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公开(公告)号：WO2007072164A3
公开(公告)日：2007-10-04
申请号：PCT/IB2006003671
申请日：2006-12-11
申请人： PFIZER PROD INC , BAILEY SIMON , BARRETT STEPHEN DOUGLAS , BRATTON LARRY DON , FAKHOURY STEPHEN ALAN , JENNINGS SANDRA MARIE , MITCHELL LORNA HELEN , RAHEJA RAJ KUMAR , SHANMUGASUNDARAM VEERABAHU
发明人： BAILEY SIMON , BARRETT STEPHEN DOUGLAS , BRATTON LARRY DON , FAKHOURY STEPHEN ALAN , JENNINGS SANDRA MARIE , MITCHELL LORNA HELEN , RAHEJA RAJ KUMAR , SHANMUGASUNDARAM VEERABAHU
IPC分类号： C07D261/08 , A61K31/42 , A61K31/4245 , A61K31/4439 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P17/00 , C07D413/08 , C07D413/12 , C07D413/14 , C07D417/08 , C07D471/04
CPC分类号： C07D261/08 , C07D261/18 , C07D413/08 , C07D413/12 , C07D413/14 , C07D417/08 , C07D471/04
摘要： The present application is directed to a new class of isoxazoles and their use as estrogen modulators.
摘要翻译： 本申请涉及一类新的异恶唑及其作为雌激素调节剂的用途。
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公开(公告)号：WO2007017754A2
公开(公告)日：2007-02-15
申请号：PCT/IB2006/002227
申请日：2006-07-27
申请人： WARNER-LAMBERT COMPANY LLC , BOYS, Mark, Laurence , BRUENDL, Michelle, Marie , DOWNS, Victoria, Leigh , FAKHOURY, Stephen, Alan , HARTER, William, Glen , HU, Lain-Yen , JENNINGS, Sandra, Marie , LEFKER, Bruce, Allen , MITCHELL, Lorna, Helen , RAHEJA, Raj, Kumar , SMITH, Yvonne, Dorothy
发明人： BOYS, Mark, Laurence , BRUENDL, Michelle, Marie , DOWNS, Victoria, Leigh , FAKHOURY, Stephen, Alan , HARTER, William, Glen , HU, Lain-Yen , JENNINGS, Sandra, Marie , LEFKER, Bruce, Allen , MITCHELL, Lorna, Helen , RAHEJA, Raj, Kumar , SMITH, Yvonne, Dorothy
CPC分类号： C07C255/54 , C07C2601/02 , C07D213/30 , C07D213/64 , C07D213/65 , C07D309/12 , C07D319/20
摘要： The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译： 本发明涉及一类新的苯腈和它们作为雄激素受体调节剂的用途。 本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。
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3.发明申请PHARMACEUTICAL COMPOSITIONS COMPRISING MALONAMIDE DERIVATIVES FOR DECREASING SEBUM PRODUCTION 审中-公开包含用于减少黑麦生产的马来酰胺衍生物的药物组合物
公开(公告)号：WO2005034931A1
公开(公告)日：2005-04-21
申请号：PCT/IB2004/003156
申请日：2004-09-27
申请人： WARNER-LAMBERT COMPANY LLC , KOSTLAN, Catherine, Rose , RAHEJA, Raj, Kumar , TUGNAIT, Meera , WADE, Kimberly, Jane
IPC分类号： A61K31/167
CPC分类号： A61K31/664 , A61K8/42 , A61K8/49 , A61K8/4926 , A61K8/494 , A61K8/4946 , A61K8/4973 , A61K8/498 , A61K31/16 , A61K31/167 , A61K31/17 , A61K31/216 , A61K31/341 , A61K31/351 , A61K31/41 , A61K31/44 , A61K31/4402 , A61K31/505 , A61K31/5375 , A61K2800/782 , A61Q19/00 , A61Q19/008
摘要： The present invention is directed to the topical application of the malonamide ACAT inhibitors described by Formula I. Other aspects of the invention are directed to topical formulations of these diamides, their use to treat sebaceous gland disorders and their use to alleviate oily skin.
