公开(公告)号：WO2010101722A2

公开(公告)日：2010-09-10

申请号：PCT/US2010/024827

申请日：2010-02-19

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  LUDWIG, Florian, N. ,  STANKUS, John ,  TROLLSAS, Mikael

Inventor： LUDWIG, Florian, N. ,  STANKUS, John ,  TROLLSAS, Mikael

IPC: A61L31/10

CPC classification number: A61L31/10 ,  A61K31/436 ,  A61K47/32 ,  A61L29/085 ,  A61L31/16 ,  A61L33/06 ,  C08F220/28 ,  Y10T428/31935

Abstract: A polymer comprising a phosphoryl choline moiety(ies), a composition comprising the polymer and optionally a bioactive agent, an implantable device such as a DES or a non-implantable device such as an angioplasty balloon comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.

Abstract translation: 包含磷酰胆碱部分的聚合物，包含聚合物和任选的生物活性剂的组合物，可植入装置例如DES或非可植入装置，例如血管成形术球囊，其上包括包含聚合物的涂层和任选的 提供了生物活性剂，以及使用该装置来治疗人的病症的方法。

公开(公告)号：WO2009025926A2

公开(公告)日：2009-02-26

申请号：PCT/US2008/067015

申请日：2008-06-13

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  LUDWIG, Florian, N. ,  HOSSAINY, Syed, F., A. ,  MURASE, Katsuyuki ,  ZHAO, Li ,  ASTAFIEVA, Irina

Inventor： LUDWIG, Florian, N. ,  HOSSAINY, Syed, F., A. ,  MURASE, Katsuyuki ,  ZHAO, Li ,  ASTAFIEVA, Irina

IPC: A61L27/34 ,  A61L27/54

CPC classification number: A61L31/10 ,  A61K9/1075 ,  A61K9/127 ,  A61K9/51 ,  A61L31/16 ,  A61L2300/624 ,  A61L2300/626 ,  A61L2400/12

Abstract: Nanoparticle-coated medical devices, nanoparticle-containing formulations and methods of using for treating a vascular disease are disclosed.

Abstract translation: 公开了纳米颗粒涂覆的医疗装置，含纳米颗粒的制剂和用于治疗血管疾病的方法。

公开(公告)号：WO2008151299A3

公开(公告)日：2008-12-11

申请号：PCT/US2008/065981

申请日：2008-06-05

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  KRAMER-BROWN, Pamela, A. ,  GALE, David, C. ,  KLEINER, Lothar, Walter ,  ASTAFIEVA, Irina ,  CHIU, Jessica ,  LUDWIG, Florian, N.

Inventor： KRAMER-BROWN, Pamela, A. ,  GALE, David, C. ,  KLEINER, Lothar, Walter ,  ASTAFIEVA, Irina ,  CHIU, Jessica ,  LUDWIG, Florian, N.

IPC: A61L31/02 ,  A61L31/16 ,  A61L31/14

Abstract: Implantable medical devices adapted to erodibly release delivery media for local and regional treatment are disclosed.

公开(公告)号：WO2008144146A1

公开(公告)日：2008-11-27

申请号：PCT/US2008/061050

申请日：2008-04-21

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS, INC. ,  EL-NOUNOU, Fozan, O. ,  LUDWIG, Florian, N. ,  HOSSAINY, Syed Faiyaz, Ahmed ,  CONSIGNY, Paul

Inventor： EL-NOUNOU, Fozan, O. ,  LUDWIG, Florian, N. ,  HOSSAINY, Syed Faiyaz, Ahmed ,  CONSIGNY, Paul

IPC: A61M25/00

CPC classification number: A61M25/0082 ,  A61M25/01 ,  A61M2025/0004 ,  A61M2025/0073 ,  A61M2206/11

Abstract: Catheters (110) with laminar flow bioactive agent delivery properties.

Abstract translation: 导管（110）具有层流生物活性剂输送性能。

公开(公告)号：WO2008109230A2

公开(公告)日：2008-09-12

申请号：PCT/US2008/053707

申请日：2008-02-12

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  LUDWIG, Florian, N. ,  HOSSAINY, Syed Faiyaz, Ahmed ,  PACETTI, Stephen, D.

Inventor： LUDWIG, Florian, N. ,  HOSSAINY, Syed Faiyaz, Ahmed ,  PACETTI, Stephen, D.

IPC: A61K9/16 ,  A61K9/51 ,  A61K47/48

CPC classification number: A61K9/0087 ,  A61K47/6907 ,  A61K47/6911 ,  A61K47/6913 ,  A61K47/6915 ,  A61K47/6935 ,  B82Y5/00

Abstract: A composition that includes nanoparticles with binding affinity for platelets, and methods for using this composition to treat vascular disease are disclosed.

Abstract translation: 公开了一种包含对血小板具有结合亲和力的纳米颗粒的组合物，以及使用该组合物治疗血管疾病的方法。

公开(公告)号：WO2008048387A3

公开(公告)日：2008-07-24

申请号：PCT/US2007018598

申请日：2007-08-22

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  GLAUSER THIERRY ,  DAVALIAN DARIUSH ,  LUDWIG FLORIAN NIKLAS ,  TROLLSAS MIKAEL

Inventor： GLAUSER THIERRY ,  DAVALIAN DARIUSH ,  LUDWIG FLORIAN NIKLAS ,  TROLLSAS MIKAEL

IPC: C08L53/00 ,  A61K9/51

CPC classification number: A61K9/0009 ,  A61K9/0019 ,  C08L53/005

Abstract: Compositions, methods of fabrication and methods of treatment for the controlled release of a therapeutic substance to a treatment region are disclosed herein. In some embodiments, block copolymer-based release platforms (modified or unmodified) can be used to deliver a therapeutic substance to an inflamed site in, for example, the coronary tree or the kidney glomeri. The platforms can be carriers of at least one therapeutic substance. An external "trigger", or stimulus, such as radiation, ultrasound, temperature, a magnetic field, a change in pH, a change in ionic strength or release of an enzyme, can be used to destabilize the platform in order to release its payload in a controlled manner once at a treatment site. Delivery devices can include a syringe, an infusion catheter, a porous balloon catheter, a double balloon catheter and the like.

