公开(公告)号：WO2010116282A8

公开(公告)日：2011-11-03

申请号：PCT/IB2010051337

申请日：2010-03-26

申请人： PFIZER ,  ARHANCET GRACIELA BARBIERI ,  CASIMIRO-GARCIA AGUSTIN ,  CHEN XIANGYANG ,  HEPWORTH DAVID ,  MEYERS MARVIN JAY ,  PIOTROWSKI DAVID WALTER ,  RAHEJA RAJ KUMAR

发明人： ARHANCET GRACIELA BARBIERI ,  CASIMIRO-GARCIA AGUSTIN ,  CHEN XIANGYANG ,  HEPWORTH DAVID ,  MEYERS MARVIN JAY ,  PIOTROWSKI DAVID WALTER ,  RAHEJA RAJ KUMAR

IPC分类号： C07D401/04 ,  A61K31/44 ,  A61P3/04 ,  A61P9/00 ,  A61P29/00 ,  C07D401/14 ,  C07D413/14

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D413/14

摘要： Mineralocorticoid receptor antagonists (MRa), pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetic nephropathy and hypertension in mammals, including humans.

摘要翻译： 皮质激素受体拮抗剂（MRa），含有这些抑制剂的药物组合物，以及这些抑制剂在哺乳动物（包括人）中治疗例如糖尿病肾病和高血压的用途。

公开(公告)号：WO2010116282A1

公开(公告)日：2010-10-14

申请号：PCT/IB2010/051337

申请日：2010-03-26

申请人： PFIZER INC. ,  ARHANCET, Graciela Barbieri ,  CASIMIRO-GARCIA, Agustin ,  CHEN, Xiangyang ,  HEPWORTH, David ,  MEYERS, Marvin Jay ,  PIOTROWSKI, David Walter ,  RAHEJA, Raj Kumar

发明人： ARHANCET, Graciela Barbieri ,  CASIMIRO-GARCIA, Agustin ,  CHEN, Xiangyang ,  HEPWORTH, David ,  MEYERS, Marvin Jay ,  PIOTROWSKI, David Walter ,  RAHEJA, Raj Kumar

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  A61K31/44 ,  A61P3/04 ,  A61P29/00 ,  A61P9/00

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D413/14

摘要： Mineralocorticoid receptor antagonists (MRa), pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetic nephropathy and hypertension in mammals, including humans.

摘要翻译： 皮质激素受体拮抗剂（MRa），含有这些抑制剂的药物组合物，以及这些抑制剂在哺乳动物（包括人）中治疗例如糖尿病肾病和高血压的用途。

公开(公告)号：WO2008053300A1

公开(公告)日：2008-05-08

申请号：PCT/IB2007/003207

申请日：2007-10-17

申请人： PFIZER PRODUCTS INC. ,  MEYERS, Marvin Jay ,  ARHANCET, Graciela Barbieri ,  CHEN, Xiangyang ,  HOCKERMAN, Susan Landis ,  LONG, Scott, Allen ,  MAHONEY, Matthew, William ,  REITZ, David, Bruce ,  RICO, Joseph Gerace

发明人： MEYERS, Marvin Jay ,  ARHANCET, Graciela Barbieri ,  CHEN, Xiangyang ,  HOCKERMAN, Susan Landis ,  LONG, Scott, Allen ,  MAHONEY, Matthew, William ,  REITZ, David, Bruce ,  RICO, Joseph Gerace

IPC分类号： C07D231/54 ,  C07D401/04 ,  C07D405/04 ,  C07D493/04 ,  A61K31/416 ,  A61K31/4162 ,  A61P9/12

CPC分类号： C07D231/54 ,  C07D401/04 ,  C07D405/04 ,  C07D493/04

摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R1, R2, R3A, R3B, R4, R5, R6, R7, R8, and X are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, and intermediates are also disclosed.

摘要翻译： 公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有式I的结构：其中R1，R2，R3A，R3B，R4，R5，R6，R7，R8和X如在 本发明。 还公开了相应的药物组合物，治疗方法和中间体。

公开(公告)号：WO2008047229A3

公开(公告)日：2008-04-24

申请号：PCT/IB2007/003202

申请日：2007-10-05

申请人： PFIZER PRODUCTS INC. ,  FAY, Lorraine, Kathleen ,  JOHNSON, Douglas, Scott ,  LAZERWITH, Scott, Edward ,  MORRIS, Mark, Anthony ,  WANG, Lijuan, Jane ,  MEYERS, Marvin, Jay ,  KESTEN, Suzanne, Ross ,  STIFF, Cory, Michael

发明人： FAY, Lorraine, Kathleen ,  JOHNSON, Douglas, Scott ,  LAZERWITH, Scott, Edward ,  MORRIS, Mark, Anthony ,  WANG, Lijuan, Jane ,  MEYERS, Marvin, Jay ,  KESTEN, Suzanne, Ross ,  STIFF, Cory, Michael

IPC分类号： C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D471/04 ,  A61K31/444 ,  A61P29/02

摘要： The present invention relates to compounds of Formula (I) or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity.