摘要翻译： 本发明涉及局部应用由式I描述的丙二酰胺ACAT抑制剂。本发明的其它方面涉及这些二酰胺的局部制剂，其用于治疗皮脂腺疾病及其用于缓解油性皮肤的用途。
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公开(公告)号：WO2006018723A3
公开(公告)日：2006-08-24
申请号：PCT/IB2005002690
申请日：2005-08-08
申请人： WARNER LAMBERT CO , BARVIAN NICOLE CHANTEL , DU DANIEL YUNLONG , HU LAIN-YEN , IULA DONNA MICHELE , LEFKER BRUCE ALLEN , LEI HUANGSHU , RAHEJA RAJ KUMAR , SMITH YVONNE DOROTHY
发明人： BARVIAN NICOLE CHANTEL , DU DANIEL YUNLONG , HU LAIN-YEN , IULA DONNA MICHELE , LEFKER BRUCE ALLEN , LEI HUANGSHU , RAHEJA RAJ KUMAR , SMITH YVONNE DOROTHY
IPC分类号： A61K31/275 , A61P5/26 , A61P19/10 , A61P35/00
CPC分类号： A61K31/275
摘要： The present invention is directed to the discovery of a new class of androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease sebum secretion and to stimulate hair growth.
摘要翻译： 本发明涉及新型雄激素受体调节剂的发现。 本发明的其它方面涉及这些化合物减少皮脂分泌和刺激毛发生长的用途。
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公开(公告)号：WO2021127250A1
公开(公告)日：2021-06-24
申请号：PCT/US2020/065719
申请日：2020-12-17
申请人： ORPHAGEN PHARMACEUTICALS, INC. , RAHEJA, Raj Kumar , CROWE, Paul Damian , TAO, Haiyan , THACHER, Scott McNear
IPC分类号： C07D311/58 , A61P15/16 , A61P29/00 , A61P35/00 , A61K31/353
摘要： Modulators of retinoid acid receptor-alpha (RARα) of formula (I) are provided herein, as well as pharmaceutical compositions and methods relating thereto.
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公开(公告)号：WO2007072164A2
公开(公告)日：2007-06-28
申请号：PCT/IB2006/003671
申请日：2006-12-11
申请人： PFIZER PRODUCTS INC. , BAILEY, Simon , BARRETT, Stephen, Douglas , BRATTON, Larry, Don , FAKHOURY, Stephen, Alan , JENNINGS, Sandra, Marie , MITCHELL, Lorna, Helen , RAHEJA, Raj, Kumar , SHANMUGASUNDARAM, Veerabahu
发明人： BAILEY, Simon , BARRETT, Stephen, Douglas , BRATTON, Larry, Don , FAKHOURY, Stephen, Alan , JENNINGS, Sandra, Marie , MITCHELL, Lorna, Helen , RAHEJA, Raj, Kumar , SHANMUGASUNDARAM, Veerabahu
IPC分类号： C07D261/08 , C07D413/08 , C07D413/12 , C07D417/08 , C07D413/14
CPC分类号： C07D261/08 , C07D261/18 , C07D413/08 , C07D413/12 , C07D413/14 , C07D417/08 , C07D471/04
摘要： The present application is directed to a new class of isoxazoles and their use as estrogen modulators.
