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16 条记录 (耗时 0.018 秒)

    AMINOPYRIDINE DERIVATIVES AS SELECTIVE DOPAMINE D3 AGONISTS
    2.
    发明申请
    AMINOPYRIDINE DERIVATIVES AS SELECTIVE DOPAMINE D3 AGONISTS 审中-公开
    氨基吡啶衍生物作为选择性多巴胺D3激动剂

    公开(公告)号：WO2005115985A1

    公开(公告)日：2005-12-08

    申请号：PCT/IB2005/001554

    申请日：2005-05-17

    申请人： PFIZER LIMITED ,  PFIZER INC. ,  ALLERTON, Charlotte, Moira, Norfor ,  COOK, Andrew, Simon ,  HEPWORTH, David ,  MILLER, Duncan, Charles

    发明人： ALLERTON, Charlotte, Moira, Norfor ,  COOK, Andrew, Simon ,  HEPWORTH, David ,  MILLER, Duncan, Charles

    IPC分类号： C07D213/73

    CPC分类号： C07D213/73 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04

    摘要： The present invention provides for compounds of formula (I) which are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. These compounds are useful for the treatment and/or prevention of sexual dysfunction, for example female sexual dysfunction (FSD), in particular female sexual arousal disorder (FSAD), hypoactive sexual desire disorder (HSDD; lack of interest in sex), female orgasmic disorder (FOD; inability to achieve orgasm); and male sexual dysfunction, in particular male erectile dysfunction (MED). Male sexual dysfunction as referred to herein is meant to include ejaculatory disorders such as premature ejaculation, anorgasmia (inability to achieve orgasm) or desire disorders such as hypoactive sexual desire disorder (HSDD; lack of interest in sex). These compounds are also useful in treating neuropsychiatric disorders and neurodegenerative disorders.

    摘要翻译： 本发明提供了作为一类多巴胺激动剂的式（I）化合物，更具体地，一类在D3上对D2有选择性的一类激动剂。 这些化合物可用于治疗和/或预防性功能障碍，例如女性性功能障碍（FSD），特别是女性性唤醒障碍（FSAD），性欲低下症（HSDD;对性不感兴趣），女性高潮 无效（FOD;无法达到性高潮）; 男性性功能障碍，特别是男性勃起功能障碍（MED）。 本文所提及的男性性功能障碍意在包括射精性疾病，例如早泄，无汗（无法达到性高潮）或期望障碍，如性欲低下症（HSDD;对性不感兴趣）。 这些化合物也可用于治疗神经精神障碍和神经变性疾病。

    IMPROVED FIBRE REINFORCED MATERIAL
    6.
    发明申请
    IMPROVED FIBRE REINFORCED MATERIAL 审中-公开
    改进的纤维增强材料

    公开(公告)号：WO2007104990A1

    公开(公告)日：2007-09-20

    申请号：PCT/GB2007/000903

    申请日：2007-03-14

    申请人： CELLUCOMP LIMITED ,  WHALE, Eric ,  HEPWORTH, David

    发明人： WHALE, Eric ,  HEPWORTH, David

    IPC分类号： C08L1/00 ,  B32B5/10

    CPC分类号： B32B27/04 ,  A01K87/00 ,  B32B5/10 ,  B32B5/12 ,  B32B5/26 ,  B32B27/306 ,  B32B27/38 ,  B32B27/40 ,  B32B2260/021 ,  B32B2260/023 ,  B32B2260/046 ,  B32B2262/062 ,  B32B2262/106 ,  B32B2307/54 ,  B32B2307/546 ,  B32B2307/7265 ,  B32B2307/728 ,  B32B2307/73 ,  C08J5/045 ,  C08L1/02 ,  C08L29/04 ,  C08L2666/04

    摘要： A fibre reinforced material (1) and methods of production thereof are described. The fibre reinforced material (1) comprises a matrix material made from a biocomposite material (3) produced through the extraction of cellulose from plants. Within the biocomposite material (3) are located a plurality of fibres (2). The described material (1) exhibits a physical stiffness, strength and toughness that is greater that that for known carbon fibre reinforced plastics. Furthermore the composition of the material (1) also makes it inherently impermeable to water. This makes the fibre reinforced material (1) ideally suited for making monolithic.structures, laminate structures (12) and rod structures for use in a variety of fields, for example as fishing rods.