公开(公告)号：WO2010049841A1

公开(公告)日：2010-05-06

申请号：PCT/IB2009/054560

申请日：2009-10-16

申请人： PFIZER INC. ,  LONG, Scott Allen ,  MEYERS, Marvin Jay ,  PELC, Matthew James ,  SCHWEITZER, Barbara Ann ,  THORARENSEN, Atli ,  WANG, Lijuan Jane

发明人： LONG, Scott Allen ,  MEYERS, Marvin Jay ,  PELC, Matthew James ,  SCHWEITZER, Barbara Ann ,  THORARENSEN, Atli ,  WANG, Lijuan Jane

IPC分类号： C07D403/14 ,  C07D413/14 ,  C07D413/12 ,  C07D403/12 ,  C07D417/14 ,  A61K31/501 ,  A61K31/444 ,  A61K31/438 ,  A61K31/513 ,  A61P9/00 ,  A61P25/00 ,  A61P29/00 ,  A61P37/00

CPC分类号： C07D403/14 ,  C07D403/12

摘要： Provided herein are 7-azaspiro[3.5]nonane-7-carboxamide compounds and the pharmaceutically acceptable salts of such compounds useful in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity, conditions including including acute pain, chronic pain, neuropathic pain, nociceptive pain, inflammatory pain, cancer and cancer pain, fibromyalgia, rheumatoid arthritis, inflammatory bowel disease, lupus, diabetes, allergic asthma, vascular inflammation, urinary incontinence, overactive bladder, emesis, cognitive disorders, anxiety, depression, sleeping disorders, eating disorders, movement disorders, glaucoma, psoriasis, multiple sclerosis, cerebrovascular disorders, brain injury, gastrointestinal disorders, hypertension, or cardiovascular disease.

摘要翻译： 本文提供的是7-氮杂螺[3.5]壬烷-7-甲酰胺化合物和可用于治疗与脂肪酰胺水解酶（FAAH）活性相关的疾病或病症的化合物的药学上可接受的盐，包括急性疼痛，慢性疼痛，神经性 疼痛，伤害性疼痛，炎性疼痛，癌症和癌症疼痛，纤维肌痛，类风湿性关节炎，炎性肠病，狼疮，糖尿病，过敏性哮喘，血管炎症，尿失禁，膀胱过度活动，呕吐，认知障碍，焦虑症，抑郁症，睡眠障碍， 饮食失调，运动障碍，青光眼，牛皮癣，多发性硬化，脑血管障碍，脑损伤，胃肠道疾病，高血压或心血管疾病。

公开(公告)号：WO2009127949A1

公开(公告)日：2009-10-22

申请号：PCT/IB2009005255

申请日：2009-04-09

申请人： PFIZER ,  MEYERS MARVIN JAY ,  PELC MATTHEW JAMES ,  THORARENSEN ALTI

发明人： MEYERS MARVIN JAY ,  PELC MATTHEW JAMES ,  THORARENSEN ALTI

IPC分类号： C07D211/70 ,  A61K31/4427 ,  A61K31/445 ,  A61P9/00 ,  A61P25/00 ,  A61P29/00 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04

CPC分类号： C07D401/14 ,  C07D413/14 ,  C07D471/04

摘要： The present invention relates to compounds of Formula (I), wherein Ar is optionally substituted phenyl or heteroaryl and X, Y and Z are independently N or CH; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity.

摘要翻译： 本发明涉及式（I）化合物，其中Ar为任选取代的苯基或杂芳基，X，Y和Z独立地为N或CH; 或其药学上可接受的盐; 化合物的制备方法; 用于制备化合物的中间体; 含有这些化合物的组合物; 以及该化合物在治疗与脂肪酰胺水解酶（FAAH）活性相关的疾病或病症中的用途。

公开(公告)号：WO2009127944A8

公开(公告)日：2009-10-22

申请号：PCT/IB2009/005246

申请日：2009-04-09

申请人： PFIZER INC. ,  FAY, Lorraine Kathleen ,  JOHNSON, Douglas Scott ,  MEYERS, Marvin Jay ,  THORARENSEN, Atli ,  WANG, Lijuan Jane