Abstract translation: 本文公开了将治疗物质控制释放到治疗区域的组合物，制造方法和治疗方法。 在一些实施方案中，基于嵌段共聚物的释放平台（经修饰或未修饰）可用于将治疗物质递送至例如冠状动脉树或肾小球中的发炎部位。 平台可以是至少一种治疗物质的载体。 可以使用外部“触发”或刺激，例如辐射，超声，温度，磁场，pH变化，离子强度的变化或酶的释放，以破坏平台的稳定性，以释放其有效载荷 以受控的方式一次在治疗部位。 输送装置可以包括注射器，输注导管，多孔气囊导管，双气囊导管等。

公开(公告)号：WO2008076847A3

公开(公告)日：2008-06-26

申请号：PCT/US2007/087487

申请日：2007-12-13

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  PACETTI, Stephen, D. ,  CONSIGNY, Paul ,  HEIL, Ronald, W. ,  LUDWIG, Florian, N. ,  DAVALIAN, Dariush ,  ZHAO, Li ,  ASTAFIEVA, Irina ,  WAN, Jinping ,  EL-NOUNOU, Fozan ,  MURASE, Katsuyuki ,  HOSSAINY, Syed, Faiyaz Ahmed ,  BRIGHT, Rachel ,  ELLIS, Jeffrey

Inventor： PACETTI, Stephen, D. ,  CONSIGNY, Paul ,  HEIL, Ronald, W. ,  LUDWIG, Florian, N. ,  DAVALIAN, Dariush ,  ZHAO, Li ,  ASTAFIEVA, Irina ,  WAN, Jinping ,  EL-NOUNOU, Fozan ,  MURASE, Katsuyuki ,  HOSSAINY, Syed, Faiyaz Ahmed ,  BRIGHT, Rachel ,  ELLIS, Jeffrey

IPC: A61M29/02 ,  A61F2/84 ,  A61F2/82

Abstract: The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.

公开(公告)号：WO2008036144A2

公开(公告)日：2008-03-27

申请号：PCT/US2007/014657

申请日：2007-06-21

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  LUDWIG, Florian, Niklas ,  PACETTI, Stephen, D. ,  HOSSAINY, Syed, F.A. ,  DAVALIAN, Dariush

Inventor： LUDWIG, Florian, Niklas ,  PACETTI, Stephen, D. ,  HOSSAINY, Syed, F.A. ,  DAVALIAN, Dariush

CPC classification number: A61K9/5031 ,  A61K9/0004 ,  A61K9/0019 ,  A61K9/5115 ,  A61K9/5138 ,  A61K38/446 ,  A61K41/0052 ,  A61K47/6923 ,  A61K47/6925 ,  A61K47/6929 ,  A61K47/6931 ,  A61L31/16 ,  A61L2300/00 ,  A61L2400/06 ,  A61L2400/12 ,  B01J13/02 ,  B22F1/025 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/906 ,  Y10T428/2991 ,  Y10T428/2998

Abstract: Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.

Abstract translation: 提供包含纳米壳的纳米构建体和使用纳米构建体治疗或改善医学状况的方法。

公开(公告)号：WO2008031097A1

公开(公告)日：2008-03-13

申请号：PCT/US2007/078035

申请日：2007-09-10

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  KRAMER-BROWN, Pamela A. ,  LUDWIG, Florian N.

Inventor： KRAMER-BROWN, Pamela A. ,  LUDWIG, Florian N.

IPC: A61F2/06

CPC classification number: A61F2/92 ,  A61F2250/0067

Abstract: A bioactive agent-containing implantable open ring-shaped medical device and methods of using for the treatment of disease are disclosed.

Abstract translation: 公开了一种含生物活性剂的可植入开环形医疗装置及其用于治疗疾病的方法。

公开(公告)号：WO2007133382A3

公开(公告)日：2008-01-10

申请号：PCT/US2007009526

申请日：2007-04-18

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  KLEINER LOTHAR W ,  HOSSAINY SYED ,  ASTAFIEVA IRINA ,  PACETTI STEPHEN ,  GLAUSER THIERRY ,  DESNOYER JESSICA ,  LUDWIG FLORIAN N

Inventor： KLEINER LOTHAR W ,  HOSSAINY SYED ,  ASTAFIEVA IRINA ,  PACETTI STEPHEN ,  GLAUSER THIERRY ,  DESNOYER JESSICA ,  LUDWIG FLORIAN N

IPC: A61K9/00 ,  A61L31/16

CPC classification number: A61K9/0019 ,  A61K9/143 ,  A61K9/1611 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/602

Abstract: Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device.

Abstract translation: 公开了用于持续释放治疗剂以治疗闭塞的血管和受影响的组织和/或器官的方法和组合物。 多孔或无孔生物可吸收玻璃，金属或陶瓷珠，棒或纤维颗粒可以加载处理剂和任选的图像增强剂，并涂覆有持续释放的涂层以递送至闭塞的血管并受影响 组织和/或器官通过递送装置。