公开(公告)号：WO2012167129A1

公开(公告)日：2012-12-06

申请号：PCT/US2012/040526

申请日：2012-06-01

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  GUTIERREZ, Christian, A. ,  MENG, Ellis

Inventor： GUTIERREZ, Christian, A. ,  MENG, Ellis

IPC: G01F11/04 ,  A61M5/145 ,  A61M5/168 ,  G01M3/00 ,  G01F11/08

CPC classification number: G01F11/086 ,  A61M5/14593 ,  A61M5/16886 ,  G01F11/08

Abstract: Electrochemical impedance may be used for accurate and real-time tracking and control of fluid delivery from fluid-filled chambers, such as from drug delivery devices. At least two measurement electrodes may be placed within the chamber in contact with the fluid to be sensed. Application of a small alternating current using these electrodes through the fluid/drug may allow measurement of electrochemical impedance. Volumetric changes of the compressible chamber due to movement of at least one surface within the compressible chamber (such as an actuating bellows or flexible diaphragm), may induce changes in the measured electrochemical impedance. Measuring these changes may allow for tracking of ejected liquid volumes from the compressible chamber. By taking the time-derivative of this signal, the rate of volume change can be tracked and therefore the rate of ejected fluid (flow rate) can be deduced.

Abstract translation: 电化学阻抗可用于精确和实时跟踪和控制从填充液体的腔室（例如来自药物输送装置）的流体输送。 至少两个测量电极可以放置在室内与要感测的流体接触。 使用这些电极通过流体/药物施加小的交流电流可以测量电化学阻抗。 由于可压缩室内的至少一个表面的移动（例如致动波纹管或柔性隔膜），可压缩室的体积变化可能引起测量的电化学阻抗的变化。 测量这些变化可以允许跟踪来自可压缩室的喷射液体体积。 通过采用该信号的时间导数，可以跟踪体积变化率，因此可以推导出喷射流体的速率（流量）。

公开(公告)号：WO2011119886A3

公开(公告)日：2012-04-19

申请号：PCT/US2011029866

申请日：2011-03-24

Applicant: UNIV SOUTHERN CALIFORNIA ,  GUTIERREZ CHRISTIAN A ,  MENG ELLIS

Inventor： GUTIERREZ CHRISTIAN A ,  MENG ELLIS

IPC: G01L7/18 ,  B81B1/00 ,  G01L7/00 ,  G01L9/00

CPC classification number: G01L11/00 ,  G01L11/02 ,  G01L11/04 ,  Y10T29/49002

Abstract: A pressure transducer for measuring pressure may include an all-polymer chamber that has no dimension greater than 1 mm. There may be fluid within the chamber, a gaseous bubble trapped within the fluid, and electrodes in contact with the fluid. The electrodes may enable a measurement of changes in the impedance of the fluid caused by changes in the volume of the gaseous bubble caused by changes in the pressure to be measured. The pressure transducer may be made by depositing the chamber, placing the fluid within the chamber, and generating the gaseous bubble within the fluid with electrolysis.

Abstract translation: 用于测量压力的压力传感器可以包括没有尺寸大于1mm的全聚合物室。 室内可能存在流体，被捕获在流体内的气泡和与流体接触的电极。 电极可以测量由待测量的压力变化引起的气泡体积变化引起的流体阻抗的变化。 压力传感器可以通过沉积室，将流体放置在室内，并通过电解产生流体内的气泡来制造。

