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1.发明申请
公开(公告)号：WO2012170957A3
公开(公告)日：2013-04-11
申请号：PCT/US2012041761
申请日：2012-06-08
申请人： NITTO DENKO CORP , QUARK PHARMACEUTICALS INC , NNTSU YOSHIRO , PAYNE JOSEPH E , KNOPOV VICTOR , AKOPIAN VIO ETTA , W TTE RICHARD P , AHMADIAN MOHAMMAD , PERELMAN LOREN A , TANAKA YASUNOBU , FEINSTEIN ELENA , AVK N-NAHUM SHARON , KAL NSKI HAGAR , METT IGOR , MINOMI KENJIRO , Y NG WENBIN , LUI YUN
发明人： NNTSU YOSHIRO , PAYNE JOSEPH E , KNOPOV VICTOR , AKOPIAN VIO ETTA , W TTE RICHARD P , AHMADIAN MOHAMMAD , PERELMAN LOREN A , TANAKA YASUNOBU , FEINSTEIN ELENA , AVK N-NAHUM SHARON , KAL NSKI HAGAR , METT IGOR , MINOMI KENJIRO , Y NG WENBIN , LUI YUN
IPC分类号： C12N15/113 , A61K31/713 , C12N15/11
CPC分类号： A61K9/1271 , A61K9/127 , A61K31/713 , C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2320/32 , C12N2320/52
摘要： What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPTNHl_45a (SEQ ID NOS: 98 and 165), and SERPTNH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 espresssion, including fibrosis.
摘要翻译： 所描述的是包含双链核酸分子的药物组合物，所述双链核酸分子包含有义链和反义链，其中有义链和反义链选自描述为SERPINH1_2（SEQ ID NOS：60和127），SERPTNH1_45a（SEQ ID NO： NOS：98和165）和SERPTNH1_51（SEQ ID NOS：101和168），以及包含类视色素和脂质囊泡混合物的药物载体，以及使用这些药物组合物治疗与hsp47表达相关的疾病的方法，包括 纤维化。
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公开(公告)号：WO2010088518A3
公开(公告)日：2011-01-27
申请号：PCT/US2010022588
申请日：2010-01-29
申请人： KALYPSYS INC , KAHRAMAN MEHMET , SMITH NICHOLAS D , BONNEFOUS CELINE , NOBLE STEWART A , PAYNE JOSEPH E
IPC分类号： C07D487/14 , A61P3/00 , A61P3/10 , C07D403/14 , C07D487/04
CPC分类号： C07D487/04
摘要： Disclosed herein are compounds and methods which may be useful as inhibitors of GPRl 19 for the treatment or prevention of diseases including cardiovascular and metabolic diseases.
摘要翻译： 本文公开了可用作GPR111抑制剂用于治疗或预防包括心血管和代谢疾病在内的疾病的化合物和方法。
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公开(公告)号：WO2010014739A2
公开(公告)日：2010-02-04
申请号：PCT/US2009/052142
申请日：2009-07-29
IPC分类号： C07D487/04 , A61K31/395 , A61K31/13 , A61P31/18 , A61P25/28
CPC分类号： C07D475/02
摘要： Disclosed herein are compounds useful as modulators of TGR5 and methods for the treatment or prevention of metabolic, cardiovascular, and inflammatory diseases.
摘要翻译： 本文公开了用作TGR5调节剂的化合物以及用于治疗或预防代谢疾病，心血管疾病和炎性疾病的方法。
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公开(公告)号：WO2007117778A2
公开(公告)日：2007-10-18
申请号：PCT/US2007062769
申请日：2007-02-23
申请人： KALYPSYS INC , ROPPE JEFFREY R , BONNEFOUS CELINE , SMITH NICHOLAS D , LINDSTROM ANDREW K , NOBLE STEWART A , HASSIG CHRISTIAN A , PAYNE JOSEPH E , ZHUANG HUI , CHEN XIAOHONG , DURON SERGIO G
发明人： ROPPE JEFFREY R , BONNEFOUS CELINE , SMITH NICHOLAS D , LINDSTROM ANDREW K , NOBLE STEWART A , HASSIG CHRISTIAN A , PAYNE JOSEPH E , ZHUANG HUI , CHEN XIAOHONG , DURON SERGIO G
CPC分类号： C07D405/12 , A61K31/4704 , A61K31/4709 , C07D215/227 , C07D401/06 , C07D401/12 , C07D409/12
摘要： The present invention relates to novel quinolones of Formula (I) that inhibit inducible NOS synthase together with methods of synthesizing and using the compounds including methods for inhibiting or modulating nitric oxide synthesis and/or lowering nitric oxide levels in a patient by administering the compounds for the treatment of disease.
