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公开(公告)号：WO2007106575A2
公开(公告)日：2007-09-20
申请号：PCT/US2007/006571
申请日：2007-03-15
Applicant: VAXDESIGN CORPORATION , WARREN, William, L. , PARKHILL, Robert , NGUYEN, Michael, N. , SANCHEZ-SCHMITZ, Guzman , FAHLENKAMP, Heather , HIGBEE, Russell , DRAKE, Donald, III , KACHURIN, Anatoly, M. , MOE, David
Inventor： WARREN, William, L. , PARKHILL, Robert , NGUYEN, Michael, N. , SANCHEZ-SCHMITZ, Guzman , FAHLENKAMP, Heather , HIGBEE, Russell , DRAKE, Donald, III , KACHURIN, Anatoly, M. , MOE, David
CPC classification number: C12N5/0697 , B01L3/5027 , C12N2501/21 , C12N2502/094 , C12N2502/11 , C12N2502/1107 , C12N2502/1114 , C12N2502/1121 , C12N2502/1192 , C12N2502/28 , C12N2503/02 , C12N2503/04 , C12N2531/00 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/5082 , G01N33/5088
Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system.
Abstract translation: 本发明涉及构建整合人工免疫系统的方法，所述整合人工免疫系统包含适当的体外细胞和组织构建体或其等同物以模拟与疫苗相互作用的正常组织 哺乳动物。 人造免疫系统可用于体外测试疫苗候选物的功效，因此可用于加速疫苗开发和测试与免疫系统的药物和化学相互作用。
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公开(公告)号：WO2005104755A2
公开(公告)日：2005-11-10
申请号：PCT/US2005/014444
申请日：2005-04-28
Applicant: VAXDESIGN CORPORATION , WARREN, William, L. , FAHLENKAMP, Heather , HIGBEE, Russell , KACHURIN, Anatoly , LI, Conan, K., N. , NGUYEN, Mike , PARKHILL, Robert , SANCHEZ, Guzman , IRVINE, Darrell, J. , RANDLOLPH, Gwendalyn , NACOHEN, Nir , TORBETT, Bruce
Inventor： WARREN, William, L. , FAHLENKAMP, Heather , HIGBEE, Russell , KACHURIN, Anatoly , LI, Conan, K., N. , NGUYEN, Mike , PARKHILL, Robert , SANCHEZ, Guzman , IRVINE, Darrell, J. , RANDLOLPH, Gwendalyn , NACOHEN, Nir , TORBETT, Bruce
CPC classification number: C12N5/0697 , C12N2501/21 , C12N2502/11 , C12N2502/28 , C12N2503/04 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/5047 , G01N33/5064 , G01N33/5088
Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.
Abstract translation: 本发明涉及构建综合人造免疫系统的方法，其包括适当的体外细胞和组织构建体或其等同物以模拟与哺乳动物中的疫苗相互作用的正常组织。 人工免疫系统可用于测试疫苗候选物在体外的功效，因此可用于加速疫苗开发和测试与免疫系统的药物和化学相互作用。
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公开(公告)号：WO2007106575A3
公开(公告)日：2007-11-22
申请号：PCT/US2007006571
申请日：2007-03-15
Applicant: VAXDESIGN CORP , WARREN WILLIAM L , PARKHILL ROBERT , NGUYEN MICHAEL N , SANCHEZ-SCHMITZ GUZMAN , FAHLENKAMP HEATHER , HIGBEE RUSSELL , DRAKE DONALD III , KACHURIN ANATOLY M , MOE DAVID
Inventor： WARREN WILLIAM L , PARKHILL ROBERT , NGUYEN MICHAEL N , SANCHEZ-SCHMITZ GUZMAN , FAHLENKAMP HEATHER , HIGBEE RUSSELL , DRAKE DONALD III , KACHURIN ANATOLY M , MOE DAVID
CPC classification number: C12N5/0697 , B01L3/5027 , C12N2501/21 , C12N2502/094 , C12N2502/11 , C12N2502/1107 , C12N2502/1114 , C12N2502/1121 , C12N2502/1192 , C12N2502/28 , C12N2503/02 , C12N2503/04 , C12N2531/00 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/5082 , G01N33/5088
Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. In particular the claimed artificial immune system comprises a vaccination site, comprising a first matrix and a plurality of cells attached to said matrix, wherein a plurality of said vaccination sites are organized in a multi-well format; and a three-dimensional artificial lymphoid tissue, comprising a second matrix and a plurality of lymphocytes and leukocytes, wherein a plurality of said three-dimensional artificial lymphoid tissues are organized in a second multi-well format. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system.
