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    BONE REPLACEMENT MATERIAL MIXING AND DELIVERY DEVICES AND METHODS OF USE
    1.
    发明申请
    BONE REPLACEMENT MATERIAL MIXING AND DELIVERY DEVICES AND METHODS OF USE 审中-公开
    骨替代材料混合和递送装置及其使用方法

    公开(公告)号：WO2011159869A3

    公开(公告)日：2012-04-12

    申请号：PCT/US2011040642

    申请日：2011-06-16

    Applicant: WARSAW ORTHOPEDIC INC ,  MCKAY WILLIAM F

    Inventor： MCKAY WILLIAM F

    IPC: A61M5/14 ,  A61L24/00 ,  A61M5/178 ,  B01F3/00

    CPC classification number: A61B17/8833 ,  A61B2017/8838

    Abstract: Bone cement mixing and delivery devices and methods of using the devices are provided. The bone cement mixing and delivery devices and methods comprise a container having a bottom opening that can be sealed by a spacer in a syringe where movement of the plunger of the syringe moves the spacer away from the bottom opening in the container to dispense bone cement into the syringe. In some embodiments, the devices and methods increases efficiency and reduce the mess associated with transferring the bone cement to the syringe for delivery to a patient.

    Abstract translation: 提供了骨水泥混合输送装置及其使用方法。 骨水泥混合和递送装置和方法包括具有底部开口的容器，该底部开口可以通过注射器中的间隔件密封，其中注射器的柱塞的移动使垫片远离容器中的底部开口移动以将骨水泥分配到 注射器。 在一些实施例中，装置和方法提高了效率并减少了将骨粘固剂转移到注射器以用于递送给患者的混乱。

    A MATRIX THAT PROLONGS GROWTH FACTOR RELEASE
    2.
    发明申请
    A MATRIX THAT PROLONGS GROWTH FACTOR RELEASE 审中-公开
    一个弥补增长因素的矩阵

    公开(公告)号：WO2010102123A4

    公开(公告)日：2011-03-10

    申请号：PCT/US2010026234

    申请日：2010-03-04

    Applicant: WARSAW ORTHOPEDIC INC ,  MCKAY WILLIAM F

    Inventor： MCKAY WILLIAM F

    IPC: A61L27/56 ,  A61F2/30 ,  A61L27/02 ,  A61L27/14 ,  A61L27/24 ,  A61L27/28 ,  A61L27/40 ,  A61L27/54

    CPC classification number: A61L27/56 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2300/604

    Abstract: An implantable matrix is provided, the matrix having a porous interior configured to release a growth factor and to allow influx of at least progenitor, bone and/or cartilage cells therein; and a biodegradable membrane disposed on the porous interior, the biodegradable membrane being less porous than the porous interior and configured to retain the growth factor and release the growth factor from the porous interior as the biodegradable membrane degrades at or near the target tissue site. In some embodiments, a method for making the implantable collagen matrix is provided, the method comprising: providing a porous collagen layer configured to release a growth factor and to allow influx of at least progenitor, bone and/or cartilage cells therein, and disposing a collagen membrane on the porous collagen layer, the collagen membrane being less porous than the porous collagen layer and configured to retain the growth factor.

    Abstract translation: 提供可植入基质，所述基质具有多孔内部，所述多孔内部构造成释放生长因子并允许其中至少祖细胞，骨和/或软骨细胞的流入; 以及设置在所述多孔内部上的可生物降解的膜，所述可生物降解的膜比所述多孔内部多孔，并且被配置为当所述可生物降解的膜在所述靶组织部位处或附近降解时，保留所述生长因子并从所述多孔内部释放所述生长因子。 在一些实施方案中，提供了一种用于制备可植入胶原基质的方法，所述方法包括：提供构造成释放生长因子并允许其中至少祖细胞，骨和/或软骨细胞流入的多孔胶原层， 多孔胶原层上的胶原膜，胶原膜比多孔胶原层多孔，并且被构造成保留生长因子。

    DRUG DEPOT DELIVERY DEVICE AND METHODS
    3.
    发明申请
    DRUG DEPOT DELIVERY DEVICE AND METHODS 审中-公开
    药物递送装置和方法

    公开(公告)号：WO2010053786A3

    公开(公告)日：2010-09-16

    申请号：PCT/US2009062374

    申请日：2009-10-28

    Applicant: WARSAW ORTHOPEDIC INC ,  SIMONTON THOMAS A ,  MCKAY WILLIAM F

    Inventor： SIMONTON THOMAS A ,  MCKAY WILLIAM F

    IPC: A61M5/178 ,  A61M5/00

    CPC classification number: A61M31/007 ,  A61B17/3468 ,  A61M37/0069

    Abstract: Drug depot delivery devices and methods for delivering a drug depot to a site beneath the skin of a patient are provided. In various embodiments, a device for delivering a drug depot to a site beneath the skin of patient is provided, the device comprising: a cannula capable of insertion to the site beneath the skin of the patient and having an opening for passage of the drug depot; a drug cartridge comprising at least two chambers, wherein each chamber is configured to store and release a drug depot into the cannula when the cannula is aligned with a first chamber and the plunger. In some embodiments, the drug depot delivery device and methods provide dial-a-dose technology for delivering the drug depot to the target tissue site.

