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公开(公告)号：WO2011115684A3
公开(公告)日：2012-08-09
申请号：PCT/US2011000502
申请日：2011-03-19
Applicant: MASSACHUSETTS INST TECHNOLOGY , IRVINE DARRELL J , MOON JAEHYUN
Inventor： IRVINE DARRELL J , MOON JAEHYUN
CPC classification number: A61K9/1271 , A61K9/127 , A61K9/1273 , A61K31/437 , A61K31/713 , A61K38/19 , A61K38/20 , A61K39/00 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/35 , A61K39/39 , A61K39/39558 , A61K45/06 , A61K47/48815 , A61K47/6911 , A61K2039/505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/572 , A61K2039/575 , C07K14/005 , C07K16/28 , C12N7/00 , C12N2740/16222 , C12N2740/16234 , Y10T428/2984
Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
Abstract translation: 本发明提供由稳定的多层泡囊组成的递送系统，以及组合物，合成方法及其使用方法。 稳定的多层囊泡可以包含预防性，治疗和/或诊断剂。
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2.发明申请CONTROLLING DENDRITIC CELL MATURATION STATE IN THE LYMPHOID TISSUE EQUIVALENT OF AN ARTIFICIAL IMMUNE SYSTEM 审中-公开控制人工免疫系统淋巴组织等效性中的细胞成熟状态
公开(公告)号：WO2008108794A3
公开(公告)日：2009-01-22
申请号：PCT/US2007014272
申请日：2007-06-19
Applicant: VAXDESIGN CORP , MASSACHUSETTS INST TECHNOLOGY , SANCHEZ-SCHMITZ GUZMAN , HIGBEE RUSSELL , FAHLENKAMP HEATHER , IRVINE DARRELL J , WARREN WILLIAM L , DRAKE DONALD
Inventor： SANCHEZ-SCHMITZ GUZMAN , HIGBEE RUSSELL , FAHLENKAMP HEATHER , IRVINE DARRELL J , WARREN WILLIAM L , DRAKE DONALD
IPC: C12N5/071 , C12N5/0784 , G01N33/50
CPC classification number: C12N5/0639 , C12N5/0651 , C12N5/0697 , C12N2501/21 , C12N2502/1107 , C12N2502/1114 , C12N2502/1121 , C12N2502/1192 , C12N2502/28 , C12N2503/04 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/5047
Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system.
Abstract translation: 本发明涉及构建综合人造免疫系统的方法，其包括适当的体外细胞和组织构建体或其等同物以模拟与哺乳动物中的疫苗相互作用的正常组织。 人造免疫系统可用于测试疫苗候选物在体外的功效，因此可用于加速疫苗开发和测试与免疫系统的药物和化学相互作用。
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公开(公告)号：WO2017112940A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/068541
申请日：2016-12-23
Applicant: DANA-FARBER CANCER INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , GOLDBERG, Michael, Solomon , SCHMID, Daniela , IRVINE, Darrell, J.
Inventor： GOLDBERG, Michael, Solomon , SCHMID, Daniela , IRVINE, Darrell, J.
IPC: A61K9/14 , A61K31/80 , A61K31/785
CPC classification number: A61K45/06 , A61K9/0019 , A61K9/5153 , A61K31/4245 , A61K31/519 , A61K47/6849 , A61K47/6937 , A61K2039/505 , C07K16/2803 , C07K16/2815 , C07K16/2818 , C07K2317/54 , A61K2300/00
Abstract: The present disclosure provides particles with a polymeric core containing a pharmaceutically active agent; and an antibody fragment conjugated to the surface of the particle, wherein the antibody fragment targets an endogenous immune cell subset ( e.g. , an endogenous T-cell or a myeloid-derived suppressor cell). The present invention provides methods for forming and methods for using the particles. The particles described herein may be useful in treating and/or preventing proliferative disease, inflammatory disease, or neoplastic disorders ( e.g. , cancer, autoimmune diseases). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a particle described herein.