摘要翻译： 本申请涉及一类新的异恶唑及其作为雌激素调节剂的用途。
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公开(公告)号：WO2007017754A3
公开(公告)日：2007-04-26
申请号：PCT/IB2006002227
申请日：2006-07-27
申请人： WARNER LAMBERT CO , BOYS MARK LAURENCE , BRUENDL MICHELLE MARIE , DOWNS VICTORIA LEIGH , FAKHOURY STEPHEN ALAN , HARTER WILLIAM GLEN , HU LAIN-YEN , JENNINGS SANDRA MARIE , LEFKER BRUCE ALLEN , MITCHELL LORNA HELEN , RAHEJA RAJ KUMAR , SMITH YVONNE DOROTHY
发明人： BOYS MARK LAURENCE , BRUENDL MICHELLE MARIE , DOWNS VICTORIA LEIGH , FAKHOURY STEPHEN ALAN , HARTER WILLIAM GLEN , HU LAIN-YEN , JENNINGS SANDRA MARIE , LEFKER BRUCE ALLEN , MITCHELL LORNA HELEN , RAHEJA RAJ KUMAR , SMITH YVONNE DOROTHY
IPC分类号： C07C255/54 , A61K31/277 , C07D213/30
CPC分类号： C07C255/54 , C07C2601/02 , C07D213/30 , C07D213/64 , C07D213/65 , C07D309/12 , C07D319/20
摘要： The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译： 本发明涉及一类新的苯并腈及其作为雄激素受体调节剂的用途。 本发明的其他方面涉及这些化合物用于减少过量皮脂分泌物和刺激毛发生长的用途。
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8.发明申请
公开(公告)号：WO2010116282A8
公开(公告)日：2011-11-03
申请号：PCT/IB2010051337
申请日：2010-03-26
申请人： PFIZER , ARHANCET GRACIELA BARBIERI , CASIMIRO-GARCIA AGUSTIN , CHEN XIANGYANG , HEPWORTH DAVID , MEYERS MARVIN JAY , PIOTROWSKI DAVID WALTER , RAHEJA RAJ KUMAR
发明人： ARHANCET GRACIELA BARBIERI , CASIMIRO-GARCIA AGUSTIN , CHEN XIANGYANG , HEPWORTH DAVID , MEYERS MARVIN JAY , PIOTROWSKI DAVID WALTER , RAHEJA RAJ KUMAR
IPC分类号： C07D401/04 , A61K31/44 , A61P3/04 , A61P9/00 , A61P29/00 , C07D401/14 , C07D413/14
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14
摘要： Mineralocorticoid receptor antagonists (MRa), pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetic nephropathy and hypertension in mammals, including humans.
摘要翻译： 皮质激素受体拮抗剂（MRa），含有这些抑制剂的药物组合物，以及这些抑制剂在哺乳动物（包括人）中治疗例如糖尿病肾病和高血压的用途。
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9.发明申请
公开(公告)号：WO2010116282A1
公开(公告)日：2010-10-14
申请号：PCT/IB2010/051337
申请日：2010-03-26
申请人： PFIZER INC. , ARHANCET, Graciela Barbieri , CASIMIRO-GARCIA, Agustin , CHEN, Xiangyang , HEPWORTH, David , MEYERS, Marvin Jay , PIOTROWSKI, David Walter , RAHEJA, Raj Kumar
发明人： ARHANCET, Graciela Barbieri , CASIMIRO-GARCIA, Agustin , CHEN, Xiangyang , HEPWORTH, David , MEYERS, Marvin Jay , PIOTROWSKI, David Walter , RAHEJA, Raj Kumar
IPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , A61K31/44 , A61P3/04 , A61P29/00 , A61P9/00
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14
摘要： Mineralocorticoid receptor antagonists (MRa), pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetic nephropathy and hypertension in mammals, including humans.
摘要翻译： 皮质激素受体拮抗剂（MRa），含有这些抑制剂的药物组合物，以及这些抑制剂在哺乳动物（包括人）中治疗例如糖尿病肾病和高血压的用途。
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公开(公告)号：WO2006117677A1
公开(公告)日：2006-11-09
申请号：PCT/IB2006/001266
申请日：2006-04-24
申请人： WARNER-LAMBERT COMPANY LLC , BARRETT, Stephen, Douglas , FEDIJ, Victor , HU, Lain-Yen , IULA, Donna, Michele , LEFKER, Bruce, Allen , RAHEJA, Raj, Kumar , SEXTON, Karen, Elaine , VAN CAMP, Jennifer, Ann
发明人： BARRETT, Stephen, Douglas , FEDIJ, Victor , HU, Lain-Yen , IULA, Donna, Michele , LEFKER, Bruce, Allen , RAHEJA, Raj, Kumar , SEXTON, Karen, Elaine , VAN CAMP, Jennifer, Ann
IPC分类号： C07D207/26 , A61K31/4015 , A61P5/28
CPC分类号： C07D207/273 , C07D207/27 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译： 本发明涉及一类新的苯并腈及其作为雄激素受体调节剂的用途。 本发明的其它方面涉及这些化合物用于减少过量皮脂分泌物和刺激毛发生长的用途。
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