    Abstract translation: 提供了药物仓库递送装置和用于将药物仓库递送至患者皮肤下方的部位的方法。 在各种实施例中，提供一种用于将药物贮库运送到患者皮肤下方的部位的装置，所述装置包括：套管，其能够插入患者皮肤下方的部位并具有用于药物贮存库的通道的开口 ; 药筒，其包括至少两个腔室，其中每个腔室被构造成当套管与第一腔室和柱塞对准时将药物贮存器存储并释放到套管中。 在一些实施方案中，药物长效物输送装置和方法提供用于将药物长效输送物递送至靶组织部位的dial-a-dose技术。

    APPARATUS FOR DELIVERY OF THERAPEUTIC MATERIAL TO AN INTERVERTEBRAL DISC AND METHOD OF USE
    4.
    发明申请
    APPARATUS FOR DELIVERY OF THERAPEUTIC MATERIAL TO AN INTERVERTEBRAL DISC AND METHOD OF USE 审中-公开
    将治疗药物输送到椎间盘内的装置和使用方法

    公开(公告)号：WO2010078406A2

    公开(公告)日：2010-07-08

    申请号：PCT/US2009069790

    申请日：2009-12-30

    Applicant: WARSAW ORTHOPEDIC INC ,  MCKAY WILLIAM F

    Inventor： MCKAY WILLIAM F

    IPC: A61M31/00 ,  A61F2/958 ,  A61M5/158 ,  A61M25/00 ,  A61M29/02

    CPC classification number: A61M5/158 ,  A61B17/3401 ,  A61B17/3472 ,  A61B17/8811 ,  A61B2017/00261 ,  A61B2017/3419 ,  A61F2002/4435 ,  A61M25/10 ,  A61M2205/32

    Abstract: An apparatus, for introducing fluent therapeutic material through an annulus fibrosus of an intervertebral disc, includes a needle having a distal end for insertion through an entry site of the annulus fibrosus. The needle defines a first conduit through which the pressurized fluent therapeutic material is introduced. An expandable seal is disposed about an exterior surface of the needle. The expandable seal has a non-expanded, non-sealing configuration to facilitate penetration of the needle through the annulus fibrosus and withdrawal of the needle therefrom. The expandable seal also has an expanded, sealing configuration during introduction of the fluent therapeutic material. The expandable seal then engages the annulus fibrosus in its expanded, sealing configuration to prevent or minimize leakage of fluent therapeutic material through the entry site. The expandable seal assumes its expanded, sealing configuration during introduction of fluent therapeutic material under pressure into the annulus fibrosus.

    Abstract translation: 用于通过椎间盘的纤维环引入流体治疗材料的装置包括具有用于插入通过纤维环的进入部位的远端的针。 针限定了第一导管，通过该第一导管加压加压流体治疗材料。 可膨胀密封件围绕针的外表面设置。 可膨胀密封件具有非扩张的非密封构造，以便于针穿过纤维环并从其中取出针头。 可膨胀密封件在引入流体治疗材料期间也具有膨胀的密封构型。 然后，可膨胀密封件以其膨胀的密封构造接合纤维环，以防止或最小化通过入口部位的流体治疗材料的泄漏。 在将流体治疗材料在压力下引入纤维环中时，可膨胀密封件假定其膨胀的密封构型。

    DRUG DEPOT WITH ANCHOR
    5.
    发明申请
    DRUG DEPOT WITH ANCHOR 审中-公开

    公开(公告)号：WO2010059378A3

    公开(公告)日：2010-05-27

    申请号：PCT/US2009/062591

    申请日：2009-10-29

    Applicant: WARSAW ORTHOPEDIC, INC. ,  MCKAY, William, F.

    Inventor： MCKAY, William, F.

    IPC: A61M5/14 ,  A61M31/00 ,  A61M37/00

    Abstract: A drug depot implantable at or near a target tissue site beneath the skin of a patient is provided, the drug depot comprising a therapeutically effective amount of a drug; at least one line having a distal end and a proximal end, the proximal end of the line attached to the drug depot; an anchor attached to the distal end of the line and configured to limit movement of the drug depot at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutically effective amount of the drug over a period of at least one day. In some embodiments, the drug depot provided can include an effective amount of at least analgesic and/or at least one anti-inflammatory agent at or near a target site, and can reduce, prevent or treat inflammation and/or pain.

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