Abstract translation: 本发明涉及构建综合人造免疫系统的方法，其包括适当的体外细胞和组织构建体或其等同物以模拟与哺乳动物中的疫苗相互作用的正常组织。 特别地，所要求的人造免疫系统包括疫苗接种部位，其包含第一基质和附着于所述基质的多个细胞，其中多个所述疫苗接种部位以多孔形式组织; 以及包括第二基质和多个淋巴细胞和白细胞的三维人造淋巴组织，其中多个所述三维人造淋巴组织以第二多孔格式组织。 人造免疫系统可用于测试疫苗候选物在体外的功效，因此可用于加速疫苗开发和测试与免疫系统的药物和化学相互作用。
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公开(公告)号：WO2008073635A3
公开(公告)日：2008-06-19
申请号：PCT/US2007/083795
申请日：2007-11-06
Applicant: VAXDESIGN CORPORATION , WARREN, William L. , PARKHILL, Robert , NGUYEN, Michael N. , SANCHEZ-SCHMITZ, Guzman , FAHLENKAMP, Heather , HIGBEE, Russell , DRAKE III, Donald , KACHURIN, Anatoly , MOE, David
Inventor： WARREN, William L. , PARKHILL, Robert , NGUYEN, Michael N. , SANCHEZ-SCHMITZ, Guzman , FAHLENKAMP, Heather , HIGBEE, Russell , DRAKE III, Donald , KACHURIN, Anatoly , MOE, David
IPC: G01N33/53 , G01N33/531 , C12Q1/00
Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system.
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公开(公告)号：WO2007108835A2
公开(公告)日：2007-09-27
申请号：PCT/US2006/043563
申请日：2006-11-08
Applicant: VAXDESIGN CORPORATION , WARREN, William, L. , PARKHILL, Robert , NGUYEN, Michael, N. , SANCHEZ-SCHMITZ, Guzman , FAHLENKAMP, Heather , HIGBEE, Russell , DRAKE, Donald, III , KACHURIN, Anatoly , MOE, David
Inventor： WARREN, William, L. , PARKHILL, Robert , NGUYEN, Michael, N. , SANCHEZ-SCHMITZ, Guzman , FAHLENKAMP, Heather , HIGBEE, Russell , DRAKE, Donald, III , KACHURIN, Anatoly , MOE, David
CPC classification number: C12N5/0697 , B01L3/5027 , C12N2501/21 , C12N2502/094 , C12N2502/11 , C12N2502/1107 , C12N2502/1114 , C12N2502/1121 , C12N2502/1192 , C12N2502/28 , C12N2503/02 , C12N2503/04 , C12N2531/00 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/5082 , G01N33/5088
Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system.