发明人： FAY, Lorraine Kathleen ,  JOHNSON, Douglas Scott ,  MEYERS, Marvin Jay ,  THORARENSEN, Atli ,  WANG, Lijuan Jane

IPC分类号： C07D211/70 ,  C07D401/12 ,  C07D413/12 ,  A61K31/4427 ,  A61P29/00 ,  A61P25/00 ,  A61P9/00

摘要： The present invention relates to compounds of Formula (I) wherein Ar is optionally substituted phenyl or 6-membered heteroaryl moiety, or a benzisoxazole, pyrrolopyridine, or benzotriazole group; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity, including pain, urinary incontinence, overactive bladder, emesis, cognitive disorders, anxiety, depression, sleeping disorders, eating disorders, movement disorders, glaucoma, psoriasis, multiple sclerosis, cerebrovascular disorders, brain injury, gastrointestinal disorders, hypertension, or cardiovascular disease.

公开(公告)号：WO2008047229A2

公开(公告)日：2008-04-24

申请号：PCT/IB2007003202

申请日：2007-10-05

申请人： PFIZER PROD INC ,  FAY LORRAINE KATHLEEN ,  JOHNSON DOUGLAS SCOTT ,  LAZERWITH SCOTT EDWARD ,  MORRIS MARK ANTHONY ,  WANG LIJUAN JANE ,  MEYERS MARVIN JAY ,  KESTEN SUZANNE ROSS ,  STIFF CORY MICHAEL

发明人： FAY LORRAINE KATHLEEN ,  JOHNSON DOUGLAS SCOTT ,  LAZERWITH SCOTT EDWARD ,  MORRIS MARK ANTHONY ,  WANG LIJUAN JANE ,  MEYERS MARVIN JAY ,  KESTEN SUZANNE ROSS ,  STIFF CORY MICHAEL

CPC分类号： C07D401/14 ,  C07D401/06 ,  C07D401/12 ,  C07D413/14

摘要： The present invention relates to compounds of Formula (I) or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity.

摘要翻译： 本发明涉及式（I）的化合物或其药学上可接受的盐; 制备化合物的方法; 用于制备该化合物的中间体; 含有化合物的组合物; 以及这些化合物在治疗与脂肪酸酰胺水解酶（FAAH）活性相关的疾病或病症中的用途。

公开(公告)号：WO2009127948A8

公开(公告)日：2009-10-22

申请号：PCT/IB2009/005254

申请日：2009-04-09

申请人： PFIZER INC. ,  MEYERS, Marvin, Jay ,  PELC, Matthew, James ,  THORARENSEN, Atli ,  SCHWEITZER, Barbara, Ann

发明人： MEYERS, Marvin, Jay ,  PELC, Matthew, James ,  THORARENSEN, Atli ,  SCHWEITZER, Barbara, Ann

IPC分类号： C07D211/70 ,  C07D401/12 ,  C07D413/12 ,  A61K31/4427 ,  A61K31/445 ,  A61P29/00 ,  A61P25/00 ,  A61P9/00 ,  C07D413/14

摘要： The present invention relates to compounds of Formula (I), wherein Ar is a 5-membered heteroaryl moiety and X, Y and Z are independently N or CH; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity.

公开(公告)号：WO2009127948A1

公开(公告)日：2009-10-22

申请号：PCT/IB2009005254

申请日：2009-04-09

申请人： PFIZER ,  MEYERS MARVIN JAY ,  PELC MATTHEW JAMES ,  THORARENSEN ALTI ,  SCHWEITZER BARBARA ANN

发明人： MEYERS MARVIN JAY ,  PELC MATTHEW JAMES ,  THORARENSEN ALTI ,  SCHWEITZER BARBARA ANN

IPC分类号： C07D211/70 ,  A61K31/4427 ,  A61K31/445 ,  A61P9/00 ,  A61P25/00 ,  A61P29/00 ,  C07D401/12 ,  C07D413/12 ,  C07D413/14

CPC分类号： C07D413/12 ,  C07D413/14

摘要： The present invention relates to compounds of Formula (I), wherein Ar is a 5-membered heteroaryl moiety and X, Y and Z are independently N or CH; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity.

摘要翻译： 本发明涉及式（I）化合物，其中Ar是5元杂芳基部分，X，Y和Z独立地是N或CH; 或其药学上可接受的盐; 化合物的制备方法; 用于制备化合物的中间体; 含有这些化合物的组合物; 以及该化合物在治疗与脂肪酰胺水解酶（FAAH）活性相关的疾病或病症中的用途。