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    ENGINEERING POLYMERASES AND REACTION CONDITIONS FOR MODIFIED INCORPORATION PROPERTIES
    2.
    发明申请
    ENGINEERING POLYMERASES AND REACTION CONDITIONS FOR MODIFIED INCORPORATION PROPERTIES 审中-公开
    工程聚合物和改性剂的反应条件

    公开(公告)号：WO2010027484A2

    公开(公告)日：2010-03-11

    申请号：PCT/US2009004993

    申请日：2009-09-04

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA ,  PATEL PRANAV ,  KORLACH JONAS ,  BIBILLO ARKADIUSZ ,  BJORNSON KEITH ,  HANES JEREMIAH

    Inventor： PATEL PRANAV ,  KORLACH JONAS ,  BIBILLO ARKADIUSZ ,  BJORNSON KEITH ,  HANES JEREMIAH

    IPC: C12Q1/68 ,  C12N15/11 ,  C12Q1/25

    CPC classification number: C12Q1/6869 ,  C12N9/1252 ,  C12Q2527/113 ,  C12Q2521/101 ,  C12Q2527/137 ,  C12Q2537/161 ,  C12Q2525/101 ,  C12Q2563/107

    Abstract: Provided are methods for enhanced sequencing of nucleic acid templates. Also provided are reaction conditions that increase branching fractions during polymerization reactions. Also provided are compositions comprising modified recombinant polymerases that exhibit branching fractions that are higher than the branching fractions of the polymerases from which they were derived. Provided are compositions comprising modified recombinant polymerases that exhibit delayed translocation relative to the polymerases from which they were derived. Also provided are compositions comprising modified recombinant polymerases that exhibit increased nucleotide or nucleotide analog residence time at an active site of the polymerase. Provided are methods for generating polymerases with the aforementioned phenotypes and methods of using such polymerases to sequence a DNA template or make a DNA. Also provided are methods and nucleic acid sequencing systems for determining which labeled nucleotide is incorporated at a site during a template-dependent polymerization reaction.

    Abstract translation: 提供了用于增强核酸模板测序的方法。 还提供了在聚合反应期间增加支化馏分的反应条件。 还提供了包含改性重组聚合酶的组合物，其表现出高于其衍生的聚合酶的支化部分的支化部分。 提供了包含修饰的重组聚合酶的组合物，其相对于衍生自其的聚合酶表现出延迟的移位。 还提供了包含修饰的重组聚合酶的组合物，其在聚合酶的活性位点表现出增加的核苷酸或核苷酸类似物停留时间。 提供了使用上述表型产生聚合酶的方法和使用这种聚合酶来顺序DNA模板或制备DNA的方法。 还提供了用于在模板依赖性聚合反应期间确定哪个标记的核苷酸被掺入位点的方法和核酸测序系统。

    A HORIZONTAL FORM, FILL AND SEAL MACHINE FOR CREATING POUCHES HAVING A PARTITION AND A METHOD THEREOF
    3.
    发明申请
    A HORIZONTAL FORM, FILL AND SEAL MACHINE FOR CREATING POUCHES HAVING A PARTITION AND A METHOD THEREOF 审中-公开

    公开(公告)号：WO2019123484A1

    公开(公告)日：2019-06-27

    申请号：PCT/IN2018/050868

    申请日：2018-12-21

    Applicant: PATEL, Pranav

    Inventor： PATEL, Pranav

    IPC: B65B5/02 ,  B65B9/02 ,  B65B9/10

    Abstract: The present invention discloses a horizontal form-fill-and seal machine for creating pouches, having a partition, dividing the pouch cavity into two compartments for two components of a product, to be separately contained. The said horizontal machine comprises an unwinding station, having more than one unwind web reel, configured for forming front and back web faces of said pouches along with a partition web membrane. The machine discloses a sensing means configured for sensing a photo mark position, in at least one of said unwound webs, and providing a feedback of said photo mark position, to align a longitudinal position of a web face with respect to another web face or marks, when a print matter, on either or both said webs faces, is to be registered, in a longitudinal direction, before being fed to a common nip.