Abstract translation: 本公开提供了具有含药物活性剂的聚合物芯的颗粒; 和缀合至颗粒表面的抗体片段，其中所述抗体片段靶向内源性免疫细胞亚群（例如，内源性T细胞或骨髓衍生的抑制性细胞）。 本发明提供了用于形成颗粒的方法和使用该颗粒的方法。 本文所述的颗粒可用于治疗和/或预防增殖性疾病，炎性疾病或肿瘤性疾病（例如癌症，自身免疫性疾病）。 本发明还提供了包括或使用本文所述颗粒的药物组合物，试剂盒，方法和用途。
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公开(公告)号：WO2011115684A2
公开(公告)日：2011-09-22
申请号：PCT/US2011/000502
申请日：2011-03-19
Inventor： IRVINE, Darrell, J. , MOON, Jaehyun
IPC: A61K9/127
CPC classification number: A61K9/1271 , A61K9/127 , A61K9/1273 , A61K31/437 , A61K31/713 , A61K38/19 , A61K38/20 , A61K39/00 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/35 , A61K39/39 , A61K39/39558 , A61K45/06 , A61K47/48815 , A61K47/6911 , A61K2039/505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/572 , A61K2039/575 , C07K14/005 , C07K16/28 , C12N7/00 , C12N2740/16222 , C12N2740/16234 , Y10T428/2984
Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
Abstract translation: 本发明提供由稳定的多层泡囊组成的递送系统，以及组合物，合成方法及其使用方法。 稳定的多层囊泡可以包含预防性，治疗和/或诊断剂。
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公开(公告)号：WO2009126801A3
公开(公告)日：2010-02-18
申请号：PCT/US2009040059
申请日：2009-04-09
Applicant: MASSACHUSETTS INST TECHNOLOGY , SWISTON ALBERT JOSEPH , RUBNER MICHAEL F , COHEN ROBERT EDWARD , IRVINE DARRELL J
Inventor： SWISTON ALBERT JOSEPH , RUBNER MICHAEL F , COHEN ROBERT EDWARD , IRVINE DARRELL J
CPC classification number: C12N5/0006 , C12N5/0634 , C12N2533/30
Abstract: Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells remain viable after attachment of the functional patch. The patch does not completely occlude the cellular surface from the surrounding environment. Functional payloads carried by the patch may include, for example, drugs or other small molecules, peptides, proteins, thermally responsive polymers, and nanoparticles, or any other material that can be incorporated in a polymer patch of subcellular dimensions. The patch can include one or more polyelectrolyte multilayers (PEMs).
Abstract translation: 均匀的功能性聚合物贴剂可以附着在活细胞表面积的一部分。 这些表面修饰的细胞在附着功能性贴片后保持活性。 贴片不会完全遮挡周围环境中的细胞表面。 由贴片携带的功能性有效载荷可以包括例如药物或其它小分子，肽，蛋白质，热响应聚合物和纳米颗粒，或可并入亚细胞尺寸的聚合物贴片中的任何其它材料。 贴剂可以包括一种或多种聚电解质多层（PEM）。
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Patent Agency Ranking
公开(公告)号：WO2005104755A2
公开(公告)日：2005-11-10
申请号：PCT/US2005/014444
申请日：2005-04-28
Applicant: VAXDESIGN CORPORATION , WARREN, William, L. , FAHLENKAMP, Heather , HIGBEE, Russell , KACHURIN, Anatoly , LI, Conan, K., N. , NGUYEN, Mike , PARKHILL, Robert , SANCHEZ, Guzman , IRVINE, Darrell, J. , RANDLOLPH, Gwendalyn , NACOHEN, Nir , TORBETT, Bruce
Inventor： WARREN, William, L. , FAHLENKAMP, Heather , HIGBEE, Russell , KACHURIN, Anatoly , LI, Conan, K., N. , NGUYEN, Mike , PARKHILL, Robert , SANCHEZ, Guzman , IRVINE, Darrell, J. , RANDLOLPH, Gwendalyn , NACOHEN, Nir , TORBETT, Bruce
CPC classification number: C12N5/0697 , C12N2501/21 , C12N2502/11 , C12N2502/28 , C12N2503/04 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/5047 , G01N33/5064 , G01N33/5088
Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.