    摘要翻译： 对纤维增强材料（1）及其制造方法进行说明。 纤维增强材料（1）包括由通过从植物提取纤维素产生的生物复合材料（3）制成的基质材料。 生物复合材料（3）内的多个纤维（2）。 所描述的材料（1）表现出比已知的碳纤维增强塑料的物理刚度，强度和韧性大。 此外，材料（1）的组成也使其固有地不透水。 这使得纤维增强材料（1）理想地适用于制造用于各种领域的整体结构，层压结构（12）和杆结构，例如作为钓竿。

    MORPHOLINE DERIVATIVES FOR USE AS DOPAMINE AGONISTS IN THE TREATMENT OF I.A. SEXUAL DYSFUNCTION
    7.
    发明申请
    MORPHOLINE DERIVATIVES FOR USE AS DOPAMINE AGONISTS IN THE TREATMENT OF I.A. SEXUAL DYSFUNCTION 审中-公开
    用于多巴胺激动剂的多巴酚丁胺衍生物在治疗I.A. 性功能障碍

    公开(公告)号：WO2004052372A1

    公开(公告)日：2004-06-24

    申请号：PCT/IB2003/005683

    申请日：2003-12-02

    申请人： PFIZER LIMITED ,  PFIZER INC. ,  ALLERTON, Charlotte, Moria, Norfor ,  BAXTER, Andrew, Douglas ,  COOK, Andrew, Simon ,  HEPWORTH, David ,  WONG, Stephen, Kwok-Fung

    发明人： ALLERTON, Charlotte, Moria, Norfor ,  BAXTER, Andrew, Douglas ,  COOK, Andrew, Simon ,  HEPWORTH, David ,  WONG, Stephen, Kwok-Fung

    IPC分类号： A61K31/5375

    CPC分类号： C07D265/30 ,  C07D413/04

    摘要： The present invention provides for compounds of formula (I), (la) and (lb) Wherein: A is selected from C-X and N, B is selected from C-Y and N, R 1 is selected from H and (C 1 -C 6 )alkyl R 2 is selected from H and (C 1 -C 6 )alkyl, X is selected from H, HO, C(O)NH 2 , NH 2 Y is selected from H HO,, NH 2 , Br, Cl and F Z is selected from H, HO, F, CONH2 and CN; And pharmaceutically acceptable salts, solvates and prodrugs thereof; With the provisos that: for a compound of formula (I), (la) or (lb), when A is C-X, B is C-Y, at least one of X, Y and Z must be OH; for a compound of formula (I), when A is C-X and B is C-Y, Y is H, Z is H, R 1 is H and R 2 is H, then X cannot be OH; these compounds are useful as dopamine agonists for the treatment of i.a. secual dysfunction.

    摘要翻译： 本发明提供式（I），（Ia）和（Ib）的化合物，其中A选自CX和N，B选自CY和N，R 1选自H和（C 1 -C 6 ）烷基R 2选自H和（C 1 -C 6）烷基，X选自H，HO，C（O）NH 2，NH 2 Y选自H，HO，NH 2，Br，Cl和FZ 来自H，HO，F，CONH 2和CN; 其药学上可接受的盐，溶剂合物和前药; 条件是：对于式（I），（Ia）或（Ib）的化合物，当A是C-X时，B是C-Y，X，Y和Z中的至少一个必须是OH; 对于式（I）化合物，当A为C-X且B为C-Y时，Y为H，Z为H，R 1为H且R 2为H，则X不能为OH; 这些化合物可用作治疗i.a的多巴胺激动剂。 二次功能障碍

    INDAZOLE AND INDOLONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
    8.
    发明申请
    INDAZOLE AND INDOLONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS 审中-公开
    吲哚酚和吲哚酚衍生物及其作为药物的用途