    ENGINEERING POLYMERASES AND REACTION CONDITIONS FOR MODIFIED INCORPORATION PROPERTIES
    4.
    发明申请
    ENGINEERING POLYMERASES AND REACTION CONDITIONS FOR MODIFIED INCORPORATION PROPERTIES 审中-公开
    工程聚合物与改性掺入特性的反应条件

    公开(公告)号：WO2010027484A3

    公开(公告)日：2010-06-24

    申请号：PCT/US2009004993

    申请日：2009-09-04

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA ,  PATEL PRANAV ,  KORLACH JONAS ,  BIBILLO ARKADIUSZ ,  BJORNSON KEITH ,  HANES JEREMIAH

    Inventor： PATEL PRANAV ,  KORLACH JONAS ,  BIBILLO ARKADIUSZ ,  BJORNSON KEITH ,  HANES JEREMIAH

    IPC: C12Q1/68 ,  C12N15/11 ,  C12Q1/25

    CPC classification number: C12Q1/6869 ,  C12N9/1252 ,  C12Q2527/113 ,  C12Q2521/101 ,  C12Q2527/137 ,  C12Q2537/161 ,  C12Q2525/101 ,  C12Q2563/107

    Abstract: Provided are methods for enhanced sequencing of nucleic acid templates. Also provided are reaction conditions that increase branching fractions during polymerization reactions. Also provided are compositions comprising modified recombinant polymerases that exhibit branching fractions that are higher than the branching fractions of the polymerases from which they were derived. Provided are compositions comprising modified recombinant polymerases that exhibit delayed translocation relative to the polymerases from which they were derived. Also provided are compositions comprising modified recombinant polymerases that exhibit increased nucleotide or nucleotide analog residence time at an active site of the polymerase. Provided are methods for generating polymerases with the aforementioned phenotypes and methods of using such polymerases to sequence a DNA template or make a DNA. Also provided are methods and nucleic acid sequencing systems for determining which labeled nucleotide is incorporated at a site during a template-dependent polymerization reaction.

    Abstract translation: 提供了用于增强核酸模板测序的方法。 还提供了在聚合反应期间增加支化部分的反应条件。 还提供了包含修饰的重组聚合酶的组合物，其表现出比衍生它们的聚合酶的支化部分更高的支化部分。 提供了包含相对于衍生它们的聚合酶显示延迟易位的修饰的重组聚合酶的组合物。 还提供了包含修饰的重组聚合酶的组合物，所述修饰的重组聚合酶在聚合酶的活性位点显示增加的核苷酸或核苷酸类似物停留时间 提供了产生具有上述表型的聚合酶的方法和使用这些聚合酶测序DNA模板或制备DNA的方法。 还提供了用于确定哪些标记的核苷酸在模板依赖性聚合反应期间在位点处掺入的方法和核酸测序系统。

    UTILIZATION SYSTEM AND ASSOCIATED METHOD
    7.
    发明申请
    UTILIZATION SYSTEM AND ASSOCIATED METHOD 审中-公开
    利用系统及相关方法

    公开(公告)号：WO2011053408A3

    公开(公告)日：2011-11-24

    申请号：PCT/US2010048763

    申请日：2010-09-14

    Applicant: GEN ELECTRIC ,  PATEL PRANAV N ,  MCCLINTIC SHAWN A

    Inventor： PATEL PRANAV N ,  MCCLINTIC SHAWN A

    IPC: H02J3/28 ,  H02J3/32 ,  H02J9/06

    CPC classification number: H02J3/28 ,  H02J9/062 ,  H02J2003/146 ,  Y02B10/72 ,  Y04S20/224 ,  Y10T307/615 ,  Y10T307/625

    Abstract: A system (100) includes an energy storage system (114) capable of receiving electrical energy from an energy source (102) and can supply electrical energy to a first load during a first period and to the first load during a second period. The first load differs in usage rate from the first period relative to the second period. A system controller maintains the energy storage system such that the energy storage system maintains a first amount of stored electrical energy during a first mode, and a second amount of electrical energy during a second mode. The system controller maintains the energy storage system in the first mode during a first portion of the first period, and in the second mode during a second portion of the first period.