公开(公告)号：WO2010141118A3

公开(公告)日：2011-03-10

申请号：PCT/US2010024808

申请日：2010-02-19

Applicant: UNIV SOUTHERN CALIFORNIA ,  MENG ELLIS ,  LI PO-YING ,  HOANG TUAN

Inventor： MENG ELLIS ,  LI PO-YING ,  HOANG TUAN

IPC: A61M31/00 ,  A61F2/14 ,  A61F9/00 ,  A61M37/00 ,  F04B45/02

CPC classification number: A61M5/14276 ,  A61M2210/0612

Abstract: An implantable fluid delivery system may include a fluid reservoir configured to hold a supply of fluid, to dispense that fluid under the control of an actuator, and to be implanted within the body of a living host. An actuator within the fluid reservoir may cause the fluid to be controllably dispensed from the fluid reservoir. The actuator may include a bellows configured to expand in a direction when inflated. The bellows may have folds with surfaces which run substantially perpendicular to the direction of expansion in a collapsed state and which define a stacked set of convolutions. Each convolution may have a collapsed height of no more than 1 mm and a width perpendicular to the direction of expansion of no more than 8 mm. Electrodes may be configured to come in electrical contact with an electrolyte within the bellows and to cause electricity to run through the electrolyte, thereby causing the electrolyte to break down into a gas and, in turn, to cause the bellows to expand. Methods of making the bellows which utilize stacked sheets are also disclosed.

Abstract translation: 可植入流体输送系统可以包括被配置为保持流体供应的流体储存器，以在致动器的控制下分配该流体并且植入到活体的体内。 流体储存器内的致动器可以使流体从流体储存器被可控地分配。 致动器可以包括构造成在膨胀的方向上膨胀的波纹管。 波纹管可以具有折叠，其表面在折叠状态下基本上垂直于膨胀方向延伸，并且限定了一组堆叠的卷积。 每个卷积可以具有不大于1mm的折叠高度和垂直于不大于8mm的膨胀方向的宽度。 电极可以被配置为与波纹管​​内的电解质电接触并导致电流穿过电解质，从而导致电解质分解成气体，从而导致波纹管膨胀。 还公开了制造利用堆叠片材的波纹管的方法。

公开(公告)号：WO2010099210A2

公开(公告)日：2010-09-02

申请号：PCT/US2010/025248

申请日：2010-02-24

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  GUTIERREZ, Christian, A. ,  MENG, Ellis

Inventor： GUTIERREZ, Christian, A. ,  MENG, Ellis

IPC: A61F2/68 ,  A61F2/74

CPC classification number: G01L1/20 ,  G01D1/00 ,  G01D15/00 ,  G01D21/00 ,  G01L9/18

Abstract: Embodiments of the present disclosure are directed to MEMS-based medical devices including a flexible housing that forms a chamber for encapsulating a fluid or liquid. The devices also include encapsulated electrodes, portions of which are exposed to the fluid or liquid within the chamber for sensing and/or physical actuation (controlled movement). Such medical devices can function specifically as: contact force sensors; and/or out-of-plane actuators. Device function is enabled by the encapsulation of liquid within the microchamber. Depending on the kind of electrical input applied, the encapsulated electrodes can function as electrochemical sensing elements; and/or electrolytic generation electrodes. Devices according to the present disclosure can have a fluidic coupling to the external environment or can be isolated. Fluidic isolation from the surrounding environment can be accomplished by the inclusion of an annular-plate stiction valve within the device. Related methods of use and fabrication are also described.

Abstract translation: 本公开的实施例涉及基于MEMS的医疗装置，其包括形成用于封装流体或液体的腔室的柔性壳体。 这些装置还包括封装的电极，其部分暴露于腔室内的流体或液体，用于感测和/或物理致动（受控运动）。 这样的医疗设备可以具有如下功能：接触力传感器; 和/或平面外致动器。 通过在微型仓中将液体封装起来可以实现器件功能。 根据施加的电气输入种类，封装的电极可以用作电化学传感元件; 和/或电解生成电极。 根据本公开的装置可以具有与外部环境的流体耦合或者可以被隔离。 与周围环境的流体隔离可以通过在设备内包括环形板静止阀来实现。 还描述了相关的使用和制造方法。

公开(公告)号：WO2011119886A2

公开(公告)日：2011-09-29

申请号：PCT/US2011/029866

申请日：2011-03-24

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  GUTIERREZ, Christian, A. ,  MENG, Ellis

Inventor： GUTIERREZ, Christian, A. ,  MENG, Ellis

CPC classification number: G01L11/00 ,  G01L11/02 ,  G01L11/04 ,  Y10T29/49002

Abstract: A pressure transducer for measuring pressure may include an all-polymer chamber that has no dimension greater than 1 mm. There may be fluid within the chamber, a gaseous bubble trapped within the fluid, and electrodes in contact with the fluid. The electrodes may enable a measurement of changes in the impedance of the fluid caused by changes in the volume of the gaseous bubble caused by changes in the pressure to be measured. The pressure transducer may be made by depositing the chamber, placing the fluid within the chamber, and generating the gaseous bubble within the fluid with electrolysis.