摘要翻译： 本发明涉及抑制诱导型NOS合成的新型喹诺酮，以及合成和使用化合物的方法，包括用于抑制或调节一氧化氮合成和/或降低患者一氧化氮水平的方法，所述方法包括给予 治疗疾病。
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5.发明申请NOVEL 2-OXO-1,2,3,4-TETRAHYDROPYRIMIDINES, BICYCLIC PYRIMIDINE DIONES AND IMIDAZOLIDINE-2,4-DIONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS 审中-公开新型2-氧代-1,2,3,4-四氢嘧啶，双环吡啶二酮和咪唑烷-2,4-二酮作为可诱导的氧化氮合酶抑制剂有用
公开(公告)号：WO2007101213A2
公开(公告)日：2007-09-07
申请号：PCT/US2007062903
申请日：2007-02-27
申请人： KALYPSYS INC , ROPPE JEFFREY R , ZHUANG HUI , CHEN XIAOHONG , BONNEFOUS CELINE , PAYNE JOSEPH E , SMITH NICHOLAS D , HASSIG CHRISTIAN A , NOBLE STEWART A
发明人： ROPPE JEFFREY R , ZHUANG HUI , CHEN XIAOHONG , BONNEFOUS CELINE , PAYNE JOSEPH E , SMITH NICHOLAS D , HASSIG CHRISTIAN A , NOBLE STEWART A
IPC分类号： A61K31/513 , A61K31/4166 , A61K31/519 , A61K31/522 , C07D211/86 , C07D211/90 , C07D403/10 , C07D405/04 , C07D413/10 , C07D417/10
CPC分类号： C07D239/22 , A61K31/4166 , A61K31/513 , A61K31/519 , A61K31/522 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D413/10 , C07D417/10
摘要： The present invention relates to novel 2-oxo-l,2,3,4-tetrahydropyrimidines, bicyclic pyrimidine diones and imidizolidine-2,4-diones and methods useful as inhibitors of nitric oxide synthase.
摘要翻译： 本发明涉及新的2-氧代-1,2,3,4-四氢嘧啶，双环嘧啶二酮和咪唑烷-2,4-二酮，以及可用作一氧化氮合酶抑制剂的方法。
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公开(公告)号：WO2006055381A3
公开(公告)日：2006-08-03
申请号：PCT/US2005040727
申请日：2005-11-10
申请人： MERCK & CO INC , MUNOZ BENITO , PAYNE JOSEPH E , PRASIT PETPIBOON , REGER THOMAS S , SMITH NICHOLAS D
IPC分类号： C07C69/02 , C07C317/00 , C07D243/08 , C07D311/80
CPC分类号： C07C69/24 , C07C53/128 , C07C257/14 , C07C317/46 , C07D217/02 , C07D311/80
摘要： Disclosed are prodrugs of (2R)-2-propyloctanoic acid, and pharmaceutical compositions comprising them, which may be effective in modulating multiple events in the biochemical cascade of stroke. Also disclosed are methods of treating patients who have had a stroke, or are at risk of stroke, by administering the compounds or compositions of the invention.
摘要翻译： 公开了（2R）-2-丙基辛酸的前药和包含它们的药物组合物，其可以有效调节中风的生物化学级联中的多个事件。 还公开了通过施用本发明的化合物或组合物来治疗患有中风或有中风风险的患者的方法。
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公开(公告)号：WO2006055404A3
公开(公告)日：2006-05-26
申请号：PCT/US2005/040851
申请日：2005-11-10
申请人： MERCK & CO., INC. , MUNOZ, Benito , PAYNE, Joseph, E. , PRASIT, Petpiboon , REGER, Thomas, S. , SMITH, Nicholas, D. , STOCK, Nicholas, S. , MCGUIRE, Angela, R.
发明人： MUNOZ, Benito , PAYNE, Joseph, E. , PRASIT, Petpiboon , REGER, Thomas, S. , SMITH, Nicholas, D. , STOCK, Nicholas, S. , MCGUIRE, Angela, R.
IPC分类号： A61K31/41 , A61K31/34 , A61K31/505 , C07D249/04 , C07D319/02 , C07D239/02
摘要： Disclosed are compounds for treating stroke, and pharmaceutical compositions comprising them, which may be effective in modulating multiple events in the biochemical cascade of stroke. Also disclosed are methods of treating patients who have had a stroke, or are at risk of stroke, by administering the compounds or compositions of the invention.