    Abstract translation: 系统（100）包括能够从能量源（102）接收电能的能量存储系统（114），并且可以在第一时段期间向第一负载提供电能并且在第二时段期间向第一负载提供电能。 第一负载在使用率与第一周期相对于第二周期不同。 系统控制器维持能量存储系统，使得能量存储系统在第一模式期间保持第一量的存储电能，并且在第二模式期间维持第二量的电能。 系统控制器在第一时段的第一部分期间将能量存储系统维持在第一模式，并且在第一时段的第二部分期间将能量存储系统维持在第二模式。

    UTILIZATION SYSTEM AND ASSOCIATED METHOD
    8.
    发明申请
    UTILIZATION SYSTEM AND ASSOCIATED METHOD 审中-公开
    利用系统及相关方法

    公开(公告)号：WO2011053408A2

    公开(公告)日：2011-05-05

    申请号：PCT/US2010/048763

    申请日：2010-09-14

    Applicant: GENERAL ELECTRIC COMPANY ,  PATEL, Pranav, N. ,  MCCLINTIC, Shawn, A.

    Inventor： PATEL, Pranav, N. ,  MCCLINTIC, Shawn, A.

    IPC: H02J9/06

    CPC classification number: H02J3/28 ,  H02J9/062 ,  H02J2003/146 ,  Y02B10/72 ,  Y04S20/224 ,  Y10T307/615 ,  Y10T307/625

    Abstract: A system includes an energy storage system capable of receiving electrical energy from an energy source and can supply electrical energy to a first load during a first period and to the first load during a second period. The first load differs in usage rate from the first period relative to the second period. A system controller maintains the energy storage system such that the energy storage system maintains a first amount of stored electrical energy during a first mode, and a second amount of electrical energy during a second mode. The system controller maintains the energy storage system in the first mode during a first portion of the first period, and in the second mode during a second portion of the first period.

    Abstract translation: 一种系统包括能量存储系统，其能够从能量源接收电能，并且可以在第一时段期间向第一负载提供电能并且在第二时段期间向第一负载提供电能。 第一负载在使用率与第一周期相对于第二周期不同。 系统控制器维持能量存储系统，使得能量存储系统在第一模式期间保持第一量的存储电能，并且在第二模式期间维持第二量的电能。 系统控制器在第一时段的第一部分期间将能量存储系统维持在第一模式，并且在第一时段的第二部分期间将能量存储系统维持在第二模式。

    PROCESSES FOR PREPARING METFORMIN HYDROCHLORIDE
    10.
    发明申请
    PROCESSES FOR PREPARING METFORMIN HYDROCHLORIDE 审中-公开
    制备羟基氯化氢的方法

    公开(公告)号：WO2010146604A2

    公开(公告)日：2010-12-23

    申请号：PCT/IN2010/000417

    申请日：2010-06-17

    Applicant: EXEMED PHARMACEUTICALS ,  PATEL, Pranav, Dushyant ,  PATEL, Dinesh, Ramanlal

    Inventor： PATEL, Pranav, Dushyant ,  PATEL, Dinesh, Ramanlal

    IPC: C07C277/02

    CPC classification number: C07C277/08 ,  C07C277/02 ,  C07C279/26

    Abstract: A process for reducing dimethylamine content in metformin hydrochloride is disclosed. The process comprises: (a) providing metformin hydrochloride having dimethylamine content more than 15 ppm; (b) pulverizing the metformin hydrochloride; (c) slurrying the metformin hydrochloride in one or more Cj-C4 alcohol solvents; and (d) isolating the metformin hydrochloride.

    Abstract translation: 公开了一种降低二甲双胍盐酸盐中二甲胺含量的方法。 该方法包括：（a）提供二甲基胺含量大于15ppm的二甲双胍盐酸盐; （b）粉碎盐酸二甲双胍; （c）将盐酸二甲双胍在一种或多种Cj-C4醇溶剂中制浆; 和（d）分离盐酸二甲双胍。

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