    公开(公告)号：WO2005116027A3

    公开(公告)日：2006-04-13

    申请号：PCT/IB2005001513

    申请日：2005-05-17

    申请人： PFIZER LIMTED ,  PFIZER ,  ALLERTON CHARLOTTE MOIRA NORFO ,  HEPWORTH DAVID ,  MILLER DUNCAN CHARLES

    发明人： ALLERTON CHARLOTTE MOIRA NORFO ,  HEPWORTH DAVID ,  MILLER DUNCAN CHARLES

    IPC分类号： A61K31/397 ,  A61K31/403 ,  A61K31/416 ,  A61K31/454 ,  A61K31/5377 ,  A61P15/00 ,  A61P15/10 ,  C07D205/04 ,  C07D209/34 ,  C07D211/10 ,  C07D231/56 ,  C07D265/30 ,  C07D401/04 ,  C07D413/04 ,  C07D471/04

    CPC分类号： C07D401/04 ,  C07D413/04

    摘要： The present invention provides for compounds of formula (I), which are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. These compounds are useful for the treatment and/or prevention of sexual dysfunction, for example female sexual dysfunction (FSD), in particular female sexual arousal disorder (FSAD), hypoactive sexual desire disorder (HSDD; lack of interest in sex), female orgasmic disorder (FOD; inability to achieve orgasm); and male sexual dysfunction, in particular male erectile dysfunction (MED). Male sexual dysfunction as referred to herein is meant to include ejaculatory disorders such as premature ejaculation, anorgasmia (inability to achieve orgasm) or desire disorders such as hypoactive sexual desire disorder (HSDD; lack of interest in sex). These compounds are also useful in treating neuropsychiatric disorders and neurodegenerative disorders.

    摘要翻译： 本发明提供式（I）化合物，其是一类多巴胺激动剂，更具体地，一类在D3上对D2具有选择性的激动剂。 这些化合物可用于治疗和/或预防性功能障碍，例如女性性功能障碍（FSD），特别是女性性唤起障碍（FSAD），性欲低下症（HSDD;对性不感兴趣），女性高潮 无效（FOD;无法达到性高潮）; 男性性功能障碍，特别是男性勃起功能障碍（MED）。 本文所提及的男性性功能障碍意在包括射精性疾病，例如早泄，无汗（无法达到性高潮）或期望障碍，如性欲低下症（HSDD;对性不感兴趣）。 这些化合物也可用于治疗神经精神障碍和神经变性疾病。

    DIARYL COMPOUNDS AS MONOAMINE REUPTAKE INHIBITORS
    10.
    发明申请
    DIARYL COMPOUNDS AS MONOAMINE REUPTAKE INHIBITORS 审中-公开
    DIARYL化合物作为单胺类抑制剂

    公开(公告)号：WO2004016593A1

    公开(公告)日：2004-02-26

    申请号：PCT/IB2003/003510

    申请日：2003-08-04

    申请人： PFIZER LIMITED ,  PFIZER INC. ,  ANDREWS, Mark, David ,  HEPWORTH, David ,  MIDDLETON, Donald, Stuart

    发明人： ANDREWS, Mark, David ,  HEPWORTH, David ,  MIDDLETON, Donald, Stuart

    IPC分类号： C07D213/38

    CPC分类号： C07D213/70 ,  C07D213/38

    摘要： The invention relates to compounds of formula (I) which inhibit monoamine re-uptake. Compounds of the present invention activity as selective serotonin re-uptake inhibitors (SSRIs) and have utility therefore in a variety of therapeutic areas. Notably the compounds of the present invention are useful in the treatment or prevention of a variety of disorders, including those in which the regulation of monoamine transporter function is implicated, such as depression, attention deficit hyperactivity disorder, obsessive-compulsive disorder, post-traumatic stress disorder, substance abuse disorders and sexual dysfunction including premature ejaculation.

    摘要翻译： 本发明涉及抑制单胺再摄取的式（I）化合物。 作为选择性5-羟色胺再摄取抑制剂（SSRI）的本发明化合物活性，因此可用于多种治疗领域。 值得注意的是，本发明的化合物可用于治疗或预防各种疾病，包括涉及调节单胺转运蛋白功能的疾病，例如抑郁症，注意缺陷多动障碍，强迫症，创伤后 应激障碍，药物滥用障碍和性功能障碍，包括早泄。