Abstract translation: 本发明涉及构建综合人造免疫系统的方法，其包括适当的体外细胞和组织构建体或其等同物以模拟与哺乳动物中的疫苗相互作用的正常组织。 人工免疫系统可用于测试疫苗候选物在体外的功效，因此可用于加速疫苗开发和测试与免疫系统的药物和化学相互作用。
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公开(公告)号：WO2010147655A2
公开(公告)日：2010-12-23
申请号：PCT/US2010/001743
申请日：2010-06-17
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY , CORNELL UNIVERSITY , IRVINE, Darrell, J. , UM, Soong, Ho , LUO, Dan
Inventor： IRVINE, Darrell, J. , UM, Soong, Ho , LUO, Dan
CPC classification number: A61K31/00 , A61K9/0019 , A61K9/06 , A61K9/127 , A61K9/1271 , A61K31/704 , A61K31/7105 , A61K31/711 , A61K49/0002 , C07H21/00 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2310/3519 , C12N2310/52 , C12N2320/32 , C12N2330/30 , C12P19/34
Abstract: The invention provides compositions and methods relating to delivery of agents in vivo or in vitro. In some instances, the invention provides nanoparticles synthesized from crosslinked nucleic acids, optionally having a lipid shell or coating, and may further comprise for example small molecule or high molecular weight compounds as therapeutic or diagnostic agents.
Abstract translation: 本发明提供了与体内或体外递送试剂有关的组合物和方法。 在一些情况下，本发明提供了由交联的核酸合成的纳米颗粒，任选地具有脂壳或涂层，并且还可包含例如作为治疗剂或诊断剂的小分子或高分子量化合物。
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公开(公告)号：WO2010059253A9
公开(公告)日：2010-10-14
申请号：PCT/US2009006290
申请日：2009-11-24
Applicant: MASSACHUSETS INST OF TECHNOLOG , IRVINE DARRELL J , STEPHAN MATTHIAS , MOON JAEHYUN , BERSHTEYN ANNA
Inventor： IRVINE DARRELL J , STEPHAN MATTHIAS , MOON JAEHYUN , BERSHTEYN ANNA
IPC: A61K9/16 , A61K9/127 , A61K31/7105 , A61K31/711 , A61P35/00
CPC classification number: A61K9/127 , A61K9/146 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/7105 , A61K31/711 , A61K35/28 , A61K38/19 , A61K38/20 , A61K38/2086 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/06 , A61K47/46 , A61K47/6901 , A61K47/6911 , A61K47/6937 , A61K2035/124 , B82Y5/00 , C07K16/00 , C12N5/0006 , C12N5/0636 , C12N5/0647 , C12N15/113 , C12N15/87 , C12N2310/14 , A61K2300/00
Abstract: The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
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公开(公告)号：WO2010059253A2
公开(公告)日：2010-05-27
申请号：PCT/US2009006290
申请日：2009-11-24
Applicant: MASSACHUSETS INST OF TECHNOLOG , IRVINE DARRELL J , STEPHAN MATTHIAS , MOON JAEHYUN , BERSHTEYN ANNA
Inventor： IRVINE DARRELL J , STEPHAN MATTHIAS , MOON JAEHYUN , BERSHTEYN ANNA
IPC: A61K9/16 , A61K9/127 , A61K31/7105 , A61K31/711 , A61P35/00
CPC classification number: A61K9/127 , A61K9/146 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/7105 , A61K31/711 , A61K35/28 , A61K38/19 , A61K38/20 , A61K38/2086 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/06 , A61K47/46 , A61K47/6901 , A61K47/6911 , A61K47/6937 , A61K2035/124 , B82Y5/00 , C07K16/00 , C12N5/0006 , C12N5/0636 , C12N5/0647 , C12N15/113 , C12N15/87 , C12N2310/14 , A61K2300/00
Abstract: The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
Abstract translation: 本发明提供了通过将负载载体的纳米颗粒与具有归巢能力的细胞结合来将药剂递送到体内的局部区域，组织或器官的组合物和方法。 这些试剂可以分别是治疗剂或诊断剂，例如癌症化学治疗剂和成像剂。
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公开(公告)号：WO2020146700A1
公开(公告)日：2020-07-16
申请号：PCT/US2020/013024
申请日：2020-01-10
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY , IRVINE, Darrell, J. , WEISS, Ron , KITADA, Tasuku , MELO, Mariane , ZHANG, Yuan
Inventor： IRVINE, Darrell, J. , WEISS, Ron , KITADA, Tasuku , MELO, Mariane , ZHANG, Yuan
Abstract: Disclosed herein are lipid nanoparticles having a specific composition, compositions including such lipid nanoparticles, and methods of treatment using such lipid nanoparticles and compositions.
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