Abstract translation: 用于测量压力的压力传感器可以包括没有尺寸大于1mm的全聚合物室。 室内可能存在流体，被捕获在流体内的气泡和与流体接触的电极。 电极可以测量由待测量的压力变化引起的气泡体积的变化引起的流体阻抗的变化。 压力传感器可以通过沉积室，将流体放置在室内，并通过电解产生流体内的气泡来制造。

公开(公告)号：WO2010096651A3

公开(公告)日：2010-08-26

申请号：PCT/US2010/024730

申请日：2010-02-19

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  MENG, Ellis ,  MANN, Ronalee, Lo

Inventor： MENG, Ellis ,  MANN, Ronalee, Lo

IPC: A61M37/00 ,  A61M31/00 ,  A61M5/14 ,  A61M39/22

Abstract: A drug delivery device may include a drug reservoir configured to contain and controllably deliver a fluidic drug. A tube may be configured to deliver the fluid from the drug reservoir through a lumen in the tube to another location. A valve wholly within the lumen of the tube may regulates the flow of the fluid through the tube without substantially diverting the direction in which the fluid flows through the tube. The valve may contain only a single member which moves during operation of the valve. The valve may be configured to regulate the flow of fluid in a bandpass manner by allowing fluid to flow through the valve only when the pressure of the fluid is above a minimum and below a maximum. The valve may be held in place within the tube solely by frictional force between the valve and a wall of the tube.

公开(公告)号：WO2010096651A2

公开(公告)日：2010-08-26

申请号：PCT/US2010024730

申请日：2010-02-19

Applicant: UNIV SOUTHERN CALIFORNIA ,  MENG ELLIS ,  MANN RONALEE LO

Inventor： MENG ELLIS ,  MANN RONALEE LO

IPC: A61M37/00 ,  A61M5/14 ,  A61M31/00 ,  A61M39/22

CPC classification number: A61M5/00 ,  A61F9/0017 ,  A61M5/14276 ,  A61M5/16881 ,  A61M2039/2413 ,  A61M2039/242 ,  A61M2210/0612

Abstract: A drug delivery device may include a drug reservoir configured to contain and controllably deliver a fluidic drug. A tube may be configured to deliver the fluid from the drug reservoir through a lumen in the tube to another location. A valve wholly within the lumen of the tube may regulates the flow of the fluid through the tube without substantially diverting the direction in which the fluid flows through the tube. The valve may contain only a single member which moves during operation of the valve. The valve may be configured to regulate the flow of fluid in a bandpass manner by allowing fluid to flow through the valve only when the pressure of the fluid is above a minimum and below a maximum. The valve may be held in place within the tube solely by frictional force between the valve and a wall of the tube.

Abstract translation: 药物递送装置可以包括被配置为容纳和可控地递送流体药物的药物储存器。 管可以被配置成将来自药物储存器的流体通过管中的管腔输送到另一位置。 完全在管腔中的阀可以调节流体通过管的流动，而不会使流体流过管的方向基本上转向。 阀可以仅包含在阀操作期间移动的单个构件。 阀可以被配置为通过仅当流体的压力高于最小值并且低于最大值时允许流体流过阀门才能以带通方式调节流体的流动。 阀可以仅通过阀和管壁之间的摩擦力保持在管内的适当位置。

