymer backbone having a plurality of hydroxyaromatic pendant side groups or derivatives thereof. For example, in some cases, a pendant side group may be a phenol or a substituted derivative thereof. In some cases, the pendant side group may be an oxidized hydroxyaromatic group, such as a quinone. In some embodiments, self-assembled structures comprising one or more of the polymer conjugates are provided. For example, the polymer conjugates may be combined with a complexing agent to form a particle. In some cases, a polymer conjugate may form a hydrogel. In some embodiments, the self-assembled structures may contain an agent, such as a pharmaceutically active agent. Also provided are methods and kits for forming the compositions, methods of using the compositions, and the like.

    摘要翻译： 本文描述了与聚合物缀合物有关的本发明组合物和方法，特别是具有包含环部分的侧基的聚合物缀合物。 在一个方面，实施方案通常涉及模拟天然存在的多酚化合物的组合物。 在一些实施方案中，组合物包含具有多个羟基芳族侧基侧基或其衍生物的聚合物主链。 例如，在一些情况下，侧基可以是苯酚或其取代的衍生物。 在一些情况下，侧基可以是氧化的羟基芳族基团，例如醌。 在一些实施方案中，提供包含一种或多种聚合物共轭物的自组装结构。 例如，聚合物共轭物可以与络合剂组合以形成颗粒。 在一些情况下，聚合物缀合物可以形成水凝胶。 在一些实施方案中，自组装结构可以含有试剂，例如药物活性剂。 还提供了用于形成组合物的方法和试剂盒，使用组合物的方法等。

    pH SENSITIVE BIODEGRADABLE POLYMERIC PARTICLES FOR DRUG DELIVERY
    8.
    发明申请
    pH SENSITIVE BIODEGRADABLE POLYMERIC PARTICLES FOR DRUG DELIVERY 审中-公开
    pH敏感的生物可降解的药物递送聚合物颗粒

    公开(公告)号：WO2010120385A1

    公开(公告)日：2010-10-21

    申请号：PCT/US2010/001158

    申请日：2010-04-18

    申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  RADOVIC-MORENO, Aleksandar, Filip ,  GAO, Weiwei ,  MUKHERJEE, Archana ,  GOLOMB, Gershon ,  LANGER, Robert, S. ,  FAROKHZAD, Omid, C.

    发明人： RADOVIC-MORENO, Aleksandar, Filip ,  GAO, Weiwei ,  MUKHERJEE, Archana ,  GOLOMB, Gershon ,  LANGER, Robert, S. ,  FAROKHZAD, Omid, C.

    IPC分类号： A61K9/51 ,  A61K48/00

    CPC分类号： A61K9/51 ,  A61K48/0008 ,  C12N15/111 ,  C12N15/115 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2320/32

    摘要： The present invention generally relates to polymers and particles, such as nanoparticles. The particles and polymers generally include one or more buffering components. Additionally, the particles and polymers may include two or more components that impart useful properties (functionalities). The particles and polymers, for example, may include a buffering component and a degradable component. As described herein, the particles and polymers may also include a hydrophilic component and/or a cleavable bond component. The particles and polymers described herein have been found to be particularly effective when used for delivery of one or more agents, such as one or more pharmaceutical agents. Other aspects of the invention are directed to methods of using or administering such particles or polymers, kits involving such particles or polymers, and the like. The present invention also relates to particles containing a cleavable bond component and one or more fluorescence resonance energy transfer (FRET) pairs as well as methods of detecting the cleavage of the cleavable bond component of such particles.

    摘要翻译： 本发明一般涉及聚合物和颗粒，例如纳米颗粒。 颗粒和聚合物通常包括一种或多种缓冲组分。 此外，颗粒和聚合物可以包括赋予有用性质（功能）的两种或更多种组分。 颗粒和聚合物例如可以包括缓冲组分和可降解组分。 如本文所述，颗粒和聚合物还可以包括亲水组分和/或可裂解键组分。 已经发现本文所述的颗粒和聚合物在用于递送一种或多种试剂如一种或多种药剂时是特别有效的。 本发明的其它方面涉及使用或施用此类颗粒或聚合物的方法，涉及这种颗粒或聚合物的试剂等。 本发明还涉及含有可切割键组分和一种或多种荧光共振能量转移（FRET）对的颗粒以及检测这些颗粒的可裂解键组分的切割的方法。