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    PEPTIDE-BASED REGULATION OF GAP JUNCTIONS
    1.
    发明申请
    PEPTIDE-BASED REGULATION OF GAP JUNCTIONS 审中-公开
    基于肽基的GAP结构调节

    公开(公告)号：WO2009012224A2

    公开(公告)日：2009-01-22

    申请号：PCT/US2008069980

    申请日：2008-07-14

    申请人： UNIV NEW YORK STATE RES FOUND ,  DELMAR MARIO ,  TAFFET STEVEN M ,  LARSEN BJARNE DUE

    发明人： DELMAR MARIO ,  TAFFET STEVEN M ,  LARSEN BJARNE DUE

    IPC分类号： A61K38/10

    CPC分类号： A61K38/10

    摘要： The present invention relates to proteins and polypeptides that (i) have the formula A - [Wm - A]n where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; each W is independently a linker; m is 1 or 2; and n is any number from 1 through 5; (ii) consist essentially of the formula XnRXPXm where each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to fifteen, m is any number from zero to fifteen, and the sum of n and m is any number from eight to fifteen; (iii) have the formula A - An where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; and n is any number from 1 through 5; or (iv) consist essentially of the formula XnRXPXm where each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to seven, m is any number from zero to seven, and the sum of n and m is any number from zero to seven. Methods using these proteins and polypeptides to: identify the location of an RXP -binding domain of Cx43CT, modulate a Cx43 gap junction channel, screen for compounds that modulate Cx43CT, and measure Cx43CT-binding affinity of a compound that binds to Cx43CT, are also disclosed.

    摘要翻译： 本发明涉及（i）具有式A - [Wm-A] n的蛋白质和多肽，其中每个A独立地是式XXXXRXPXXXX的肽，其中每个X独立地是任何氨基酸，R是精氨酸，P是脯氨酸 ; 每个W独立地是一个连接体; m为1或2; n是从1到5的任何数字; （ii）基本上由式XnRXPXm组成，其中每个X独立地是任何氨基酸，R是精氨酸，P是脯氨酸，n是从零到十五的任何数，m是从零到十五的任何数，以及n和 m是从8到15的任何数字; （iii）具有式A-An，其中每个A独立地是式XXXXRXPXXXX的肽，其中每个X独立地是任何氨基酸，R是精氨酸，P是脯氨酸; n是从1到5的任何数字; 或（iv）基本上由式XnRXPXm组成，其中每个X独立地是任何氨基酸，R是精氨酸，P是脯氨酸，n是从0到7的任何数字，m是从0到7的任何数字，并且n的总和 m是从零到七的任何数字。 使用这些蛋白质和多肽的方法：鉴定Cx43CT的RXP结合结构域的位置，调节Cx43间隙连接通道，筛选调节Cx43CT的化合物和测量与Cx43CT结合的化合物的Cx43CT结合亲和力，也是 披露。

    IMPROVED SOLID-PHASE PEPTIDE SYNTHESIS AND AGENT FOR USE IN SUCH SYNTHESIS
    6.
    发明申请
    IMPROVED SOLID-PHASE PEPTIDE SYNTHESIS AND AGENT FOR USE IN SUCH SYNTHESIS 审中-公开
    改进的固相肽合成和用于此类合成的试剂

    公开(公告)号：WO1998011125A1

    公开(公告)日：1998-03-19

    申请号：PCT/DK1997000375

    申请日：1997-09-09

    申请人： HOLM, Arne ,  LARSEN, Bjarne, Due

    IPC分类号： C07K01/04

    CPC分类号： C07K1/042 ,  C07K1/04 ,  Y02P20/55

    摘要： Peptides X-AA1-AA2...AAn-Y, wherein AA is an L- or D-amino acid residue, X is hydrogen or an amino protective group, Y is OH, NH2 or an amino acid sequence comprising from 3 to 9 amino acid residues and n is an integer greater than 2, are prepared by solid phase synthesis, preferably using Fmoc-chemistry, the improvement consisting in that the C-terminal part attached to the solid phase comprises a pre-sequence comprising from 3 to 9, preferably from 5 to 7, amino acid residues independently selected from native L-amino acids having a side chain functionality which is suitably protected during the coupling steps and having a propensity factor P alpha > 0.57 and a propensity factor P beta > 1.10, preferably Lys and/or Glu, or the corresponding D-amino acids and said pre-sequence is optionally cleaved from the formed peptide.

    摘要翻译： 肽X-AA1-AA2 ... AAn-Y，其中AA是L-或D-氨基酸残基，X是氢或氨基保护基，Y是OH，NH2或包含3至9的氨基酸序列 氨基酸残基和n是大于2的整数，通过固相合成制备，优选使用Fmoc化学，其改进在于连接到固相的C末端部分包含3至9个的前序列 ，优选5-7个氨基酸残基，其独立地选自具有侧链官能度的天然L-氨基酸，所述天然L-氨基酸在偶联步骤期间被适当地保护并且具有倾向因子Pα> 0.57和倾向因子Pβ> 1.10，优选地 Lys和/或Glu，或相应的D-氨基酸和所述前序列任选地从形成的肽切割。

    PEPTIDE-BASED REGULATION OF GAP JUNCTIONS
    9.
    发明申请
    PEPTIDE-BASED REGULATION OF GAP JUNCTIONS 审中-公开

    公开(公告)号：WO2009012224A3

    公开(公告)日：2009-01-22

    申请号：PCT/US2008/069980

    申请日：2008-07-14

    申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK ,  DELMAR, Mario ,  TAFFET, Steven, M. ,  LARSEN, Bjarne, Due

    发明人： DELMAR, Mario ,  TAFFET, Steven, M. ,  LARSEN, Bjarne, Due

    IPC分类号： C07K14/00

    摘要： The present invention relates to proteins and polypeptides that (i) have the formula A - [Wm - A]n where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; each W is independently a linker; m is 1 or 2; and n is any number from 1 through 5; (ii) consist essentially of the formula X n RXPX m where each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to fifteen, m is any number from zero to fifteen, and the sum of n and m is any number from eight to fifteen; (iii) have the formula A - A n where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; and n is any number from 1 through 5; or (iv) consist essentially of the formula X n RXPX m where each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to seven, m is any number from zero to seven, and the sum of n and m is any number from zero to seven. Methods using these proteins and polypeptides to: identify the location of an RXP -binding domain of Cx43CT, modulate a Cx43 gap junction channel, screen for compounds that modulate Cx43CT, and measure Cx43CT-binding affinity of a compound that binds to Cx43CT, are also disclosed.