公开(公告)号：WO2005121735A3

公开(公告)日：2006-11-23

申请号：PCT/US2005020244

申请日：2005-06-07

Applicant: CALIFORNIA INST OF TECHN ,  TAI YU-CHONG ,  MENG ELLIS ,  CHEN PO-JUI ,  RODGER DAMIEN C ,  HUMAYUN MARK

Inventor： TAI YU-CHONG ,  MENG ELLIS ,  CHEN PO-JUI ,  RODGER DAMIEN C ,  HUMAYUN MARK

IPC: G01L7/00 ,  A61B3/16 ,  A61B5/00 ,  G01L7/04 ,  G01L7/08

CPC classification number: A61B3/16 ,  A61B2562/02 ,  A61B2562/028 ,  G01L7/045

Abstract: A biocompatible, mechanical, micromachined pressure sensor and methods of manufacturing such a pressure sensor are provided. The pressure sensor of the current invention comprises a high-aspect-ratio curved-tube structure fabricated through a one-layer parylene process. The pressure sensor of the current invention requires zero power consumption and indicates the pressure variation by changes of the in situ in-plane motion of the sensor, which can be gauged externally by a direct and convenient optical observation. In one embodiment, the pressure sensor of the current invention has been shown to work as an IOP sensor for eye implantation where the intraocular in-plane motion of the sensor can be recorded from outside of the eye, such that the intraocular pressure in glaucoma patients can be constantly monitored.

Abstract translation: 提供生物相容的，机械的，微加工的压力传感器以及制造这种压力传感器的方法。 本发明的压力传感器包括通过一层帕利灵法制造的高纵横比弯曲管结构。 本发明的压力传感器需要零功率消耗，并且通过传感器的原位面内运动的变化来指示压力变化，其可以通过直接和方便的光学观察在外部测量。 在一个实施例中，本发明的压力传感器已被证明可用作眼睛植入的IOP传感器，其中可以从眼睛外部记录传感器的眼内平面内运动，使得青光眼患者的眼内压 可以不断监控。

公开(公告)号：WO2009089094A2

公开(公告)日：2009-07-16

申请号：PCT/US2009/030019

申请日：2009-01-02

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  MENG, Ellis ,  HUMAYUN, Mark ,  LO, Ronalee ,  LEE, Po-Ying ,  SAATI, Saloomeh

Inventor： MENG, Ellis ,  HUMAYUN, Mark ,  LO, Ronalee ,  LEE, Po-Ying ,  SAATI, Saloomeh

IPC: A61M5/158 ,  A61F7/00

CPC classification number: A61M5/427 ,  A61F9/0017 ,  A61M5/14276 ,  A61M5/158 ,  A61M5/46 ,  A61M39/0208 ,  A61M2005/14284 ,  A61M2039/0238 ,  A61M2205/3523 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/6054 ,  A61M2205/6063 ,  A61M2209/045 ,  A61M2210/0612

Abstract: In various embodiments, a needle is employed in refilling drug-delivery devices.

Abstract translation: 在各种实施方案中，使用针来重新填充药物递送装置。

公开(公告)号：WO2005121735A2

公开(公告)日：2005-12-22

申请号：PCT/US2005/020244

申请日：2005-06-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  TAI, Yu-Chong ,  MENG, Ellis ,  CHEN, Po-Jui ,  RODGER, Damien, C. ,  HUMAYUN, Mark

Inventor： TAI, Yu-Chong ,  MENG, Ellis ,  CHEN, Po-Jui ,  RODGER, Damien, C. ,  HUMAYUN, Mark

IPC: G01L7/08

CPC classification number: A61B3/16 ,  A61B2562/02 ,  A61B2562/028 ,  G01L7/045

Abstract: A biocompatible, mechanical, micromachined pressure sensor and methods of manufacturing such a pressure sensor are provided. The pressure sensor of the current invention comprises a high-aspect-ratio curved-tube structure fabricated through a one-layer parylene process. The pressure sensor of the current invention requires zero power consumption and indicates the pressure variation by changes of the in situ in-plane motion of the sensor, which can be gauged externally by a direct and convenient optical observation. In one embodiment, the pressure sensor of the current invention has been shown to work as an IOP sensor for eye implantation where the intraocular in-plane motion of the sensor can be recorded from outside of the eye, such that the intraocular pressure in glaucoma patients can be constantly monitored.

Abstract translation: 提供生物相容的，机械的，微加工的压力传感器以及制造这种压力传感器的方法。 本发明的压力传感器包括通过一层聚对二甲苯工艺制造的高纵横比弯曲管结构。 本发明的压力传感器需要零功率消耗，并且通过传感器的原位面内运动的变化来指示压力变化，其可以通过直接和方便的光学观察在外部测量。 在一个实施例中，本发明的压力传感器已经被证明可用作眼睛植入的IOP传感器，其中可以从眼睛外部记录传感器的眼内平面内运动，使得青光眼患者的眼内压 可以不断监控。