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公开(公告)号：WO2013185116A1
公开(公告)日：2013-12-12
申请号：PCT/US2013/044849
申请日：2013-06-07
申请人： PAYNE, Joseph, E. , GAUDETTE, John, A. , HOU, Zheng , AHMADIAN, Mohammad , YU, Lei , KNOPOV, Victor , AKOPIAN, Violetta , KARMALI, Priya , WITTE, Richard, P. , SAFARZADEH, Neda , YING, Wenbin , ZHANG, Jun
发明人： PAYNE, Joseph, E. , GAUDETTE, John, A. , HOU, Zheng , AHMADIAN, Mohammad , YU, Lei , KNOPOV, Victor , AKOPIAN, Violetta , KARMALI, Priya , WITTE, Richard, P. , SAFARZADEH, Neda , YING, Wenbin , ZHANG, Jun
IPC分类号： C07C271/16 , C07D333/40 , C07C317/44 , C07C321/14 , C07C333/04 , C07C235/08 , C07C237/08 , C07D207/16 , A61K47/16 , A61K47/18 , A61K47/22
CPC分类号： A61K47/20 , A61K9/1272 , A61K47/14 , A61K47/18 , A61K47/22 , C07C235/08 , C07C237/08 , C07C237/16 , C07C271/16 , C07C317/44 , C07C323/60 , C07C333/04 , C07D207/16 , C07D333/38 , C07D333/40 , Y10T428/2998
摘要： The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.
摘要翻译： 该描述针对可用于增强脂质体中治疗剂递送的可离子化脂质。
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公开(公告)号：WO2012170957A2
公开(公告)日：2012-12-13
申请号：PCT/US2012041761
申请日：2012-06-08
申请人： NITTO DENKO CORP , QUARK PHARMACEUTICALS INC , NNTSU YOSHIRO , PAYNE JOSEPH E , KNOPOV VICTOR , AKOPIAN VIO ETTA , W TTE RICHARD P , AHMADIAN MOHAMMAD , PERELMAN LOREN A , TANAKA YASUNOBU , FEINSTEIN ELENA , AVK N-NAHUM SHARON , KAL NSKI HAGAR , METT IGOR , MINOMI KENJIRO , Y NG WENBIN , LUI YUN
发明人： NNTSU YOSHIRO , PAYNE JOSEPH E , KNOPOV VICTOR , AKOPIAN VIO ETTA , W TTE RICHARD P , AHMADIAN MOHAMMAD , PERELMAN LOREN A , TANAKA YASUNOBU , FEINSTEIN ELENA , AVK N-NAHUM SHARON , KAL NSKI HAGAR , METT IGOR , MINOMI KENJIRO , Y NG WENBIN , LUI YUN
CPC分类号： A61K9/1271 , A61K9/127 , A61K31/713 , C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2320/32 , C12N2320/52
摘要： What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPTNHl_45a (SEQ ID NOS: 98 and 165), and SERPTNH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 espresssion, including fibrosis.
摘要翻译： 所描述的是包含包含有义链和反义链的双链核酸分子的药物组合物，其中有义链和反义链选自描述为SERPINH1_2的寡核苷酸（SEQ ID NO：60和127），SERPTNH1_45a（SEQ ID NO： NOS：98和165）和SERPTNH1_51（SEQ ID NO：101和168）和包含类视黄醇和脂质囊泡的混合物的药物载体，以及使用这些药物组合物治疗与hsp47浓缩有关的疾病的方法，包括 纤维化。
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10.发明申请
公开(公告)号：WO2011112731A3
公开(公告)日：2012-01-12
申请号：PCT/US2011027771
申请日：2011-03-09
申请人： KALYPSYS INC , BORCHARDT ALLEN , DAVIS ROBERT , BEAUREGARD CLAY , BECKER DANIEL , GAMACHE DANIEL , NOBLE STEWART A , HELLBERG MARK R , KLIMKO PETER G , ZHIHAI QUI , PAYNE JOSEPH E , YANNI JOHN
发明人： BORCHARDT ALLEN , DAVIS ROBERT , BEAUREGARD CLAY , BECKER DANIEL , GAMACHE DANIEL , NOBLE STEWART A , HELLBERG MARK R , KLIMKO PETER G , ZHIHAI QUI , PAYNE JOSEPH E , YANNI JOHN
IPC分类号： C07D471/04 , A61K31/437 , A61K31/519 , A61P29/00 , A61P37/00 , C07D487/04 , C07D498/04
CPC分类号： C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
摘要翻译： 本发明涉及可用作H1R和/或H4R抑制剂的化合物和方法，用于治疗或预防炎症，自身免疫，变应性和眼部疾病。
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