Abstract translation: 本发明涉及构建综合人造免疫系统的方法，其包括适当的体外细胞和组织构建体或其等同物以模拟与哺乳动物中的疫苗相互作用的正常组织。 人工免疫系统可用于测试疫苗候选物在体外的功效，因此可用于加速疫苗开发和测试与免疫系统的药物和化学相互作用。
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Patent Agency Ranking
公开(公告)号：WO2007108835A3
公开(公告)日：2008-01-24
申请号：PCT/US2006043563
申请日：2006-11-08
Applicant: VAXDESIGN CORP , WARREN WILLIAM L , PARKHILL ROBERT , NGUYEN MICHAEL N , SANCHEZ-SCHMITZ GUZMAN , FAHLENKAMP HEATHER , HIGBEE RUSSELL , DRAKE DONALD III , KACHURIN ANATOLY , MOE DAVID
Inventor： WARREN WILLIAM L , PARKHILL ROBERT , NGUYEN MICHAEL N , SANCHEZ-SCHMITZ GUZMAN , FAHLENKAMP HEATHER , HIGBEE RUSSELL , DRAKE DONALD III , KACHURIN ANATOLY , MOE DAVID
CPC classification number: C12N5/0697 , B01L3/5027 , C12N2501/21 , C12N2502/094 , C12N2502/11 , C12N2502/1107 , C12N2502/1114 , C12N2502/1121 , C12N2502/1192 , C12N2502/28 , C12N2503/02 , C12N2503/04 , C12N2531/00 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/5082 , G01N33/5088
Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system.
Abstract translation: 本发明涉及构建综合人造免疫系统的方法，其包括适当的体外细胞和组织构建体或其等同物以模拟与哺乳动物中的疫苗相互作用的正常组织。 人造免疫系统可用于测试疫苗候选物在体外的功效，因此可用于加速疫苗开发和测试与免疫系统的药物和化学相互作用。
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7.发明申请
公开(公告)号：WO2005072088A2
公开(公告)日：2005-08-11
申请号：PCT/US2004041404
申请日：2004-12-13
Applicant: SCIPERIO INC , HIGBEE RUSSELL G , BARBER GLEN N , KACHURIN ANATOLY M , KACHURINA OLGA M , GAPPA-FAHLEKAMP HEATHER , WARREN WILLIAM L , BALACHANDRAN SIDDHARTH , THOMAS EMMANUEL , PARKHILL ROBERT
Inventor： HIGBEE RUSSELL G , BARBER GLEN N , KACHURIN ANATOLY M , KACHURINA OLGA M , GAPPA-FAHLEKAMP HEATHER , WARREN WILLIAM L , BALACHANDRAN SIDDHARTH , THOMAS EMMANUEL , PARKHILL ROBERT
IPC: A61K9/14 , A61K9/16 , A61K39/39 , A61K47/36 , A61K47/48 , A61K48/00 , C12N15/113 , C12N15/117 , C12P21/06
CPC classification number: C12N15/117 , A61K9/1647 , A61K9/1652 , A61K9/167 , A61K39/39 , A61K47/36 , A61K47/59 , A61K47/593 , A61K47/61 , A61K47/645 , A61K47/6927 , A61K2039/55555 , A61K2039/55561 , A61K2039/55583 , C12N15/1135 , C12N2310/13 , C12N2310/17 , C12N2310/351
Abstract: The present invention directs to compositions and methods for modulating immune system. One aspect of the present invention relates to a composition comprising FADD-dependent signaling pathway modulators. Another aspect of the present invention relates to biodegradable microparticles, such as a chitosan microparticle, or PLGA/PEI microparticle, designed to deliver nucleic acids and/or proteins, such as FADD-dependent signaling pathway modulators, to boost different pathways of an immune response. Another aspect of the present invention relates to the method of making biodegradable microparticles. The further aspect of the present invention relates to the use of the chitosan and other polycationic microparticles to deliver FADD-dependent signaling pathway modulators to modulate immune system for the prevention and/or treatment infectious diseases and cancers.
Abstract translation: 本发明涉及调节免疫系统的组合物和方法。 本发明的一个方面涉及包含FADD依赖性信号通路调节剂的组合物。 本发明的另一方面涉及可生物降解的微粒，例如壳聚糖微粒或PLGA / PEI微粒，其设计用于递送核酸和/或蛋白质，例如FADD依赖性信号通路调节剂，以促进免疫应答的不同途径 。 本发明的另一方面涉及制造可生物降解的微粒的方法。 本发明的另一方面涉及壳聚糖和其它聚阳离子微粒用于递送FADD依赖性信号通路调节剂以调节用于预防和/或治疗感染性疾病和癌症的免疫系统的用途。
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公开(公告)号：WO2008073635A9
公开(公告)日：2008-10-23
申请号：PCT/US2007083795
申请日：2007-11-06
Applicant: VAXDESIGN CORP , WARREN WILLIAM L , PARKHILL ROBERT , NGUYEN MICHAEL N , SANCHEZ-SCHMITZ GUZMAN , FAHLENKAMP HEATHER , HIGBEE RUSSELL , DRAKE III DONALD , KACHURIN ANATOLY , MOE DAVID
Inventor： WARREN WILLIAM L , PARKHILL ROBERT , NGUYEN MICHAEL N , SANCHEZ-SCHMITZ GUZMAN , FAHLENKAMP HEATHER , HIGBEE RUSSELL , DRAKE III DONALD , KACHURIN ANATOLY , MOE DAVID
IPC: G01N33/53 , C12Q1/00 , G01N33/531
CPC classification number: G01N33/5088 , G01N33/5047
Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system.
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公开(公告)号：WO2005104755A3
公开(公告)日：2008-08-21
申请号：PCT/US2005014444
申请日：2005-04-28
Applicant: VAXDESIGN CORP , WARREN WILLIAM L , FAHLENKAMP HEATHER , HIGBEE RUSSELL , KACHURIN ANATOLY , LI CONAN K N , NGUYEN MIKE , PARKHILL ROBERT , SANCHEZ GUZMAN , IRVINE DARRELL J , RANDLOLPH GWENDALYN , NACOHEN NIR , TORBETT BRUCE
Inventor： WARREN WILLIAM L , FAHLENKAMP HEATHER , HIGBEE RUSSELL , KACHURIN ANATOLY , LI CONAN K N , NGUYEN MIKE , PARKHILL ROBERT , SANCHEZ GUZMAN , IRVINE DARRELL J , RANDLOLPH GWENDALYN , NACOHEN NIR , TORBETT BRUCE
CPC classification number: C12N5/0697 , C12N2501/21 , C12N2502/11 , C12N2502/28 , C12N2503/04 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/5047 , G01N33/5064 , G01N33/5088
Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.
Abstract translation: 本发明涉及构建综合人造免疫系统的方法，其包括适当的体外细胞和组织构建体或其等同物以模拟与哺乳动物中的疫苗相互作用的正常组织。 人工免疫系统可用于测试疫苗候选物在体外的功效，因此可用于加速疫苗开发和测试与免疫系统的药物和化学相互作用。
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公开(公告)号：WO2008073635A2
公开(公告)日：2008-06-19
申请号：PCT/US2007083795
申请日：2007-11-06
Applicant: VAXDESIGN CORP , WARREN WILLIAM L , PARKHILL ROBERT , NGUYEN MICHAEL N , SANCHEZ-SCHMITZ GUZMAN , FAHLENKAMP HEATHER , HIGBEE RUSSELL , DRAKE III DONALD , KACHURIN ANATOLY , MOE DAVID
Inventor： WARREN WILLIAM L , PARKHILL ROBERT , NGUYEN MICHAEL N , SANCHEZ-SCHMITZ GUZMAN , FAHLENKAMP HEATHER , HIGBEE RUSSELL , DRAKE III DONALD , KACHURIN ANATOLY , MOE DAVID
IPC: G01N33/53 , C12Q1/00 , G01N33/531
CPC classification number: G01N33/5088 , G01N33/5047
Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system.
Abstract translation: 本发明涉及构建整合人工免疫系统的方法，所述整合人工免疫系统包含适当的体外细胞和组织构建体或其等价物以模拟与哺乳动物中的疫苗相互作用的正常组织。 人造免疫系统可用于体外检测候选疫苗的功效，因此可用于加速疫苗开发和检测与免疫系统的药物和化学相互作用。
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